Glucosylceramide synthase inhibitors prevent replication of SARS-CoV-2 and Influenza virus

Glucosylceramide synthase maintains influenza virus entry and infection

(2020) Kelly Drews et al.   PLoS One

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

Glucosylceramidase Maintains Influenza Infection By Regulating Endocytosis

(2019) Kelly Drews et al.   JOURNAL OF VIROLOGY

Challenges and opportunities with drug repurposing: finding strategies to find alternative uses of therapeutics

(2019) Alan Talevi et al.   Expert Opinion on Drug Discovery

Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes

(2018) Nunya Chotiwan et al.   PLoS Pathogens

Management and monitoring recommendations for the use of eliglustat in adults with type 1 Gaucher disease in Europe

(2017) Nadia Belmatoug et al.   European Journal of Internal Medicine

A role for glycolipid biosynthesis in severe fever with thrombocytopenia syndrome virus entry

(2017) Mary Jane Drake et al.   PLoS Pathogens

Induction of the type I interferon response in neurological forms of Gaucher disease

(2016) Einat B. Vitner et al.   Journal of Neuroinflammation

CNS-accessible Inhibitor of Glucosylceramide Synthase for Substrate Reduction Therapy of Neuronopathic Gaucher Disease

(2016) John Marshall et al.   MOLECULAR THERAPY

Cytomegalovirus Restructures Lipid Rafts via a US28/CDC42-Mediated Pathway, Enhancing Cholesterol Efflux from Host Cells

(2016) Hann Low et al.   Cell Reports

Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases—Not Glycolipid Processing Enzymes

(2016) Andrew C. Sayce et al.   PLoS Neglected Tropical Diseases

A Lipidomics Approach in the Characterization of Zika-Infected Mosquito Cells: Potential Targets for Breaking the Transmission Cycle

(2016) Carlos Fernando Odir Rodrigues Melo et al.   PLoS One

Effect of Oral Eliglustat on Splenomegaly in Patients With Gaucher Disease Type 1

(2015) Pramod K. Mistry et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Eliglustat tartrate

(2014) J.A. Shayman   DRUGS OF THE FUTURE

Strain-specific antiviral activity of iminosugars against human influenza A viruses

(2014) S. Hussain et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lipidomics identifies a requirement for peroxisomal function during influenza virus replication

(2014) Lukas Bahati Tanner et al.   JOURNAL OF LIPID RESEARCH

Modulation of Hepatitis C Virus Genome Replication by Glycosphingolipids and Four-Phosphate Adaptor Protein 2

(2014) I. Khan et al.   JOURNAL OF VIROLOGY

Sphingolipid lysosomal storage disorders

(2014) Frances M. Platt   NATURE

Liposome-Mediated Delivery of Iminosugars Enhances Efficacy against Dengue VirusIn Vivo

(2012) Joanna L. Miller et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection

(2012) Wenquan Yu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Systemic Delivery of a Glucosylceramide Synthase Inhibitor Reduces CNS Substrates and Increases Lifespan in a Mouse Model of Type 2 Gaucher Disease

(2012) Mario A. Cabrera-Salazar et al.   PLoS One

Inhibitors of Endoplasmic Reticulum α-Glucosidases Potently Suppress Hepatitis C Virus Virion Assembly and Release

(2010) Xiaowang Qu et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Targeting a host process as an antiviral approach against dengue virus

(2010) Andrew C. Sayce et al.   TRENDS IN MICROBIOLOGY

N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome delivery

(2008) Stephanie Pollock et al.   AIDS

Influenza Virus Infection Augments NK Cell Inhibition through Reorganization of Major Histocompatibility Complex Class I Proteins

(2008) H. Achdout et al.   JOURNAL OF VIROLOGY