Article
Biochemistry & Molecular Biology
Can Liu, Andrew J. Martins, William W. Lau, Nicholas Rachmaninoff, Jinguo Chen, Luisa Imberti, Darius Mostaghimi, Danielle L. Fink, Peter D. Burbelo, Kerry Dobbs, Ottavia M. Delmonte, Neha Bansal, Laura Failla, Alessandra Sottini, Eugenia Quiros-Roldan, Kyu Lee Han, Brian A. Sellers, Foo Cheung, Rachel Sparks, Tae-Wook Chun, Susan Moir, Michail S. Lionakis, Camillo Rossi, Helen C. Su, Douglas B. Kuhns, Jeffrey Cohen, Luigi D. Notarangelo, John S. Tsang
Summary: This study longitudinally assessed various factors in single peripheral immune cells of COVID-19 patients and identified primary correlates of disease severity and outcome. Timing was emphasized as crucial in the analysis, clinical monitoring, and therapeutic intervention of COVID-19.
Article
Immunology
Alessandra Aiello, Adriano Grossi, Silvia Meschi, Marcello Meledandri, Valentina Vanini, Linda Petrone, Rita Casetti, Gilda Cuzzi, Andrea Salmi, Anna Maria Altera, Luca Pierelli, Gina Gualano, Tommaso Ascoli Bartoli, Concetta Castilletti, Chiara Agrati, Enrico Girardi, Fabrizio Palmieri, Emanuele Nicastri, Enrico Di Rosa, Delia Goletti
Summary: This study aimed to characterize the early immune responses to SARS-CoV-2 infection in household contacts of COVID-19 cases. The findings showed that plasmatic IFN-alpha and IFN-gamma T-cell specific response could appear early in the absence of seroconversion, and had a higher positivity rate compared to the serological response in individuals with positive swabs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Marion Cremoni, Jonathan Allouche, Daisy Graca, Kevin Zorzi, Celine Fernandez, Maxime Teisseyre, Sylvia Benzaken, Caroline Ruetsch-Chelli, Vincent L. M. Esnault, Jean Dellamonica, Michel Carles, Jerome Barriere, Michel Ticchioni, Vesna Brglez, Barbara Seitz-Polski
Summary: This study investigated IFN-gamma as a predictive biomarker for the risk of hospitalization at an early stage of SARS-CoV-2 infection. It was found that individuals with lower IFN-gamma levels were more likely to be hospitalized, along with age >65 and no vaccination. Additionally, there was a significant inverse correlation between low IFN-gamma response and high IL-6 levels in plasma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Alessandra Aiello, Saeid Najafi Fard, Elisa Petruccioli, Linda Petrone, Valentina Vanini, Chiara Farroni, Gilda Cuzzi, Assunta Navarra, Gina Gualano, Silvia Mosti, Luca Pierelli, Emanuele Nicastri, Delia Goletti
Summary: The whole-blood platform was used to detect a SARS-CoV-2-specific T cell response, with pool S and MegaPool being the most potent immunogenic stimuli. The assay showed good sensitivity and high specificity, making it a powerful diagnostic tool for clinical laboratories.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Dorcas O. Owusu, Ernest Adankwah, Wilfred Aniagyei, Isaac Acheampong, Difery Minadzi, Augustine Yeboah, Joseph F. Arthur, Millicent Lamptey, Monika M. Vivekanandan, Mohammed K. Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Linda Batsa Debrah, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen
Summary: In Nigeria, BCG vaccination leads to immune conversion and changes in the phenotype of tuberculosis-specific T cells. A study comparing BCG-vaccinated and non-vaccinated infants showed that BCG vaccination causes delayed immune conversion and differences in cell phenotype among tuberculosis patients.
Article
Computer Science, Interdisciplinary Applications
Mayowa M. Ojo, Olumuyiwa James Peter, Emile Franc Doungmo Goufo, Kottakkaran Sooppy Nisar
Summary: We developed and analyzed a deterministic mathematical model to study the co-infection and impact of COVID-19 and tuberculosis in a given population. The existence and stability of disease-free equilibrium were established based on reproduction numbers. We examined the effect of vaccination and conditions for COVID-19 eradication. Furthermore, we analyzed the endemic equilibria and criteria for backward bifurcation of the COVID-19 sub-model.
