Glutathione peroxidase-1 and neuromodulation: Novel potentials of an old enzyme

Glutathione peroxidase (GPx) acts in co-ordination with other signaling molecules to exert its own antioxidant role. We have demonstrated the protective effects of GPx,/GPx-1, a selenium-dependent enzyme, on various neurodegenerative disorders (i.e., Parkinson's disease, Alzheimer's disease, cerebral ischemia, and convulsive disorders). In addition, we summarized the recent findings indicating that GPx-1 might play a role as a neuro-modulator in neuropsychiatric conditions, such as, stress, bipolar disorder, schizophrenia, and drug intoxication. In this review, we attempted to highlight the mechanistic scenarios mediated by the GPx/GPx-1 gene in impacting these neurodegenerative and neuropsychiatric disorders, and hope to provide new insights on the therapeutic interventions against these disorders.

Automated summary

Glutathione peroxidase (GPx) acts in coordination with other signaling molecules to exert its antioxidant role and may serve as a neuro-modulator in certain neuropsychiatric conditions. This review aims to highlight the mechanistic scenarios mediated by the GPx/GPx-1 gene in impacting neurodegenerative and neuropsychiatric disorders, providing new insights for therapeutic interventions.