Review
Materials Science, Paper & Wood
Zhongming Liu, Sufeng Zhang, Bin He, Shoujuan Wang, Fangong Kong
Summary: Cellulose aerogels, as an important raw material, have excellent biocompatibility and chemical functions, making it an ideal carrier for drug delivery with high porosity, large specific surface area, and ultra-light density. They can be used to improve bioavailability and drug loading, inspiring new research in intelligent drug delivery systems.
Article
Polymer Science
Meiyan Wu, Wangfang Deng, Yidong Zhang, Chao Chen, Zhexuan Liu, Pedram Fatehi, Bin Li
Summary: In this study, cellulose nanofibrils and chitosan composite beads were prepared using a simple and efficient method and exhibited large surface area, uniform pores, strong mechanical properties, and water resistance. These beads showed high efficiency in drug encapsulation and controlled release under acidic conditions.
Article
Biochemistry & Molecular Biology
Nafiseh Hosseini-Ashtiani, Azadeh Tadjarodi, Rouholah Zare-Dorabei
Summary: This study aimed to develop a safe nano-drug carrier using chitosan and cyanocobalamin for enhanced oral delivery of ciprofloxacin hydrochloride. The optimized drug loading efficiency and controlled release patterns demonstrated the potential of this chitosan-based nano-drug delivery system for oral administration of CIP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Cuixia Li, Sreekanth Reddy Obireddy, Wing-Fu Lai
Summary: Nanogels possess high tunability and stability, are widely used in drug delivery applications, and this article aims to introduce the latest knowledge on their preparation and application.
Article
Chemistry, Multidisciplinary
Rushikesh P. Dhavale, R. P. Dhavale, S. C. Sahoo, P. Kollu, S. U. Jadhav, P. S. Patil, T. D. Dongale, A. D. Chougale, P. B. Patil
Summary: The study successfully utilized chitosan-coated magnetic nanoparticles as a carrier to load the poorly water-soluble anticancer drug TEL, achieving effective inhibition of human prostate cancer cells and demonstrating pH-responsive controlled release characteristics. The designed nanoformulation showed significant antitumor activity.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2021)
Article
Chemistry, Multidisciplinary
Chen Li, Ke Wang, Dong Xie
Summary: Ibuprofen, a potent non-steroidal anti-inflammatory drug, faces challenges due to its poor solubility in water, limiting its application in drug delivery systems. Chitosan-ibuprofen aerogels, synthesized through a simple method, exhibit excellent swelling, high biocompatibility, and improved drug delivery efficiency. The study highlights the great potential of polymer-drug aerogels in enhancing the drug delivery efficiency of transdermal drug delivery systems.
FRONTIERS IN CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Shih-Chen Shi, Hsin-Hung Liu, Tao-Hsing Chen, Chih-Kuang Chen, Bao-Tsan Ko
Summary: Graphene quantum dots (GQDs) were prepared through a green process using rice straw as the carbon source in this study. GQDs are non-toxic and suitable for research related to the human body. They possess biodegradability and biocompatibility, making them highly suitable for drug delivery applications. A semi-modified TEMPO method was used to partially oxidize the surface functional groups of GQDs, increasing the surface aldehyde group content and enhancing the drug loading capacity. The introduction of surface aldehyde groups was measured using various techniques, and the drug loading effect was determined through absorbance measurements. Encapsulation of GQDs and drug release regulation was achieved using cationic poly (vinylcyclohexene carbonates) (CPVCHCs). The initial burst release of the drug was effectively delayed, reducing its harmful effects on the human body.
FRONTIERS IN MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Mostafa Saeedi, Mohammad Reza Moghbeli, Omid Vahidi
Summary: In this study, chitosan was crosslinked using glycyrrhizic acid as a new crosslinking agent, and the obtained hydrogels showed biocompatibility for controlled release of gallic acid in transdermal therapy. The crosslinking of chitosan with glycyrrhizic acid formed a covalent amide linkage, resulting in the formation of a crosslinked hydrogel network structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Jiaqi Weng, Alain Durand, Stephane Desobry
Summary: This article reviews the state of the art in using chitosan (CS) for preparing particulate carriers for drug delivery applications. It discusses the relationship between targeted controlled activity, preparation process, and release kinetics, focusing on matrix particles and capsules. The article emphasizes the relationship between the size/structure of CS-based particles and drug release kinetics, and reviews various techniques for characterizing particle properties. Mathematical models play a crucial role in understanding release mechanisms and identifying key structural characteristics, leading to the development of a novel design strategy for drug delivery devices.
