Article
Multidisciplinary Sciences
Chih-Wei Lin, Tianqing Zheng, Geramie Grande, Alex R. Nanna, Christoph Rader, Richard A. Lerner
Summary: This study successfully identified an effective target TrkB for triple-negative breast cancer treatment, and demonstrated its potential efficacy and selectivity through the development of specific ADCs format.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Tianfeng Yang, Runze Yu, Cheng Cheng, Jian Huo, Zhengyan Gong, Hanbing Cao, Yu Hu, Bingling Dai, Yanmin Zhang
Summary: This study reveals that cantharidin may be a potential candidate for TNBC treatment by downregulating EGFR through miR-607. It inhibits TNBC cell growth and induces apoptosis. Mechanistic study shows that cantharidin blocks the downstream PI3K/AKT/mTOR and ERK/MAPK signaling pathways.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Pratelli, Daniela Carlisi, Diana Di Liberto, Antonietta Notaro, Michela Giuliano, Antonella D'Anneo, Marianna Lauricella, Sonia Emanuele, Giuseppe Calvaruso, Anna De Blasio
Summary: TNBC is an aggressive subtype of breast cancer characterized by resistance to anoikis, high invasiveness, and metastatic potential, as well as epithelial-mesenchymal transition (EMT) and stemness features. Inhibition of MCL1 using A-1210477 BH3-mimetic promotes anoikis/apoptosis, impairs focal adhesions, reduces migration and invasiveness, and downregulates EMT and stemness markers in MDA-MB-231 cell line.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Ibrahim H. Eissa, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Dalal Z. Husein, Ibrahim M. Ibrahim, Bshra A. Alsfouk, Ahmed S. Doghish, Hesham A. El-Mahdy, Ahmed M. Kenawy, Nehal El-Deeb, Ahmed M. Metwaly
Summary: A new EGFR inhibitor T-1-MMPA was developed and found to effectively bind to and inhibit EGFR protein through computational studies and in vitro experiments. It exhibited anticancer potential against triple-negative breast cancer and other cancer cell lines.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Oncology
Siang-Boon Koh, Kenneth Ross, Steven J. Isakoff, Nsan Melkonjan, Lei He, Karina J. Matissek, Andrew Schultz, Erica L. Mayer, Tiffany A. Traina, Lisa A. Carey, Hope S. Rugo, Minetta C. Liu, Vered Stearns, Adam Langenbucher, Srinivas Vinod Saladi, Sridhar Ramaswamy, Michael S. Lawrence, Leif W. Ellisen
Summary: This study identifies high levels of RASAL2 as predictors of chemotherapy response and long-term outcomes in TNBC. RASAL2 rewires MAPK feedback and cross-talk to confer resistance to MEK1/2 and EGFR inhibitors while also indicating sensitivity to these inhibitors.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Xia Liu, Valery Adorno-Cruz, Ya-Fang Chang, Yuzhi Jia, Madoka Kawaguchi, Nurmaa K. Dashzeveg, Rokana Taftaf, Erika K. Ramos, Emma J. Schuster, Lamiaa El-Shennawy, Dhwani Patel, Youbin Zhang, Massimo Cristofanilli, Huiping Liu
Summary: Research has shown that inhibiting EGFR can block the circulating cancer stem cell (cCSC) clustering and lung metastasis of triple-negative breast cancer (TNBC). In addition to CD44, microRNA-30c also plays a negative regulatory role in cCSC clustering and lung metastasis.
Article
Oncology
Xiyin Li, Hairui Wang, Xing Yang, Xiaoqi Wang, Lina Zhao, Li Zou, Qin Yang, Zongliu Hou, Jing Tan, Honglei Zhang, Jianyun Nie, Baowei Jiao
Summary: Through research, it was found that GABRP can sustain the stemness of TNBC by modulating EGFR expression, affecting sensitivity to chemotherapy drugs, indicating that GABRP may be a potential therapeutic target.
Article
Cell Biology
Heizel Rosado-Galindo, Maribella Domenech
Summary: This study demonstrates that surface roughness can influence oncogenic activity in triple-negative breast cancer (TNBC) cells and enrich cancer stem cell (CSC) populations in planar cultures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Oncology
Marine Lemesle, Marine Geoffroy, Fabien Alpy, Catherine-Laure Tomasetto, Sandra Kuntz, Isabelle Grillier-Vuissoz
Summary: This study investigated the role of CLDN1 in triple-negative breast cancer (TNBC) and found that CLDN1 can increase the sensitivity of TNBC cells to chemotherapy drugs. The findings support the use of CLDN1 as a predictive marker for chemotherapy response in TNBC.
Article
Biochemistry & Molecular Biology
Chaoyu Zhang, Wenjie Sheng, Marwah Al-Rawe, T. M. Mohiuddin, Marcus Niebert, Felix Zeppernick, Ivo Meihold-Heerlein, Ahmad Fawzi Hussain
Summary: This study developed promising antibody drug conjugates (ADCs) for the treatment of triple-negative breast cancer (TNBC) by conjugating benzylguanine (BG)-modified monomethyl auristatin E (MMAE) to EpCAM- and EGFR-specific SNAP-tagged single chain antibody fragments (scFvs). The ADCs showed specific cytotoxicity to EGFR or EpCAM positive cell lines, making them potential targeted therapies for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Medicine, General & Internal
Ryan Sun, Lee-Jen Wei
Summary: This article discusses the clinical benefits of pembrolizumab combined with chemotherapy in patients with triple-negative breast cancer. The authors suggest that both hazard values and ratios should be considered when evaluating clinical benefits.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Xu Yang, Li Deng, Xianhong Diao, Siyuan Yang, Li Zou, Qin Yang, Jian Li, Jianyun Nie, Lina Zhao, Baowei Jiao
Summary: The compound zinc pyrithione (ZnPT) has been identified as a potent inhibitor of triple-negative breast cancer (TNBC) progression by disrupting copper homeostasis, offering a potential experimental foundation for exploring cuproptosis as a target for drug discovery in TNBC patients.
Article
Cell Biology
Xinghan Wu, Huan Sheng, Liping Zhao, Mingxia Jiang, Han Lou, Yue Miao, Ni Cheng, Weifen Zhang, Dejun Ding, Wentong Li
Summary: This study found that inhibition of EGFR can reduce the proportion of CD24(low)CD44(high) cells and the size of tumor spheres in TNBC cells, and promote the expression of LC3B-II through the YAP/mTOR signaling pathway, thus contributing to ferroptosis. Combined treatment with lapatinib and PAB can inhibit the viability of TNBC cells and the formation of tumor spheres, accompanied by increased intracellular ROS levels.
CELL DEATH & DISEASE
(2022)
Article
Biotechnology & Applied Microbiology
Quanyuan Wan, Zihua Zeng, Jianjun Qi, Zhenghu Chen, Xiaohui Liu, Youli Zu
Summary: The study demonstrates the effectiveness of targeted chemotherapy for triple-negative breast cancer using a DNA nanoparticle to deliver doxorubicin to cancer cells, showing promising results in vitro and in animal experiments while potentially reducing side effects for patients.
Article
Oncology
Rui Han, Hongxing Yang, Changquan Ling, Lingeng Lu
Summary: In this study, the therapeutic potential of Tiliroside (TS) in triple negative breast cancer (TNBC) was evaluated. The results showed that TS exhibited anti-cancer activity, reduced tumor burden, and improved survival rate in TNBC. Additionally, TS acted as a CAXII inhibitor to suppress TNBC progression.
CANCER CELL INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Manigandan Nagarajan, Gobichettipalayam Balasubramaniam Maadurshni, Jeganathan Manivannan
Summary: This study found that exposure to BPA exacerbates hypertension-induced pathological changes, including renal fibrosis, oxidative stress, elevated angiotensin-converting enzyme activity, dysfunction of antioxidant and tricarboxylic acid cycle enzymes, tissue lipid abnormalities, and expression of inflammatory factors. In addition, high levels of BPA have dose-dependent effects on kidney cells, including oxidative stress, mitochondrial dysfunction, and lipid peroxidation. Therefore, a precise investigation of BPA exposure in hypertensive populations is highly recommended during risk assessment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Haiping Bao, Qiang Zhang, Yu Li, Chen Nie
Summary: In this study, the role of circDLGAP4 in Parkinson's disease (PD) was investigated. The results showed that circDLGAP4 upregulated HMGA2 by recruiting EIF4A3, thus alleviating neuronal injury in PD.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Lina Yang, Tianwei He, Yanming Yu
Summary: This study found that uric acid induces kidney injury by inducing IL-17 expression, and treatment with anti-IL-17 antibody can alleviate uric acid-induced kidney injury.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ediandra T. Castro, Amalia G. Alves, Daniela de Bittencourt Maia, Larissa S. Magalhaes, Mariana P. Paim, Filipe Penteado, Caroline S. Gomes, Eder J. Lenardao, Cesar A. Bruning, Cristiani F. Bortolatto
Summary: This study investigated the antioxidant activity and toxicity of selenium-containing compounds in liver tissue. The results showed that these compounds have potential antioxidant effects, which can be attributed to their ability to scavenge free radicals and mimic enzyme activity. Additionally, one of the compounds exhibited low toxicity.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2024)