Germ cell differentiation requires Tdrd7-dependent chromatin and transcriptome reprogramming marked by germ plasm relocalization

A cell cycle-coordinated Polymerase II transcription compartment encompasses gene expression before global genome activation

(2019) Yavor Hadzhiev et al.   Nature Communications

Retention of paternal DNA methylome in the developing zebrafish germline

(2019) Ksenia Skvortsova et al.   Nature Communications

Zebrafish preserve global germline DNA methylation while sex-linked rDNA is amplified and demethylated during feminisation

(2019) Oscar Ortega-Recalde et al.   Nature Communications

P Granules Protect RNA Interference Genes from Silencing by piRNAs

(2019) John Paul T. Ouyang et al.   DEVELOPMENTAL CELL

Placeholder Nucleosomes Underlie Germline-to-Embryo DNA Methylation Reprogramming

(2018) Patrick J. Murphy et al.   CELL

Slow calcium waves mediate furrow microtubule reorganization and germ plasm compaction in the early zebrafish embryo

(2018) Celeste Eno et al.   DEVELOPMENT

Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain

(2018) Bushra Raj et al.   NATURE BIOTECHNOLOGY

Single-cell reconstruction of developmental trajectories during zebrafish embryogenesis

(2018) Jeffrey A. Farrell et al.   SCIENCE

Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development

(2018) Lucas J.T. Kaaij et al.   Cell Reports

Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification

(2018) Elke F. Roovers et al.   DEVELOPMENTAL CELL

Genomic insights into chromatin reprogramming to totipotency in embryos

(2018) Sabrina Ladstätter et al.   JOURNAL OF CELL BIOLOGY

Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

(2018) Peter W. S. Hill et al.   NATURE

Functional equivalence of germ plasm organizers

(2018) Pritesh Krishnakumar et al.   PLoS Genetics

Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish

(2017) Xiangyan Dai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B

(2017) Chih-Yung Sean Lee et al.   eLife

A high-resolution mRNA expression time course of embryonic development in zebrafish

(2017) Richard J White et al.   eLife

Establishing Chromatin Regulatory Landscape during Mouse Preimplantation Development

(2016) Falong Lu et al.   CELL

DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells

(2016) Hongshan Guo et al.   CELL RESEARCH

Differential Nanos 2 protein stability results in selective germ cell accumulation in the sea urchin

(2016) Nathalie Oulhen et al.   DEVELOPMENTAL BIOLOGY

Chromatin Control of Developmental Dynamics and Plasticity

(2016) Matteo Perino et al.   DEVELOPMENTAL CELL

Does mouse embryo primordial germ cell activation start before implantation as suggested by single-cell transcriptomics dynamics?

(2016) Daniela Gerovska et al.   MOLECULAR HUMAN REPRODUCTION

Active DNA demethylation at enhancers during the vertebrate phylotypic period

(2016) Ozren Bogdanović et al.   NATURE GENETICS

Whole-organism lineage tracing by combinatorial and cumulative genome editing

(2016) Aaron McKenna et al.   SCIENCE

The Transcriptome and DNA Methylome Landscapes of Human Primordial Germ Cells

(2015) Fan Guo et al.   CELL

DNA Demethylation Dynamics in the Human Prenatal Germline

(2015) Sofia Gkountela et al.   CELL

A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

(2015) Walfred W.C. Tang et al.   CELL

A functional Bucky ball-GFP transgene visualizes germ plasm in living zebrafish

(2015) Stephan Riemer et al.   GENE EXPRESSION PATTERNS

Specifying and protecting germ cell fate

(2015) Susan Strome et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond

(2015) Achim Breiling et al.   Epigenetics & Chromatin

Two independent transcription initiation codes overlap on vertebrate core promoters

(2014) Vanja Haberle et al.   NATURE

Regulation of the X Chromosomes in Caenorhabditis elegans

(2014) S. Strome et al.   Cold Spring Harbor Perspectives in Biology

DAZL Limits Pluripotency, Differentiation, and Apoptosis in Developing Primordial Germ Cells

(2014) Hsu-Hsin Chen et al.   Stem Cell Reports

Identification of the zebrafish maternal and paternal transcriptomes

(2013) Steven A. Harvey et al.   DEVELOPMENT

CaMK-II activation is essential for zebrafish inner ear development and acts through Delta–Notch signaling

(2013) Sarah C. Rothschild et al.   DEVELOPMENTAL BIOLOGY

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

Transcriptional Silencing of Transposons by Piwi and Maelstrom and Its Impact on Chromatin State and Gene Expression

(2012) Grzegorz Sienski et al.   CELL

Ectopic formation of primordial germ cells by transplantation of the germ plasm: Direct evidence for germ cell determinant in Xenopus

(2012) Haru Tada et al.   DEVELOPMENTAL BIOLOGY

Dynamics of enhancer chromatin signatures mark the transition from pluripotency to cell specification during embryogenesis

(2012) O. Bogdanovic et al.   GENOME RESEARCH

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Interaction between NANOS2 and the CCR4-NOT Deadenylation Complex Is Essential for Male Germ Cell Development in Mouse

(2012) Atsushi Suzuki et al.   PLoS One

Primordial Germ Cells in Mice

(2012) M. Saitou et al.   Cold Spring Harbor Perspectives in Biology

Antagonism between MES-4 and Polycomb Repressive Complex 2 Promotes Appropriate Gene Expression in C. elegans Germ Cells

(2012) Laura J. Gaydos et al.   Cell Reports

Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish

(2011) Hsin-Yi Huang et al.   EMBO JOURNAL

Synthetic spike-in standards for RNA-seq experiments

(2011) L. Jiang et al.   GENOME RESEARCH

P granules extend the nuclear pore complex environment in theC. elegansgerm line

(2011) Dustin L. Updike et al.   JOURNAL OF CELL BIOLOGY

The Nanos3-3′UTR Is Required for Germ Cell Specific NANOS3 Expression in Mouse Embryos

(2010) Hitomi Suzuki et al.   PLoS One

The Histone H3K36 Methyltransferase MES-4 Acts Epigenetically to Transmit the Memory of Germline Gene Expression to Progeny

(2010) Andreas Rechtsteiner et al.   PLoS Genetics

A Signaling Principle for the Specification of the Germ Cell Lineage in Mice

(2009) Yasuhide Ohinata et al.   CELL

Bucky Ball Organizes Germ Plasm Assembly in Zebrafish

(2009) Franck Bontems et al.   CURRENT BIOLOGY

TBP2 is essential for germ cell development by regulating transcription and chromatin condensation in the oocyte

(2009) E. Gazdag et al.   GENES & DEVELOPMENT

Control over the morphology and segregation of Zebrafish germ cell granules during embryonic development

(2008) Markus J Strasser et al.   BMC DEVELOPMENTAL BIOLOGY

Global Transcriptional Repression in C. elegans Germline Precursors by Regulated Sequestration of TAF-4

(2008) Tugba Guven-Ozkan et al.   CELL

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice

(2008) K. Kurimoto et al.   GENES & DEVELOPMENT

Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells

(2008) Kazuko Hanyu-Nakamura et al.   NATURE