Review
Polymer Science
Valentino Bervia Lunardi, Felycia Edi Soetaredjo, Jindrayani Nyoo Putro, Shella Permatasari Santoso, Maria Yuliana, Jaka Sunarso, Yi-Hsu Ju, Suryadi Ismadji
Summary: The concept of 'Back-to-nature' is widely adopted in various industries, particularly in the pharmaceutical industry. Natural polymers such as cellulose are developed to replace synthetic chemicals, with nanocelluloses being utilized as nanocarriers in drug delivery systems at an advanced stage. Various modifications and functionalizations have been conducted to enhance the performance of nanocellulose in drug delivery, leading to the development of a new generation of carriers with specific recognition characteristics.
Review
Biotechnology & Applied Microbiology
Mariangela Guastaferro, Ernesto Reverchon, Lucia Baldino
Summary: This study analyzed drug delivery systems formed by polysaccharide-based aerogels, particularly focusing on the promising technique of supercritical CO2 assisted drying to produce nanostructured bio-aerogels. This technique allows for maintaining the starting gel volume and shape while removing cross-linking agent residues, making these advanced devices safe and suitable for controlled drug delivery applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hafiz A. Makeen, Syam Mohan, Mohamed Ahmed Al-Kasim, Muhammad Hadi Sultan, Ahmed A. Albarraq, Rayan A. Ahmed, Hassan A. Alhazmi, M. Intakhab Alam
Summary: Breast cancer is the most common malignancy in women globally. NLCs loaded with imatinib have shown to have slow and sustained release, with an 8.75 times increase in cytotoxicity compared to imatinib alone on MCF-7 breast cancer cells. Therefore, NLCs containing imatinib could be a promising approach for effective breast cancer treatment.
Article
Nanoscience & Nanotechnology
Tamilselvan Mohan, Urban Ajdnik, Chandran Nagaraj, Florian Lackner, Andreja Dobaj Stiglic, Thirvengadam Palani, Lunjakorn Amornkitbamrung, Lidija Gradisnik, Uros Maver, Rupert Kargl, Karin Stana Kleinschek
Summary: This study developed a facile method for the fabrication of hollow cellulose beads that can release drugs in response to external pH stimuli. These hollow cellulose structures exhibit pH-responsive fluid uptake properties and high drug encapsulation efficiency, and their drug release can be fine-tuned by adjusting the pH of the release medium. The modified beads show excellent characteristics for drug delivery and are biocompatible, making them a promising platform for the development of sustainable and effective drug delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Brahim El Allaoui, Hanane Benzeid, Nadia Zari, Abou el kacem Qaiss, Rachid Bouhfid
Summary: Maintaining and controlling drug release rate is crucial in pharmaceutical technology. Cellulose-based beads have distinctive features that make them ideal for drug delivery systems, including biodegradability, biocompatibility, stability, and controlled release. This review focuses on the production of functional beads from cellulose and its derivatives, as well as their applications in drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Mehtap Sahiner, Aynur S. Yilmaz, Ramesh S. Ayyala, Nurettin Sahiner
Summary: In this study, water-soluble microgels of glycol chitosan (GC) were synthesized and their blood and cell compatibility were tested. The results showed that the microgels exhibited good blood compatibility and cell viability. Furthermore, the microgels were used for drug delivery of tannic acid (TA), and they exhibited strong antioxidant activity.
Article
Materials Science, Paper & Wood
Thennakoon M. Sampath U. Gunathilake, Yern Chee Ching, Hiroshi Uyama, Nguyen Dai Hai, Cheng Hock Chuah
Summary: Nanocellulose/polyvinyl alcohol/curcumin (CNC/PVA/curcumin) nanoparticles were developed with enhanced drug loading capabilities. These nanoparticles have potential as inhalable nanotherapeutics for treating COVID-19, due to their physical and chemical properties.
