Article
Biochemistry & Molecular Biology
Hanzhang Zhu, Weijiang Zhou, Yafeng Wan, Jun Lu, Ke Ge, Changku Jia
Summary: This study investigated the treatment benefit of a reactive oxygen species (ROS)-responsive Ptx nanoprodrug for liver cancer. The results showed that the PPa/Ptx NPs exhibited superior cytotoxicity to HepG2 cells and decreased tumor growth when combined with light irradiation, indicating their potential as a promising treatment option for liver cancer.
Article
Engineering, Biomedical
Panpan Sun, Le Jia, Jun Hai, Siyu Lu, Fengjuan Chen, Kun Liang, Shihao Sun, Hanwen Liu, Xu Fu, Yanhong Zhu, Baodui Wang
Summary: A novel CO prodrug system has been developed, which releases sufficient quantities of CO and radicals to destruct cancer cells through a coordination assembled strategy, while maintaining non-toxicity to surrounding normal tissues.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li, Xuanrong Sun
Summary: The lytic peptide PTP7-drug paclitaxel conjugate assembling nanoparticles (PPP) is a targeted anti-tumor drug that can respond to dual stimuli in the tumor microenvironment, providing passive tumor-targeted delivery and on-demand release of a tumor lytic peptide (PTP-7) as well as a chemotherapeutic agent of paclitaxel (PTX).
Article
Engineering, Biomedical
Ping Huang, Yao Yang, Wenyan Wang, Zimu Li, Nansha Gao, Hongzhong Chen, Xiaowei Zeng
Summary: We report a multifunctional nanoprodrug platform that combines ferroptosis, photothermal therapy, and immunotherapy to awaken immune responses and block the indoleamine 2,3-diox-ygenase (IDO) pathway, thereby overcoming the limitations of tumor immunotherapy. The platform improved the delivery efficiency of indoximod (IND) and strengthened immune response through the self-driven release of IND and the amplification of oxidative stress. This study provides a new perspective on immunotherapeutics for cancer treatment.
Review
Biochemistry & Molecular Biology
Victor Albarran, Diana Isabel Rosero, Jesus Chamorro, Javier Pozas, Maria San Roman, Ana Maria Barrill, Victor Alia, Pilar Sotoca, Patricia Guerrero, Juan Carlos Calvo, Inmaculada Orejana, Patricia Perez de Aguado, Pablo Gajate
Summary: Metastatic urothelial cancer is a major cause of cancer-related death, but new treatment approaches targeting Her-2 show promise, especially with the emergence of antibody-drug conjugates as a novel therapy for advanced cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Guanghui Hou, Junmin Qian, Min Guo, Weijun Xu, Jinlei Wang, Yaping Wang, Aili Suo
Summary: This study developed a multifunctional coordination nanoprodrug HBCI based on unique cisplatin-hydrazide and cisplatin-indocyanine green (ICG) coordination reactions. The nanoprodrug exhibited high drug loading efficiency and dual-responsive drug release behavior, showing potential in treating hepatocellular carcinoma.
CARBOHYDRATE POLYMERS
(2022)
Article
Oncology
Aaron J. Sorrin, Cindy Liu, Julia Cicalo, Jocelyn Reader, Daniel Najafali, Yuji Zhang, Dana M. Roque, Huang-Chiao Huang
Summary: The study investigated the combination of photodynamic priming and prostaglandin E receptor 4 inhibition in reducing ovarian cancer cell migration and invasion, showing promising results in attenuating metastatic behavior. The synergistic effects of the combination therapy were found to be mediated by key signaling pathways, providing insights for developing targeted strategies in cancer treatment.
Article
Chemistry, Multidisciplinary
Zheng Liu, Zhiyuan Feng, Mohan Chen, Jiayin Zhan, Rong Wu, Yang Shi, Yunsheng Xue, Ran Liu, Jun-Jie Zhu, Jingjing Zhang
Summary: A nanoprodrug based on CRISPR-Cas13d was designed for the optical modulation of gene editing and prodrug release, effectively improving cancer therapy. The experiment showed that the nanoprodrug could control gene editing and drug release through light activation, and successfully eliminated primary tumors and prevented liver metastasis. This study expands the research in gene editing and nanomedicine, accelerating the discovery of new therapeutic approaches.
