Article
Endocrinology & Metabolism
Geremia B. Bolli, Francesca Porcellati, Paola Lucidi, Carmine G. Fanelli
Summary: The development of insulin therapy indicates the importance of mimicking the physiological process of pancreatic insulin secretion in treating diabetes. Replacing insulin through a basal-bolus mode effectively controls blood sugar levels in diabetic patients, prevents complications, and ensures quality of life.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Endocrinology & Metabolism
Sebastian M. N. Heimburger, Chris N. Nielsen, Salvatore Calanna, Jens J. Holst, Tina Vilsboll, Filip K. Knop, Mikkel B. Christensen
Summary: The study showed that exogenous GIP can increase plasma glycerol and free fatty acid concentrations in patients with type 1 diabetes during hyperglycemia and stable basal insulin levels, indicating a direct lipolytic effect of GIP at high glucose and low levels of plasma insulin.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
David Herzig, David Studer, Christos T. Nakas, Christina Kuenzli, Thomas P. Stauffer, Roman Hovorka, Lia Bally
Summary: This study retrospectively assessed the effects of fully automated closed-loop insulin delivery using faster (FA) versus standard insulin aspart (IAsp) in adults with type 2 diabetes. The results showed that FA had higher 10-hour exposure compared to IAsp, but this did not significantly impact endogenous insulin secretion or other gluco-regulatory hormones. Further research is needed to explore the metabolic and endocrine effects of novel insulins with accelerated pharmacokinetic properties.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Gillian L. Garden, Brian M. Frier, Julia L. Hine, Ewan J. Hutchison, Stuart J. Mitchell, Kenneth M. Shaw, Simon R. Heller, Gerd Koehler, Veronika Hofmann, Thomas P. Gaffney, Declan Maher, Graham A. Roberts, David L. Russell-Jones
Summary: The study examined blood glucose measurements in airline pilots with insulin-treated diabetes and found that the traffic light system was effective in reducing the frequency of values outside the normal range.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, General & Internal
Jennifer McVean, Gregory P. Forlenza, Roy W. Beck, Colleen Bauza, Ryan Bailey, Bruce Buckingham, Linda A. DiMeglio, Jennifer L. Sherr, Mark Clements, Anna Neyman, Carmella Evans-Molina, Emily K. Sims, Laurel H. Messer, Laya Ekhlaspour, Ryan McDonough, Michelle Van Name, Diana Rojas, Shannon Beasley, Stephanie DuBose, Craig Kollman, Antoinette Moran, CLVer Study Grp
Summary: The study aimed to determine the effectiveness of intensive diabetes management to achieve near normalization of glucose levels on preservation of pancreatic beta cell function in youth with newly diagnosed type 1 diabetes. The results showed that although the intensive management group achieved excellent glucose control, it did not affect the decline in pancreatic C-peptide secretion at 52 weeks.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Neurosciences
Katherine M. Roberts-Thomson, Lewan Parker, Andrew C. Betik, Glenn D. Wadley, Paul A. Della Gatta, Thomas H. Marwick, Michelle A. Keske
Summary: Insulin infusion increases skeletal muscle microvascular blood flow in healthy individuals, but this effect is impaired during insulin resistance. The route of glucose administration (oral versus intravenous) influences muscle microvascular blood flow, with oral glucose loading impairing blood flow while intravenous glucose infusion stimulates blood flow. Gut-derived hormones, such as gastric inhibitory polypeptide and glucagon-like peptide-1, may play a role in modulating skeletal muscle blood flow in response to glucose administration.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Uliana Semaniuk, Olha Strilbytska, Karina Malinovska, Kenneth B. Storey, Alexander Vaiserman, Volodymyr Lushchak, Oleh Lushchak
Summary: This study focuses on the expression profiles of DILP2, DILP3, and DILP5 produced by insulin-producing cells in the brain of Drosophila. The data suggest that the transcript levels of DILPs are influenced by various conditions such as nutrition, environment, and gene manipulation.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Emergency Medicine
Pedro Garrido, Pitter Cueto, Conxita Rovira, Elisabet Garcia, Ana Parra, Raquel Enriquez, Armando Pinos, Manuel Sosa, Anna Hernandez-Aguilera, Immaculada Vallverdu
Summary: In this single-center retrospective cohort study of COVID-19 patients admitted between March and May 2020, non-survivors in the ICU had significantly higher initial blood PCT levels compared to survivors.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Endocrinology & Metabolism
Angela X. Chen, Anjana Radhakutty, Anthony Zimmermann, Stephen N. Stranks, Campbell H. Thompson, Morton G. Burt
Summary: This study evaluated the association between glucocorticoid treatment and hyperglycaemia in hospitalised patients and found that factors such as sex, HbA1c levels, diabetes status and treatment, and weight were related to daily insulin requirements. Therefore, calculating insulin doses based on these factors may improve glycaemic control compared to weight-based dosing.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Nutrition & Dietetics
Laura Aponte Becerra, Anna Gavrieli, Faizan Khan, Peter Novak, Vasileios Lioutas, Long H. Ngo, Vera Novak, Christos S. Mantzoros
Summary: Centrally administered insulin reduces appetite in animal studies but results are conflicting in humans. This study aimed to investigate the effect of intranasal insulin (INI) on food intake and other measures. The study found that INI had no effect on food intake, appetite, or body weight in older adults with and without type 2 diabetes.
CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Caitlin E. M. Vink, Tim P. van de Hoef, M. J. W. Goette, E. C. Eringa, Yolande Appelman
Summary: INOCA, a subtype of ischemic heart disease, is more common in women. MBV may be reduced in INOCA patients, potentially due to conditions like diabetes and obesity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Endocrinology & Metabolism
Wellington S. Silva Junior, Monica Andrade Lima Gabbay, Rodrigo Nunes Lamounier, Luis Eduardo Calliari, Marcello Casaccia Bertoluci
Summary: This article is part of the Brazilian Diabetes Society's guidelines, providing information and recommendations on insulin therapy for type 1 diabetes. The authors conducted a literature review and presented several recommendations for insulin treatment.
DIABETOLOGY & METABOLIC SYNDROME
(2022)
Article
Chemistry, Multidisciplinary
Junwei Zhang, Xiaohong Peng, Yunxiang Wu, Huixia Ren, Jingfu Sun, Shiyan Tong, Tianyan Liu, Yiwen Zhao, Shusen Wang, Chao Tang, Liangyi Chen, Zhixing Chen
Summary: This study presents a class of red- and far-red-emitting Zn2+ probes, suitable for real-time monitoring high concentrations of Zn2+ co-released with insulin during vesicular secretion. Introduction of morpholino auxochromes in the probes eliminates phototoxicity, enabling long-term live recording of isolated islets. Additionally, a Si-rhodamine-based Zn2+ probe with high turn-on ratio allows simultaneous recording of various signals in isolated islets, showcasing the potential impact of biocompatible fluorophores in islet endocrinology and system biology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Tao Huang, Shijun Chen, Ke Ding, Baoqing Zheng, Weiqi Lv, Xiaobo Wang, Yadan Zhong, Hongxin Huang, Xin Zhang, Shufeng Ma, Bin Yang, Xiaohua Wang, Zhili Rong
Summary: SLC35E1 is highly expressed in keratinocytes of psoriasis patients, and its deficiency inhibits keratinocyte proliferation. The regulation of zinc ion concentrations and supplementation can alleviate psoriasis symptoms, indicating a potential therapy for psoriasis.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Mohsen Akbarian
Summary: Proteins and peptides are widely used in various industries such as pharmaceutical, health, food, textile, and biofuel, attracting attention especially in the pharmaceutical field. The demand for these drugs is increasing annually due to their high performance and low side effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Letter
Endocrinology & Metabolism
Bruce W. Bode, Keith Bowering, David Russell-Jones
Article
Endocrinology & Metabolism
David Russell-Jones, Arnaud Dauchy, Elias Delgado, George Dimitriadis, Hans A. Frandsen, Luiza Popescu, Bernd Schultes, Krzysztof Strojek, Mireille Bonnemaire, Aude Roborel de Climens, Melanie Davies
DIABETES OBESITY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
Melanie J. Davies, David Russell-Jones, Thomas M. Barber, Fernando J. Lavalle-Gonzalez, Gagik R. Galstyan, Dalong Zhu, Mike Baxter, Cecile Dessapt-Baradez, Rory J. McCrimmon
DIABETES OBESITY & METABOLISM
(2019)
Editorial Material
Endocrinology & Metabolism
D. L. Russell-Jones, B. M. Frier, K. M. Shaw
Review
Endocrinology & Metabolism
David Russell-Jones, Roselle Herring
Summary: Research spanning over 100 years has delved into the role of insulin in glucose, protein, and free fatty acid metabolism. By exploring evolution and changes in management, the impact on diabetes care is better understood. The article highlights the discrimination faced and recent advances to empower and counteract it.
Article
Endocrinology & Metabolism
Melanie J. Davies, Julio Rosenstock, Amar Ali, David Russell-Jones, Elisabeth Souhami, Karen Palmer, Chen Ji, Elisabeth Niemoeller, Neil Skolnik
Summary: The study demonstrated that in adults with type 2 diabetes inadequately controlled on two oral antidiabetes drugs, iGlarLixi provided better glycemic control compared to iGlar or Lixi, without increasing the risk of hypoglycemia.
DIABETES OBESITY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Athena Philis-Tsimikas, Harpreet S. Bajaj, Kamilla Begtrup, Roman Cailleteau, Amoolya Gowda, Ildiko Lingvay, Chantal Mathieu, David Russell-Jones, Julio Rosenstock
Summary: This article describes the clinical development program ONWARDS phase 3a, which investigates the use of once-weekly basal insulin icodec in the treatment of type 2 and type 1 diabetes. Six trials are being conducted to evaluate the efficacy and safety of icodec, with consideration of different clinical scenarios and comparator treatments.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
David Russell-Jones, Bruce W. Bode, Christophe De Block, Edward Franek, Simon R. Heller, Chantal Mathieu, Athena Philis-Tsimikas, Ludger Rose, Vincent C. Woo, Anne Birk Osterskov, Tina Graungaard, Richard M. Bergenstal