MATHEMATICS AND COMPUTERS IN SIMULATION
(2023)
Article
Multidisciplinary Sciences
Mikhael Haruo Fernandes de Lima, Caio Cavalcante Machado, Daniele Carvalho Nascimento, Camila Meirelles S. Silva, Juliana Escher Toller-Kawahisa, Tamara Silva Rodrigues, Flavio Protassio Veras, Marjorie Cornejo Pontelli, Italo A. Castro, Dario Simoes Zamboni, Jose-Carlos A. Filho, Thiago M. Cunha, Eurico Arruda, Larissa Dias da Cunha, Rene D. R. Oliveira, Fernando Q. Cunha, Paulo Louzada-Junior
Summary: Expansion of TIGIT(+)Tregs in COVID-19 patients is associated with inflammation, lung dysfunction, bacteremia, and fatal outcome.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Tatjana Adzic-Vukicevic, Maja Stosic, Gordana Antonijevic, Miroslav Jevtic, Aleksandra Radovanovic-Spurnic, Jelena Velickovic
Summary: The impact of COVID-19 on tuberculosis has resulted in reduced TB cases, delayed diagnosis and treatment, and increased mortality rates. The TB/COVID-19 co-infected cohort in Serbia showed some differences compared to the global cohort, but achieved a higher treatment success rate.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Belela Samuel Kotola, Shewafera Wondimagegnhu Teklu, Yohannes Fissha Abebaw
Summary: This paper formulates and analyzes a mathematical model for the transmission dynamics of HIV/AIDS and COVID-19 co-infection, considering protection and treatment for the infected groups. The non-negativity and boundedness of the co-infection model solutions are proven, and the steady states of the single infection models are analyzed. The basic reproduction numbers are calculated using the next generation matrix approach, and the existence and local stability of equilibriums are investigated using Routh-Hurwiz stability criteria. The model exhibits the phenomenon of backward bifurcation whenever its effective reproduction number is less than unity. Optimal control strategies are incorporated, and necessary conditions for the optimal control of the disease are derived using Pontryagin's Maximum Principle. Numerical simulations show that the combination of all possible protection and treatment strategies is the most effective strategy for minimizing the transmission of HIV/AIDS and COVID-19 co-infection.
Article
Multidisciplinary Sciences
Tesfaneh Debele Batu, Legesse Lemecha Obsu, Chernet Tuge Deressa
Summary: The study investigates the impact of intervention strategies on the death risk of people living with HIV when infected with COVID-19. It develops a mathematical model to analyze the transmission dynamics of COVID-19 and HIV co-infection. The findings indicate that increasing COVID-19 vaccination and treating co-infected individuals can reduce the death risk of HIV-infected individuals due to the co-infection burden.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Zenebe Shiferaw Kifle, Legesse Lemecha Obsu
Summary: This study proposes a mathematical model to thoroughly examine the dynamics of COVID-19 and tuberculosis (TB). It investigates the single infection dynamics of COVID-19 and TB, as well as their co-dynamics. The model's equilibria and their stability are analyzed, and numerical simulations are conducted to validate the analytical findings.
Review
Immunology
Pingying Qing, Chenyang Lu, Zhihui Liu, Xiuzhen Wen, Bo Chen, Zhiguo Lin, Yingbing Ma, Yi Zhao, Yi Liu, Chunyu Tan
Summary: IgG4-RD is a systemic fibro-inflammatory disease involving multiple organs. This study showed a high frequency of TB/LTBI in IgG4-RD patients, with 36.2% presenting concurrent TB disease or latent TB infection. The findings suggest the need for close monitoring for TB resurgence in IgG4-RD patients with LTBI, and further investigation into the potential risk of TB in IgG4-RD.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Anna Malkova, Irina Dovgaluk, Dmitry Kudlay
Summary: COVID-19 infection affects the detection and immune response of tuberculosis (Tbc), and it is important to understand the immune response alterations in latent tuberculosis infection and in tuberculosis patients with SARS-CoV-2 infection. The findings suggest that COVID-19 may lead to disturbed immune responses and increase the risk of developing severe tuberculosis.
