Article
Engineering, Biomedical
Xu Xue, Yan Hu, Sicheng Wang, Xiao Chen, Yingying Jiang, Jiacan Su
Summary: Bone tissue engineering provides promising tools for the treatment of bone-related diseases using biomimetic hydrogels. This article discusses the fabrication of biomimetic hydrogels using thermal sensitive polymers, mineral ions, chemically triggered agents, photo crosslinking initiators, and enzyme triggers. These hydrogels accelerate bone regeneration and the article also highlights key factors influencing therapeutic effects.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Lei Huang, Yun Chu, Lulu Zhang, Xiru Liu, Wangping Hao, Yanyan Chen, Jianwu Dai
Summary: A double crosslinking pure chitosan (CS) hydrogel material has been designed, which shows significantly increased strength and toughness due to the synergistic effect of chemical covalent network, hydrophobic interactions, and enhanced intermolecular hydrogen bonding. The results suggest great potential applications of this hydrogel in tissue engineering and regenerative medicine.
BIOMEDICAL MATERIALS
(2021)
Article
Pharmacology & Pharmacy
Mohammad Samiei, Elaheh Dalir Abdolahinia, Marziyeh Fathi, Jaleh Barar, Yadollah Omidi
Summary: In this study, chitosan-based hydrogels were used to improve the proliferation and differentiation of dental pulp stem cells (DPSCs), with CS/GN hydrogel showing better features in enhancing DPSCs viability and osteogenic differentiation.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Cristina Gila-Vilchez, Mari Carmen Manas-Torres, Oscar Dario Garcia-Garcia, Alfredo Escribano-Huesca, Laura Rodriguez-Arco, Victor Carriel, Ismael Rodriguez, Miguel Alaminos, Modesto Torcuato Lopez-Lopez, Luis Alvarez de Cienfuegos
Summary: Fibrin hydrogels made by self-assembly of fibrinogen from human plasma are highly biocompatible and biodegradable. However, they have limited mechanical properties and are expensive to obtain. To address these issues, composite hydrogels made of fibrinogen, Fmoc-FF, and Fmoc-RGD were prepared. These composite gels exhibited improved mechanical properties compared to pure fibrin gels and showed excellent biocompatibility ex vivo. In vivo experiments showed that these gels do not cause inflammation or tissue damage and are completely resorbed, making them suitable for cell, drug, or growth factor release vehicles.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Cristina Gila-Vilchez, Mari Carmen Manas-Torres, Oscar Dario Garcia-Garcia, Alfredo Escribano-Huesca, Laura Rodriguez-Arco, Victor Carriel, Ismael Rodriguez, Miguel Alaminos, Modesto Torcuato Lopez-Lopez, Luis Alvarez de Cienfuegos
Summary: Fibrin hydrogels made from human plasma fibrinogen have excellent biocompatibility and biodegradability and are widely used in regenerative medicine. By combining fibrinogen with Fmoc-FF and Fmoc-RGD, we have developed composite hydrogels that have improved mechanical properties compared to pure fibrin gels. These composite gels show excellent biocompatibility in vitro and do not cause any inflammatory response or tissue damage in vivo, making them potential vehicles for drug or growth factor release.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Xu Xue, Yan Hu, Yonghui Deng, Jiacan Su
Summary: Hydrogels are promising candidates for bone tissue engineering due to their unique 3D network structure. Injectable hydrogels based on biocompatible materials offer advantages in minimally invasive surgery and drug delivery. Advanced approaches and innovative ideas of bioactive hydrogels are expected to enhance the quality of life for patients with bone injuries.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Applied
Sofie Houben, Louis M. Pitet
Summary: Ionically crosslinked alginate hydrogels are widely used in tissue engineering. Different crosslinking methods and metal ions have been studied in the formation of hybrid hydrogels. The mechanical properties of the resulting gels are strongly influenced by the preparation protocol and the identity of the counter-ion.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Review
Polymer Science
Suraj Arora, Gotam Das, Mohammed Alqarni, Vishakha Grover, Suheel Manzoor Baba, Priyanka Saluja, Saeed Awod Bin Hassan, Anshad M. Abdulla, Shashit Shetty Bavabeedu, Shahabe Saquib Abullais, Gurparkash Singh Chahal, Anchal Ohri
Summary: The article introduces the application of biopolymers in biomedical engineering and the dental industry, with a focus on the uses and benefits of chitosan in clinical dentistry. Chitosan is used to enhance antimicrobial activity and biocompatibility of dental materials. Its solubility allows it to be combined with other substances to create various products.
Article
Polymer Science
Gabriela Fletes-Vargas, Hugo Espinosa-Andrews, Jose Manuel Cervantes-Uc, Isaias Limon-Rocha, Gabriel Luna-Barcenas, Milton Vazquez-Lepe, Norma Morales-Hernandez, Jorge Armando Jimenez-Avalos, Dante Guillermo Mejia-Torres, Paris Ramos-Martinez, Rogelio Rodriguez-Rodriguez
Summary: Chitosan hydrogels were prepared by freeze-drying at different concentrations and molecular weights, and sodium bicarbonate was used as a crosslinking agent for physical crosslinking of chitosan sponges. XPS analysis confirmed the physical crosslinking of chitosan hydrogels using sodium bicarbonate. The chitosan hydrogels exhibited semi-crystalline nature, highly porous structure, high water absorption, and thermal stability, as well as non-cytotoxicity towards HT29 cells. Therefore, physically crosslinked chitosan hydrogels show great potential as biomaterials for biomedical applications.
Article
Engineering, Biomedical
Qinghe Wang, Yan Zhang, Yue Ma, Miao Wang, Guoqing Pan
Summary: Nano-crosslinked dynamic hydrogels, which combine the properties of dynamic hydrogels and nanomaterials, have been extensively studied in biomedical applications. By incorporating nanomaterials as crosslinkers, the mechanical properties of hydrogels can be improved and additional functionalities can be achieved. These hydrogels show excellent biocompatibility and can promote cell proliferation and differentiation.
MATERIALS TODAY BIO
(2023)
Article
Chemistry, Applied
Mina Rajabi, Michelle McConnell, Jaydee Cabral, M. Azam Ali
Summary: Tissue engineering and regenerative medicine have progressed to a new stage due to recent advancements in biology, material sciences, and 3D printing. Chitosan-based hydrogels, widely used in biomedical applications, hold promise for future development when combined with 3D printing technology. This combination has the potential to create next generation biomedical implants.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Sofie Houben, Ana A. Aldana, An-Sofie Huysecom, Winy Mpinganzima, Ruth Cardinaels, Matthew B. Baker, Louis M. Pitet
Summary: Compositional changes in hydrogels' chemical makeup allow for precise control of their mechanical properties, catering to specific applications. The versatile system introduced here can be used in tissue engineering for various characteristics, such as blood vessels and cartilage, which require materials with different mechanical profiles. The reliance on dynamic, non-covalent cross-linking enables opportunities for 3D printing and injectability. This study presents a highly tunable system based on hydrogen bonding and ionic interactions, exploring single network hydrogels and hybrid hydrogels. By combining orthogonal cross-linking strategies and adjusting the ratio of components, a wide range of mechanical properties can be achieved. Extensive testing was conducted, including tensile testing, compression testing, and rheological measurements. Preliminary cell viability studies showed that the final scaffolds were non-cytotoxic for human dermal fibroblasts.
ACS APPLIED POLYMER MATERIALS
(2023)
Review
Chemistry, Physical
Ankur Sood, Seong Min Ji, Anuj Kumar, Sung Soo Han
Summary: Developing bioactive hydrogels for bone tissue engineering is a key challenge, with enzyme-based crosslinking methods considered the optimal approach for designing efficient hydrogel systems. Utilizing different enzymes as crosslinking agents allows for efficient preparation of hydrogels and their application in bone tissue engineering.
Article
Polymer Science
Ramona Lungu, Maria-Alexandra Paun, Dragos Peptanariu, Daniela Ailincai, Luminita Marin, Mihai-Virgil Nichita, Vladimir-Alexandru Paun, Viorel-Puiu Paun
Summary: This study investigates a supramolecular hydrogel based on chitosan and monoaldehydes as a bioabsorbable wound dressing. The hydrogel's structural and supramolecular properties, as well as its biocompatibility, antimicrobial activity, and biodegradability, were analyzed through various experiments and analyses. The results demonstrate that the hydrogel meets the expected high standards.
Article
Polymer Science
Pablo Sanchez-Cid, Mercedes Jimenez-Rosado, Jose Fernando Rubio-Valle, Alberto Romero, Francisco J. Ostos, Mohammed Rafii-El-Idrissi Benhnia, Victor Perez-Puyana
Summary: Hydrogels based on collagen and chitosan were developed and evaluated for their properties in this study. The combination of collagen and chitosan improved the thermomechanical properties and cell viability of the hydrogels, making them potential biomaterials for Tissue Engineering.
