Article
Environmental Sciences
Bingru Zhang, Shaowei Wang, Yunbing Tang, Zhiyan Hu, Lei Shi, Jialin Lu, Huitao Li, Yiyan Wang, Yang Zhu, Han Lin, Ren-shan Ge
Summary: This study found that bisphenols (BPs) can interfere with the activity of 11β-hydroxysteroid dehydrogenase 2 (1113-HSD2) in the human body and rats, thereby affecting the functions of the kidney and placenta. In addition, it also found that different BPs have different inhibitory effects on 1113-HSD2 with different functions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Immunology
Shubham Chakravarty, Layla Ramos-Hegazy, Abigail Gasparovic, Gregory G. Anderson
Summary: The overexpression of polB significantly reduced T3SS transcription and repressed translation of the master T3SS regulator ExsA. Furthermore, polB does not act through previously described genetic pathways that post-transcriptionally regulate ExsA.
MICROBES AND INFECTION
(2021)
Article
Endocrinology & Metabolism
Nathalie Esser, Thomas O. Mundinger, Breanne M. Barrow, Sakeneh Zraika
Summary: The peptidase neprilysin plays a role in glucose homeostasis by cleaving and inactivating insulinotropic peptides, such as glucagon-like peptide-1 (GLP-1). Inhibition of neprilysin enhances beta-cell function through GLP-1 receptor signaling. This study investigates the effect of selective pharmacological inhibition of intestinal neprilysin on glucose-stimulated insulin secretion.
Article
Neurosciences
Kevin B. Smith, Emma Murray, James Gardner Gregory, Jacky Liang, Nafissa Ismail
Summary: Puberty is a critical period for cortical and neuronal development, with stress potentially leading to long-term anxiety and depression. Probiotic treatment shows promise in mitigating these mental health issues and influencing the programming of the HPA axis. Sex-specific differences in the gut microbiome's impact on HPA axis programming during puberty warrant further investigation.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Sofia A. Lopez, Eman Mubarak, Charlotte Yang, Aram Parsegian, Marin Klumpner, Paolo Campus, Shelly B. Flagel
Summary: Environmental cues can guide behavior through learned associations, but for some individuals they may lead to maladaptive motivational states. The goal-tracker (GT)/sign-tracker (ST) animal model captures individual differences in cue-motivated behaviors, showing distinctions in cue-reward learning styles, while no significant differences were observed in stress-related and anxiety-related behaviors between GTs and STs.
Article
Endocrinology & Metabolism
Yi Zheng, Hao-Qi Wang, Hai-Xiang Guo, Heng-Li Xie, Wei-Di Zhang, Dong-Xu Han, Hao Jiang, Bao Yuan, Jia-Bao Zhang
Summary: This study found that miRNAs and circRNAs in the rat pineal gland are expressed with a daily rhythm and are associated with the regulation of melatonin secretion and other biological functions. It further revealed that circR-WNK2 may be involved in the regulation of melatonin secretion through the competitive endogenous RNA mechanism. Additionally, the study showed that ncRNA expression in the pineal gland is regulated by signals from the suprachiasmatic nucleus.