Article
Immunology
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Summary: Individuals aged >61 show intrinsic changes in T cell responses during SARS-CoV-2 infection, including reduced cytokine production capacity and increased PD-1(+) cells. These findings may provide insights into dysregulated immune responses in COVID-19 in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
H. Li, W. Ren, Q. Liang, X. Zhang, Q. Li, Y. Shang, L. Ma, S. Li, Y. Pang
Summary: This study aimed to identify potential antigen-specific biomarkers for differentiating latent TB infection (LTBI) from active TB (ATB). The results showed that CCL8 and CXCL9 could effectively discriminate between LTBI and TB cases, and the combination of these two markers achieved the highest diagnostic efficiency.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)
Article
Infectious Diseases
Delia Goletti, Giovanni Delogu, Alberto Matteelli, Giovanni Battista Migliori
Summary: The article discusses the tests available for diagnosing tuberculosis (TB) infection, options for preventive therapy, and the importance of a TB infection registry in controlling the disease. The current tests lack accuracy in identifying individuals who will develop TB disease from those who will not. Shorter duration preventive therapies are available but need global implementation. The establishment of a TB infection registry is crucial for improving the cascade of care and achieving better TB control.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Ivana Palucci, Alessandro Salustri, Flavio De Maio, Maria del Carmen Pereyra Boza, Francesco Paglione, Michela Sali, Luca Occhigrossi, Manuela D'Eletto, Federica Rossin, Delia Goletti, Maurizio Sanguinetti, Mauro Piacentini, Giovanni Delogu
Summary: This study aimed to test the potential activity of cysteamine and cystamine against Mycobacterium abscessus. The results showed that these drugs restricted the growth of M. abscessus in human macrophages and had enhanced activity when combined with amikacin. The treatment with these drugs was more effective against MAB-S infection and reduced the inflammatory response triggered by MAB-R infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Alessandra Aiello, Andrea Coppola, Serena Ruggieri, Chiara Farroni, Anna Maria Gerarda Altera, Andrea Salmi, Valentina Vanini, Gilda Cuzzi, Linda Petrone, Silvia Meschi, Daniele Lapa, Aurora Bettini, Shalom Haggiag, Luca Prosperini, Simonetta Galgani, Maria Esmeralda Quartuccio, Nazario Bevilacqua, Anna Rosa Garbuglia, Chiara Agrati, Vincenzo Puro, Carla Tortorella, Claudio Gasperini, Emanuele Nicastri, Delia Goletti
Summary: COVID-19 vaccine booster strengthens humoral and Th1-cell responses and increases T-EM cells in patients with multiple sclerosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Louise Pierneef, Anouk van Hooij, Danielle de Jong, Elisa M. Tjon Kon Fat, Krista E. van Meijgaarden, Elisa Petruccioli, Valentina Vanini, Anna H. E. Roukens, Delia Goletti, Paul L. A. M. Corstjens, Simone A. Joosten, Annemiek Geluk, BEAT COVID Study Grp
Summary: Diagnostic services for TB and COVID-19 are not easily accessible in low-resource settings. This study demonstrates the potential of non-sputum lateral flow assays as adjunct diagnostics and treatment monitoring for both diseases based on quantitative detection of multiple host biomarkers.
Editorial Material
Infectious Diseases
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Rhea Coler, Catherine Wei Min Ong, Susanna Maria Roberta Esposito, Marina Tadolini, Alberto Matteelli, Daniela Cirillo, Elisa Nemes, Alimuddin Zumla, Eskild Petersen
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Serena Ruggieri, Alessandra Aiello, Carla Tortorella, Assunta Navarra, Valentina Vanini, Silvia Meschi, Daniele Lapa, Shalom Haggiag, Luca Prosperini, Gilda Cuzzi, Andrea Salmi, Maria Esmeralda Quartuccio, Anna Maria Gerarda Altera, Anna Rosa Garbuglia, Tommaso Ascoli Bartoli, Simonetta Galgani, Stefania Notari, Chiara Agrati, Vincenzo Puro, Emanuele Nicastri, Claudio Gasperini, Delia Goletti
Summary: This study investigated the antibody and T-cell immune responses in multiple sclerosis patients (PwMS) undergoing different disease-modifying treatments (DMTs) after receiving the two-dose schedule of a COVID-19 mRNA vaccine. The results showed a significant decrease in seroconversion rate and anti-receptor-binding domain (RBD)-IgG titers from the first dose to 24 weeks later, and a significant increase after the booster dose. The booster dose improved both humoral and cell-mediated immune responses, especially in PwMS, highlighting the need for tailored strategies for immunocompromised patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Gherard Batisti Biffignandi, Ambra Vola, Davide Sassera, Saeid Najafi-Fard, Maria Angeles Gomez Morales, Enrico Brunetti, Antonella Teggi, Delia Goletti, Linda Petrone, Francesca Tamarozzi
Summary: This study used bioinformatics analysis and peptide microarray to identify antigenic peptides for the diagnosis of cystic echinococcosis (CE). They validated eight candidates, but found that reactivity to one peptide had suboptimal diagnostic accuracy.
PLOS NEGLECTED TROPICAL DISEASES
(2023)
Review
Microbiology
Linda Petrone, Alessandro Sette, Rory D. de Vries, Delia Goletti
Summary: Neutralizing antibodies and T-cell responses are crucial factors in protecting against SARS-CoV-2 infection and severe COVID-19. T-cell responses after vaccination are similar to those after natural infection in terms of magnitude and functional capacity, but differ in breadth. T-cell responses provide long-term defense and retain reactivity against SARS-CoV-2 variants, making continuous monitoring necessary.
Article
Biochemistry & Molecular Biology
Annapaola Santoro, Andrea Capri, Daniele Petrone, Francesca Colavita, Silvia Meschi, Giulia Matusali, Klizia Mizzoni, Stefania Notari, Chiara Agrati, Delia Goletti, Patrizio Pezzotti, Vincenzo Puro
Summary: This study investigated the incidence of vaccine breakthrough infections in COVID-19-free individuals after receiving the mRNA third dose vaccine, based on B- and T-cell immune responses. The results showed that there were no protective thresholds for SARS-CoV-2 infection in terms of antibody levels or cellular immune response. Therefore, measuring vaccine-induced humoral immune response is not recommended as a marker for assessing protective immunity against SARS-CoV-2.
Review
Pathology
Tonino Alonzi, Federica Repele, Delia Goletti
Summary: Despite efforts, tuberculosis remains a major global health threat with a quarter of the world's population estimated to be infected by Mycobacterium tuberculosis (Mtb). Currently, there is no gold standard test for diagnosing tuberculosis infection (TBI) although new methodologies have been attempted.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2023)
Article
Cell Biology
Alessandra Romagnoli, Martina Di Rienzo, Elisa Petruccioli, Carmela Fusco, Ivana Palucci, Lucia Micale, Tommaso Mazza, Giovanni Delogu, Giuseppe Merla, Delia Goletti, Mauro Piacentini, Gian Maria Fimia
Summary: In this study, the role of TRIM proteins in the host response to Mtb infection was investigated. TRIM32 was identified as a novel factor involved in the intracellular response to Mtb infection, promoting autophagy-mediated Mtb degradation. Silencing TRIM32 expression in THP1 cells resulted in increased intracellular growth of Mtb, impaired Mtb ubiquitination, reduced recruitment of autophagy proteins to Mtb, and decreased autophagosome formation. These findings suggest that TRIM32 plays an important role in the host response to Mtb infection and could be a promising target for tuberculosis therapies.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Andrea Picchianti-Diamanti, Assunta Navarra, Alessandra Aiello, Bruno Lagana, Gilda Cuzzi, Andrea Salmi, Valentina Vanini, Fabrizio Maggi, Silvia Meschi, Giulia Matusali, Stefania Notari, Chiara Agrati, Simonetta Salemi, Roberta Di Rosa, Damiano Passarini, Valeria Di Gioia, Giorgio Sesti, Fabrizio Conti, Francesca Romana Spinelli, Angela Corpolongo, Maria Sole Chimenti, Mario Ferraioli, Gian Domenico Sebastiani, Maurizio Benucci, Francesca Li Gobbi, Anna Paola Santoro, Andrea Capri, Vincenzo Puro, Emanuele Nicastri, Delia Goletti
Summary: Breakthrough infections (BIs) in rheumatoid arthritis (RA) patients after a COVID-19 vaccination booster dose were analyzed. Older age, receiving conventional synthetic disease modifying antirheumatic drugs (csDMARDs), and higher neutralising antibody titres were identified as protective factors, while anti-IL6R treatment and anti-CD20 therapy increased the risk. The incidence of hospitalization for BIs was significantly higher in RA patients compared to healthcare workers.
Article
Immunology
Giulia Matusali, Elisa Petruccioli, Eleonora Cimini, Francesca Colavita, Aurora Bettini, Eleonora Tartaglia, Settimia Sbarra, Silvia Meschi, Daniele Lapa, Massimo Francalancia, Licia Bordi, Valentina Mazzotta, Sabrina Coen, Klizia Mizzoni, Alessia Beccacece, Emanuele Nicastri, Luca Pierelli, Andrea Antinori, Enrico Girardi, Francesco Vaia, Alessandro Sette, Alba Grifoni, Delia Goletti, Vincenzo Puro, Fabrizio Maggi
Summary: This study found that a high proportion of individuals who received the smallpox vaccine 40 to 60 years ago have humoral cross-immunity to MPXV, while a smaller group of vaccinated individuals showed a T-cell-specific response against MPXV.
Article
Respiratory System
[Anonymous]
Summary: The objective of this study is to describe country-specific lockdown measures and tuberculosis indicators during the first year of the COVID-19 pandemic. The results showed that although lockdown measures effectively contained COVID-19 cases, several indicators of tuberculosis were affected during the pandemic.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
