Article
Multidisciplinary Sciences
Donghui Zhang, Qi Chen, Yufang Bi, Haodong Zhang, Minzhang Chen, Jianglin Wan, Chao Shi, Wenjing Zhang, Junyu Zhang, Zhongqian Qiao, Jin Li, Shengfu Chen, Runhui Liu
Summary: The authors demonstrate that a highly water soluble, biocompatible, and easily accessible poly-DL-serine hydrogel can mitigate foreign-body response caused by implantation, showing promising potential for wide application in implantable biomaterials and biomedical devices.
NATURE COMMUNICATIONS
(2021)
Article
Materials Science, Multidisciplinary
Yikai Wang, Zhongru Gou, Siyuan Ma, Zhihui Jin, Sen Chen, Jia Ye, Zhigang Nie, Zhihui Wan, Chongda Zhang, Yuxiao Ye, Xiaohua Yu, Zhaoming Ye, Yijun Ren
Summary: By combining nanofiber porous structure, ion exchange, and mineralization strategy, a lamellar magnesium calcium phosphate coating with late-term antibacterial properties was successfully synthesized. This work highlights the pivotal role of magnesium ions in mediating the growth of the total morphosynthesis of the calcium phosphate coating and eliminating delayed infections.
MATERIALS & DESIGN
(2023)
Article
Orthopedics
Houssam Bouloussa, Zoe Durand, Emmanuel Gibon, Antonia F. Chen, Matthew Grant, Azzam Saleh-Mghir, Mohsin Mirza, Bradley Stutzman, Claudio Vergari, James Yue, Nelson Anzala, Dorian Bonnot, Sandrine Albac, Othman Bouloussa, Delphine Croisier
Summary: This study aimed to demonstrate the in vivo safety and antibacterial efficacy of titanium implants treated with a novel broad-spectrum biocidal compound (DBG21) against methicillin-resistant Staphylococcus aureus (MRSA). The results showed that DBG21-treated implants significantly reduced the number of MRSA biofilm without associated toxicity. Preventing biofilm formation has been recognized as a key element of preventing implant-related infections.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Review
Infectious Diseases
Michael C. Tanner, Christian Fischer, Gerhard Schmidmaier, Patrick Haubruck
Summary: Based on current literature, there is no clear evidence to show a significant advantage of titanium implants over stainless steel in reducing implant-associated infections. However, implants that preserve periosteal blood flow and minimize soft tissue trauma show statistically significant benefits in reducing the incidence of implant-associated infections.
Review
Multidisciplinary Sciences
Junjie Liu, Shaoxing Qu, Zhigang Suo, Wei Yang
Summary: Hydrogels are polymer networks that swell in water and can be made compatible with living tissues, providing advantages such as lubricity, biocompatibility, and anti-biofouling properties. Research has focused on applications, methods of coating different substrates with tough adhesion, and testing the adhesion between functional hydrogel coatings and substrates.
NATIONAL SCIENCE REVIEW
(2021)
Article
Nanoscience & Nanotechnology
Yanhui Liu, Ting Dong, Yuhang Chen, Na Sun, Qi Liu, Zhenkai Huang, Yafeng Yang, Hao Cheng, Kan Yue
Summary: This study proposes an antibiotics-free strategy to address implant-associated infection (IAI) challenges by using a biodegradable and cytocompatible hydrogel coating. The developed GelMA-octylQAS hydrogel exhibits good mechanical properties, biodegradability, excellent bactericidal activity against various types of bacteria, and high cytocompatibility. When coated onto the implant, it demonstrates superior antimicrobial ability in the infective model of femoral fracture of rats. The GelMA-octylQAS hydrogel might provide a promising platform for preventing and treating IAI.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Medicine, General & Internal
Kazuhiko Hashimoto, Shunji Nishimura, Yu Shinyashiki, Tomohiko Ito, Ryosuke Kakinoki, Masao Akagi
Summary: This study introduces the use of wrapping vancomycin-containing cement around a mega-prosthesis as a novel method to prevent prosthetic joint infection after reconstruction surgery for malignant bone and soft tissue tumors. The findings suggest that this method is effective in preventing joint infection and has favorable clinical outcomes.
Article
Chemistry, Multidisciplinary
Yiran Li, Dan Li, Jiacheng Wang, Tingting Ye, Qianming Li, Luhe Li, Rui Gao, Yuanzhen Wang, Junye Ren, Fangyan Li, Jiang Lu, Er He, Yiding Jiao, Lie Wang, Ye Zhang
Summary: A temperature-sensing hydrogel coating has been developed for medical surgical catheters, allowing real-time infection monitoring. The hydrogel coating has a high temperature coefficient of resistance and remains stable in vivo. It forms a mechanically compatible catheter-tissue interface and reduces the risk of inflammatory responses. By using this coated catheter for early detection of infections in the brain, the individual survival rate has increased to 90%.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Surgery
Hozan Mufty, Mats Van den Bergh, Bart Meuris, Willem-Jan Metsemakers, Inge Fourneau
Summary: This study investigated the efficacy of vascular graft coatings in preventing vascular graft infection in the aortic position. The results showed that known antimicrobial coating strategies such as antibiotics and silver did not provide significant protection. New types of grafts or long acting coating strategies are needed in the future to prevent this complication.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Infectious Diseases
Daniele De Meo, Gianluca Cera, Roberta Pica, Fabiano Perfetti, Paolo Martini, Beatrice Perciballi, Giancarlo Ceccarelli, Pietro Persiani, Ciro Villani
Summary: The study aimed to evaluate the efficacy and safety of antibiotic-coated implants in preventing fracture-related infections (FRIs) after surgical treatment in patients with increased infectious risk. A retrospective observational study was conducted on patients with upper and lower limb fractures treated with internal fixation or prosthetic replacements, using a gentamicin coated nail (CN) and/or antibiotic-loaded hydrogel applied to the implant of choice (ALH). The study found that local antibiotic prophylaxis by coating resulted in a reduction in the incidence FRI, as compared to the estimated preoperative risk.
Article
Engineering, Biomedical
Yunyun Wei, Jianfeng Qiu, Ziqiang Han, Xuanyi Wang, Hui Zhang, Xinya Hou, Xiangwei Lv, Xiaolong Mao
Summary: In this study, a bioactive material carrying the overexpressed MCP1 gene of Saccharomyces boulardii was constructed to inhibit the adhesion of Candida albicans. The material showed good biocompatibility and reduced tissue invasion and virulence of C. albicans.
BIOMATERIALS RESEARCH
(2023)
Review
Nanoscience & Nanotechnology
Brinta Bhattacharjee, Sreyan Ghosh, Dipanjana Patra, Jayanta Haldar
Summary: The escalating medical expenses due to infectious diseases are causing huge socioeconomic pressure globally, with antibiotic resistance further aggravating the issue. Various strategies including antibacterial agent delivering matrices and bactericidal coatings have been developed to address these clinical problems. Additionally, implant/device-surface coating strategies exploiting the release-active mechanism of bacterial killing are discussed in detail.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
David P. Perrault, Ayushi Sharma, Jessica F. Kim, Geoffrey C. Gurtner, Derrick C. Wan
Summary: Infections of surgically placed implants have a significant impact across surgical specialties, causing negative effects on patient quality of life, increased morbidity and mortality, and higher healthcare costs. Extensive research has been conducted to reduce implant infection rates, with recent interest in antimicrobial approaches. These approaches include antibacterial implant coatings, nanostructured implant surfaces, and antibiotic-releasing implants. While implant-specific modalities have proven effective, most applications are still in the preclinical or early clinical stages.
BIOENGINEERING-BASEL
(2022)
Review
Infectious Diseases
Ivan Yuste, Francis C. Luciano, Brayan J. Anaya, Pablo Sanz-Ruiz, Almudena Ribed-Sanchez, Elena Gonzalez-Burgos, Dolores R. Serrano
Summary: The use of additive manufacturing or 3D printing in biomedicine has grown rapidly, especially in pharmaceutical development and manufacturing. It shows promise as a tool for preventing and treating periprosthetic joint infections through the development of novel therapies using 3D-printing techniques. This review provides an in-depth understanding of different approaches and strategies for the current management and prophylaxis of PJIs using 3D printing.
Article
Biotechnology & Applied Microbiology
Michael A. Lee, Xiaojia Jin, Sureshkumar Muthupalani, Naveed A. Bakh, Xun Gong, Michael S. Strano
Summary: Nanotechnology-enabled sensors show promise in various in-vivo life science applications, but tissue responses depend on cell types and nanocomponent properties. Encapsulation formulation may help mitigate adverse reactions. This study implanted hydrogel-encapsulated nanosensors into mice to investigate inflammatory responses and determine design rules for encapsulation and minimizing such responses.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Oncology
Giovanni Beltrami, Gabriele Ristori, Alberto Galeotti, Guido Scoccianti, Angela Tamburini, Domenico Campanacci, Rodolfo Capanna, Marco Innocenti
Summary: The study introduced a surgical technique combining hollow, custom-made titanium prostheses with microsurgical flaps and bone graft, which showed promising results in terms of bone integration and low complication rates. However, further studies with longer follow-up periods and larger sample sizes are needed to confirm the findings and reliability of this approach.
SURGICAL ONCOLOGY-OXFORD
(2021)
Article
Medicine, General & Internal
Giovanni Beltrami, Gabriele Ristori, Anna Maria Nucci, Alberto Galeotti, Angela Tamburini, Guido Scoccianti, Domenico Campanacci, Marco Innocenti, Rodolfo Capanna
Summary: This study described the use of custom-made implants for reconstruction of bony defects in pediatric patients with skeletal tumors, showing good functional outcomes but also cases of patient death and complications. Further research is needed to explore the potential benefits of 3D prostheses for pediatric limb salvage surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Pierluigi Cuomo, Guido Scoccianti, Alberto Schiavo, Valentina Tortolini, Catrin Wigley, Francesco Muratori, Davide Matera, Mariia Kukushkina, Philipp Theodor Funovics, Marie-Theres Lingitz, Reinhard Windhager, Sander Dijkstra, Jorrit Jasper, Daniel A. Muller, Dominik Kaiser, Tamas Perlaky, Andreas Leithner, Maria Anna Smolle, Domenico Andrea Campanacci
Summary: This retrospective multicenter study aimed to compare outcomes of desmoid tumor fibromatosis (DTF) after different treatment modalities, assess prognostic factors for recurrence following surgical excision, and assess prognostic factors for progression during observation. Results showed no significant differences in terms of tumor recurrence or progression between the treatment groups, suggesting that observation in DTF seems justified, considering surgery in case of dimensional progression and painful lesions, with particular attention to lesions around the shoulder gridle.
Article
Orthopedics
Matteo Innocenti, Francesco Muratori, Lorenzo Foschi, Saverio Bartolini, Maurizio Scorianz, Guido Scoccianti, Domenico Andrea Campanacci
Summary: Megaprosthesis is commonly used for limb salvage after tumor resection, but it is associated with high complication rates and potential limb amputation. This study found that multiple revision surgeries increase the incidence of complications, particularly after infection, leading to a higher amputation rate.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Medicine, General & Internal
Carmine Zoccali, Jacopo Baldi, Dario Attala, Alessandra Scotto di Uccio, Luca Cannavo, Gennaro Scotto, Alessandro Luzzati
Summary: Analysis of 14 patients who underwent pelvis reconstruction with 3DPTCMP after tumor removal showed it as an effective resource, yet further studies are needed to evaluate long-term results and improve infection rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pediatrics
Carmine Zoccali, Silvia Careri, Dario Attala, Michela Florio, Giuseppe Maria Milano, Marco Giordano
Summary: This study presents a possible reconstruction solution for very young patients with Ewing's sarcoma of the proximal femur through the use of a composite prosthesis. The patient, an infant, underwent surgery where a femoral stem was cemented into a homoplastic humerus, and a carbon fiber plate was used for stabilization. The patient was disease-free and able to walk normally at the one-year follow-up, indicating promising results for this technique in small patients.
