Article
Multidisciplinary Sciences
Alexander B. Smith, Matthew L. Jenior, Orlaith Keenan, Jessica L. Hart, Jonathan Specker, Arwa Abbas, Paula C. Rangel, Chao Di, Jamal Green, Katelyn A. Bustin, Jennifer A. Gaddy, Maribeth R. Nicholson, Clare Laut, Brendan J. Kelly, Megan L. Matthews, Daniel R. Evans, Daria Van Tyne, Emma E. Furth, Jason A. Papin, Frederic D. Bushman, Jessi Erlichman, Robert N. Baldassano, Michael A. Silverman, Gary M. Dunny, Boone M. Prentice, Eric P. Skaar, Joseph P. Zackular
Summary: Enterococci can shape the metabolic environment in the gut and enhance the fitness and pathogenesis of Clostridioides difficile through nutrient restriction and cross-feeding. This microbial interaction plays a role in the susceptibility to and the severity of C. difficile infection.
Article
Microbiology
Jennifer J. Dawkins, Jessica R. Allegretti, Travis E. Gibson, Emma McClure, Mary Delaney, Lynn Bry, Georg K. Gerber
Summary: This study conducted a longitudinal analysis of the gut microbiome and metabolome changes in patients with primary Clostridioides difficile infection (CDI). The results showed that metabolomic data can accurately predict the recurrence of CDI, providing important insights for the development of diagnostic tests and treatments.
Article
Multidisciplinary Sciences
Pieter de Jager, Oliver Smith, Stefan Bolon, Juno Thomas, Guy A. Richards
Summary: This study aimed to estimate the burden of Clostridioides difficile infection in the South African public sector. The incidence of CD in South Africa was found to be comparable to European countries but lower than that in the United States, with a relatively lower CD recurrence rate compared to high-income countries.
Article
Plant Sciences
Young-Jin Son, Young-Rok Kim, Sang-Hun Oh, Sungji Jung, Marco A. Ciufolini, Hee-Jong Hwang, Jin-Hwan Kwak, Hyunjoo Pai
Summary: Clostridioides difficile infection is a global health threat and micrococcin P2 (MP2) has shown promising results as an effective antimicrobial agent against the hypervirulent C. difficile strain through in vitro and in vivo studies.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Infectious Diseases
Elena Novakova, Zuzana Stofkova, Vladimira Sadlonova, Lukas Hleba
Summary: This study analyzed the phenotypic and genotypic characteristics of C. difficile isolates from patients with CDI in Slovakia, revealing a high prevalence of RT176 and 001.
Review
Microbiology
Joshua Heuler, Louis-Charles Fortier, Xingmin Sun
Summary: Clostridioides difficile, formerly known as Clostridium difficile, is the causative agent of C. difficile infections, which pose challenges in healthcare settings. Antibiotic-induced dysbiosis allows C. difficile colonization in the gut. Phage infection offers potential new treatment strategies against C. difficile infections.
FEMS MICROBIOLOGY REVIEWS
(2021)
Review
Microbiology
Joshua Heuler, Louis-Charles Fortier, Xingmin Sun
Summary: Clostridioides difficile, previously known as Clostridium difficile, is the causative agent of CDI. Antibiotics-induced dysbiosis of the microbiota is the primary factor allowing C. difficile to colonize the gut and cause diseases. Phages infecting C. difficile could offer new treatment strategies and insights into its biology.
FEMS MICROBIOLOGY REVIEWS
(2021)
Article
Gastroenterology & Hepatology
Kelsey E. Huus, Marcin Frankowski, Maja Pucic-Bakovic, Frano Vuckovic, Gordan Lauc, Benjamin H. Mullish, Julian R. Marchesi, Tanya M. Monaghan, Dina Kao, B. Brett Finlay
Summary: This study found that IgA-bacterial interactions are reestablished in human FMT recipients to resemble that of the healthy fecal donor. The data suggests that the IgA-bacterial interactions are influenced by the bacterial species and the fecal donor identity in the FMT recipients.
