Review
Biochemistry & Molecular Biology
Francesca Parisi, Roberta Milazzo, Valeria M. Savasi, Irene Cetin
Summary: Overweight and obesity during pregnancy can lead to increased birth weight, childhood obesity, and noncommunicable diseases in the offspring, perpetuating metabolic derangements across generations. The key components in intrauterine developmental programming are still to be identified, and inflammation may induce intrauterine derangements with a threshold effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Katarzyna Suchta, Monika Grymowicz, Anna Calik-Ksepka, Katarzyna Smolarczyk, Anna M. Duszewska, Roman Smolarczyk, Blazej Meczekalski
Summary: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, often leading to health issues like obesity and insulin resistance. Studies suggest a link between PCOS and chronic inflammation, which may contribute to cardiovascular diseases and other complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Emma Morris, Claire M. Edwards
Summary: Multiple myeloma is an incurable hematological malignancy characterized by abnormal plasma cell proliferation in the bone marrow. The bone marrow adipocytes play a crucial role in supporting MM progression by providing energy and secreted substances for tumor cell growth and survival. Understanding the interaction between bone marrow adipocytes and MM cells is essential for elucidating the pathogenesis of the disease.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Environmental Sciences
Roger Pero-Gascon, Lieselot Y. Hemeryck, Giulia Poma, Gwen Falony, Tim S. Nawrot, Jeroen Raes, Lynn Vanhaecke, Marthe De Boevre, Adrian Covaci, Sarah De Saeger
Summary: FLEXiGUT is the first large-scale exposomics study focusing on chronic low-grade inflammation. By analyzing biomonitoring data and applying advanced omics techniques in two Flemish prospective cohorts, this study aims to uncover the associations between environmental exposure and gut inflammation.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Cell Biology
Thassio Mesquita, Yen-Nien Lin, Ahmed Ibrahim
Summary: HFpEF is the predominant form of heart failure with a significant increase in risk with age. Low-grade inflammation, termed inflammaging, is a common feature of HFpEF pathology. Suppression of proinflammatory pathways has been associated with attenuated disease severity and improved outcomes in HFpEF. Inflammasome signaling plays a central role in mediating chronic inflammation and cardiovascular disease progression.
Review
Endocrinology & Metabolism
Mari van de Vyver
Summary: Inflammation is a vital immune response that defends against harmful bacteria and pathogens, and also plays a crucial role in tissue maintenance and repair. However, under pathological conditions, there can be persistent inflammation without infection, known as sterile metabolic inflammation or metainflammation. This disruption of the immune response is associated with disease progression, immune senescence, and should not be overlooked in clinical management.
JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Cell Biology
Jozef Ban, Valerie Fock, Dave N. T. Aryee, Heinrich Kovar
Summary: Bone and bone marrow are common metastatic sites of cancer, often associated with poor disease prognosis. Current therapeutic options for bone metastases are limited and mainly palliative. Further research into the molecular pathways of bone metastasis is needed to develop more successful treatments for improved patient outcomes.
Article
Public, Environmental & Occupational Health
Mariana De Santis Filgueiras, Milene Cristine Pessoa, Josefina Bressan, Aline Siqueira Fogal Vegi, Ariene Silva do Carmo, Fernanda Martins de Albuquerque, Danielle Soares Gardone, Juliana Farias de Novaes
Summary: This study found that obesogenic environmental characteristics around schools were associated with body adiposity and adipokine concentrations in Brazilian children. The results showed that a higher density of predominantly ultra-processed food stores and a lower percentage of green spaces were associated with higher total and android body fat, as well as higher pro-inflammatory adipokine levels. The densities of public physical activity facilities and crime were inversely associated with leptin levels.
PUBLIC HEALTH NUTRITION
(2023)
Article
Medicine, General & Internal
Hisaki Aiba, Tomoharu Nakazato, Hideo Matsuo, Hiroaki Kimura, Shiro Saito, Takao Sakai, Hideki Murakami, Jun Kawai, Shingo Kawasaki, Yasuhiro Imamura
Summary: Systemic osteosclerotic lesions are rare complications of gastric cancer, typically caused by multiple bone metastases or systemic metabolic disorders. This case report describes a rare case of gastric cancer recurrence presenting with mixed osteoblastic and osteolytic bone lesions resembling Paget's disease. Accurate diagnosis was achieved through bone biopsy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Immunology
Samira Rastgoo, Ghazaleh Shimi, Farideh Shiraseb, Ashkan Karbasi, Damoon Ashtary-Larky, Mohsen Yousefi, Elnaz Golalipour, Omid Asbaghi, Mohammad Zamani
Summary: This systematic review and meta-analysis examined the effects of conjugated linoleic acid (CLA) supplementation on inflammatory cytokines and adipokines. The results showed that CLA supplementation significantly decreased IL-6 and TNF-alpha levels, slightly increased CRP levels, and had no effect on adiponectin and leptin levels. Subgroup analysis revealed that CLA supplementation reduced adiponectin and leptin in women.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Igor Soares, Bruna L. Belote, Elizabeth Santin, Gabriela C. Dal Pont, Michael H. Kogut
Summary: Production animals are frequently exposed to environmental and dietary factors that may lead to chronic intestinal inflammation. This condition affects their productivity and well-being, necessitating research to understand its causes and develop control strategies. By measuring cellular components released into the blood and/or feces, biomarkers can be identified and used to diagnose and quantify the inflammatory process without invasive methods.
Review
Cell Biology
Maryam Rostamtabar, Sedigheh Esmaeilzadeh, Mehdi Tourani, Abolfazl Rahmani, Masoud Baee, Fatemeh Shirafkan, Kiarash Saleki, Sajedeh S. Mirzababayi, Soheil Ebrahimpour, Hamid Reza Nouri
Summary: PCOS is the most common hormonal imbalance disease in reproductive-aged women, characterized by ovulatory dysfunction and ovarian overproduction of androgens. Recent studies have shown that inflammation processes are involved in ovulation and play a key role in ovarian follicular dynamics.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Fei Yang, Meng Duan, Faxiang Zheng, Lei Yu, Yuan Wang, Guowei Wang, Jie Lin, Shuang Han, Da Gan, Zhuoxian Meng, Shankuan Zhu
Summary: Obesity-related inflammation can promote cardiometabolic diseases and obesity-related tumors, but the mechanisms involved are not fully understood. This study found that increased TNF-alpha in adipocytes promoted lung metastasis of colon cancer cells via Fas signaling, mediated by the activation of NF-kappa B and MAPK pathways. The interaction between Fas and Bmx in adipocyte inflammation may provide new clues for potential treatments for obesity-related diseases.
Article
Oncology
Jingyao Chen, Wenhan Huang, Xiaohong Xu, Shaonan Fan, Qi Zhang, Xuan Li, Zhaochong Zeng, Jian He
Summary: This study aimed to investigate the prognostic value of systemic inflammation index in hepatocellular carcinoma (HCC) patients with bone metastasis (BM) treated with radiotherapy. The results showed that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) were associated with overall survival (OS) and progression-free survival (PFS) in HCC patients with BM. These indicators could be considered reliable prognostic biomarkers for HCC patients with BM.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Baoding Huang, Qianfen Wan, Tianyu Li, Lexiang Yu, Wen Du, Carmen Calhoun, Kam W. Leong, Li Qiang
Summary: As a solution to the chronic inflammation and local adiposity caused by obesity, cationic polyamidoamine (PAMAM) treatment has shown promising results in improving metabolic functions and reducing body weight in diet-induced obese (DIO) mice. The treatment involves the use of PAMAM generation 3 (P-G3) scavenger and complexing P-G3 with human serum albumin (HSA) to achieve sustained release. Local injection of HSA-PG3 successfully restricts the distribution of the complex within the targeted adipose tissue and reduces focal adiposity.
