Interactions of SARS-CoV-2 with the Blood–Brain Barrier

The chronic neuropsychiatric sequelae of COVID‐19: The need for a prospective study of viral impact on brain functioning

(2021) Gabriel A. Erausquin et al.   Alzheimers & Dementia

SARS-CoV-2 encephalitis is a cytokine release syndrome: evidences from cerebrospinal fluid analyses

(2021) Andrea Pilotto et al.   CLINICAL INFECTIOUS DISEASES

A Comprehensive Systematic Review of CSF analysis that defines Neurological Manifestations of COVID-19

(2021) Medha Tandon et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Neuroinvasion of SARS-CoV-2 in human and mouse brain

(2021) Eric Song et al.   JOURNAL OF EXPERIMENTAL MEDICINE

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

(2021) Chaolin Huang et al.   LANCET

No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor

(2021) Jarrod Shilts et al.   Scientific Reports

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

(2020) Sean P. Colgan et al.   Annual Review of Immunology

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

(2020) Chaolin Huang et al.   LANCET

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

(2020) Xiaobo Yang et al.   Lancet Respiratory Medicine

Neuroimaging Findings in Patients with COVID-19

(2020) Patrick Nicholson et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2

(2020) Vanessa Monteil et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes

(2020) Lihua Zhu et al.   Cell Metabolism

Prominent changes in blood coagulation of patients with SARS-CoV-2 infection

(2020) Huan Han et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Prognostic value of C-reactive protein in patients with COVID-19

(2020) Xiaomin Luo et al.   CLINICAL INFECTIOUS DISEASES

Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study

(2020) Andrea Giacomelli et al.   CLINICAL INFECTIOUS DISEASES

Coronavirus Infections and Type 2 Diabetes—Shared Pathways with Therapeutic Implications

(2020) Daniel J Drucker   ENDOCRINE REVIEWS

Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers

(2020) Jordi Rello et al.   EUROPEAN RESPIRATORY JOURNAL

COVID-19 spike-host cell receptor GRP78 binding site prediction

(2020) Ibrahim M. Ibrahim et al.   JOURNAL OF INFECTION

Central Nervous System Involvement by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2)

(2020) Alberto Paniz‐Mondolfi et al.   JOURNAL OF MEDICAL VIROLOGY

APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort

(2020) Chia-Ling Kuo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Endothelial cell infection and endotheliitis in COVID-19

(2020) Zsuzsanna Varga et al.   LANCET

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

(2020) Fei Zhou et al.   LANCET

APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline

(2020) Axel Montagne et al.   NATURE

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young

(2020) Thomas J. Oxley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019

(2020) Adeel S. Zubair et al.   JAMA Neurology

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China

(2020) Ling Mao et al.   JAMA Neurology

In vitro modeling of blood–brain barrier and interface functions in neuroimmune communication

(2020) Michelle A. Erickson et al.   Fluids and Barriers of the CNS

SARS-CoV-2 and Coronavirus Disease 2019: What We Know So Far

(2020) Firas A. Rabi et al.   Pathogens

Distribution of ACE2, CD147, CD26 and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

(2020) U. Radzikowska et al.   ALLERGY

Why COVID-19 Silent Hypoxemia Is Baffling to Physicians

(2020) Martin J. Tobin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Massive transient damage of the olfactory epithelium associated with infection of sustentacular cells by SARS-CoV-2 in golden Syrian hamsters

(2020) Bertrand Bryche et al.   BRAIN BEHAVIOR AND IMMUNITY

Pericyte alteration sheds light on micro-vasculopathy in COVID-19 infection

(2020) Nathalie Cardot-Leccia et al.   INTENSIVE CARE MEDICINE

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

(2020) Benjamin Israelow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Serum Amyloid A is a biomarker of severe Coronavirus Disease and poor prognosis

(2020) Huan Li et al.   JOURNAL OF INFECTION

The ApoE locus and COVID-19: are we going where we have been?

(2020) Caleb E Finch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Neurological associations of COVID-19

(2020) Mark A Ellul et al.   LANCET NEUROLOGY

Hypoxia in COVID-19: Sign of Severity or Cause for Poor Outcomes

(2020) Kianoush B. Kashani   MAYO CLINIC PROCEEDINGS

Association Between Hypoxemia and Mortality in Patients With COVID-19

(2020) Jiang Xie et al.   MAYO CLINIC PROCEEDINGS

Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications

(2020) Joan T. Merrill et al.   Nature Reviews Rheumatology

New onset neurologic events in people with COVID-19 infection in three regions in China

(2020) Weixi Xiong et al.   NEUROLOGY

Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid

(2020) Johan Virhammar et al.   NEUROLOGY

Long-Haul COVID

(2020) Avindra Nath   NEUROLOGY

Neuropathological Features of Covid-19

(2020) Isaac H. Solomon et al.   NEW ENGLAND JOURNAL OF MEDICINE

The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries

(2020) Michael C. Grant et al.   PLoS One

Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier

(2020) Marion Clé et al.   mBio

Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction

(2020) Goodwell Nzou et al.   Scientific Reports

Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19

(2020) Paolo Boscolo-Rizzo et al.   JAMA Otolaryngology-Head & Neck Surgery

Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia

(2020) David H. Brann et al.   Science Advances

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

COVID-19-Related Disseminated Leukoencephalopathy (CRDL): A Retrospective Study of Findings on Brain MRI

(2020) Colbey W. Freeman et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

(2020) Ana Campos Codo et al.   Cell Metabolism

SARS-CoV-2 infects the brain choroid plexus and disrupts the blood-CSF-barrier in human brain organoids

(2020) Laura Pellegrini et al.   Cell Stem Cell

Cytokine release syndrome‐associated encephalopathy in patients with COVID‐19

(2020) P. Perrin et al.   EUROPEAN JOURNAL OF NEUROLOGY

COVID-19: Thinking about further mental and neurological disorders

(2020) Renato Sobral Monteiro-Junior   MEDICAL HYPOTHESES

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function

(2020) Emma S. Winkler et al.   NATURE IMMUNOLOGY

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

(2020) Qian Zhang et al.   SCIENCE

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

(2020) Paul Bastard et al.   SCIENCE

COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2

(2020) Anshumali Mittal et al.   PLoS Pathogens

The SARS-COV-2 Spike Protein Binds Sialic Acids and Enables Rapid Detection in a Lateral Flow Point of Care Diagnostic Device

(2020) Alexander N. Baker et al.   ACS Central Science

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

Cerebrospinal Fluid Features in Patients With Coronavirus Disease 2019 and Neurological Manifestations: Correlation with Brain Magnetic Resonance Imaging Findings in 58 Patients

(2020) François Lersy et al.   JOURNAL OF INFECTIOUS DISEASES

Facing up to long COVID

(2020) The Lancet   LANCET

The S1 protein of SARS-CoV-2 crosses the blood–brain barrier in mice

(2020) Elizabeth M. Rhea et al.   NATURE NEUROSCIENCE

The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier

(2020) Tetyana P. Buzhdygan et al.   NEUROBIOLOGY OF DISEASE

Microvascular Injury in the Brains of Patients with Covid-19

(2020) Myoung-Hwa Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

(2020) Jonas Nascimento Conde et al.   mBio

SARS-CoV-2 Is Not Detected in the Cerebrospinal Fluid of Encephalopathic COVID-19 Patients

(2020) Dimitris G. Placantonakis et al.   Frontiers in Neurology

Conformational dynamics of SARS-CoV-2 trimeric spike glycoprotein in complex with receptor ACE2 revealed by cryo-EM

(2020) Cong Xu et al.   Science Advances

Evidence of thrombotic microangiopathy in children with SARS-CoV-2 across the spectrum of clinical presentations

(2020) Caroline Diorio et al.   Blood Advances

Transcranial Doppler Ultrasound Evidence of Active Cerebral Embolization in COVID-19

(2020) Ayush Batra et al.   Journal of Stroke & Cerebrovascular Diseases

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Non-invasive bioluminescence imaging of HCoV-OC43 infection and therapy in the central nervous system of live mice

(2019) Junwei Niu et al.   ANTIVIRAL RESEARCH

Systemic infusions of anti-interleukin-1β neutralizing antibodies reduce short-term brain injury after cerebral ischemia in the ovine fetus

(2018) Xiaodi Chen et al.   BRAIN BEHAVIOR AND IMMUNITY

Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models

(2018) Slava Rom et al.   MOLECULAR NEUROBIOLOGY

Leucine competes with kynurenine for blood-to-brain transport and prevents lipopolysaccharide-induced depression-like behavior in mice

(2018) Adam K. Walker et al.   MOLECULAR PSYCHIATRY

Neuroimmune Axes of the Blood–Brain Barriers and Blood–Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions

(2018) Michelle A. Erickson et al.   PHARMACOLOGICAL REVIEWS

Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain

(2018) Andrée-Anne Berthiaume et al.   Cell Reports

Hepatitis C Virus Strain-Dependent Usage of Apolipoprotein E Modulates Assembly Efficiency and Specific Infectivity of Secreted Virions

(2017) Romy Weller et al.   JOURNAL OF VIROLOGY

Syndromes of Thrombotic Microangiopathy

(2017) Joseph J. Shatzel et al.   MEDICAL CLINICS OF NORTH AMERICA

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

(2017) Benjamin J. Andreone et al.   NEURON

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

(2017) Costantino Iadecola   NEURON

Neutralizing anti-interleukin-1β antibodies reduce ischemia-related interleukin-1β transport across the blood–brain barrier in fetal sheep

(2017) Aparna Patra et al.   NEUROSCIENCE

White matter injury induced by diabetes in acute stroke is clinically relevant: A preliminary study

(2016) Xinfeng Yu et al.   Diabetes & Vascular Disease Research

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

(2016) Anusha Mishra et al.   NATURE NEUROSCIENCE

Pericytes of the neurovascular unit: key functions and signaling pathways

(2016) Melanie D Sweeney et al.   NATURE NEUROSCIENCE

Formation of fibroblastic reticular network in the brain after infection with neurovirulent murine coronavirus

(2016) Rihito Watanabe et al.   NEUROPATHOLOGY

Role of the immune system in HIV-associated neuroinflammation and neurocognitive implications

(2015) Suzi Hong et al.   BRAIN BEHAVIOR AND IMMUNITY

The regulation of immune cell trafficking by the extracellular matrix

(2015) Rupert Hallmann et al.   CURRENT OPINION IN CELL BIOLOGY

Brain barriers: Crosstalk between complex tight junctions and adherens junctions

(2015) Silvia Tietz et al.   JOURNAL OF CELL BIOLOGY

Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice

(2015) Michael Fritz et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

(2015) Xiaodi Chen et al.   NEUROBIOLOGY OF DISEASE

Host cell proteases: Critical determinants of coronavirus tropism and pathogenesis

(2015) Jean Kaoru Millet et al.   VIRUS RESEARCH

Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System

(2015) Brian P. Daniels et al.   PLoS Pathogens

Everything You Always Wanted to Know About Rabies Virus (But Were Afraid to Ask)

(2015) Benjamin M. Davis et al.   Annual Review of Virology

Long-Distance Interferon Signaling within the Brain Blocks Virus Spread

(2014) A. N. van den Pol et al.   JOURNAL OF VIROLOGY

Mfsd2a is critical for the formation and function of the blood–brain barrier

(2014) Ayal Ben-Zvi et al.   NATURE

The Coronavirus Nucleocapsid Is a Multifunctional Protein

(2014) Ruth McBride et al.   Viruses-Basel

Drug and xenobiotic biotransformation in the blood–brain barrier: a neglected issue

(2014) José A. G. Agúndez et al.   Frontiers in Cellular Neuroscience

Proteolytic activation of the SARS-coronavirus spike protein: Cutting enzymes at the cutting edge of antiviral research

(2013) Graham Simmons et al.   ANTIVIRAL RESEARCH

Differential Cell Line Susceptibility to the Emerging Novel Human Betacoronavirus 2c EMC/2012: Implications for Disease Pathogenesis and Clinical Manifestation

