CRIg+ Macrophages Prevent Gut Microbial DNA–Containing Extracellular Vesicle–Induced Tissue Inflammation and Insulin Resistance

Intrahepatic bacterial metataxonomic signature in non-alcoholic fatty liver disease

(2020) Silvia Sookoian et al.   GUT

cGAS in action: Expanding roles in immunity and inflammation

(2019) Andrea Ablasser et al.   SCIENCE

The Microbiota-Produced N-Formyl Peptide fMLF Promotes Obesity-Induced Glucose Intolerance

(2019) Joshua Wollam et al.   DIABETES

STING signaling and host defense against microbial infection

(2019) Jeonghyun Ahn et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The integrative biology of type 2 diabetes

(2019) Michael Roden et al.   NATURE

An Integrated View of Immunometabolism

(2018) Yun Sok Lee et al.   CELL

The circulating microbiome signature and inferred functional metagenomics in alcoholic hepatitis

(2018) Puneet Puri et al.   HEPATOLOGY

Microglial control of astrocytes in response to microbial metabolites

(2018) Veit Rothhammer et al.   NATURE

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

(2018) Liping Zhao et al.   SCIENCE

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Efficient RNA drug delivery using red blood cell extracellular vesicles

(2018) Waqas Muhammad Usman et al.   Nature Communications

Gram-Positive Bacterial Extracellular Vesicles and Their Impact on Health and Disease

(2018) Yue Liu et al.   Frontiers in Microbiology

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Expression of STING Is Increased in Liver Tissues From Patients With NAFLD and Promotes Macrophage-Mediated Hepatic Inflammation and Fibrosis in Mice

(2018) Xianjun Luo et al.   GASTROENTEROLOGY

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Inflammatory mechanisms linking obesity and metabolic disease

(2017) Alan R. Saltiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial membrane vesicles transport their DNA cargo into host cells

(2017) Natalie J. Bitto et al.   Scientific Reports

Dual-Track Clearance of Circulating Bacteria Balances Rapid Restoration of Blood Sterility with Induction of Adaptive Immunity

(2016) Steven P. Broadley et al.   Cell Host & Microbe

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria

(2016) Zhutian Zeng et al.   Cell Host & Microbe

Changes in blood microbiota profiles associated with liver fibrosis in obese patients: A pilot analysis

(2016) Benjamin Lelouvier et al.   HEPATOLOGY

EpCAM-dependent extracellular vesicles from intestinal epithelial cells maintain intestinal tract immune balance

(2016) Lingling Jiang et al.   Nature Communications

Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery

(2015) Tek N. Lamichhane et al.   MOLECULAR PHARMACEUTICS

NOD1 and NOD2: Signaling, Host Defense, and Inflammatory Disease

(2014) Roberta Caruso et al.   IMMUNITY

Bacterial DNA Translocation Holds Increased Insulin Resistance and Systemic Inflammatory Levels in Morbid Obese Patients

(2014) Sergio Ortiz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Complement Receptor of the Ig Superfamily Enhances Complement-Mediated Phagocytosis in a Subpopulation of Tissue Resident Macrophages

(2014) N. N. Gorgani et al.   JOURNAL OF IMMUNOLOGY

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

A High-Fat Diet Is Associated With Endotoxemia That Originates From the Gut

(2012) Swaroop Pendyala et al.   GASTROENTEROLOGY

CRIg mediates early Kupffer cell responses to adenovirus

(2012) J. Q. He et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulation of CRIg Expression and Phagocytosis in Human Macrophages by Arachidonate, Dexamethasone, and Cytokines

(2011) Nick N. Gorgani et al.   AMERICAN JOURNAL OF PATHOLOGY

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE