Article
Biochemistry & Molecular Biology
Mustafa Genco Erdem, Ozge Unlu, Fatma Ates, Denizhan Karis, Mehmet Demirci
Summary: The study found that the oral microbiota of male patients with treated and untreated hyperthyroidism differ, while the treatment method has no impact on the oral microbiota. By conducting extensive multicenter studies to identify the core oral microbiota and long-term monitoring of hyperthyroidism, important data for understanding the pathogenesis of the disease may be obtained.
Article
Biochemistry & Molecular Biology
Nikola Ralchev Ralchev, Aleksandar Mishel Markovski, Inna Angelova Yankova, Iliyan Konstantinov Manoylov, Irini Atanas Doytchinova, Nikolina Mihaylova Mihaylova, Alexander Dimitrov Shinkov, Andrey Ivanov Tchorbanov
Summary: This study aims to selectively suppress anti-thyroglobulin IgG antibody-producing B lymphocytes in Hashimoto's thyroiditis patients using a chimeric protein molecule. The results show that this treatment method can reduce B-cell autoreactivity and promote apoptosis in targeted cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Mengyuan Fang, Mengjie Lei, Xuexue Chen, Hong Cao, Xingxing Duan, Hongxia Yuan, Lili Guo
Summary: This study analyzed the clinical and ultrasound radiomics features of thyroid nodules in patients with Hashimoto's thyroiditis and constructed a model for differentiating between benign and malignant nodules in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Maja Cvek, Dean Kalicanin, Ana Baric, Marko Vuletic, Ivana Gunjaca, Vesela Torlak Lovric, Veselin Skrabic, Ante Punda, Vesna Boraska Perica
Summary: Our study found no significant association between vitamin D and HT, but there may be a slight decrease in vitamin D levels associated with overt hypothyroidism. A significant correlation was identified between vitamin D and TSH in all HT patients, as well as a correlation between vitamin D and systolic blood pressure in OVERT HT patients.
Article
Immunology
Likun Cui, Chaoting Zhang, Huirong Ding, Dongdong Feng, Hongying Huang, Zheming Lu, Baoguo Liu
Summary: This study investigated the intratumor heterogeneity (ITH) of tumor infiltrating lymphocytes (TILs) in papillary thyroid carcinoma (PTC) with and without coexistent Hashimoto's thyroiditis (HT). The results revealed differences in T cell numbers and TCR repertoires between the two groups, suggesting the importance of distinct strategies based on the immune background in different situations.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Filip Lebiedzinski, Katarzyna Aleksandra Lisowska
Summary: Hashimoto's thyroiditis (HT) is an autoimmune disease affecting the thyroid gland and often requires lifelong treatment. Vitamin D deficiency is associated with a higher prevalence of thyroid autoimmunity, and vitamin D supplementation shows promise in reducing antibody levels and improving thyroid function in HT patients. Studies suggest that vitamin D may impact various immune mechanisms and improve clinical outcomes, but further research is needed.
Review
Immunology
Alessio Mazzieri, Pia Montanucci, Giuseppe Basta, Riccardo Calafiore
Summary: In Hashimoto's thyroiditis, the genetic basis, particularly the HLA genes, play a significant role in the development of the disease. Other genes and transcription factors, including BACH2, are also involved in the autoimmune background of HT. The interaction between these genes and environmental factors leads to autoimmunity and ultimately damage to the thyroid gland. The role of Th17 and Treg cells in HT is still not well-defined compared to Th1 cells and cytotoxic lymphocytes. imbalanced Th17/Treg ratio serves as a prognostic factor for gland damage. Genetic panels and immunotherapy may provide better targeted treatment and preventive interventions for individuals with potential or early stage HT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Jiangyue Xu, Ke Ding, Lan Mu, Jiangsheng Huang, Fei Ye, Yu Peng, Can Guo, Chutong Ren
Summary: This study found that Hashimoto's thyroiditis (HT) is associated with thyroid carcinoma (TC), where HT is a risk factor for TC and papillary thyroid carcinoma (PTC), but acts as a protective factor against PTC progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Xue Jiang, Yin Huang, Yanan Li, Yuxiao Xia, Lina Liu, Feng Lin, Yuhong Shi
Summary: This study aimed to explore the clinical effects of Vitamin D supplements for Hashimoto's Thyroiditis. The results showed that Vitamin D supplementation can effectively slow the progression of hypothyroidism, improve thyroid function, and reduce the levels of anti-thyroid antibodies.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
A. P. Weetman
Summary: Recent studies have provided new insights into the genetic, environmental, and pathogenic mechanisms of HT, including the identification of multiple cytokine networks, various defects in T regulatory cells, and possible disease associations. Additionally, there is growing evidence suggesting a direct role of the autoimmune process in causing persistent symptoms in a subset of patients with levothyroxine-treated HT.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
B. Sigman, D. F. Linder, J. L. Waller, W. B. Bollag, S. L. Baer, S. Tran, M. Kheda, L. Young, A. Mohammed, C. M. Isales, B. Siddiqui
Summary: The purpose of this study is to examine the association of Hashimoto's thyroiditis (HT) with the risk of renal transplant failure. The results showed that patients with HT had a significantly increased risk of renal transplant failure. These findings suggest that thyroid health and HT may play a significant role in the development of increased risk of renal transplant failure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Peter P. Issa, Mahmoud Omar, Yusef Buti, Chad P. Issa, Bert Chabot, Christopher J. Carnabatu, Ruhul Munshi, Mohammad Hussein, Mohamed Aboueisha, Mohamed Shama, Ralph L. Corsetti, Eman Toraih, Emad Kandil
Summary: This study analyzed the influence of Hashimoto's thyroiditis (HT) on patients with papillary thyroid cancer (PTC) and its effect on lymph node metastasis (LNM) in BRAF mutant tumors. The results showed that HT reduces the risk of LNM in PTC patients, especially for those with BRAF mutation. This research has important implications for treatment decisions by endocrinologists, oncologists, and surgeons.
