Contributions of human ACE2 and TMPRSS2 in determining host–pathogen interaction of COVID-19

Cross‐species transmission of the newly identified coronavirus 2019‐nCoV

(2020) Wei Ji et al.   JOURNAL OF MEDICAL VIROLOGY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study

(2020) Nanshan Chen et al.   LANCET

The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future

(2020) Jin-Yan Li et al.   MICROBES AND INFECTION

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

The effect of travel restrictions on the spread of the 2019 novel coronavirus (COVID-19) outbreak

(2020) Matteo Chinazzi et al.   SCIENCE

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation

(2020) Daniel Wrapp et al.   SCIENCE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Comparative genetic analysis of the novel coronavirus (2019-nCoV/SARS-CoV-2) receptor ACE2 in different populations

(2020) Yanan Cao et al.   Cell Discovery

The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

(2020) B. Coutard et al.   ANTIVIRAL RESEARCH

Spike protein recognition of mammalian ACE2 predicts the host range and an optimized ACE2 for SARS-CoV-2 infection

(2020) Junwen Luan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A review on the cleavage priming of the spike protein on coronavirus by angiotensin-converting enzyme-2 and furin

(2020) Anwarul Hasan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

An in-silico evaluation of different Saikosaponins for their potency against SARS-CoV-2 using NSP15 and fusion spike glycoprotein as targets

(2020) Saurabh K. Sinha et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural and Simulation analysis of hot spot residues interactions of SARS-CoV 2 with Human ACE2 receptor

(2020) Ganesh Kumar Veeramachaneni et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Molecular Docking, Simulation and MM-PBSA Studies of Nigella Sativa Compounds: A Computational Quest to identify Potential Natural Antiviral for COVID-19 Treatment

(2020) Sajjad Ahmad et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria

(2020) Imane Abdelli et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Withanone and withaferin-A are predicted to interact with transmembrane protease serine 2 (TMPRSS2) and block entry of SARS-CoV-2 into cells

(2020) Vipul Kumar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

First comprehensive computational analysis of functional consequences of TMPRSS2 SNPs in susceptibility to SARS-CoV-2 among different populations

(2020) Alireza Paniri et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Truncated human angiotensin converting enzyme 2; a potential inhibitor of SARS-CoV-2 spike glycoprotein and potent COVID-19 therapeutic agent

(2020) Abdul Basit et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Drug repurposing for coronavirus (COVID-19): in silico screening of known drugs against coronavirus 3CL hydrolase and protease enzymes

(2020) Ammar D. Elmezayen et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Identification of potential natural inhibitors of SARS-CoV2 main protease by molecular docking and simulation studies

(2020) Sanjay Gupta et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Antiviral Effects of Probiotic metabolites on COVID-19

(2020) Firoz Anwar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

The potential chemical structure of anti‐SARS‐CoV‐2 RNA‐dependent RNA polymerase

(2020) Jrhau Lung et al.   JOURNAL OF MEDICAL VIROLOGY

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

(2020) Mushtaq Hussain et al.   JOURNAL OF MEDICAL VIROLOGY

Predicting the angiotensin converting enzyme 2 (ACE2) utilizing capability as the receptor of SARS-CoV-2

(2020) Ye Qiu et al.   MICROBES AND INFECTION

Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2)

(2020) Noor Rahman et al.   MOLECULES

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19

(2020) Muthiah Vaduganathan et al.   NEW ENGLAND JOURNAL OF MEDICINE

A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2

(2020) Yan Wu et al.   SCIENCE

In Silico Discovery of Candidate Drugs against Covid-19

(2020) Claudia Cava et al.   Viruses-Basel

Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases

(2020) Cynthia Liu et al.   ACS Central Science

Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site

(2020) Umesh Kalathiya et al.   Journal of Clinical Medicine

Assessment of risk conferred by coding and regulatory variations of TMPRSS2 and CD26 in susceptibility to SARS-CoV-2 infection in human