Review
Endocrinology & Metabolism
Giovanni Lombardi, Edgard Delvin
Summary: Osteoporosis is a prevalent bone disease and circulating microRNAs have shown potential as diagnostic and prognostic markers. However, the lack of standardization and harmonization of methods limits their application.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Physiology
Marta Gomarasca, Katarzyna Micielska, Martina Faraldi, Marta Flis, Silvia Perego, Giuseppe Banfi, Ewa Ziemann, Giovanni Lombardi
Summary: Exercise can alleviate the chronic low-grade inflammatory status in elderly individuals by inhibiting the activation of the inflammasome and downstream effectors. Aerobic training reduces the expression of inflammasome and Toll-like receptors and decreases the secretion of pro-inflammatory cytokines. However, participants experience an acute inflammatory response at the end of the training.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Ramin Mahdipour, Alireza Ebrahimzadeh-Bideskan, Mahmoud Hosseini, Sara Shahba, Giovanni Lombardi, Amir Mohammad Malvandi, Abbas Mohammadipour
Summary: Neurological disorders have a significant impact on global health, and grape seed extract shows potential as a valuable therapeutic agent due to its antioxidant, anti-inflammatory, and protein homeostasis maintenance properties.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Ewa Aleksandra Rodziewicz-Flis, Malgorzata Kawa, Jan Jacek Kaczor, Marzena Szaro-Truchan, Damian Jozef Flis, Giovanni Lombardi, Ewa Ziemann
Summary: The study aimed to evaluate the impact of folk-dance and balance training on physical performance, insulin resistance, and blood pressure in older adults. Both training programs effectively improved physical performance and blood pressure, accompanied by changes in selected exerkines. Folk-dance training also enhanced insulin sensitivity.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Paola Maroni, Marta Gomarasca, Giovanni Lombardi
Summary: Long non-coding RNAs (lncRNAs) have potential as biomarkers for early cancer diagnosis, prognosis, and therapeutic targets. Bone metastasis is a common progression of advanced cancers, particularly breast, prostate, and lung cancers. Understanding the pathophysiology of bone metastasis and improving clinical management are challenging but important areas of research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Chiara Verdelli, Giulia Stefania Tavanti, Irene Forno, Valentina Vaira, Riccardo Maggiore, Leonardo Vicentini, Paolo Dalino Ciaramella, Francesca Perticone, Giovanni Lombardi, Sabrina Corbetta
Summary: This study found that osteocalcin (OC), a bone matrix protein, can modulate the function of parathyroid tumor cells by activating the calcium sensing receptor (CASR). OC reduces the activity of pERK/ERK and increases the levels of active beta-catenin through CASR activation. It also affects the expression of related genes to influence the physiological functions of parathyroid tumor cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Biomedical
Carlotta Mondadori, Amit Chandrakar, Silvia Lopa, Paul Wieringa, Giuseppe Talo, Silvia Perego, Giovanni Lombardi, Alessandra Colombini, Matteo Moretti, Lorenzo Moroni
Summary: The study investigated the ability of scaffold architecture to modulate macrophage polarization. The rhombus architecture was found to promote the release of certain cytokines by M2a macrophages, which may have a positive impact on the healing process.
BIOACTIVE MATERIALS
(2023)
Review
Cell Biology
Laura Gerosa, Amir Mohammad Malvandi, Marco Malavolta, Mauro Provinciali, Giovanni Lombardi
Summary: The locomotor system, consisting of skeletal muscles and bones, plays a vital role in maintaining function and preventing frailty. As individuals age, chronic disorders of the locomotor system may arise, negatively impacting bone and muscle function. Senescent cells, which accumulate in muscle tissue with advancing age or under pathological conditions, impair muscle regeneration and contribute to muscle weakness. Additionally, senescence in the bone microenvironment affects bone turnover, increasing the risk of osteoporosis. Understanding the mechanisms underlying cellular senescence in musculoskeletal tissues may aid in developing effective biomarkers for early detection of tissue flaws.
AGEING RESEARCH REVIEWS
(2023)
Article
Medical Laboratory Technology
Anna Ksiazek, Aleksandra Zagrodna, Giovanni Lombardi, Malgorzata Slowinska-Lisowska
Summary: The main objective of this study was to assess 25-(OH)DF, vitamin D metabolites, and VMRs in inactive men and athletes. The results showed that regular long-term physical activity had no effect on the concentration of vitamin D metabolites at rest. Furthermore, free vitamin D did not correlate more strongly with vitamin D metabolites and VMRs compared to total.
