Critically evaluating sweet taste receptor expression and signaling through a molecular pharmacology lens

Characterization of the taste receptor‐related G‐protein, α‐gustducin, in pancreatic β‐cells

(2020) Haruhide Udagawa et al.   Journal of Diabetes Investigation

Structural basis of the activation of a metabotropic GABA receptor

(2020) Hamidreza Shaye et al.   NATURE

A subset of broadly responsive Type III taste cells contribute to the detection of bitter, sweet and umami stimuli

(2020) Debarghya Dutta Banik et al.   PLoS Genetics

Structural architecture of a dimeric class C GPCR based on co-trafficking of sweet taste receptor subunits

(2019) Jihye Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances

(2019) Liang-Dar Hwang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Introducing a New Model of Sweet Taste Receptor, a Class C G-protein Coupled Receptor (C GPCR)

(2019) Elaheh Kashani-Amin et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Insights on modulators in perception of taste modalities: a review

(2019) Shanmugamprema Deepankumar et al.   NUTRITION RESEARCH REVIEWS

Human Sweet Receptor T1R3 is Functional in Human Gastric Parietal Tumor Cells (HGT-1) and Modulates Cyclamate and Acesulfame K-Induced Mechanisms of Gastric Acid Secretion

(2018) Muhammet Zopun et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Pharmacological Perspective on the Study of Taste

(2018) R. Kyle Palmer   PHARMACOLOGICAL REVIEWS

A novel functional screening assay to monitor sweet taste receptor activation in vitro

(2017) Shanna Bastiaan-Net et al.   FLAVOUR AND FRAGRANCE JOURNAL

Evaluation of the association between the TAS1R2 and TAS1R3 variants and food intake and nutritional status in children

(2017) Silvia V. Melo et al.   GENETICS AND MOLECULAR BIOLOGY

The anatomy of mammalian sweet taste receptors

(2017) Jean-Baptiste Chéron et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural basis for perception of diverse chemical substances by T1r taste receptors

(2017) Nipawan Nuemket et al.   Nature Communications

What Does Diabetes “Taste” Like?

(2016) Fabrice Neiers et al.   Current Diabetes Reports

Characterization of the Binding Site of Aspartame in the Human Sweet Taste Receptor

(2015) Emeline L. Maillet et al.   CHEMICAL SENSES

A global reference for human genetic variation

(2015) Richard A. Gibbs et al.   NATURE

Genetics of Taste Receptors

(2014) Alexander Bachmanov et al.   CURRENT PHARMACEUTICAL DESIGN

Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice

(2014) George A. Kyriazis et al.   ENDOCRINOLOGY

Distinct Human and Mouse Membrane Trafficking Systems for Sweet Taste Receptors T1r2 and T1r3

(2014) Madoka Shimizu et al.   PLoS One

Multimodal function of the sweet taste receptor expressed in pancreatic ^|^beta;-cells: generation of diverse patterns of intracellular signals by sweet agonists

(2013) Yuko Nakagawa et al.   ENDOCRINE JOURNAL

Structural mechanism of ligand activation in human GABAB receptor

(2013) Yong Geng et al.   NATURE

A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells

(2013) Yosuke Masubuchi et al.   PLoS One

Structure and ligand recognition of class C GPCRs

(2012) Lei Chun et al.   ACTA PHARMACOLOGICA SINICA

Characterization of the Modes of Binding between Human Sweet Taste Receptor and Low-Molecular-Weight Sweet Compounds

(2012) Katsuyoshi Masuda et al.   PLoS One

Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion

(2012) G. A. Kyriazis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taste receptor signalling - from tongues to lungs

(2011) S. C. Kinnamon   Acta Physiologica

Human Genetic Polymorphisms in T1R1 and T1R3 Taste Receptor Subunits Affect Their Function

(2011) M. Raliou et al.   CHEMICAL SENSES

The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)

(2011) R.E. Steinert et al.   CLINICAL NUTRITION

Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations

(2010) Karen M Eny et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor

(2010) Takamasa Imada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

REEP2 Enhances Sweet Receptor Function by Recruitment to Lipid Rafts

(2010) E. Ilegems et al.   JOURNAL OF NEUROSCIENCE

Positive allosteric modulators of the human sweet taste receptor enhance sweet taste

(2010) G. Servant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism of the sweet taste enhancers

(2010) F. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation by Ca2+-Signaling Pathways of Adenylyl Cyclases

(2010) M. L. Halls et al.   Cold Spring Harbor Perspectives in Biology

Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes

(2009) Qing-Ying Chen et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Allelic Polymorphism within the TAS1R3 Promoter Is Associated with Human Taste Sensitivity to Sucrose

(2009) Alexey A. Fushan et al.   CURRENT BIOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Sweet Taste Receptor Expressed in Pancreatic β-Cells Activates the Calcium and Cyclic AMP Signaling Systems and Stimulates Insulin Secretion

(2009) Yuko Nakagawa et al.   PLoS One