Article
Pharmacology & Pharmacy
Xiangfei Meng, Shiyi Liu, Xiumin Deng, Xintong Li, Jia Lei, Hongye Jiang, Mengyao Liu, Ning Zhang, Shiwei Liu
Summary: The study found that BIFS can effectively reduce antibody levels, improve clinical and emotional symptoms, and enhance quality of life in patients with HT.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xiao-xiong Gan, Ya-yi Li, Si-jin Li, Shi-sen Mo, Jian-hua Feng, Fei Shen, Wen-song Cai, Ye-qian Lai, Bo Xu
Summary: Papillary thyroid carcinoma (PTC) concurrent with Hashimoto's thyroiditis (HT) is associated with better clinical prognosis. DMBT1 may act as a potential factor inhibiting tumors, and its high expression could improve PTC prognosis through immune-related pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Jadwiga Kryczyk-Koziol, Ewelina Prochownik, Anna Blazewska-Gruszczyk, Marian Slowiaczek, Qian Sun, Lutz Schomburg, Ewa Ochab, Miroslaw Bartyzel, Pawel Zagrodzki
Summary: The impact of selenium on the course of Hashimoto's thyroiditis (HT) was assessed by monitoring the titer of antithyroid autoantibodies, while the imbalance in T cell activity and changes in cytokine secretion were also examined. Selenium supplementation was found to affect the production of interferon gamma and interleukin 1 beta. The study revealed interdependent factors shaping the cytokine profile in HT, including the stage of disease development, degree of thyroid dysfunction, and selenium supplementation.
Article
Endocrinology & Metabolism
Yifang Hu, Lijuan Zhang, Huanhuan Chen, Xiaoyun Liu, Xuqin Zheng, He Shi, Lin Jiang, Dai Cui
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2019)
Review
Pharmacology & Pharmacy
He Shi, Rongrong Sheng, Yifang Hu, Xiaoyun Liu, Lin Jiang, Zhongmin Wang, Dai Cui
CLINICAL THERAPEUTICS
(2020)
Article
Surgery
Shumei Miao, Mang Jing, Rongrong Sheng, Dai Cui, Shan Lu, Xin Zhang, Shenqi Jing, Xiaoliang Zhang, Tao Shan, Hongwei Shan, Tingyu Xu, Bing Wang, Zhongmin Wang, Yun Liu
Article
Cell Biology
Feng Jiang, Yifang Hu, Xiaoqin Liu, Ming Wang, Chuyan Wu
Summary: This study reveals the significance and impact of m(6)A modification patterns in the tumor microenvironment. By assessing the m(6)A modification patterns, it is possible to predict the inflammatory stage, subtype, TME interstitial activity, and prognosis of tumors, leading to the development of more effective immunotherapy strategies.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Oncology
Yifang Hu, Jiahang Song, Zhen Wang, Jingbao Kan, Yaoqi Ge, Dan Wang, Rihua Zhang, Wensong Zhang, Yun Liu
Summary: The study developed a prognostic signature based on S100 family genes for predicting glioma prognosis, identifying a high-risk group associated with poor outcomes. Furthermore, the signature was found to be closely related to the immune microenvironment, potentially providing novel insights into the diagnosis and treatment of glioma.
JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lichun Lu, Yifang Hu, Chen Wang, Feng Jiang, Chuyan Wu
Summary: The study identified potential exercise-related genes, with TLR1 identified as a promising biomarker for predicting outcomes in low-grade glioma patients. Reduced expression and hypermethylation of TLR1 were associated with better survival outcomes, suggesting its potential as a prognostic marker for this cancer. Furthermore, TLR1 was found to be involved in immune cell infiltration and immunotherapy in LGG.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Wenwen Feng, Yifang Hu, Chengzhou Zhang, He Shi, Peng Zhang, Yanli Yang, Shiying Chen, Weijiang Cui, Dai Cui
Summary: This study evaluated the benefit and safety of mycophenolate mofetil (MMF) in the treatment of Graves' orbitopathy (GO) through a meta-analysis of clinical control trials. The results showed that MMF, either alone or in combination with glucocorticoid (GC), was superior to GC alone in treating GO. MMF monotherapy was more effective than GC, and a combination of MMF and methylprednisolone (MP) was more effective than MP monotherapy. MMF treatment in GO showed promising results and was safer compared to GC therapy.
Article
Biotechnology & Applied Microbiology
Jingbao Kan, Yifang Hu, Yaoqi Ge, WenSong Zhang, Shan Lu, Cuiping Zhao, Rihua Zhang, Yun Liu
Summary: The research revealed that the reduced expression of mitochondrial functional genes may be the main cause of skeletal muscle aging, with CYCS and ESRRA potentially playing significant roles in this process.
Article
Radiology, Nuclear Medicine & Medical Imaging
Huan-Huan Chen, Hao Hu, Wen Chen, Dai Cui, Xiao-Quan Xu, Fei-Yun Wu, Tao Yang
KOREAN JOURNAL OF RADIOLOGY
(2020)