CLINICA CHIMICA ACTA
(2023)
Article
Physiology
Anna Ksiazek, Aleksandra Zagrodna, Giovanni Lombardi, Malgorzata Slowinska-Lisowska
Summary: Novel markers of vitamin D status, such as free 25-(OH)D and the vitamin D metabolite ratio, show seasonal rhythms in athletes, while markers of psychophysical stress and free 25-(OH)D do not exhibit clear rhythmicity. Additionally, strong correlations exist between vitamin D metabolites in different training periods.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Endocrinology & Metabolism
Ewa Rodziewicz-Flis, Ulana Juhas, Jakub Antoni Kortas, Joanna Jaworska, Ilona Bidzan-Bluma, Anna Babinska, Katarzyna Micielska, Malgorzata Zychowska, Giovanni Lombardi, Jedrzej Antosiewicz, Ewa Ziemann
Summary: The study showed that regular Nordic Walking training with additional resistance improved cognitive functions and physical performance in older adults. These positive effects were associated with a reduced BDNF concentration and kynurenine-to-tryptophan ratio as well as changes in the amino acid profile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Sport Sciences
Aleksandra Zagrodna, Anna Ksiazek, Malgorzata Slowinska-Lisowska, Jan Chmura, Piotr Ponikowski, Giovanni Lombardi
Summary: The aim of this study was to investigate the impact of running a marathon on sclerostin and intact PTH concentration in middle-aged males. The results showed that the levels of serum sclerostin and iPTH increased immediately after the marathon race but returned to baseline after 7 days. It was suggested that running a marathon affected skeletal metabolism by inhibiting bone formation through sclerostin expression and inducing long-lasting PTH elevation to maintain adequate calcium levels for neuromuscular activity and muscle contraction.
JOURNAL OF SPORTS SCIENCES
(2023)
Article
Geriatrics & Gerontology
Francesca Marchegiani, Rina Recchioni, Mirko Di Rosa, Francesco Piacenza, Fiorella Marcheselli, Anna Rita Bonfigli, Roberta Galeazzi, Giulia Matacchione, Maurizio Cardelli, Antonio Domenico Procopio, Andrea Corsonello, Antonio Cherubini, Roberto Antonicelli, Giovanni Lombardi, Fabrizia Lattanzio, Fabiola Olivieri
Summary: This study analyzed the association between circulating miRNA and routine laboratory biomarkers with mortality risk in geriatric patients affected by cardiovascular multimorbidity. The results suggest that lower levels of circulating miR-17 and miR-126-3p are associated with higher short- and medium-term mortality risk in hospitalized elderly patients with cardiovascular multimorbidity.
Article
Nutrition & Dietetics
Matteo Briguglio, Thomas W. Wainwright, Giovanni Lombardi
Summary: Accurately identifying malnourished patients in surgical research can enhance the prediction of postoperative recovery potential, utilizing literature-based equations built on historical data to classify patients is essential for efficient studies.
FRONTIERS IN NUTRITION
(2023)
Review
Medicine, Research & Experimental
Fabien D. Legrand, Benoit Dugue, Joe Costello, Chris Bleakley, Elzbieta Miller, James R. Broatch, Guillaume Polidori, Anna Lubkowska, Julien Louis, Giovanni Lombardi, Francois Bieuzen, Paolo Capodaglio
Summary: Whole-body cryotherapy is a non-pharmacological treatment that influences inflammatory events and has various benefits, such as improved sleep quality, faster neuromuscular recovery, and chronic pain relief. It may also have positive effects on mental health and cognitive functions. There have been concerns about its safety, but these concerns are often based on misunderstandings regarding the differences between whole-body cryotherapy and partial-body cryotherapy. This article reviews the literature and concludes that the safety risks associated with whole-body cryotherapy are within acceptable limits and can be prevented by following existing recommendations and guidelines.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
