Article
Clinical Neurology
Cody L. Goessl, Jeffrey J. VanWormer, Ram D. Pathak, Edward F. Ellerbeck, Daniel L. Kurz, Christie A. Befort
Summary: This analysis examined how the mental component score (MCS-12) from the Short Form health survey changed over 24 months in weight loss trial participants with vs. without treatment seeking for affective symptoms (TxASx) and by weight change quintiles. The results showed that participants with TxASx who lost the most weight had the largest increase in MCS-12 scores (+5.3 points [12%]), while participants without TxASx who gained the most weight had the largest decrease in MCS-12 scores (-1.8 points [-3%]).
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Sai Krupa Das, Rachel E. Silver, Taylor A. Vail, Meghan K. Chin, Caroline M. Blanchard, Stephanie L. Dickinson, Xiwei Chen, Lisa Ceglia, Edward Saltzman, David B. Allison, Susan B. Roberts
Summary: This study assessed the effectiveness of a new lifestyle intervention in work sites, which focuses on reducing hunger and building healthy food preferences without calorie counting. The results showed that this intervention led to clinically impactful weight loss in employees.
Article
Endocrinology & Metabolism
Friedrich C. Jassil, Alisia Carnemolla, Helen Kingett, Jacqueline Doyle, Amy Kirk, Neville Lewis, Gemma Montagut, Parastou Marvasti, David Boniface, Adrian Brown, Kusuma Chaiyasoot, Roxanna Zakeri, Jessica Mok, Kalpana Devalia, Chetan Parmar, Rachel L. Batterham
Summary: The aim of the study was to investigate the impact of a 12-month adjunctive lifestyle intervention on weight loss and health outcomes after bariatric surgery. Results showed significant reductions in body weight, fat mass, and improvements in health-related quality of life and depressive symptomatology. However, the adjunctive lifestyle program implemented immediately after surgery had no favorable impact upon weight loss and health outcomes.
Article
Nutrition & Dietetics
Maggie A. Stanislawski, Daniel N. Frank, Sarah J. Borengasser, Danielle M. Ostendorf, Diana Ir, Purevsuren Jambal, Kristen Bing, Liza Wayland, Janet C. Siebert, Daniel H. Bessesen, Paul S. MacLean, Edward L. Melanson, Victoria A. Catenacci
Summary: The ongoing weight loss trial comparing daily caloric restriction to intermittent fasting in overweight or obese adults found significant improvements in clinical health measures and altered composition and diversity of fecal microbiota in the first three months. Significant associations were observed between gut microbiota features and clinical measures such as weight and waist circumference. Differences in the relative abundance of Akkermansia were also seen between the intervention groups.
Article
Nutrition & Dietetics
Xiaochen Zhang, Victoria R. Descenza, Zachary L. Chaplow, Megan Kilar, Jessica Bowman, Alex Buga, Madison L. Kackley, Abigail B. Shoben, Ashley S. Felix, Electra D. Paskett, Brian C. Focht
Summary: This pilot study examined the effect of a telephone-based lifestyle intervention on weight, body composition, lipids, and inflammatory biomarkers among rural Ohio residents. The lifestyle intervention group showed superior improvements in total cholesterol and LDL compared to the control group, but no significant between-group differences were observed in weight, body composition, or inflammation.
Article
Psychology, Biological
Ariana M. Chao, Yingjie Zhou, Guray Erus, Christos Davatzikos, Michelle I. Cardel, Gary D. Foster, Thomas A. Wadden
Summary: This study aimed to evaluate the effects of behavioral weight loss (BWL) compared to wait list control (WLC) on hippocampal volume and neurocognition. The results showed that the BWL group lost more weight than the WLC group, but there were no significant differences in changes in hippocampal volume or neurocognition between the two groups. Baseline hippocampal volume and neurocognition were not associated with weight loss.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Gastroenterology & Hepatology
Zobair M. Younossi, Kathleen E. Corey, Joseph K. Lim
Summary: NAFLD is a leading cause of chronic liver disease globally, affecting over 25% of the population. Lifestyle modification for weight loss is the primary intervention for patients with NAFLD. Evidence-based interventions and best practice advice are provided for clinical management of NAFLD.
