4.7 Article

A novel hydrogel with self-healing property and bactericidal activity

期刊

JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 584, 期 -, 页码 484-494

出版社

ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2020.09.105

关键词

Dynamic crosslinked hydrogel; Wound dressings; Self-healing; Bactericidal activity

资金

  1. National Key R&D Program of China [2016YFD0400203]
  2. National Natural Science Foundation of China [31771914, 31800498]
  3. Research on science and technology of education department of Liaoning province project [J2020058]

向作者/读者索取更多资源

The novel VNV hydrogel dressing with good self-healing properties and bactericidal activity can effectively accelerate wound healing and has potential applications in wound dressings.
In this study, we have designed and synthesized a novel poly (4 - vinyl benzene boronic acid - co - N - vinyl pyrrolidone - co - 1 - vinyl - 3 - butylimidazolium bromide) hydrogel (VNV hydrogel) dressing with good self-healing properties and bactericidal activity. The gelation and self-healing of this hydrogel are mainly achieved by the formation of a dynamic B-O-B bond between the polymer chains, which is fractured by external forces and subsequently reformed. This self-healing mechanism is studied in detail through the molecular design of the hydrogel. The introduction of hydrophilic chemical groups can effectively improve the porous structures, water absorption and molecular migration. These properties have a positive effect on improving self-healing properties of dynamic crosslinked hydrogels. Furthermore, this VNV hydrogel dressing displays good antibacterial activity against E. coli, S. aureus, and C. albicans. The application of VNV hydrogel dressing on rat wound surface can effectively accelerate wound healing. These results indicate that this novel VNV hydrogel dressing with good self-healing properties and bactericidal activity has potential applications in wound dressings. (C) 2020 Elsevier Inc. All rights reserved.

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