Article
Chemistry, Applied
Soledad Roig-Sanchez, Doron Kam, Nanthilde Malandain, Ela Sachyani-Keneth, Oded Shoseyov, Shlomo Magdassi, Anna Laromaine, Anna Roig
Summary: Acrylate hydrogels are potential soft tissue implants, but their weak mechanical properties and dimensional changes in liquids limit their applications. By fabricating double network hydrogels, the mechanical properties and swelling behavior of acrylate hydrogels can be improved.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Hailin Wu, Jing Chen, Jiyoung Kim, Peizhi Zhu, Jiadeng Zhu, Qiang Gao, Chunxia Gao
Summary: In this study, a transparent poly (gamma-glutamic acid) modified polyvinyl alcohol (gamma-PGA/PVA) hydrogel with excellent mechanical properties was prepared by immersion method. The hydrogel showed high tensile strength, toughness, torsion, knotting, and puncture resistance, as well as good conductivity and sensitivity to external strain. The cytocompatibility of the hydrogel with MC3T3-E1 cells was also demonstrated.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Mengmeng Wang, Erwei Zhang, Chenrui Yu, Dandan Liu, Shiguang Zhao, Maodong Xu, Xiaofeng Zhao, Wenjin Yue, Guangjun Nie
Summary: In this study, Dendrobium officinale enzyme (DOE) was used to improve the properties of chitosan/gamma-poly(glutamic acid) (CS/gamma-PGA) hydrogel. The results showed that DOE can enhance the toughness of the hydrogel and improve its skincare effects.
Article
Engineering, Biomedical
Min Hee Kim, Jeehee Lee, Jee Na Lee, Haeshin Lee, Won Ho Park
Summary: The adhesion of catechol-functionalized nanocomposite hydrogels can be greatly enhanced by tuning the cohesive strength through secondary crosslinking with Laponite. This dual-crosslinked hydrogel shows strong tissue adhesive property and excellent hemostatic properties, making it a promising biological tissue adhesive for various tissue types.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Masahiko Nakamoto, Moe Noguchi, Akihiro Nishiguchi, Joao F. F. Mano, Michiya Matsusaki, Mitsuru Akashi
Summary: Researchers have developed a highly stretchable hydrogel based on the crosslinking structure between calcium cations and alendronates conjugated with poly-gamma-glutamate. The hydrogel exhibits 2000% stretchability and reversible stretching without failure at a strain of 250%. By adjusting the concentration of the crosslinker or calcium chloride, the fracture strain and stress of the hydrogel can be controlled. This biodegradable polymer-based hydrogel shows promise in applications such as tissue engineering.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Applied
Hee Cheol Kim, Eunu Kim, Bo Min Hong, Su A. Park, Won Ho Park
Summary: In this study, a tyramine-modified poly(γ-glutamic acid) was synthesized for 3D bioprinting of a photocrosslinked hydrogel. The gelation time decreased with increasing tyramine substitution, and the optimal photoinitiation conditions were found to be Ru2+ concentration of 0.5 mM and sodium persulfate of 40 mM. The mechanical properties of the hydrogel were in agreement with the crosslinking density and molecular weight between crosslinks. The cytotoxicity and proliferative ability of the hydrogel were excellent, and a lattice structure was successfully fabricated via 3D bioprinting.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Engineering, Biomedical
Rong Yang, Xin Liu, Yanhan Ren, Wenliang Xue, Shuai Liu, Penghui Wang, Ming Zhao, Hong Xu, Bo Chi
Summary: The bionic extracellular matrix hydrogels developed in this study possess dynamic covalent network and self-healing capability, showing typical viscoelastic characteristics, degradation property, and free radical scavenging capability. The properties of the hydrogels can be tuned by adjusting polymer content, and they significantly enhance wound healing process by promoting angiogenesis and collagen deposition, demonstrating great application potential in biomedical areas.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Hee Cheol Kim, Jee Na Lee, Eunu Kim, Min Hee Kim, Won Ho Park
Summary: The study demonstrates that the γ-PGA/DA/CHI-O hydrogels exhibit excellent self-healing properties and adhesion strength, making them promising as self-healing and tissue adhesive biomaterials.
Article
Biochemistry & Molecular Biology
Ziwei Hu, Dandan Liu, Mengmeng Wang, Chenrui Yu, Zhenxing Han, Maodong Xu, Wenjin Yue, Guangjun Nie
Summary: The introduction of amino acid (AA) can enhance the crosslinking and mechanical properties of chitosan (CS)/poly-(gamma-glutamic acid) (gamma-PGA) hydrogel. 0.5% beta-alanine (beta-Ala) can strengthen the load and release capacity of benzalkonium chlorides (BAC) in alkaline environment, making CS/beta-Ala/gamma-PGA hydrogel a potential material for wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biotechnology & Applied Microbiology
Zheng Zhang, Penghui He, Dongbo Cai, Shouwen Chen
Summary: This review focuses on the genetic and metabolic engineering of microorganisms for gamma-PGA production, including strategies to enhance raw materials utilization, precursor supply, gamma-PGA synthetase gene cluster, transcription regulation, cofactor regeneration, energy engineering, and blocking synthetic pathways of by-products. The expression of gamma-PGA synthetase, glutamate racemase, and gamma-PGA hydrolase were manipulated to obtain gamma-PGA with different configurations and molecular weights. The review also discusses the metabolic engineering of other hosts for high-level production of gamma-PGA.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Junwen Peng, Hanmeng Yuan, Tingting Ren, Zhihuan Liu, Jianzheng Qiao, Qiang Ma, Xin Guo, Guoxin Ma, Yiqiang Wu
Summary: A fluorescent nanocellulose-based hydrogel incorporating titanate nanofibers was developed as an effective adsorbent for the sorption and detection of Cr(VI) ion. The hydrogel exhibited excellent sorption capacity and rapid visual response to Cr(VI) due to its three-dimensional porous structure.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Chunyan Dou, Zheng Li, Ying Luo, Jixian Gong, Qiujin Li, Jianfei Zhang, Qingsong Zhang, Changsheng Qiao
Summary: A hybrid double-network (DN) full biological hydrogel was successfully constructed by introducing a physically cross-linked gelatin (GEL) network in a covalently cross-linked poly (gamma-glutamic acid) (gamma-PGA) network. The gamma-PGA-GEL DN hydrogel exhibited excellent mechanical properties and biocompatibility, with ultra-high compression performance and satisfactory tensile performance. It also showed better recovery and healing properties compared to the gamma-PGA single-network (SN) hydrogel. In addition, the gamma-PGA-GEL DN hydrogel had good transparency, swelling, and degradability. In vitro cell experiments demonstrated its benefits in cell adhesion and proliferation. Evaluation on a rat skin defect model showed that the gamma-PGA-GEL DN hydrogel could significantly accelerate wound healing, making it an ideal candidate material for wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Yue Jiao, Ya Lu, Kaiyue Lu, Yiying Yue, Xinwu Xu, Huining Xiao, Jian Li, Jingquan Han
Summary: The composite hydrogel composed of polyaniline, polyacrylic acid, and oxidized cellulose nanofibrils exhibits excellent mechanical properties, electrical conductivity, and self-healing abilities, making it a promising material for applications in health monitoring and smart robotics.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Applied
Xin Liu, Shuai Liu, Rong Yang, Penghui Wang, Wenjie Zhang, Xiaoyan Tan, Yanhan Ren, Bo Chi
Summary: A gradient hydrogel scaffold was designed based on the structure and composition distribution in biological cartilage tissue, showing excellent physical properties and cell compatibility. The scaffold can mimic the function of natural cartilage, making it a potential option for cartilage tissue engineering.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
X. Ma, R. Yang, P. Wang, S. Liu, H. Xu, Z. Ye, B. Chi
Summary: A facile strategy based on dynamic chemistry was presented to prepare injectable hydrogels using hyaluronic acid and poly(gamma-glutamic acid), enabling efficient stem cell delivery. The hydrogels showed stable structure, rapid self-healing ability, and injectability with dual dynamic networks. Remarkably, the hydrogels promoted stem cell viability, proliferation, and cartilage regeneration in preclinical models.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)