Mitochondrial Unfolded Protein Responses in White Adipose Tissue: Lipoatrophy, Whole-Body Metabolism and Lifespan

A Conserved Mito-Cytosolic Translational Balance Links Two Longevity Pathways

(2020) Marte Molenaars et al.   Cell Metabolism

An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models

(2020) Min Jeong Choi et al.   DIABETOLOGIA

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease

(2019) Yasutoshi Koga et al.   MITOCHONDRION

Molecular chaperone HSP70 and key regulators of apoptosis

(2019) Rabih Roufayel   CURRENT MOLECULAR MEDICINE

Impact of aging and caloric restriction on fibroblast growth factor 21 signaling in rat white adipose tissue

(2019) Namiki Fujii et al.   EXPERIMENTAL GERONTOLOGY

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

What lipodystrophies teach us about the metabolic syndrome

(2019) Jake P. Mann et al.   JOURNAL OF CLINICAL INVESTIGATION

Cryo-EM structure of the ClpXP protein degradation machinery

(2019) Christos Gatsogiannis et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice

(2018) Sathyaseelan S. Deepa et al.   AGING CELL

Loss of mitochondrial protease ClpP protects mice from diet‐induced obesity and insulin resistance

(2018) Shylesh Bhaskaran et al.   EMBO REPORTS

The mitochondrial unfolded protein response and mitohormesis: a perspective on metabolic diseases

(2018) Hyon-Seung Yi et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Reduced oxidative capacity in macrophages results in systemic insulin resistance

(2018) Saet-Byel Jung et al.   Nature Communications

The MIC-1/GDF15-GFRAL Pathway in Energy Homeostasis: Implications for Obesity, Cachexia, and Other Associated Diseases

(2018) Vicky W.W. Tsai et al.   Cell Metabolism

Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis

(2018) María Rodríguez-Hidalgo et al.   Scientific Reports

Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21

(2018) Lisa Michelle Restelli et al.   Cell Reports

Redox regulation of GRPEL2 nucleotide exchange factor for mitochondrial HSP70 chaperone

(2018) Svetlana Konovalova et al.   Redox Biology

Growth hormone deficiency: health and longevity

(2018) Manuel H Aguiar-Oliveira et al.   ENDOCRINE REVIEWS

Mitochondrial intermediate peptidase is a novel regulator of sirtuin-3 activation by caloric restriction

(2017) Masaki Kobayashi et al.   FEBS LETTERS

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

The mitochondrial UPR: mechanisms, physiological functions and implications in ageing

(2017) Tomer Shpilka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury

(2017) Hyo Kyun Chung et al.   Scientific Reports

Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders

(2016) Yasunori Fujita et al.   Geriatrics & Gerontology International

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

(2016) Hyo Kyun Chung et al.   JOURNAL OF CELL BIOLOGY

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

(2016) Xingya Wang et al.   Aging-US

The clinical heterogeneity of coenzyme Q10 deficiency results from genotypic differences in the Coq9 gene

(2015) M. Luna-Sanchez et al.   EMBO Molecular Medicine

Mitochondrial Heat Shock Protein (Hsp) 70 and Hsp10 Cooperate in the Formation of Hsp60 Complexes

(2015) Lena Böttinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity

(2015) Richard M. Monaghan et al.   NATURE CELL BIOLOGY

New roles for mitochondrial proteases in health, ageing and disease

(2015) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Complex IV-deficientSurf1−/−mice initiate mitochondrial stress responses

(2014) Daniel A. Pulliam et al.   BIOCHEMICAL JOURNAL

Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications

(2014) Cecile Vernochet et al.   FASEB JOURNAL

NAG-1/GDF-15 prevents obesity by increasing thermogenesis, lipolysis and oxidative metabolism

(2014) K Chrysovergis et al.   INTERNATIONAL JOURNAL OF OBESITY

Lipoatrophy and severe metabolic disturbance in mice with fat-specific deletion of PPAR 

(2013) F. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

(2012) Soung Jung Kim et al.   Cell Metabolism

Adipose-Specific Deletion of TFAM Increases Mitochondrial Oxidation and Protects Mice against Obesity and Insulin Resistance

(2012) Cecile Vernochet et al.   Cell Metabolism

βKlotho Is Required for Fibroblast Growth Factor 21 Effects on Growth and Metabolism

(2012) Xunshan Ding et al.   Cell Metabolism

Improved insulin sensitivity associated with reduced mitochondrial complex IV assembly and activity

(2012) Sathyaseelan S. Deepa et al.   FASEB JOURNAL

A Novel Adipose-Specific Gene Deletion Model Demonstrates Potential Pitfalls of Existing Methods

(2012) Shannon E. Mullican et al.   MOLECULAR ENDOCRINOLOGY

An Enhanced Immune Response of Mclk1+/− Mutant Mice Is Associated with Partial Protection from Fibrosis, Cancer and the Development of Biomarkers of Aging

(2012) Dantong Wang et al.   PLoS One

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Impairment of Lon-Induced Protection Against the Accumulation of Oxidized Proteins in Senescent Wi-38 Fibroblasts

(2011) J. K. Ngo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Identification and Characterization of a Promoter Cassette Conferring Adipocyte-Specific Gene Expression

(2010) Zhao V. Wang et al.   ENDOCRINOLOGY

Research Resource: Comprehensive Expression Atlas of the Fibroblast Growth Factor System in Adult Mouse

(2010) Klementina Fon Tacer et al.   MOLECULAR ENDOCRINOLOGY

Pparγ2 Is a Key Driver of Longevity in the Mouse

(2009) Carmen Argmann et al.   PLoS Genetics

Identification of Macrophage Inhibitory Cytokine-1 in Adipose Tissue and Its Secretion as an Adipokine by Human Adipocytes

(2008) Qi Ding et al.   ENDOCRINOLOGY

Early Mitochondrial Dysfunction in Long-livedMclk1+/-Mice

(2008) Jérôme Lapointe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY