Article
Dermatology
Ryan Fan, Audrey C. Leasure, William Damsky, Jeffrey M. Cohen
Summary: This cross-sectional study examined the association between atopic dermatitis (AD) and migraine among a cohort of US adults. The study found that adults with AD were 89% more likely to have a diagnosis of migraine after controlling for common comorbidities.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Yu Ri Woo, Minah Cho, Kyung Do Han, Sang Hyun Cho, Ji Hyun Lee
Summary: This study analyzed the incidence and risk factors of dementia in patients with atopic dermatitis (AD) and found that the risk of dementia is increased in AD patients. The effect of age and diabetes on the development of dementia in AD patients varies.
ACTA DERMATO-VENEREOLOGICA
(2023)
Review
Biochemistry & Molecular Biology
Mirella Russo, Matteo A. De Rosa, Dario Calisi, Stefano Consoli, Giacomo Evangelista, Fedele Dono, Matteo Santilli, Alberto Granzotto, Marco Onofrj, Stefano L. Sensi
Summary: Migraine is a common neurological disorder that affects the quality of life of patients. The long-term impact of drugs used to treat migraine on cognition and neurodegeneration is not consistently evaluated. Different drugs used for migraine treatment have distinct effects on the central nervous system and should be carefully evaluated when prescribing treatment. The conflicting results in the relationship between migraine and dementia need to consider the pharmacological regimens used.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Christopher H. Arehart, Michelle Daya, Monica Campbell, Meher Preethi Boorgula, Nicholas Rafaels, Sameer Chavan, Gloria David, Jon Hanifin, Mark K. Slifka, Richard L. Gallo, Tissa Hata, Lynda C. Schneider, Amy S. Paller, Peck Y. Ong, Jonathan M. Spergel, Emma Guttman-Yassky, Donald Y. M. Leung, Lisa A. Beck, Christopher R. Gignoux, Rasika A. Mathias, Kathleen C. Barnes
Summary: This study shows that polygenic risk scores (PRSs) for atopic dermatitis (AD) incorporating genetic determinants across atopic phenotypes and FLG loss-of-function variants can effectively predict the occurrence and severity of AD. Including FLG LOF mutations in genetic scoring further improves accuracy in predicting AD cases, with the best ability to distinguish individuals with severe AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Food Science & Technology
Yujie Chen, Wuke Yuan, Qi Xu, Manju B. Reddy
Summary: Parkinson's disease (PD) and Alzheimer's disease (AD) are common neurodegenerative disorders with shared molecular mechanisms, and there is currently no effective treatment. However, research suggests that consuming phytochemicals may help delay the progression of these diseases.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Allergy
Simon de Lusignan, Helen Alexander, Conor Broderick, John Dennis, Andrew McGovern, Claire Feeney, Carsten Flohr
Summary: There is an increased risk of developing autoimmune conditions among individuals newly diagnosed with AD, especially those with more severe AD.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Ju Hee Han, Hyun Ji Lee, Hwa Jung Yook, Kyungdo Han, Ji Hyun Lee, Young Min Park
Summary: This study investigated the association between atopic disorders and migraine in the Korean population. The results showed that patients with atopic dermatitis, asthma, and allergic rhinitis had an increased risk of migraine compared to the control group. Furthermore, the risk of migraine was higher in patients with multiple atopic disorders.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Sung Wook Kim, Jun Ho Lee, Bumjung Kim, Gabsik Yang, Jong Uk Kim
Summary: Alzheimer's disease and Parkinson's disease are the most common neurodegenerative diseases worldwide, with increasing incidence rates due to population aging. The exact cause and treatment methods are unknown, but research suggests specific proteins play a role in these diseases. Medications available currently only delay disease progression and have adverse effects, increasing interest in natural products with fewer side effects. This study reviewed 16 papers and found promising mechanisms of action for natural products in treating these diseases, such as antioxidant and anti-inflammatory effects, suggesting their potential as alternative treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biotechnology & Applied Microbiology
Amanda Li, Joel Tyson, Shivni Patel, Meer Patel, Sruthi Katakam, Xiaobo Mao, Weiwei He
Summary: With the aging population, the prevalence of neurodegenerative diseases such as PD and AD is expected to rise. These diseases are classified as proteinopathies with misfolded proteins like alpha-synuclein, amyloid-beta, and tau. Nanomaterials offer advantages over traditional therapies in targeting specific mechanisms, such as reducing oxidative stress or disaggregating fibrils.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Genetics & Heredity
Chuiji Chen, Le Su, Wenhao Duan, Yansen Zheng, Dianzhong Zhang, Yucai Wang
Summary: This study used bidirectional two-sample Mendelian randomization to find a causal relationship between asthma/AD and rheumatoid arthritis, but no causal relationship was found between rheumatoid arthritis and asthma/AD.
BMC MEDICAL GENOMICS
(2023)
Letter
Dermatology
P. Bortoluzzi, S. Ferrucci, D. Galimberti, F. Garavelli, F. Pozzo Giuffrida, A. Pizzati, A. V. Marzano, C. Mapelli
Summary: Our study aimed to analyze changes in ocular surface before and after 4 months of dupilumab treatment in severe AD patients. The results showed that all 25 patients had ocular surface alterations prior to dupilumab treatment, and there is a possibility of worsened clinical or subclinical pre-existing ocular alterations belonging to the spectrum of AKC caused by dupilumab.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Giorgia Condro, Marta Guerini, Michela Castello, Paola Perugini
Summary: The skin microbiota plays an important role in maintaining healthy skin, but its balance can be disrupted by various factors, leading to the development of skin diseases. The correlation between diseases like acne vulgaris, atopic dermatitis, rosacea and the skin microbiota is still unclear, and more research is needed to explore the specific subspecies and strains involved.
Review
Biochemistry & Molecular Biology
JunHyun Kim, Minhong Jeong, Wesley R. Stiles, Hak Soo Choi
Summary: Alzheimer's disease is a neurodegenerative disease with no effective treatment options yet. Early diagnosis is essential for more effective therapy, and brain imaging techniques can serve as a valuable tool in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Ellen M. Lee, Yung-Tsu Cho, Tom C. Chan, Dereck Shen, Chia -Yu Chu, Chao-Hsiun Tang
Summary: This study aimed to calculate the economic burden of atopic dermatitis in Taiwan. The out-of-pocket costs of 200 patients were estimated using a questionnaire, and work impairment was converted into quantifiable costs. The costs reimbursed by the Taiwan National Health Insurance were included in the final calculation. The estimated economic burden of atopic dermatitis for patients in Taiwan in 2018 was NT$ 37.90 billion, which accounts for 0.207% of Taiwan's gross domestic product. This substantial burden indicates the need for more effective and equitable treatment for atopic dermatitis.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Medicine, General & Internal
Brendan Andres, Sasha Taleban
Summary: Ustekinumab inhibits interleukins 12 and 23 and modulates the T helper cell-mediated immune response of Crohn's disease. However, ustekinumab may also exacerbate atopic disease by increasing the T helper 2 cell-mediated pathway. We present the first known case of exacerbation of atopic dermatitis in a patient with Crohn's disease receiving ustekinumab.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)