(2020) Sabyasachi Senapati et al.   JOURNAL OF GENETICS

Candidate drugs against SARS-CoV-2 and COVID-19

(2020) Dwight L. McKee et al.   PHARMACOLOGICAL RESEARCH

Enhanced receptor binding of SARS-CoV-2 through networks of hydrogen-bonding and hydrophobic interactions

(2020) Yingjie Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses

(2020) Muhammad Adnan Shereen et al.   Journal of Advanced Research

Bat Coronaviruses in China

(2019) Yi Fan et al.   Viruses-Basel

Repurposing host-based therapeutics to control coronavirus and influenza virus

(2019) Cui-Cui Li et al.   DRUG DISCOVERY TODAY

Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2

(2017) Lennart Michel Reinke et al.   PLoS One

Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay

(2016) Mizuki Yamamoto et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Circulating ACE2 activity correlates with cardiovascular disease development

(2016) K. Uri et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

Protease inhibitors targeting coronavirus and filovirus entry

(2015) Yanchen Zhou et al.   ANTIVIRAL RESEARCH

Androgen-Induced TMPRSS2 Activates Matriptase and Promotes Extracellular Matrix Degradation, Prostate Cancer Cell Invasion, Tumor Growth, and Metastasis

(2015) C.-J. Ko et al.   CANCER RESEARCH

A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion

(2015) Wentao Li et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

Bat-to-human: spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond

(2015) Guangwen Lu et al.   TRENDS IN MICROBIOLOGY

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

TMPRSS2 Isoform 1 Activates Respiratory Viruses and Is Expressed in Viral Target Cells

(2015) Pawel Zmora et al.   PLoS One

Human intestine luminal ACE2 and amino acid transporter expression increased by ACE-inhibitors

(2014) Raphael N. Vuille-dit-Bille et al.   AMINO ACIDS

New Perspectives in the Renin-Angiotensin-Aldosterone System (RAAS) IV: Circulating ACE2 as a Biomarker of Systolic Dysfunction in Human Hypertension and Heart Failure

(2014) Katalin Úri et al.   PLoS One

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

(2014) Jean Kaoru Millet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor recognition and cross-species infections of SARS coronavirus

(2013) Fang Li   ANTIVIRAL RESEARCH

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

(2013) Daniela Meyer et al.   BIOCHEMICAL JOURNAL

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

(2013) A. Heurich et al.   JOURNAL OF VIROLOGY

Interspecies transmission and emergence of novel viruses: lessons from bats and birds

(2013) Jasper Fuk-Woo Chan et al.   TRENDS IN MICROBIOLOGY

Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts

(2012) Stephanie Bertram et al.   PLoS One

Ready, Set, Fuse! The Coronavirus Spike Protein and Acquisition of Fusion Competence

(2012) Taylor Heald-Sargent et al.   Viruses-Basel

Mechanisms of Coronavirus Cell Entry Mediated by the Viral Spike Protein

(2012) Sandrine Belouzard et al.   Viruses-Basel

Cleavage and Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by Human Airway Trypsin-Like Protease

(2011) S. Bertram et al.   JOURNAL OF VIROLOGY

Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

(2011) I. Glowacka et al.   JOURNAL OF VIROLOGY

A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry

(2010) A. Shulla et al.   JOURNAL OF VIROLOGY

Novel insights into proteolytic cleavage of influenza virus hemagglutinin

(2010) Stephanie Bertram et al.   REVIEWS IN MEDICAL VIROLOGY

Proteolytic Activation of the Spike Protein at a Novel RRRR/S Motif Is Implicated in Furin-Dependent Entry, Syncytium Formation, and Infectivity of Coronavirus Infectious Bronchitis Virus in Cultured Cells

(2009) Y. Yamada et al.   JOURNAL OF VIROLOGY

A protein complex in the brush-border membrane explains a Hartnup disorder allele

(2008) Sonja Kowalczuk et al.   FASEB JOURNAL