期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 22, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ijms22031295
关键词
resveratrol; polyphenols; nutraceutical; ocular diseases; eyes; AMD; angiogenesis; diabetic retinopathy; cataract
资金
- ANRT [2016/0003]
- French Government [ANR-11-LABX-0021]
- Conseil Regional Bourgogne, Franche-Comte
- FEDER (European Funding for Regional Economic Development)
- Bureau Interprofessionnel des Vins de Bourgogne (BIVB)
Eye diseases are a major concern due to aging populations and lifestyle factors, with resveratrol gaining attention as a potential antioxidant against ocular diseases. Research focuses on resveratrol's mechanisms in treating eye diseases, highlighting its properties at cellular and molecular levels and potential preventive actions through epigenetic pathways.
Eye diseases are currently a major public health concern due to the growing number of cases resulting from both an aging of populations and exogenous factors linked to our lifestyles. Thus, many treatments including surgical pharmacological approaches have emerged, and special attention has been paid to prevention, where diet plays a preponderant role. Recently, potential antioxidants such as resveratrol have received much attention as potential tools against various ocular diseases. In this review, we focus on the mechanisms of resveratrol against ocular diseases, in particular age-related macular degeneration, glaucoma, cataract, diabetic retinopathy, and vitreoretinopathy. We analyze, in relation to the different steps of each disease, the resveratrol properties at multiple levels, such as cellular and molecular signaling as well as physiological effects. We show and discuss the relationship to reactive oxygen species, the regulation of inflammatory process, and how resveratrol can prevent ocular diseases through a potential epigenetic action by the activation of sirtuin-1. Lastly, various new forms of resveratrol delivery are emerging at the same time as some clinical trials are raising more questions about the future of resveratrol as a potential tool for prevention or in therapeutic strategies against ocular diseases. More preclinical studies are required to provide further insights into RSV's potential adjuvant activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据