(2013) Jasper Fuk-Woo Chan, Kwok-Hung Chan, Garnet Kwan-Yue Choi, Kelvin Kai-Wang To, Herman Tse, Jian-Piao Cai et al.   JOURNAL OF INFECTIOUS DISEASES

Dyad of CD40/CD40 Ligand Fosters Neuroinflammation at the Blood-Brain Barrier and Is Regulated via JNK Signaling: Implications for HIV-1 Encephalitis

(2013) S. H. Ramirez et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E Mediates Attachment of Clinical Hepatitis C Virus to Hepatocytes by Binding to Cell Surface Heparan Sulfate Proteoglycan Receptors

(2013) Jieyun Jiang et al.   PLoS One

C-Reactive Protein Increases BBB Permeability: Implications for Obesity and Neuroinflammation

(2012) Hung Hsuchou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells

(2012) Linda Engström et al.   ENDOCRINOLOGY

Pharmacokinetics and modeling of immune cell trafficking: quantifying differential influences of target tissues versus lymphocytes in SJL and lipopolysaccharide-treated mice

(2012) William A Banks et al.   Journal of Neuroinflammation

Human Immunodeficiency Virus-1 Uses the Mannose-6-Phosphate Receptor to Cross the Blood-Brain Barrier

(2012) Shinya Dohgu et al.   PLoS One

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF

(2011) Shinya Dohgu et al.   Journal of Neuroinflammation

Cross-Talk between Apolipoprotein E and Cytokines

(2011) Hongliang Zhang et al.   MEDIATORS OF INFLAMMATION

Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease

(2011) Yi Yang et al.   STROKE

Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B

(2010) Bo-Michael Bellander et al.   ACTA NEUROCHIRURGICA

Hypoxia-inducible factor 1: Regulator of mitochondrial metabolism and mediator of ischemic preconditioning

(2010) Gregg L. Semenza   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A structural analysis of M protein in coronavirus assembly and morphology

(2010) Benjamin W. Neuman et al.   JOURNAL OF STRUCTURAL BIOLOGY

Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study

(2010) Martin J O'Donnell et al.   LANCET

Apolipoprotein E genotype and hepatitis C, HIV and herpes simplex disease risk: a literature review

(2010) Inga Kuhlmann et al.   Lipids in Health and Disease

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Obesity Is Associated With Reduced White Matter Integrity in Otherwise Healthy Adults*

(2010) Kelly M. Stanek et al.   Obesity

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury

(2009) Da-Zhi Liu et al.   ANNALS OF NEUROLOGY

Fibrinogen induces alterations of endothelial cell tight junction proteins

(2009) Phani K. Patibandla et al.   JOURNAL OF CELLULAR PHYSIOLOGY

West Nile virus infection modulates human brain microvascular endothelial cells tight junction proteins and cell adhesion molecules: Transmigration across the in vitro blood-brain barrier

(2009) Saguna Verma et al.   VIROLOGY

Varicella-zoster virus in cerebrospinal fluid at relapses of multiple sclerosis

(2008) Julio Sotelo et al.   ANNALS OF NEUROLOGY

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS

(2008) Robert W. Mahley et al.   JOURNAL OF LIPID RESEARCH

Severe Acute Respiratory Syndrome Coronavirus Infection Causes Neuronal Death in the Absence of Encephalitis in Mice Transgenic for Human ACE2

(2008) J. Netland et al.   JOURNAL OF VIROLOGY

Strategies to advance translational research into brain barriers

(2008) Edward Neuwelt et al.   LANCET NEUROLOGY

Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice

(2008) J C O'Connor et al.   MOLECULAR PSYCHIATRY

Interferon-β stabilizes barrier characteristics of the blood–brain barrier in four different species in vitro

(2008) J Kraus et al.   Multiple Sclerosis Journal

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

(2008) E. Candelario-Jalil et al.   NEUROSCIENCE

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE  4/ 4 genotype accelerates HIV disease progression

(2008) T. D. Burt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE genotype-specific differences in the innate immune response

(2007) Michael P. Vitek et al.   NEUROBIOLOGY OF AGING