Article
Neurosciences
Meaghan V. Perdue, Marilena M. DeMayo, Tiffany K. Bell, Elodie Boudes, Mercedes Bagshawe, Ashley D. Harris, Catherine Lebel
Summary: Metabolites in the brain have important roles in development, with rapid changes during prenatal and infancy stages. However, there is limited research on neurochemistry changes in early-middle childhood. In this study, we analyzed the levels of key metabolites in two brain regions using magnetic resonance spectroscopy in children aged 2-11 years. We found significant age-related changes in metabolite levels, suggesting their involvement in structural and functional brain development.
Article
Clinical Neurology
Noreen Rahmani, Jessica Hatch, Mikaela Dimick, Melanie R. Naiberg, Lisa Fiksenbaum, Ana C. Andreazza, Christopher R. Bowie, Daniel P. Dickstein, Benjamin Goldstein
Summary: Inflammatory markers have an impact on neurocognitive function in adolescents with BD, with more balanced pro-to anti-inflammatory ratios associated with better neurocognitive flexibility. Prospective studies are needed to assess the direction of these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Jiayue Chen, Shaohong Zou, Yuan Qu, Cheng Zhang, Yi Zhang, Xiaoxiao Tang, Yongfang Ren
Summary: The study analyzed brain biochemical metabolism in BD patients with and without anxiety symptoms using 1H-MRS, finding higher levels of inositol metabolism in the right PWM of BD patients with anxiety symptoms and decreased membrane phospholipid catabolism in the left PWM with increasing age and onset age.
PSYCHIATRY RESEARCH
(2021)
Article
Clinical Neurology
David J. Bond, Ana C. Andreazza, Ivan J. Torres, William G. Honer, Raymond W. Lam, Lakshmi N. Yatham
Summary: This study found that inflammation, measured by a composite measure of total peripheral inflammation, is associated with lower white matter volumes in the frontal and temporal lobes of patients with early-stage BD. Total inflammation is a stronger predictor of lower white matter volumes than individual cytokines.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Jonathan Chabert, Etienne Allauze, Bruno Pereira, Carine Chassain, Ingrid De Chazeron, Jean-Yves Rotge, Philippe Fossati, Pierre-Michel Llorca, Ludovic Samalin
Summary: The levels of neurometabolites such as Glutamate, Glutamine, Glx, and N-acetylaspartate in various brain regions differ in patients with bipolar disorder. The altered levels of NAA and Gln may be associated with the pathogenesis of bipolar disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Hartej Gill, Nelson B. Rodrigues, Rodrigo B. Mansur, CeAnn A. Marks, Joshua D. DiVincenzo, Felicia Ceban, Joshua D. Rosenblat, Bing Cao, Jonathan M. Lieberman, Roger Ho, Roger S. McIntyre
Summary: This study aimed to evaluate the antidepressant effects of adjunctive infliximab treatment in BD patients and understand its impact on cardiovascular disease (CVD) risk. The results showed no significant differences between the infliximab-treated and placebo group in terms of Framingham risk scores (FRS), mean arterial blood pressure (MAP), and total cholesterol (TC). This suggests that immune system targets have complex effects on CVD in psychiatric populations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
Jun Shen, Jyoti Singh Tomar
Summary: Elevated brain glutamate levels in bipolar disorder may be explained by increased pyruvate carboxylase-mediated anaplerosis. Supporting evidence suggests that this mechanism is common in glutamatergic hyperactivity in bipolar disorder, as well as a positive association between bipolar disorder and obesity.
FRONTIERS IN PSYCHIATRY
(2021)
Review
Clinical Neurology
Domenico Sciortino, Alessandro Pigoni, Giuseppe Delvecchio, Eleonora Maggioni, Giandomenico Schiena, Paolo Brambilla
Summary: The results suggest that repeated Transcranial Magnetic Stimulation (rTMS) may improve cognitive symptoms in patients with Bipolar Disorder (BD) but shows limited efficacy in patients with Schizophrenia (SCZ). However, the conclusions are limited by the use of different rTMS protocols in the studies.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Neurosciences
Kirti Saxena, Alessio Simonetti, Christopher D. Verrico, Delfina Janiri, Marco Di Nicola, Antonello Catinari, Sherin Kurian, Johanna Saxena, Benson Mwangi, Jair C. Soares
Summary: The study investigates cerebellar and cognitive alterations in youth with pediatric bipolar disorder (PBD) and those at high risk (BD-OFF) to develop the disorder. Results show that youth with PBD have larger cerebellar gray matter volumes compared to BD-OFF and healthy controls, and both PBD and BD-OFF have altered emotion processing and a bias towards positive emotions. The impairment in emotion processing is correlated with greater cerebellar gray matter volumes in both groups.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Clinical Neurology
Roger S. McIntyre, Yena Lee, Nelson B. Rodrigues, Flora Nasri, Guohui Lao, Wan Zeng, Biru Ye, Ripeng Li, Joshua D. Rosenblat, Rodrigo B. Mansur, Mehala Subramaniapillai, Leanna M. W. Lui, Kayla M. Teopiz, Tao Liu, Jiaqi Xiong, Ruoxi Zhang, Weicong Lu, Guiyun Xu, Xiong Huang, Kangguang Lin
Summary: This pilot study investigated the effects of rTMS on cognitive function in patients with bipolar disorder, demonstrating significant improvements in select cognitive domains for the active rTMS group compared to the sham group. No dyscognitive effects were observed across subdomains.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Amy T. Peters, Caitlin E. Millett, Jessica Harder, Julia Potter, Raina Fichorova, Andrew A. Nierenberg, Katherine E. Burdick
Summary: The study revealed a correlation between peripheral inflammation and reduced negative target discriminability, as well as faster response times in individuals with bipolar disorder. This suggests that inflammation may be implicated in cognitive-affective processing, warranting further research.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Psychiatry
T. Jordan Walter, Nina Pocuca, Jared W. Young, Mark A. Geyer, Arpi Minassian, William Perry
Summary: Most studies suggest that cannabis use in bipolar disorder is not significantly associated with cognitive impairment, but the scope of knowledge in this field is limited, requiring more systematic research.
PSYCHIATRY RESEARCH
(2021)
Review
Psychiatry
Khushbu Agarwal, Peter Manza, Marquis Chapman, Nafisa Nawal, Erin Biesecker, Katherine McPherson, Evan Dennis, Allison Johnson, Nora D. Volkow, Paule V. Joseph
Summary: Chronic exposure to addictive drugs and stressors can increase brain vulnerability to inflammation, leading to compromised blood-brain barrier, abnormal neuronal activity, altered neuroplasticity, impaired cognitive control, and eventually promoting compulsive drug-use behaviors and worsened mood disorders.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Behavioral Sciences
Aadil Bharwani, Jake C. Szamosi, Valerie H. Taylor, Yena Lee, Asem Bala, Rodrigo Mansur, Mehala Subramaniapillai, Michael Surette, Roger S. McIntyre
Summary: The study examined the impact of infliximab treatment on the gut microbiome of BD patients, and found no overall changes in microbiota diversity and profile after treatment.
BRAIN AND BEHAVIOR
(2021)
Article
Psychology, Clinical
David J. Bond, Leonardo E. Silveira, Ivan J. Torres, Raymond W. Lam, Lakshmi N. Yatham
Summary: Clinically significant weight gain (CSWG) is a risk factor for decreasing hippocampal N-acetylaspartate in both bipolar disorder patients and healthy subjects. These results suggest that reduced N-acetylaspartate levels in bipolar disorder may be related to higher body mass index rather than the diagnosis itself.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
Michael Cronquist Christensen, Roger S. McIntyre, Ioana Florea, Henrik Loft, Andrea Fagiolini
Summary: This study analyzed the efficacy and tolerability of vortioxetine in patients with major depressive disorder. The results showed that vortioxetine 20 mg/day was more effective than 10 mg/day, with similar tolerability. In flexible-dose studies, nearly half of the patients received 20 mg/day after 1 week and two-thirds received 20 mg/day as their final dosage.