Article
Biochemistry & Molecular Biology
Yukiko Minamiyama, Shigekazu Takemura, Hiroshi Ichikawa
Summary: The exposome represents the lifetime exposure of an individual to external genetic influences and their impact on health. Certain food additives may affect sperm function, induce oxidative stress in the testes and brain, resulting in infertility and short-term memory loss.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Ying Su, Benfu Wang, Jianwen Ye, Yixuan Wang, Yanhua Cui, Chunjiang Chen, Naqi Ruan, Zhiyan Hu, Li Li, Huacheng Liu, Hong Xie
Summary: Moderate acute stress responses are important for maintaining homeostasis. This study investigated the effects of dexmedetomidine on the bed nucleus of the stria terminalis (BNST) and found that reducing the levels of neuronal nitric oxide synthase (nNOS) and serum- and glucocorticoid-inducible kinase 1 (SGK1) in the BNST can decrease serum corticosterone (CORT) release and improve behavioral performance in rats.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Alexander S. Hausl, Lea M. Brix, Jakob Hartmann, Max L. Pohlmann, Juan-Pablo Lopez, Danusa Menegaz, Elena Brivio, Clara Engelhardt, Simone Roeh, Thomas Bajaj, Lisa Rudolph, Rainer Stoffel, Kathrin Hafner, Hannah M. Goss, Johannes M. H. M. Reul, Jan M. Deussing, Matthias Eder, Kerry J. Ressler, Nils C. Gassen, Alon Chen, Mathias V. Schmidt
Summary: Research has shown that deleting Fkbp5 in the paraventricular nucleus of the hypothalamus dampens acute stress response and increases glucocorticoid receptor sensitivity, while overexpressing Fkbp5 in the PVN leads to chronic HPA axis over-activation. Additionally, the study found a cell-type-specific upregulation of Fkbp5 expression in Crh(+) neurons after stress.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Pei-Hsuan Lin, Kuan-Hua Huang, Yu-Feng Tian, Cheng-Hsien Lin, Chien-Ming Chao, Ling-Yu Tang, Kun-Lin Hsieh, Ching-Ping Chang
Summary: This study examined the effects of exertional heat stroke (EHS) on fertility, erectile function, and testicular morphology in male rats. The results showed that EHS caused testicular temperature disruption, damage to testicular tissues, and erectile dysfunction in the rats.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Yoshitsugu Nakamura, Shigeki Arawaka, Hiroyasu Sato, Asuka Sasaki, Taro Shigekiyo, Kazue Takahata, Hiroko Tsunekawa, Takeo Kato
Summary: Inhibiting MAO-B enzymatic activity can facilitate the secretion of alpha-synuclein and delay protein aggregation and loss of dopaminergic neurons in Parkinson's disease models.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Blanca Jimeno, Cedric Zimmer
Summary: This study discusses the regulatory mechanisms of the hypothalamic-pituitary-adrenal axis in response to environmental changes, particularly emphasizing the role of glucocorticoid receptors. The study suggests that the expression of glucocorticoid receptors is crucial for the ability to respond to environmental changes and the regulation and dynamics of glucocorticoids.
HORMONES AND BEHAVIOR
(2022)
Article
Biotechnology & Applied Microbiology
Hannah Northrup, Maheshika Somarathna, Savanna Corless, Isabelle Falzon, John Totenhagen, Timmy Lee, Yan-Ting Shiu
Summary: Arteriovenous fistula (AVF) plays a crucial role in hemodialysis for chronic kidney disease patients, but treatment for AVF maturation failure remains a challenge. Heterogeneity in treatment response and the importance of hemodynamics in AVF remodeling were highlighted in a study using a rat model and MRI-based computational fluid dynamics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Andreas Chatzittofis, Adrian Desai E. Bostrom, Diana M. Ciuculete, Katarina Gorts Oberg, Stefan Arver, Helgi B. Schioth, Jussi Jokinen
Summary: This study found significant hypermethylation of certain CpG sites in individuals classified as DST non-suppressors in key HPA axis genes, showing correlation with gene expression levels. These findings suggest that DNA methylation shifts play a role in HPA axis dysregulation, potentially contributing to psychiatric disorders.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
G. A. Reyes del Paso, A. Garcia-Hernandez, A. M. Contreras-Merino, C. M. Galvez-Sanchez, P. de la Coba, C. I. Montoro, D. M. Davydov
Summary: This study assessed the hair cortisol concentrations in patients with fibromyalgia (FM) and found that disease chronicity and symptom severity were predictors of cortisol levels. The results suggest that severe pain/stress leads to higher cortisol levels in the early stages of FM, but cortisol levels decrease in the long term.
EUROPEAN JOURNAL OF PAIN
(2023)
Article
Behavioral Sciences
Elizabeth R. Woodruff, Benjamin N. Greenwood, Lauren E. Chun, Sara Fardi, Laura R. Hinds, Robert L. Spencer
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Biology
Lauren E. Chun, Elizabeth R. Woodruff, Sarah Morton, Laura R. Hinds, Robert L. Spencer
JOURNAL OF BIOLOGICAL RHYTHMS
(2015)
Article
Endocrinology & Metabolism
Elizabeth R. Woodruff, Lauren E. Chun, Laura R. Hinds, Robert L. Spencer
Article
Behavioral Sciences
Lauren E. Chun, Jenny Christensen, Elizabeth R. Woodruff, Sarah J. Morton, Laura R. Hinds, Robert L. Spencer
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2018)
Review
Endocrinology & Metabolism
Robert L. Spencer, Lauren E. Chun, Matthew J. Hartsock, Elizabeth R. Woodruff
FRONTIERS IN NEUROENDOCRINOLOGY
(2018)
Article
Multidisciplinary Sciences
Laura R. Hinds, Lauren E. Chun, Elizabeth R. Woodruff, Jennifer A. Christensen, Matthew J. Hartsock, Robert L. Spencer
Review
Biochemistry & Molecular Biology
Alexandra McMellen, Elizabeth R. Woodruff, Bradley R. Corr, Benjamin G. Bitler, Marisa R. Moroney
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Marisa R. Moroney, Elizabeth Woodruff, Lubna Qamar, Andrew P. Bradford, Rebecca Wolsky, Benjamin G. Bitler, Bradley R. Corr
Summary: The study investigated the impact of Wnt/beta-catenin inhibition on endometrial cancer recurrence, with PRI724 and SM04690 showing significant inhibitory effects on CTNNB1-mutant cell lines. Targeting the Wnt/beta-catenin pathway effectively inhibited proliferation and beta-catenin/TCF transcriptional activity in CTNNB1-mutant EC, suggesting a potential therapeutic vulnerability for treatment of CTNNB1-mutant EC.
MOLECULAR CARCINOGENESIS
(2021)
Article
Oncology
Tomomi M. Yamamoto, Patricia G. Webb, Dana M. Davis, Heidi K. Baumgartner, Elizabeth R. Woodruff, Saketh R. Guntupalli, Margaret Neville, Kian Behbakht, Benjamin G. Bitler
Summary: This study examines the relationship between claudin-4 expression and the response to PARP inhibitors in ovarian cancer tumors. It suggests that claudin-4 expression could serve as both a marker of PARP inhibitor response and a therapeutic target to improve PARP inhibitor response.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Oncology
Brooke E. Sanders, Tomomi M. Yamamoto, Alexandra McMellen, Elizabeth R. Woodruff, Amber Berning, Miriam D. Post, Benjamin G. Bitler
Summary: Identifying novel and durable treatments for HGSOC is crucial for extending patient survival. This study shows that the high expression of DUSP1 is associated with worse prognosis and therapy resistance in HGSOC.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Lindsay W. Brubaker, Donald S. Backos, Vu T. Nguyen, Philip Reigan, Tomomi M. Yamamoto, Elizabeth R. Woodruff, Ritsuko Iwanaga, Michael F. Wempe, Vijay Kumar, Christianne Persenaire, Zachary L. Watson, Benjamin G. Bitler
Summary: In this study, a computational approach was used to construct a homology model of CBX2 and design blocking peptides that could directly bind to CBX2. The CBX2 blocking peptide was found to significantly inhibit the growth of ovarian cancer cells and reduce tumor volume.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Neurosciences
Elizabeth R. Woodruff, Lauren E. Chun, Laura R. Hinds, Nicholas M. Varra, Daniel Tirado, Sarah J. Morton, Colleen A. McClung, Robert L. Spencer
Article
Neurosciences
Amy E. Perkins, Elizabeth R. Woodruff, Lauren E. Chun, Robert L. Spencer, Elena Varlinskaya, Terrence Deak