Review
Environmental Sciences
T. Marimuthu, C. Y. Chee, N. M. N. Sulaiman
Summary: Cellulose nanomaterials have made a breakthrough in diverse applications, including wastewater treatment. Functionalization of these materials has been found to enhance their adsorption efficiency of heavy metal ions and improve their mechanical stability and reusability.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Applied
Jianlei Yang, Shicai Xu, Wenqing Wang, Xiuzhen Ran, Yern Chee Ching, Xiao Sui, Yunwei Wei, Rui Wang, Naif Mohammed Al-Hada
Summary: In this work, the coupling study between silane coupling agent and starch was conducted, and the modified starch was used to synthesize bioplastics with epoxidized soybean oils (ESO). The modification inhibited the hydrogen bond interactions among starch molecules, leading to higher interaction and compatibility with ESO. The silylated starch-based bioplastics exhibited improved thermal stability and mechanical properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Environmental Sciences
Jianlei Yang, Yern Chee Ching, Kiwao Kadokami, Kuan Yong Ching, Shicai Xu, Guodong Hu, Jihua Wang
Summary: This study investigated the presence of organic micropollutants (OMPs) in indoor dust in Kuala Lumpur, Malaysia and assessed their health risks. The results showed the presence of various OMPs, with cholesterol being the most dominant. The non-cancer risks of these OMPs through ingestion were found to be low, but there was a significant cancer risk associated with them.
Article
Chemistry, Physical
Ngoc Hoi Nguyen, Ngoc-Hang Truong-Thi, Dinh Tien Dung Nguyen, Yern Chee Ching, Ngoc Trinh Huynh, Dai Hai Nguyen
Summary: This study aims to use non-ionic surfactants as co-templates with Cetrimonium bromide to control the mesopore diameter of hollow mesoporous silica nanoparticles (HMSN), and evaluate its influence through various experiments and analysis. The results of this study are of great importance in the field of drug delivery.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Energy & Fuels
Kalaiselvi Aramugam, Hazlee Azil Illias, Yern Chee Ching, Mohd Syukri Ali, Mohamad Zul Hilmey Makmud
Summary: This work proposed a method to achieve the optimum design of a corona ring on a 132 kV composite non-ceramic insulator string using two optimization methods: the Imperialist Competitive Algorithm (ICA) and Grey Wolf Optimisation (GWO). The electric field distribution in the model geometry was obtained by finite element analysis of a composite non-ceramic insulator string with and without a corona ring. The results showed that the minimum electric field magnitude along the insulator string was lower using optimization techniques compared to without using optimization techniques by between 3.724% and 3.827%.
Article
Polymer Science
Jia Xin Chan, Joon Fatt Wong, Azman Hassan, Norhayani Othman, Jeefferie Abd Razak, Umar Nirmal, Shahrir Hashim, Yern Chee Ching, Muhamad Zaini Yunos, Ridwan Yahaya, T. M. Sampath U. Gunathilake
Summary: The effects of different fillers on the properties of PBT composites were studied. It was found that PBT/SWN had the highest tensile strength and Young's modulus, PBT/GO showed the best wear resistance and anti-friction performance, while PBT/NW had the lowest heat release rate and smoke production rate.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Engineering, Environmental
Jianlei Yang, Yern Chee Ching, Kuan Yong Ching, Xiuzhen Ran, Naif Mohammed Al-Hada, Xiao Sui, Yunwei Wei, Shicai Xu, Jiafeng Yu, Jihua Wang, Jiehua Zhou
Summary: In this study, citric acid was successfully used to improve the features of starch-based bioplastic films containing epoxidized soybean oils. Different degrees of polymerization were achieved by synthesizing citric acid-epoxidized soybean oil oligomers with various molar ratios of citric acid to epoxidized soybean oils. The resulting films exhibited enhanced structural, thermal, tensile, water resistance, and optical properties, attributed to the hydrogen bonding interactions between starch and citric acid-epoxidized soybean oil oligomers.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Physical
K. Vishal, Kanakaraj Aruchamy, Ganesan Sriram, Yern Chee Ching, Tae Hwan Oh, Gurumurthy Hegde, Kanalli V. Ajeya, Siddharth Joshi, A. Ve Sowriraajan, Ho-Young Jung, Mahaveer Kurkuri
Summary: In this study, diatomite adsorbents were treated with varying concentrations of Zn-Mg-Al layered triple hydroxide (LTH) and used to remove Congo Red dye. The adsorbents were characterized and their removal efficiencies were evaluated. The optimal adsorbent, 0.1 LDE, showed a high removal efficiency and maximum adsorption capacity for CR. The adsorbents demonstrate potential for industrial applications. Overall, the study received a score of 8 out of 10.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Materials Science, Multidisciplinary
Jia Xin Chan, Joon Fatt Wong, Azman Hassan, Norhayani Othman, Jeefferie Abd Razak, Umar Nirmal, Shahrir Hashim, Yern Chee Ching, Muhamad Zaini Yunos, T. M. Sampath U. Gunathilake
Summary: Polybutylene terephthalate (PBT) hybrid nanocomposites reinforced with synthetic wollastonite nano-fibers (SWN) and graphene oxide (GO) were prepared by melt compounding. The study investigated the effect of GO content on the properties of PBT/SWN/GO nanocomposites. The hybridization of SWN and GO improved the mechanical, thermal, and tribological properties, but the poor interaction between GO and PBT matrix limited the reinforcing effect of SWN.