Review
Clinical Neurology
Roger S. Mcintyre, Leslie Citrome, Hannah Cummings, Mark S. Todtenkopf, Laura A. Tan, Marni White, Sarah Akerman
Summary: The endogenous opioid system plays an important role in weight and metabolism regulation. Targeting this system may help mitigate antipsychotic-induced weight gain and metabolic dysregulation.
Article
Clinical Neurology
Houman Rashidian, Mehala Subramaniapillai, Caroline Park, Orly Lipsitz, Hannah Zuckerman, Bing Cao, Yena Lee, Hartej Gill, Roger Nelson Rodrigues, Joshua D. Di Vincenzo, Michelle Iacobucci, Saja Jaberi, Joshua D. Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: This study assessed changes in insulin resistance (IR) after antidepressant treatment and found that exacerbation of IR mediated non-response to treatment. In contrast, responders showed a reduction in IR. These findings further elucidate the role of IR in antidepressant response.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Runhua Wang, Yuanyuan Cai, Weicong Lu, Ruoxi Zhang, Robin Shao, Suk-Yu Yau, Brendon Stubbs, Roger S. McIntyre, Kuan-Pin Su, Guiyun Xu, Liangwen Qi, Kwok-Fai So, Kangguang Lin
Summary: This 3-month randomized psychoeducation-controlled trial examined the effects of exercise on gut microbiota in young adolescents with subthreshold depression. The exercise intervention group showed an increase in the relative abundance of certain genera and species of gut bacteria compared to the psychoeducation-controlled group. These changes were associated with improvements in depressive symptoms and enrichment of defense and signal transduction mechanisms.
PSYCHIATRY RESEARCH
(2023)
Review
Psychiatry
Shakila Meshkat, Sipan Haikazian, Joshua D. Di Vincenzo, Farhan Fancy, Danica Johnson, David Chen-Li, Roger S. McIntyre, Rodrigo Mansur, Joshua D. Rosenblat
Summary: This systematic review evaluates the efficacy, tolerability, and safety of oral ketamine, esketamine, and r-ketamine for unipolar and bipolar depression. The results indicate significant antidepressant effects and good tolerability of oral ketamine. However, the included randomized controlled trials had a high risk of bias, and further research with larger sample sizes and longer follow-up periods is needed to determine the antisuicidal effects and efficacy in treatment-resistant depression.
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
(2023)
Review
Clinical Neurology
Giacomo d'Andrea, Mauro Pettorruso, Giorgio Di Lorenzo, Gianluca Mancusi, Roger S. McIntyre, Giovanni Martinotti
Summary: Ketamine and esketamine have generated significant interest as potential therapeutic agents for Treatment-Resistant Depression (TRD). This article provides a comprehensive overview of their action and highlights their effectiveness on mixed features, anxiety, dysphoric mood, and bipolar traits. The complex pharmacodynamic mechanisms of action are discussed, and further research is needed to evaluate the efficacy of esketamine nasal spray in bipolar depression and the potential role of these substances as mood stabilizers.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Danica E. Johnson, Roger S. McIntyre, Rodrigo B. Mansur, Joshua D. Rosenblat
Summary: Cognitive impairment is a significant feature of bipolar disorder, affecting recovery and quality of life. While there are currently no effective treatments for cognitive impairment in bipolar disorder, various pharmacological interventions are being explored as potential options that target the underlying pathophysiology of the disorder.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Jingman Shi, Xue Han, Yuhua Liao, Hao Zhao, Beifang Fan, Huimin Zhang, Kayla M. Teopiz, Weidong Song, Lingjiang Li, Lan Guo, Ciyong Lu, Roger S. McIntyre
Summary: This study examined the association between stressful life events (SLEs) and subthreshold depressive symptoms (SDS) and major depressive disorder (MDD), with a focus on gender effects. The findings showed that individuals who experienced any SLEs were at a higher risk of SDS and MDD. The association between SLEs and SDS was stronger in females, while the association between SLEs and MDD was stronger in males.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Mi Kyoung Seo, Sehoon Jeong, Dae-Hyun Seog, Jung An Lee, Jae-Hon Lee, Yena Lee, Roger S. McIntyre, Sung Woo Park, Jung Goo Lee
Summary: This study investigated the effects of liraglutide, a GLP-1 agonist, on a depression-like phenotype in mice exposed to chronic unpredictable stress. Liraglutide treatment reduced immobility in the forced swim test and improved cognitive function in the Morris water maze test. These results suggest that GLP-1 agonists could be potential novel antidepressants.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Yanzhi Li, Lu Cheng, Lan Guo, Liwan Zhu, Hao Zhao, Caiyun Zhang, Manjun Shen, Yifeng Liu, Muhammad Youshay Jawad, Lingjiang Li, Wanxin Wang, Ciyong Lu, Roger S. McIntyre
Summary: This study explores the mediating role of personality traits in the relationship between adverse childhood experiences (ACEs) and depressive symptoms in older adults. The results suggest that maltreatment and household dysfunction induce depressive symptoms by increasing neuroticism, while poor parent-child bonding induces depressive symptoms by increasing neuroticism and reducing conscientiousness and extraversion.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Nutrition & Dietetics
Joshua Daniel Di Vincenzo, Liam O'Brien, Ira Jacobs, Muhammad Youshay Jawad, Felicia Ceban, Shakila Meshkat, Hartej Gill, Aniqa Tabassum, Lee Phan, Sebastian Badulescu, Joshua Daniel Rosenblat, Roger S. McIntyre, Rodrigo B. Mansur
Summary: Psychiatric and metabolic disorders have a bidirectional relationship, yet the mechanisms underlying this association are unknown. This review explores the use of indirect calorimetry (IC) to assess resting metabolism in psychiatric populations and reveals significant differences in energy expenditure and substrate utilization compared to healthy populations. Predictive equations for resting energy expenditure in psychiatric populations tend to overestimate values, highlighting the need for standardized IC protocols and further research into the heterogeneity of psychiatric disorders.
Review
Genetics & Heredity
Jiangbo Ying, Qian Hui Chew, Roger S. McIntyre, Kang Sim
Summary: Treatment-resistant schizophrenia (TRS) is difficult to treat and has a negative impact on patients' quality of life. Clozapine is effective for TRS but has side effects. This review summarizes the current genetic factors associated with TRS, clozapine resistance, and side effects. Further research is needed to identify risk genes and understand the interactions between genes and relevant clinical factors in TRS treatment.
Article
Psychiatry
Xiuwen Li, Huimin Zhang, Xue Han, Lan Guo, Felicia Ceban, Yuhua Liao, Jingman Shi, Wanxin Wang, Yifeng Liu, Weidong Song, Dongjian Zhu, Hongqiong Wang, Lingjiang Li, Beifang Fan, Ciyong Lu, Roger S. McIntyre
Summary: This study explored the association between somatic symptoms and subthreshold depression (SD) and Major Depressive Disorder (MDD), and determined the predictive potential of somatic symptoms in identifying SD and MDD in primary care. The results showed that somatic symptoms were associated with the presence of SD and MDD, and energy-related symptoms had good predictive potential.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Vincent Chin-Hung Chen, Shao-Lan Huang, Jing-Yu Huang, Tsai-Ching Hsu, Bor-Show Tzang, Roger S. Mcintyre
Summary: The combination of Nivolumab and Escitalopram oxalate was found to have synergistic effects in inhibiting the proliferation of liver cancer cells. This study highlights the potential of combined drug therapy as an alternative treatment option for liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Joshua D. D. Rosenblat, Froukje E. E. deVries, Zoe Doyle, Roger S. S. McIntyre, Gary Rodin, Camilla Zimmermann, Ernie Mak, Breffni Hannon, Christian Schulz-Quach, Aida Al Kindy, Zeal Patel, Madeline Li
Summary: Ketamine administered through intranasal spray has shown rapid and sustained antidepressant effects in advanced cancer patients suffering from moderate to severe depression. The treatment was well-tolerated with minimal side effects. Further larger-scale controlled trials are needed to confirm these promising findings.
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)