Review
Biochemistry & Molecular Biology
Katia Fettucciari, Alessandro Fruganti, Fabrizio Stracci, Andrea Spaterna, Pierfrancesco Marconi, Gabrio Bassotti
Summary: Clostridioides difficile (C. difficile) is a pathogen responsible for a significant number of gastrointestinal infections, with its toxins A and B playing a major role in its pathological activity. The spread of C. difficile in the human environment and its colonization in individuals have led to a global increase in C. difficile infection (CDI). CDI has been associated with the induction of senescent cells by C. difficile toxin B, and there is a direct correlation between CDI, irritable bowel syndrome (IBS), and inflammatory bowel diseases (IBD), which could result in the accumulation of senescent cells and potential functional consequences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Geraldine Moloney, David W. Eyre, Micheal Mac Aogain, Maire C. McElroy, Alison Vaughan, Tim E. A. Peto, Derrick W. Crook, Thomas R. Rogers
Summary: Genomic analysis of a diverse collection of Clostridioides difficile ribotype 078 isolates from Ireland and 9 countries in Europe revealed complex regional and international dissemination patterns, not limited to humans, but also affecting pigs. These isolates are associated with C. difficile colonization and clinical illness in both humans and pigs.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Pharmacology & Pharmacy
Jianwei Chen, Yasheng Li, Siqi Wang, Hongfang Zhang, Yujie Du, Qiang Wu, Hong Wang
Summary: This paper presents a refined focus on 16 FDA-approved drugs that could be further developed as potential anti-C. difficile drugs. Only ursodeoxycholic acid has entered Phase IV clinical trials so far. Drug repurposing promotes the study of mechanistic and therapeutic strategies, providing new options for the development of next-generation anti-C. difficile agents.
DRUG DISCOVERY TODAY
(2022)
Review
Microbiology
Mark A. Harrison, Henrik Strahl, Lisa F. Dawson
Summary: The pathogen Clostridioides difficile colonizes the gastrointestinal tract after antibiotic exposure, producing the antimicrobial compound para-cresol, which harmfully affects the beneficial gut microbiome and contributes to the pathogenesis and relapse of infection. Inhibiting this pathway could provide a specific therapeutic method.
CURRENT OPINION IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kamal Kant Sahu, Ajay Kumar Mishra, Vishal Jindal, Ahmad Daniyal Siddiqui, Susan George
Summary: This study investigated factors affecting the outcome of Clostridioides Difficile Infection in patients with solid tumors, revealing a significant association between high-risk qSOFA score and leukocytosis with higher morbidity rates.
Article
Microbiology
Brintha P. Girinathan, Nicholas DiBenedetto, Jay N. Worley, Johann Peltier, Mario L. Arrieta-Ortiz, Selva Rupa Christinal Immanuel, Richard Lavin, Mary L. Delaney, Christopher K. Cummins, Maria Hoffman, Yan Luo, Narjol Gonzalez-Escalona, Marc Allard, Andrew B. Onderdonk, Georg K. Gerber, Abraham L. Sonenshein, Nitin S. Baliga, Bruno Dupuy, Lynn Bry
Summary: Different species of Clostridia can protect against or worsen Clostridioides difficile infection in mice by modulating the pathogen's colonization, growth, and virulence through altering the gut-nutrient environment. This research lays the groundwork for mechanistically informed therapies to counter C. difficile disease using systems biology approaches to define host-commensal-pathogen interactions in vivo.
CELL HOST & MICROBE
(2021)
Review
Medicine, General & Internal
Ibrahim A. Al-Zahrani
Summary: Clostridioides difficile (C. difficile) infection is a global threat to many healthcare settings. Excessive use of antimicrobials, lack of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this health issue. Prudent use of antimicrobials and simple infection control measures can significantly reduce infection rates.
SAUDI MEDICAL JOURNAL
(2023)