Article
Chemistry, Multidisciplinary
Haisen Zhou, Yaoyi Wang, Yingqin Hou, Zhengkui Zhang, Qi Wang, Xiaodong Tian, Hua Lu
Summary: Nanoscale drug delivery systems (NDDSs) have the potential to improve therapeutic efficacy by co-delivering multiple drugs. However, most co-delivery systems are complicated. In this study, a polymeric material mPEG-b-PpY was used as a multifunctional carrier for the facile fabrication of PtCeNP, which can co-deliver cisplatin and photosensitizer Ce6. PtCeNP demonstrated improved solubility, cellular uptake, and bioavailability of the drugs, and showed strong synergistic antitumor efficacy both in vitro and in vivo.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jinseong Kim, Man Kyu Shim, Suah Yang, Yujeong Moon, Sukyung Song, Jiwoong Choi, Jeongrae Kim, Kwangmeyung Kim
Summary: The study presents a potent and safe cancer-specific combination therapy strategy using DOX prodrug nanoparticles and Bcl-2 inhibitor Navitoclax to overcome acquired drug resistance during chemotherapy, showing enhanced therapeutic efficacy in mouse models and reduced systemic toxic side effects in normal organs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Yajing Du, Lulu Luo, Xinru Xu, Xinbing Yang, Xueni Yang, Shizheng Xiong, Jiafeng Yu, Tingming Liang, Li Guo
Summary: Chemotherapy is a main method of cancer treatment, but the resistance of cancer cells to these drugs hampers their effectiveness. Synthetic lethality, which involves the simultaneous mutation of two non-lethal genes leading to specific cell death, has emerged as a promising approach to enhance the sensitivity of cancer cells to chemotherapy drugs.
Article
Chemistry, Multidisciplinary
Xiaohan Liu, Yanhua Li, Kaiye Wang, Yuanyuan Chen, Mingwan Shi, Xia Zhang, Wei Pan, Na Li, Bo Tang
Summary: The study synthesized a nanoprodrug that can inhibit glycolysis of cancer cells and alleviate the immunosuppressive microenvironment by releasing two drugs, which increased intracellular oxidative stress and induced immunogenic cell death of cancer cells. This strategy opens up new possibilities for exploring dimeric prodrugs for synergistic cancer therapy.
Article
Chemistry, Multidisciplinary
Wen Su, Wei Qiu, Shu-Jin Li, Shuo Wang, Jun Xie, Qi-Chao Yang, Jiming Xu, Junjie Zhang, Zhigang Xu, Zhi-Jun Sun
Summary: This study reports a combinational therapeutic strategy that combines tumor microenvironment-reactive oxygen species/pH dual-responsive signal transducers and activators of transcription 3 inhibitor nanoprodrugs with oncolytic herpes simplex virus 1 virotherapy to enhance immunotherapy. This strategy successfully activates robust T-cell-dependent antitumor responses, potentiating immune checkpoint blockade effects against local recurrence and pulmonary metastasis in preclinical cold murine triple-negative breast cancer and syngeneic oral cancer models.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Rui Gu, Wanlan Yang, Lifei Han, Chao Liu, Yatao Xu, Yunlong Liu, Weili Si, Wenjun Wang, Xiaochen Dong
Summary: A tumor microenvironment and photo-responsive CO nanoplatform Ca-Flav nanoparticles were developed, which could release CO in both normoxia and hypoxia conditions upon irradiation at tumor lesion. In vitro experiments demonstrated that CO could activate endoplasmic reticulum stress-related signal pathways, resulting in mitochondrial dysfunction and cell apoptosis. The Ca-Flav NPs showed excellent biocompatibility and tumor inhibition effect in vivo, providing new insight into CO as a potential treatment.
Article
Chemistry, Multidisciplinary
Rajan Sharma Bhattarai, Virender Kumar, Svetlana Romanova, Jitender Bariwal, Hao Chen, Shanshan Deng, Vijaya R. Bhatt, Tatiana Bronich, Wei Li, Ram Mahato
Summary: CH-3-8, a novel microtubule polymerization inhibitor, showed significant anti-proliferative effects on pancreatic cancer cells and induced apoptosis. Conjugating CH-3-8 with dodecanol and encapsulating it in nanoparticles resulted in high drug loading and potential for enhanced therapeutic outcomes against pancreatic cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)