Article
Food Science & Technology
Paloma Barajas-Alvarez, Gustavo A. Castillo-Herrera, Guadalupe M. Guatemala-Morales, Rosa I. Corona-Gonzalez, Enrique Arriola-Guevara, Hugo Espinosa-Andrews
Summary: In this study, a supercritical CO2-ethanol extraction method was optimized to obtain green coffee oil rich in bioactive compounds. The extraction yield and total phenolic compound content of green coffee supercritical extract (GCSE) were evaluated using a central composite design, showing that pressure and cosolvent content significantly affected yield, while temperature and cosolvent content impacted total phenolic compound content. The optimal conditions predicted an extraction yield of 7.7% with a total phenol content of 5.4 mg gallic acid equivalent g GCSE(-1), indicating the high chemical quality and antioxidant potential of GCSE for functional ingredient use.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2021)
Review
Food Science & Technology
Paloma Barajas-alvarez, Marisela Gonzalez-avila, Hugo Espinosa-Andrews
Summary: This review discusses the fundamentals of encapsulating probiotics, the variables that affect encapsulation efficiency and the viability of probiotics under storage and gastrointestinal conditions. Probiotic encapsulation provides higher viability and allows for the development of new foods that can improve human health without altering their properties.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Food Science & Technology
Alejandro Torres-Haro, Melchor Arellano-Plaza, Juan C. Mateos-Diaz, Hugo Espinosa-Andrews, Gustavo A. Castillo-Herrera
Summary: This study evaluated the recovery of astaxanthin from Xanthophyllomyces dendrorhous using high-pressure extraction methods, finding that supercritical fluid extraction achieved a higher yield compared to microfluidisation.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Paloma Barajas-Alvarez, Marisela Gonzalez-Avila, Hugo Espinosa-Andrews
Summary: The study successfully encapsulated Lactobacillus rhamnosus cells using gum arabic blended with various materials, protecting their viability. The selection of materials and encapsulation method significantly impacted the performance of microcapsules.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Sara Elisa Herrera-Rodriguez, Eristeo Garcia-Marquez, Eduardo Padilla-Camberos, Hugo Espinosa-Andrews
Summary: Ionic calcium-fiber supplementation can prevent bone deterioration, with higher calcium solubility and no cytotoxic or genotoxic activity.
Article
Materials Science, Biomaterials
Hugo Espinosa-Andrews, Norma Morales-Hernandez, Eristeo Garcia-Marquez, Rogelio Rodriguez-Rodriguez
Summary: In this study, fish oil microcapsules were prepared using mesquite gum and chitosan as wall materials, and their encapsulation efficiency, microstructure, and lipid hydroperoxide concentration were evaluated. The results showed that mesquite gum/chitosan microcapsules exhibited higher encapsulation efficiency.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2023)
Article
Polymer Science
Samantha Free-Manjarrez, Luis Mojica, Hugo Espinosa-Andrews, Norma Morales-Hernandez
Summary: This work aimed to develop a gel as a protective barrier for common bean protein hydrolysates in Greek-style yogurt and assess its sensory perception and biological potential. The gel exhibited stable characteristics and reduced bitterness and astringency in the yogurt, making it a promising option for diabetes patients.
Article
Biochemistry & Molecular Biology
Rogelio Rodriguez-Rodriguez, Paloma Barajas-Alvarez, Norma Morales-Hernandez, Rosa Maria Camacho-Ruiz, Hugo Espinosa-Andrews
Summary: This research developed gelatine-based gels using carbohydrates from Azul variety of Agave tequilana as substitutes for sucrose and glucose. The gel formulations with agave syrups and agave fructans showed improved techno-functional properties and prebiotic effects, making them suitable for producing gel soft candies.
Article
Materials Science, Multidisciplinary
Hugo Espinosa-Andrews, Celso Velasquez-Ordonez, Jose Manuel Cervantes-Uc, Rogelio Rodriguez-Rodriguez
Summary: In this study, chitosan hydrogels were prepared using different concentrations and molecular weights of chitosan. The physicochemical properties of the hydrogels were evaluated, including thermal stability, chemical structure, microstructure, water state, water sorption, and viscoelastic properties. The chitosan hydrogels showed high hydrophilicity, solid-viscoelastic behavior, and porous, interconnected structures, making them suitable for biomedical applications as polymer scaffolds.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Gabriela Fletes-Vargas, Rogelio Rodriguez-Rodriguez, Neith Pacheco, Alejandro Perez-Larios, Hugo Espinosa-Andrews
Summary: This study optimized the extraction conditions of Polygonum cuspidatum root to increase its antioxidant capacity, extraction yield, resveratrol concentration, and total polyphenolic compounds. The optimized extract showed higher biological activities compared to the infusion and could be used for developing functional beverages, antioxidants for edible oils, functional foods, and cosmetics.