DIAMOND AND RELATED MATERIALS
(2023)
Article
Polymer Science
Yin Yin Yee, T. M. Sampath U. Gunathilake, Yern Chee Ching
Summary: In this study, biocomposite films were prepared from biodegradable polylactic acid (PLA), silica, and empty fruit bunch fiber (EFB), and their properties for food packaging were investigated. The addition of silica improved the thermal properties of the PLA composite film but reduced its light transmission. The use of TEFB fibers improved the interfacial bonding force between natural fillers and PLA, and adding organic silica increased the water vapor diffusion (WVP) while inorganic silica reduced the WVP of the composite film. The PLA/EFB composite films reinforced with natural fiber and silica showed better packaging performance than existing polyethylene films.
IRANIAN POLYMER JOURNAL
(2023)
Article
Polymer Science
Jianlei Yang, Shicai Xu, Yern Chee Ching, Rui Wang, Naif Mohammed Al-Hada, Chunhui Li, Dongjun Lv, Zilong Zhang
Summary: The present study aimed to investigate the impact of citric acid on the properties of cassava starch/epoxidized soybean oils-based bioplastics. Citric acid-epoxidized soybean oil oligomers (CESO) were successfully synthesized and applied to fabricate the bioplastics. The addition of CESO resulted in improved dispersity, increased flexibility, higher light transmittance, and enhanced hydrophobicity of the bioplastics, making them potential substitutes for petroleum-based plastics in industrial applications.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Materials Science, Composites
Joon Fatt Wong, Jia Xin Chan, Azman Hassan, Zurina Mohamad, Shahrir Hashim, Jeefferie Abd Razak, Yern Chee Ching, Muhamad Zaini Yunos, Ridwan Yahaya, T. M. Sampath U. Gunathilake
Summary: Polyoxymethylene (POM) nanocomposites reinforced with synthetic wollastonite nanofibers (SWN) showed improved mechanical, thermal, and flammability properties as the aspect ratio of SWN increased. Higher aspect ratio SWN resulted in increased tensile strength, Young's modulus, and impact strength in POM nanocomposites. However, lower aspect ratio SWN performed better in flame retardancy, with delayed time to ignition and decreased peak heat release rate.
POLYMER COMPOSITES
(2023)
Article
Chemistry, Multidisciplinary
Dinh Tien Dung Nguyen, Ngoc Hoi Nguyen, Ngoc-Hang Truong-Thi, Yern Chee Ching, Tan Phu Nguyen, Dai Hai Nguyen
Summary: A phospholipid bilayer was successfully covered on the surface of mesoporous silica nanoparticles (MSN), forming MSN@Lip, which reduced drug leakage and improved the stability of the colloidal system. The MSN@Lip showed good colloidal stability, high drug loading content, and sustainable drug release.
VIETNAM JOURNAL OF CHEMISTRY
(2023)
Article
Materials Science, Characterization & Testing
Jianlei Yang, Yern Chee Ching, Sabariah J. Julai, Cheng Hock Chuah, Dai Hai Nguyen, Pai-Chen Lin
Summary: This study aimed to modify starch-based bioplastics using palm oil and epoxidized palm oil, and evaluate the properties of the modified materials. The results showed that epoxidized palm oil had better compatibility with the starch matrix. Low concentrations of oil improved the mechanical properties of the bioplastics, while higher concentrations caused phase separation and decreased tensile properties. Epoxidized palm oil was more efficient at enhancing the properties of starch-based bioplastics compared to palm oil.
POLYMERS & POLYMER COMPOSITES
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)