Review
Endocrinology & Metabolism
Samantha Aurich, Luise Mueller, Peter Kovacs, Maria Keller
Summary: In the past 50 years, the increase in overweight/obese individuals has made obesity a global public health challenge. Obesity is a complex disease influenced by genetic, epigenetic, and environmental factors. Non-genetic factors, such as eating behavior and physical activity, interact with genetic predispositions through epigenetic mechanisms. Intervention studies, particularly those documenting changes in obesity-associated epigenetic markers during lifestyle-driven weight loss, contribute to a better understanding of epigenetic reprogramming in obesity. However, further robust and larger studies are needed to identify specific DNA methylation biomarkers influencing obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Multidisciplinary Sciences
Katja Kurnik Mesaric, Jernej Pajek, Bernarda Logar Zakrajsek, Spela Bogataj, Jana Kodric
Summary: This systematic review and meta-analysis investigated the impact of cognitive behavioral therapy (CBT) on implementing lifestyle changes, considering health-related and behavioral outcomes. Multiple databases were searched for relevant studies, and nine randomized controlled trials met the inclusion criteria. The results showed a medium, significant effect of CBT interventions on weight loss and maintenance, but a low, non-significant effect on reducing HbA1c levels. The overall effect size was medium and significant. The review concluded that CBT interventions are effective in implementing lifestyle changes, particularly for weight loss and maintenance.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Christian Diener, Shizhen Qin, Yong Zhou, Sushmita Patwardhan, Li Tang, Jennifer C. Lovejoy, Andrew T. Magis, Nathan D. Price, Leroy Hood, Sean M. Gibbons
Summary: Recent human feeding studies have shown that the baseline taxonomic composition of the gut microbiome can determine responses to weight loss interventions. Our study found that specific baseline gut microbiome functional features are closely associated with weight loss responses.
Article
Public, Environmental & Occupational Health
Alisa Weiland, Lena Kasemann Nannette, Stephan Zipfel, Stefan Ehehalt, Katrin Ziser, Florian Junne, Isabelle Mack
Summary: This study systematically reviewed the predictors of body weight loss and weight loss maintenance in children and adolescents after behavioral weight loss intervention. The results showed that genetics and blood parameters were significant predictors in physiology, while behavior and environment factors were less investigated.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Janaki D. Vakharia, Tanayott Thaweethai, Paul Licht, Deborah J. Wexler, Linda M. Delahanty
Summary: The study identified the modifiable psychological and behavioral factors associated with weight loss. Autonomous motivation, self-efficacy in diet and exercise, dietary self-regulation, and improvement in depressive symptoms were found to be the most important factors in achieving weight loss. These findings provide valuable insights for the design and delivery of lifestyle intervention programs.
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Review
Gastroenterology & Hepatology
Marcia Lange, Devika Nadkarni, Lily Martin, Carolyn Newberry, Sonal Kumar, Tatyana Kushner
Summary: Despite the lack of FDA-approved treatments for NAFLD, intermittent fasting (IF) has shown promising results in improving hepatic end points and promoting weight loss in adults with NAFLD. This systematic review and meta-analysis found moderate- to high-quality evidence suggesting that IF can significantly improve body weight, body mass index, waist to hip ratio, serum alanine transaminase, aspartate aminotransferase, hepatic steatosis, and hepatic stiffness in NAFLD patients. However, larger randomized controlled studies with extended duration are needed for further validation.
HEPATOLOGY COMMUNICATIONS
(2023)
Review
Gastroenterology & Hepatology
Marcia Lange, Devika Nadkarni, Lily Martin, Carolyn Newberry, Sonal Kumar, Tatyana Kushner
Summary: Despite the lack of FDA-approved treatments for NAFLD, intermittent fasting shows promising results in improving hepatic endpoints and promoting weight loss in adults with NAFLD. However, further large-scale randomized controlled studies are needed to validate these findings.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Sander Lefere, Ellen Dupont, Ann De Guchtenaere, Stephanie Van Biervliet, Saskia Vande Velde, Xavier Verhelst, Lindsey Devisscher, Hans Van Vlierberghe, Anja Geerts, Ruth De Bruyne
Summary: NAFLD and associated fibrosis are highly prevalent in children and adolescents with severe obesity. An intensive multidisciplinary lifestyle management program not only improves liver steatosis, but also fibrosis.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
