Mechanically tuning actin filaments to modulate the action of actin-binding proteins

Structures of cofilin-induced structural changes reveal local and asymmetric perturbations of actin filaments

(2020) Andrew R. Huehn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force and phosphate release from Arp2/3 complex promote dissociation of actin filament branches

(2020) Nandan G. Pandit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

D-loop Dynamics and Near-Atomic-Resolution Cryo-EM Structure of Phalloidin-Bound F-Actin

(2020) Sanchaita Das et al.   STRUCTURE

Talin dissociates from RIAM and associates to vinculin sequentially in response to the actomyosin force

(2020) Clémence Vigouroux et al.   Nature Communications

Mechanosensing through Direct Binding of Tensed F-Actin by LIM Domains

(2020) Xiaoyu Sun et al.   DEVELOPMENTAL CELL

Myosin 1b flattens and prunes branched actin filaments

(2020) Julien Pernier et al.   JOURNAL OF CELL SCIENCE

Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism

(2020) Jonathan D. Winkelman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular mechanism for direct actin force-sensing by α-catenin

(2020) Lin Mei et al.   eLife

Structural basis for polarized elongation of actin filaments

(2020) Vilmos Zsolnay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biased localization of actin binding proteins by actin filament conformation

(2020) Andrew R. Harris et al.   Nature Communications

Torsional stress generated by ADF/cofilin on cross-linked actin filaments boosts their severing

(2019) Hugo Wioland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of actin polymerization revealed by cryo-EM structures of actin filaments with three different bound nucleotides

(2019) Steven Z. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feeling the force: formin’s role in mechanotransduction

(2019) Dennis Zimmermann et al.   CURRENT OPINION IN CELL BIOLOGY

Plastic Deformation and Fragmentation of Strained Actin Filaments

(2019) Anthony C. Schramm et al.   BIOPHYSICAL JOURNAL

Structural Polymorphism of Actin

(2019) Toshiro Oda et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanical and kinetic factors drive sorting of F-actin cross-linkers on bundles

(2019) Simon L. Freedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear actin dynamics in gene expression and genome organization

(2019) Salla Kyheröinen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Geometrical Constraints Greatly Hinder Formin mDia1 Activity

(2019) Emiko L. Suzuki et al.   NANO LETTERS

Mechanotransduction by the Actin Cytoskeleton: Converting Mechanical Stimuli into Biochemical Signals

(2018) Andrew R. Harris et al.   Annual Review of Biophysics

Helical rotation of the diaphanous-related formin mDia1 generates actin filaments resistant to cofilin

(2018) Hiroaki Mizuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for cofilin binding and actin filament disassembly

(2018) Kotaro Tanaka et al.   Nature Communications

Modulation of formin processivity by profilin and mechanical tension

(2018) Luyan Cao et al.   eLife

Mechanobiology of collective cell behaviours

(2017) Benoit Ladoux et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vinculin forms a directionally asymmetric catch bond with F-actin

(2017) Derek L. Huang et al.   SCIENCE

mDia1 senses both force and torque during F-actin filament polymerization

(2017) Miao Yu et al.   Nature Communications

Single Filaments to Reveal the Multiple Flavors of Actin

(2016) Antoine Jégou et al.   BIOPHYSICAL JOURNAL

Force Feedback Controls Motor Activity and Mechanical Properties of Self-Assembling Branched Actin Networks

(2016) Peter Bieling et al.   CELL

Mechanoaccumulative Elements of the Mammalian Actin Cytoskeleton

(2016) Eric S. Schiffhauer et al.   CURRENT BIOLOGY

Matrix mechanics controls FHL2 movement to the nucleus to activate p21 expression

(2016) Naotaka Nakazawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Appreciating force and shape — the rise of mechanotransduction in cell biology

(2014) Thomas Iskratsch et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The minimal cadherin-catenin complex binds to actin filaments under force

(2014) C. D. Buckley et al.   SCIENCE

Formin mDia1 senses and generates mechanical forces on actin filaments

(2013) Antoine Jégou et al.   Nature Communications

Molecular Cooperativity of Drebrin1-300 Binding and Structural Remodeling of F-Actin

(2012) Shivani Sharma et al.   BIOPHYSICAL JOURNAL

Actin Filaments as Tension Sensors

(2012) Vitold E. Galkin et al.   CURRENT BIOLOGY

Actin filament curvature biases branching direction

(2012) V. I. Risca et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex

(2012) M. P. Murrell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of tensile force on the mechanical behavior of actin filaments

(2011) Shinji Matsushita et al.   JOURNAL OF BIOMECHANICS

Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament

(2011) Kimihide Hayakawa et al.   JOURNAL OF CELL BIOLOGY

Stretching Actin Filaments within Cells Enhances their Affinity for the Myosin II Motor Domain

(2011) Taro Q. P. Uyeda et al.   PLoS One

Origin of Twist-Bend Coupling in Actin Filaments

(2010) Enrique M. De La Cruz et al.   BIOPHYSICAL JOURNAL

A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair

(2010) Mark A. Smith et al.   DEVELOPMENTAL CELL

Rotational Movement of the Formin mDia1 Along the Double Helical Strand of an Actin Filament

(2010) H. Mizuno et al.   SCIENCE

Mechanical Distortion of Single Actin Filaments Induced by External Force: Detection by Fluorescence Imaging

(2009) Togo Shimozawa et al.   BIOPHYSICAL JOURNAL

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

High-resolution cryo-EM structure of the F-actin-fimbrin/plastin ABD2 complex

(2008) V. E. Galkin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA