Kinetochore stretching-mediated rapid silencing of the spindle-assembly checkpoint required for failsafe chromosome segregation

Prolonged mitosis causes separase deregulation and chromosome nondisjunction

(2021) Norihisa Shindo et al.   Cell Reports

Aneuploidy: Cancer strength or vulnerability?

(2018) Giorgia Simonetti et al.   INTERNATIONAL JOURNAL OF CANCER

Multiple phosphorylations control recruitment of the KMN network onto kinetochores

(2018) Masatoshi Hara et al.   NATURE CELL BIOLOGY

HP1-Assisted Aurora B Kinase Activity Prevents Chromosome Segregation Errors

(2016) Yusuke Abe et al.   DEVELOPMENTAL CELL

Unattached kinetochores rather than intrakinetochore tension arrest mitosis in taxol-treated cells

(2016) Valentin Magidson et al.   JOURNAL OF CELL BIOLOGY

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase

(2016) Judit Pampalona et al.   PLoS One

Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T

(2015) Florencia Rago et al.   CURRENT BIOLOGY

Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores

(2015) Soonjoung Kim et al.   JOURNAL OF CELL BIOLOGY

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

(2015) Z. Ji et al.   SCIENCE

Kinetochore–microtubule attachment is sufficient to satisfy the human spindle assembly checkpoint

(2015) Banafsheh Etemad et al.   Nature Communications

Polar Ejection Forces Promote the Conversion from Lateral to End-on Kinetochore-Microtubule Attachments on Mono-oriented Chromosomes

(2015) Danica Drpic et al.   Cell Reports

Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase

(2014) Timo E. F. Kuijt et al.   CHROMOSOMA

The Architecture of CCAN Proteins Creates a Structural Integrity to Resist Spindle Forces and Achieve Proper Intrakinetochore Stretch

(2014) Aussie Suzuki et al.   DEVELOPMENTAL CELL

Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint

(2014) Edward R. Ballister et al.   JOURNAL OF CELL BIOLOGY

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

CENP-T provides a structural platform for outer kinetochore assembly

(2013) Tatsuya Nishino et al.   EMBO JOURNAL

Phosphorylation of Microtubule-binding Protein Hec1 by Mitotic Kinase Aurora B Specifies Spindle Checkpoint Kinase Mps1 Signaling at the Kinetochore

(2013) Tongge Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation

(2013) Mathijs Vleugel et al.   JOURNAL OF CELL BIOLOGY

Elevated polar ejection forces stabilize kinetochore–microtubule attachments

(2013) Stuart Cane et al.   JOURNAL OF CELL BIOLOGY

A minimal number of MELT repeats supports all the functions of KNL1 in chromosome segregation

(2013) Gang Zhang et al.   JOURNAL OF CELL SCIENCE

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

Separase Sensor Reveals Dual Roles for Separase Coordinating Cohesin Cleavage and Cdk1 Inhibition

(2012) Norihisa Shindo et al.   DEVELOPMENTAL CELL

Microtubule binding by KNL-1 contributes to spindle checkpoint silencing at the kinetochore

(2012) Julien Espeut et al.   JOURNAL OF CELL BIOLOGY

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Deformations Within Moving Kinetochores Reveal Different Sites of Active and Passive Force Generation

(2012) S. Dumont et al.   SCIENCE

Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins

(2011) Aussie Suzuki et al.   JOURNAL OF CELL BIOLOGY

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase

(2010) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Protein Architecture of the Human Kinetochore Microtubule Attachment Site

(2009) Xiaohu Wan et al.   CELL

Deviant Kinetochore Microtubule Dynamics Underlie Chromosomal Instability

(2009) Samuel F. Bakhoum et al.   CURRENT BIOLOGY

Kinetochore stretching inactivates the spindle assembly checkpoint

(2009) Kazuhiko S.K. Uchida et al.   JOURNAL OF CELL BIOLOGY

Intrakinetochore stretch is associated with changes in kinetochore phosphorylation and spindle assembly checkpoint activity

(2009) Thomas J. Maresca et al.   JOURNAL OF CELL BIOLOGY