期刊
EMBO JOURNAL
卷 40, 期 8, 页码 -出版社
WILEY
DOI: 10.15252/embj.2020105789
关键词
actin protrusions; cell communication; cell signaling; tunneling nanotubes
资金
- Neurotunn [ANR-16-CE160019]
- Canceropole Ile-de-France [2018-1-PL-03-IP-1]
- INCEPTION [ANR-16-CONV-0005]
- Institut de Convergence Q-Life awards [ANR-17-CONV-0005]
- Institut de Convergence Q-Life award [ANR-17-CONV-0005]
- Agence Nationale de la Recherche (ANR) [ANR-17-CONV-0005] Funding Source: Agence Nationale de la Recherche (ANR)
Tunneling Nanotubes (TNTs) and similar structures play crucial roles in cell communication, but challenges remain in proving their existence in vivo and understanding their formation mechanisms. To address classification ambiguity, a clear naming convention is proposed along with a comprehensive overview discussing structure, formation pathways, function, and disease implications.
The identification of Tunneling Nanotubes (TNTs) and TNT-like structures signified a critical turning point in the field of cell-cell communication. With hypothesized roles in development and disease progression, TNTs' ability to transport biological cargo between distant cells has elevated these structures to a unique and privileged position among other mechanisms of intercellular communication. However, the field faces numerous challenges-some of the most pressing issues being the demonstration of TNTs in vivo and understanding how they form and function. Another stumbling block is represented by the vast disparity in structures classified as TNTs. In order to address this ambiguity, we propose a clear nomenclature and provide a comprehensive overview of the existing knowledge concerning TNTs. We also discuss their structure, formation-related pathways, biological function, as well as their proposed role in disease. Furthermore, we pinpoint gaps and dichotomies found across the field and highlight unexplored research avenues. Lastly, we review the methods employed to date and suggest the application of new technologies to better understand these elusive biological structures.
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