Article
Medicine, General & Internal
Carmine Zoccali, Mariangela Novello, Francesco Arrigoni, Alessandra Scotto di Uccio, Dario Attala, Virginia Ferraresi
Summary: Osteoblastoma is a rare bone tumor that is difficult to diagnose. Surgical excision is the gold standard treatment, but minimally invasive radiological techniques can also be considered. Surgical indications include lesions close to nerves or joints, unclear diagnosis, and risk of fracture.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Flavia Cobianchi Bellisari, Pierpaolo Palumbo, Carlo Masciocchi, Carmine Zoccali, Antonio Barile, Francesco Arrigoni
Summary: This review discusses MRgFUS as a feasible option for the treatment of osteoid osteoma and osteoblastoma, highlighting its advantages of being less invasive, safe, effective, and providing long-lasting results compared to traditional methods.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Leonardo Vivarelli, Marco Govoni, Dario Attala, Carmine Zoccali, Roberto Biagini, Dante Dallari
Summary: By simulating the machining of massive bone allografts using different machines, the study showed that the robot outperformed the four-axes machine. This research paves the way for cleanroom machining of massive bone allografts, but further studies are needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
A. Pagnotta, V. M. Formica, A. Ascione, R. Covello, C. Zoccali
Summary: Reconstruction after bone tumor resection is crucial for restoring function and improving quality of life. This study presents a method using allograft reconstruction and creating a vascular loop to enhance graft integration. A patient with chondrosarcoma underwent surgery, and successful fusion of the allograft with favorable histology was observed during follow-up.
HAND SURGERY & REHABILITATION
(2022)
Review
Orthopedics
C. Zoccali, V. M. Formica, I. Sperduti, E. Checcucci, A. Scotto di Uccio, A. Pagnotta, C. Villani
Summary: Giant-cell tumor (GCT) located in the distal radius is highly aggressive and requires wide resection. There is no recommended standard reconstruction protocol, and surgeons have different preferences for surgical techniques. This review aims to assess the recurrence rate, results, advantages, and complications of various surgical techniques for distal radius GCT, and to provide a decision-tree for surgical indications.
HAND SURGERY & REHABILITATION
(2022)
Review
Medicine, General & Internal
Ferruccio Sgalambro, Luigi Zugaro, Federico Bruno, Pierpaolo Palumbo, Nicola Salducca, Carmine Zoccali, Antonio Barile, Carlo Masciocchi, Francesco Arrigoni
Summary: Interventional radiology (IR) has experienced significant growth and is widely used in the field of musculoskeletal. The main techniques used in IR include ablation, embolization, and cementoplasty. These techniques are used to treat bone metastases by destroying pathological tissue, blocking arterial vessels, and strengthening weakened bone segments.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Carmine Zoccali, Stefano Conti, Giovanni Zoccali, Gianluca Cinotti, Roberto Biagini
Summary: This study evaluated the outcomes of pelvic reconstruction using pedicle screw instrumentation and tibial allograft after resection of primary malignant tumors involving the sacroiliac joint. The study found that complete fusion was achieved in 57.1% of the patients, with an average fusion time of 9 months. The functional results showed an average MSTS score of 58.7% and a TESS score of 57.8%. These preliminary results suggest that this technique has promising outcomes in initial reconstruction, but further research is needed to confirm the indications and long-term effects.
SURGICAL ONCOLOGY-OXFORD
(2023)
Review
Orthopedics
Carmine Zoccali, Giuseppe Giannicola, Giovanni Zoccali, Elisa Checcucci, Alessandra Scotto di Uccio, Dario Attala, Ciro Villani
Summary: This review examined the use of stemmed acetabular cups for reconstruction and the associated complications. The main indications for these cups were post-tumor removal reconstruction and revision for aseptic loosening. The most common complications were aseptic loosening and implant failure. Limited data on functional results for degenerative cases were available, but preliminary results suggest that stemmed acetabular cups are a promising alternative for both tumor and degenerative revision cases.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
