Review
Chemistry, Multidisciplinary
Junguang Wu, Xuejing Cui, Pu Chun Ke, Monika Mortimer, Xiaoyu Wang, Lin Bao, Chunying Chen
Summary: Parkinson's disease is a complex multi-factorial disease with no cure, only mitigative therapies available at present. The development of nanomedicine has provided new opportunities for finding neuroprotective and neurorestorative therapies for PD. By exploring various mechanisms underlying PD pathology and discussing nanomaterial-based treatment strategies, there is potential for targeted therapies to be developed in the future.
Review
Pharmacology & Pharmacy
Rabia Arshad, Mahtab Razlansari, Seyedeh Maryam Hosseinikhah, Aprajita Tiwari Pandey, Narges Ajalli, Amanda-Lee Ezra Manicum, Nanasaheb Thorat, Abbas Rahdar, Yangzhi Zhu, Tanveer A. Tabish
Summary: Chronic wounds are difficult to treat and cause discomfort due to bacteria. To reduce this burden, various approaches have been explored, with bioinspired nanomaterials showing promising results in wound healing by mimicking natural ECM components and promoting cell functions. These materials can also inhibit microbial biofilm formation and inflammation, indicating their potential beyond previous studies.
DRUG DISCOVERY TODAY
(2023)
Review
Pharmacology & Pharmacy
Su Yeon An, Anca D. Petrescu, Sharon DeMorrow
Summary: The liver plays a key role in maintaining the balance between immunity and tolerance, with interleukins serving a dual role of pro-inflammatory and anti-inflammatory functions in liver injury. Interleukins are considered as potential therapeutic targets for liver fibrosis, affecting the initiation, perpetuation, and resolution of fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Yuxuan Gong, Huaying Liu, Shen Ke, Li Zhuo, Haibin Wang
Summary: Cardiovascular disease remains a leading cause of death in China, and there is a need to develop innovative methods for identifying and managing these disorders. Nanomaterials offer multiple benefits in biomedicine, and this study reviews the scientific accomplishments in this field over the past few years.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Biomedical
Cheng Zhao, Guopu Chen, Huan Wang, Yuanjin Zhao, Renjie Chai
Summary: A novel microcapsule inspired by scavenger behavior is introduced for cleaning intestinal LPS, protecting cells, and reducing inflammation. It has been demonstrated to be a promising candidate for treating metabolic syndrome and other LPS related diseases.
BIOACTIVE MATERIALS
(2021)
Review
Cardiac & Cardiovascular Systems
Rainer Kaiser, Raphael Escaig, Johanna Erber, Leo Nicolai
Summary: Neutrophils and platelets, two abundant cell types in peripheral blood, play important roles in immune responses and clot formation in cardiovascular diseases. This review describes their physical interactions, the impact of release of granule contents on each other, and their contribution to thromboinflammation in COVID-19. Targeting neutrophil-platelet interactions may provide a novel treatment strategy in cardiovascular disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Chemistry, Analytical
Nianrong Sun, Hailong Yu, Hao Wu, Xizhong Shen, Chunhui Deng
Summary: Biological compositions such as cells, proteins, nucleic acids are closely related to physiological and pathological events, serving as therapeutic targets and disease indicators. Nanomaterials with flexibility in preparation and manipulation are key to solving analysis challenges. This review elaborates on recent advancements and development trends of nanomaterials in bio-analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Yilong Xi, Yun Chen, Yi Jin, Guochen Han, Mingjie Song, Tingting Song, Yang Shi, Ling Tao, Zewei Huang, Jianping Zhou, Yang Ding, Huaqing Zhang
Summary: This article summarizes the complex pathogenesis of Alzheimer's disease (AD) and the interaction between different therapeutic targets. It discusses the key challenges in translating anti-AD nanomedicine from benchtop to bedside and highlights the recent advances in exploring pathogenesis-inspired nanomaterials in AD treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Hematology
Menno Hoekstra, Miranda Van Eck, Theo J. C. Van Berkel
Summary: Hyperlipidemia is a major risk factor for atherosclerotic cardiovascular disease, and gene therapy has shown potential in treating dyslipidemia. This review focuses on hepatocyte-directed base editing as a genetic modification approach to improve the treatment of human dyslipidemia and suggests further technological advancements.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Biology
Essam H. Houssein, Diego Oliva, Nagwan Abdel Samee, Noha F. Mahmoud, Marwa M. Emam
Summary: This paper introduces a new bio-inspired optimization algorithm called the Liver Cancer Algorithm (LCA), which provides efficient search and exploration methods by simulating the growth and spread of liver tumors. Experimental results show that the LCA algorithm outperforms other methods in handling mathematical benchmark problems and feature selection.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Chemistry, Physical
Jingsheng Niu, Chuanqi Zhao, Chun Liu, Jinsong Ren, Xiaogang Qu
Summary: Bacterial infections pose a significant threat to global health annually. Despite efforts to improve existing antibiotics, the development of multi-drug resistance remains a challenge. The design and synthesis of biomimetic sea urchin-like PdCu nanoparticles show promise in enhancing antibacterial therapy through increased interactions with bacteria and decreased antibiotic overuse.
CHEMISTRY OF MATERIALS
(2021)
Article
Engineering, Biomedical
Dan Qiao, Shuyu Cheng, Zhen Xing, Qian Zhang, Shiyuan Song, Fuhua Yan, Yangheng Zhang
Summary: A study designed and prepared MR-targeted glycosylated nano-hydroxyapatites (GHANPs) to reprogram macrophages into polarized M2s, promoting bone regeneration. The GHANPs induced macrophage M2 polarization and enhanced osteoblastic differentiation of stem cells. Mechanistic studies suggested that GHANPs might influence macrophage polarization through modulating cell metabolism. In vivo experiments using a rat cranial defect model demonstrated that GHANPs promoted bone regeneration and increased the ratio of M2/M1 macrophages during early bone repair. This study indicates the promising potential of the MR-targeted macrophage M2 polarization strategy in endogenous bone regeneration.
ACTA BIOMATERIALIA
(2023)
Review
Chemistry, Analytical
Mohammad Harun-Ur-Rashid, Israt Jahan, Tahmina Foyez, Abu Bin Imran
Summary: Exploring bio-inspired nanomaterials and incorporating them into micro/nanodevices is significant for biomedical applications. These nanomaterials imitate biological structures and processes, exhibiting exceptional attributes and potential in various domains. This article thoroughly examines the development and attributes of bio-inspired nanomaterials, focusing on their incorporation into micro/nanodevices and subsequent biomedical ramifications.
Article
Chemistry, Multidisciplinary
Zhouyue Lei, Wencheng Zhu, Xingcai Zhang, Xiongjun Wang, Peiyi Wu
Summary: The research developed a biomimetic hydrogel to address the key challenges encountered by traditional synthetic hydrogel-based ionic skins, providing stability, adhesion, hydration, sensitive detection, and enhanced treatment efficacy in ambient conditions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Engineering, Environmental
Alejandro Cabrera-Garcia, Vincent Blay, Ruben Blay-Roger, Angel G. Ravelo, Javier Gonzalez-Platas, M. Carmen Arevalo, Joaquin Sanchiz, Pedro Martin-Zarza
Summary: The novel dinuclear Ni(II) complexes, Ni-PATIO and Ni-PACO, show high catalytic activity and promise in producing hydrogen from water at significantly reduced potentials without the need for any additives.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Yan Shan Loo, Rajendran JC. Bose, Jason R. McCarthy, Intan Diana Mat Azmi, Thiagarajan Madheswaran
Summary: Smart nanocarriers derived from bacteria and viruses exhibit versatile biomimetic properties, making them suitable for use in biosensors, biomedical scaffolds, immobilization, diagnostics, and targeted or personalized treatments. Biomimetic technology plays a crucial role in pharmaceuticals, allowing for the safe integration of naturally occurring bacteria and virus particles.
DRUG DISCOVERY TODAY
(2021)
Article
Chemistry, Multidisciplinary
Khanh Ha, Xiaoxin Zheng, Chase W. Kessinger, Adam Mauskapf, Wenzhu Li, Yoichiro Kawamura, Makoto Orii, Scott A. Hilderbrand, Farouc A. Jaffer, Jason R. McCarthy
Summary: The study developed a near-infrared fluorescence probe based on tirofiban, which can rapidly and accurately visualize activated platelets in vivo, offering a potential new application for clinical diagnosis.
Article
Nanoscience & Nanotechnology
Rajendran J. C. Bose, Nagendran Tharmalingam, Yonghyun Choi, Thiagarajan Madheswaran, Ramasamy Paulmurugan, Jason R. McCarthy, Soo-Hong Lee, Hansoo Park
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2020)
Review
Pharmacology & Pharmacy
Karlie R. Sharma, Christine M. Colvis, Griffih P. Rodgers, Douglas M. Sheeley
Summary: There are many genes within the druggable genome that have not been studied, and the US National Institutes of Health's program provides resources to explore these genes, with the potential for rapid impact on human health.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, B. H. Jaswanth Gowda, Waleed H. Almalki, Tanuja Singh, Amirhossein Sahebkar, Prashant Kesharwani
Summary: Mitochondria-specific functional liposomes hold great potential for cancer therapy. This review discusses the association between mitochondria and tumor formation, as well as the advantages of liposomes in delivering drugs to mitochondria.
DRUG DISCOVERY TODAY
(2024)
Review
Pharmacology & Pharmacy
Choong Yong Ung, Cristina Correia, Hu Li, Christopher M. Adams, Jennifer J. Westendorf, Shizhen Zhu
Summary: With increasing human life expectancy, the global medical burden of chronic diseases is growing. Chronic diseases often involve malfunctioning of multiple organs, and understanding the interorgan crosstalk is crucial to understanding the etiology of chronic diseases. Researchers have proposed the locked-state model (LoSM) and cutting-edge systems biology and artificial intelligence strategies to decipher chronic multiorgan locked states. The findings have important clinical implications for improving treatments for chronic diseases.
DRUG DISCOVERY TODAY
(2024)