Article
Polymer Science
Gabriela Fletes-Vargas, Hugo Espinosa-Andrews, Jose Manuel Cervantes-Uc, Isaias Limon-Rocha, Gabriel Luna-Barcenas, Milton Vazquez-Lepe, Norma Morales-Hernandez, Jorge Armando Jimenez-Avalos, Dante Guillermo Mejia-Torres, Paris Ramos-Martinez, Rogelio Rodriguez-Rodriguez
Summary: Chitosan hydrogels were prepared by freeze-drying at different concentrations and molecular weights, and sodium bicarbonate was used as a crosslinking agent for physical crosslinking of chitosan sponges. XPS analysis confirmed the physical crosslinking of chitosan hydrogels using sodium bicarbonate. The chitosan hydrogels exhibited semi-crystalline nature, highly porous structure, high water absorption, and thermal stability, as well as non-cytotoxicity towards HT29 cells. Therefore, physically crosslinked chitosan hydrogels show great potential as biomaterials for biomedical applications.
Article
Biotechnology & Applied Microbiology
Paloma Barajas-Alvarez, Jose Nabor Haro-Gonzalez, Marisela Gonzalez-Avila, Hugo Espinosa-Andrews
Summary: This study used complex coacervation to encapsulate Lcb. rhamnosus strains in gum arabic/chitosan or gum arabic/trehalose/chitosan gels cross-linked with sodium tripolyphosphate. The results showed that crosslinking improved the encapsulation efficiency, especially when trehalose was used as a cryoprotectant. Furthermore, the encapsulation matrix preserved the viability of probiotics during storage conditions and improved the survival of Lcb. rhamnosus HN001 during digestion.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Polymer Science
Mustafa Kalay, Abidin Esidir, Mahmut Ruzi, N. Burak Kiremitler, Mustafa Serdar Onses
Summary: This study proposes stable and addressable polymer PUFs, utilizing a cross-linkable polymer system, which demonstrates high stochastic characteristics and low-cost production. The performance of the polymer features is evaluated through various analyses, and direct image authentication is achieved using feature matching algorithms.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jingyu Jin, Guoqiang Lu, Jun Nie, Xiaoqun Zhu
Summary: Photopolymerization technology is limited in the fields of food packaging and biomedicine due to the high migration of small molecules from photoinitiators. In this study, a polymerizable 2-vinyl thioxanthone (ETX) was synthesized to improve the migration stability of photoinitiators. Macromolecular photoinitiators (PPI1, PPI2) were also prepared to further reduce migration. The results showed that the ETX/TEOA system had higher initiation performance and PPI2 displayed favorable initiation ability. Additionally, the migration of ETX, PPI1, and PPI2 in photocured film was significantly reduced. These low-migration photoinitiators have potential applications in the fields of food packaging and biological materials.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Weijie Li, Jun Nie, Yingying Zhao, Xiaoqun Zhu
Summary: This study focuses on the development of high-performance, low-migration photoinitiators. A polymerizable photoinitiator (VBP) was synthesized by introducing an ethylene group into benzophenone, and three different molecular weight single-component photoinitiators (PVBN1-3) were synthesized based on VBP. The results show that these new photoinitiators have stronger absorption ability compared to benzophenone and significantly reduce the migration of initiators and co-initiators, addressing the safety concerns caused by migration.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Seira Morimune-Moriya, Yuki Iwahashi, Mitsuru Nakamura, Daisuke Ogawa, Keiji Nakamura
Summary: This study investigates the effect of plasma treatment on carbon nanotubes (CNTs) and the structure/properties of polyimide (PI) nanocomposites with ultra-low content of CNTs. The results show that plasma treatment introduces isocyanate groups on the surface of CNTs and enhances the interfacial interaction between PI and treated CNTs. This leads to a significant improvement in the mechanical properties of the nanocomposites, with even a small addition of treated CNTs showing a substantial increase in Young's modulus, tensile strength and toughness.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuanlong Li, Chaojie Chen, Guoqing Cui, Li Liu, Chao Zhou, Guangfeng Wu
Summary: In this study, a novel ion-conducting hydrogel was fabricated using a straightforward approach. The hydrogel showed excellent tensile properties and high toughness due to physical interactions and covalent binding. Additionally, the introduction of hydroxyethyl cellulose and lithium chloride improved the biocompatibility, mechanical properties, electrical conductivity, and frost resistance of the hydrogel, demonstrating its potential for cold climate applications.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Dengwei Yan, Jinxian Yang, Xuejun Pan, Xiaozheng Duan, Lianwei Li, Mo Zhu
Summary: The influence of backbone length on grafting efficiency during the graft-onto reaction process was investigated. It was found that the polydispersity effect of backbone length does not affect the final grafting efficiency, indicating that the local dynamics of chain segments dominate the graft-onto process.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Zhaoyi Luo, Xianjie Pan, Fanqi Liu, Quanxi Yi, Yanning Zeng, Yunhua Chen, Chaoyang Wang
Summary: This study provides a method to prepare high-performance epoxy materials with good malleability and thermal stability. The materials have self-healing and welding capabilities, thanks to the addition of specific chemical bonds and network structures. They exhibit mechanical properties comparable to commercial epoxy resins and show great potential for sustainable industrial development.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Chaoji Xiong, Hao Wang, Lihua Deng, Kun Liang, Chunhua Wu, Wei Wu, Qian Chen
Summary: In this study, four polyamides were synthesized and their adsorption performances for Hg2+ in aqueous systems were investigated. The polyamides exhibited high adsorption capacities and excellent reusability, with the involvement of sulfur, nitrogen, and oxygen in the chemical adsorption process of Hg2+.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Siim Laanesoo, Olivier Bonjour, Rauno Sedrik, Iris Tamsalu, Patric Jannasch, Lauri Vares
Summary: The insertion of rigid aliphatic or aromatic building blocks in polymer structures is an effective way to synthesize high -Tg polymer materials. In this study, a series of isosorbide-2-aryl carboxylate-5-methacrylate monomers (ArIMAs) were synthesized by functionalizing isosorbide 5-methacrylate with various aromatic lignin-inspired esters. These monomers were polymerized to obtain high molecular-weight poly(aryl carboxylate isosorbide methacrylates) (PArIMAs). The resulting polymers showed high glass transition temperatures and thermal stability, making them suitable for use as high-performance plastics and coatings.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Yuqian Wu, Weijie Xu, Jianliang Li, Zhangfeng Zhong, Liqing Huang, Shengke Li, Huaping Tan
Summary: This study investigates the improvement of degradation and drug release characteristics of dynamic Schiff base-mediated natural polysaccharide hydrogels using tannic acid (TA), leading to enhanced stability and functionality.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Xi Zhang, Xiangli Kong, Xin Zhou, Yiyan Gao, Yibo Sun, Guanghui Gao, Wei Liu, Kai Shi
Summary: Conductive hydrogels have great development prospects in flexible strain sensors, but long-term direct contact with human skin can cause bacterial infection. A hydrogel with antibacterial, biocompatibility, and toughness was designed and manufactured using a freeze-thaw method. The hydrogel maintains tensile properties and fatigue resistance at low temperatures and is resistant to bacteria. Therefore, hydrogel sensors can be used to monitor human movements.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Wei Zhang, Jiangang Yu, Mingyang Wu, Rui Li, Anqiang Zhang, Yaling Lin
Summary: In this study, polyacrylamide containing quaternary ammonium salts (PAM-X) were synthesized and found to effectively inhibit soil-borne pathogenic fungi while maintaining the balance of microbial population in soil. PAM-X also showed low toxicity to earthworms and fish, providing a new method for the prevention and control of soil-borne fungal diseases.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Jiawen He, Haojie Yu, Li Wang, Jian Yang, Yanhui Zhang, Wenbing Huang, Chenguang Ouyang
Summary: This review discusses the use of polymeric hydrogels for atmospheric water harvesting (AWH), including the mechanism of water sorption, fabrication methods, and strategies for optimizing the structure of hydrogels. The extended applications of hygroscopic photothermal hydrogels, such as agricultural irrigation and dehumidification, are also explored. The challenges and prospects of using polymeric hydrogels for AWH are summarized.
EUROPEAN POLYMER JOURNAL
(2024)
Article
Polymer Science
Ying Du, Shuaishuai Lu, Yuanna Sun, Qingshan Li, Xinhai He
Summary: This study introduces a method to improve the performance of hydrogels by incorporating proline, resulting in hydrogels with excellent stretchability, high conductivity, and long-term stability. The hydrogel remains flexible and conductive even at ultra-low temperatures.
EUROPEAN POLYMER JOURNAL
(2024)
