HMGA1-TRIP13 axis promotes stemness and epithelial mesenchymal transition of perihilar cholangiocarcinoma in a positive feedback loop dependent on c-Myc

Transcription factor 7 promotes the progression of perihilar cholangiocarcinoma by inducing the transcription of c-Myc and FOS-like antigen 1

(2019) Zengli Liu et al.   EBioMedicine

Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway

(2019) Rongqi Sun et al.   EBioMedicine

TRIP13 promotes the cell proliferation, migration and invasion of glioblastoma through the FBXW7/c-MYC axis

(2019) Guanghui Zhang et al.   BRITISH JOURNAL OF CANCER

A Small Molecule Inhibitor Targeting TRIP13 suppresses multiple myeloma progression

(2019) Yingcong Wang et al.   CANCER RESEARCH

Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle

(2019) Bo Qiu et al.   EBioMedicine

Lessons from the Crypt: HMGA1—Amping up Wnt for Stem Cells and Tumor Progression

(2018) Linda Resar et al.   CANCER RESEARCH

Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling

(2018) Yun-Fei Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

(2018) Claudio Alfieri et al.   NATURE

HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium

(2018) Yun-Fei Xu et al.   ONCOGENE

Silencing TRIP13 inhibits cell growth and metastasis of hepatocellular carcinoma by activating of TGF-β1/smad3

(2018) Jianning Yao et al.   Cancer Cell International

Klatskin Tumor

(2017) Ajith K. Siriwardena   JOURNAL OF CLINICAL ONCOLOGY

High mobility group A1 enhances tumorigenicity of human cholangiocarcinoma and confers resistance to therapy

(2017) Cristina Quintavalle et al.   MOLECULAR CARCINOGENESIS

Cholangiocarcinoma — evolving concepts and therapeutic strategies

(2017) Sumera Rizvi et al.   Nature Reviews Clinical Oncology

Prognostic significance of TBL1XR1 in predicting liver metastasis for early stage colorectal cancer

(2017) Hongda Liu et al.   SURGICAL ONCOLOGY-OXFORD

HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

(2017) Lingling Xian et al.   Nature Communications

A decade of transcription factor-mediated reprogramming to pluripotency

(2016) Kazutoshi Takahashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1

(2016) Chyi-Ying A. Chen et al.   NUCLEIC ACIDS RESEARCH

HMGA1 Expression in Human Hepatocellular Carcinoma Correlates with Poor Prognosis and Promotes Tumor Growth and Migration in in vitro Models

(2016) Mariacarla Andreozzi et al.   NEOPLASIA

Survival after resection of perihilar cholangiocarcinoma—development and external validation of a prognostic nomogram

(2015) B. Groot Koerkamp et al.   ANNALS OF ONCOLOGY

Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer

(2015) Elisa Maurizio et al.   MOLECULAR & CELLULAR PROTEOMICS

High-mobility group box 1 expression and lymph node metastasis in intrahepatic cholangiocarcinoma

(2015) Yun-Fei Xu et al.   WORLD JOURNAL OF GASTROENTEROLOGY

FBXW7 suppresses epithelial-mesenchymal transition, stemness and metastatic potential of cholangiocarcinoma cells

(2015) Hui Yang et al.   Oncotarget

TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

(2015) Qiaozhen Ye et al.   eLife

Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma

(2014) Yun-Fei Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

(2014) Hong-Mei Wang et al.   CELL RESEARCH

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

The effect of forced growth of cells into 3D spheres using low attachment surfaces on the acquisition of stemness properties

(2013) Guannan Su et al.   BIOMATERIALS

The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer

(2012) Bethany M. Bush et al.   CELL BIOCHEMISTRY AND FUNCTION

Losing balance: the origin and impact of aneuploidy in cancer

(2012) Andrew J Holland et al.   EMBO REPORTS

The High Mobility Group A1 Gene: Transforming Inflammatory Signals into Cancer?

(2010) L. M.S. Resar   CANCER RESEARCH

Cisplatin plus Gemcitabine versus Gemcitabine for Biliary Tract Cancer

(2010) Juan Valle et al.   NEW ENGLAND JOURNAL OF MEDICINE

HMGA1 Is Induced by Wnt/β-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer

(2009) Shin-ichi Akaboshi et al.   AMERICAN JOURNAL OF PATHOLOGY

Frequent overexpression of HMGA1 and 2 in gastroenteropancreatic neuroendocrine tumours and its relationship to let-7 downregulation

(2009) M M Rahman et al.   BRITISH JOURNAL OF CANCER

HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma

(2009) Alexandra C Hristov et al.   MODERN PATHOLOGY