Article
Oncology
Rayne de Almeida Marques Bernabe, Mariana de Souza Vieira, Vanusa Felicio de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study investigated the association between sarcopenia phenotypes and fracture risk in women with breast cancer, and found that low muscle strength was associated with fracture risk.
Article
Endocrinology & Metabolism
Aleksandra Jawiarczyk-Przybylowska, Jowita Halupczok-Zyla, Joanna Syrycka, Agnieszka Zembska, Justyna Kuliczkowska-Plaksej, Marek Bolanowski
Summary: This study aimed to assess bone mineral density (BMD) and trabecular bone score (TBS) in acromegalic patients and analyze their association with selected bone markers. The results showed that acromegalic patients have altered bone microstructure indicated by decreased TBS, but no significant difference in BMD was observed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Takao Tobe, Misaki Kubo, Takahiro Toda, Mitsuhiro Morita, Mika Watanabe, Shigeki Yamada, Atsushi Suzuki, Takahiro Hayashi
Summary: This study aimed to identify high-risk patients for primary and secondary osteoporotic fractures using fracture risk assessments, and determine the departments where they are admitted. The department of rheumatology showed the highest fracture risk and had the highest number of patients on medications that resulted in reduced bone mineral density.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2022)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Nicholas C. Harvey, John A. Kanis, Enwu Liu, Cyrus Cooper, Mattias Lorentzon, Jennifer W. Bea, Laura Carbone, Elizabeth M. Cespedes Feliciano, Deepika R. Laddu, Peter F. Schnatz, Aladdin H. Shadyab, Marcia L. Stefanick, Jean Wactawski-Wende, Carolyn J. Crandall, Helena Johansson, Eugene McCloskey
Summary: In the WHI study, associations between baseline appendicular lean mass (ALM) and incident fractures, falls, and mortality in older postmenopausal women were investigated. Higher ALM/height(2) was associated with lower risk of MOF but higher risk of death. These associations were independent of prior falls but attenuated by other factors such as FRAX probability and FN BMD T-score.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
M. Schini, H. Johansson, N. C. Harvey, M. Lorentzon, J. A. Kanis, E. V. McCloskey
Summary: FRAX is a simple-to-use fracture risk calculator that assists clinicians in determining the need for further investigation and treatment to prevent fractures. This review explores the literature on osteoporosis and how FRAX has changed its management, presenting the characteristics of the tool and discussing the use of thresholds. Arguments for considering screening with FRAX are presented, along with an assessment of the limitations of FRAX.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
G. Adami, A. Biffi, G. Porcu, R. Ronco, R. Alvaro, R. Bogini, A. P. Caputi, L. Cianferotti, B. Frediani, D. Gatti, S. Gonnelli, G. Iolascon, A. Lenzi, S. Leone, S. Migliaccio, T. Nicoletti, M. Paoletta, A. Pennini, E. Piccirilli, U. Tarantino, M. L. Brandi, G. Corrao, M. Rossini, R. Michieli
Summary: The purpose of this study is to prevent fragility fractures by treating osteoporosis. The clinical performance of three commonly used fracture risk assessment tools (DeFRA, FRAX, and FRA-HS) was evaluated in at-risk patients. The study found no statistically significant differences among different prediction tools, indicating that any of these tools can be used for fracture risk assessment based on the specific situation.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
N. Sagalla, C. Colon-Emeric, R. Sloane, K. Lyles, J. Vognsen, R. Lee
Summary: FRAX without BMD showed good concordance, sensitivity, and specificity in predicting treatment recommendations after low trauma non-hip/non-vertebral fractures, offering a useful tool for risk stratification and treatment decision-making in such patients.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Pilar Vizcarra, Ana Moreno, Maria J. Vivancos, Alfonso Muriel Garcia, Margarita Ramirez Schacke, Juan Gonzalez-Garcia, Adrian Curran, Rosario Palacios, Antonio Jesus Sanchez Guirao, Sergio Reus Banuls, Santiago Moreno Guillen, Jose L. Casado, Spanish HIV Res Network CoRIS
Summary: This study aimed to develop a model for predicting the long-term risk of fragility fractures in people with HIV. The model accurately predicted the 5- and 10-year risk of fragility fractures and showed better performance compared to the existing prediction tool.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
I-Ting Liu, Fu-Wen Liang, Chia-Chun Li, Yin-Fan Chang, Zih-Jie Sun, Tsung-Hsueh Lu, Chin-Sung Chang, Chih-Hsing Wu
Summary: The Taiwan FRAX(R) calculator has been validated for predicting incident fractures and cutoff values have been proposed for fracture risk prediction in Taiwanese individuals.
ARCHIVES OF OSTEOPOROSIS
(2022)
Review
Endocrinology & Metabolism
Kento Ikegawa, Yukihiro Hasegawa
Summary: Turner syndrome patients are at high risk of osteoporosis and fractures, with hypogonadism as a major contributing factor. Estrogen deficiency leads to low bone mineral density and increased fracture prevalence. Estrogen replacement therapy improves bone density, but other factors may also contribute to low bone density.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Huiran Jia, Wei Qu, Xiaoting Cai, Meiye Li, Ying Qian, Zhaoshun Jiang, Zongjing Zhang
Summary: This study investigated the fracture risk assessment method for patients receiving TSH suppressive therapy after thyroid cancer surgery. The results showed that the FRAX tool, when combined with TSH weighted by age in the absence of bone mineral density data, can improve the accuracy of osteoporosis diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Pongsthorn Chanplakorn, Thamrong Lertudomphonwanit, Nuttorn Daraphongsataporn, Chanika Sritara, Suphaneewan Jaovisidha, Paphon Sa-Ngasoongsong
Summary: This study developed a prediction model for asymptomatic OVCF screening in women without clinical risk factors, showing that age, height loss, and femoral neck T-score can predict OVCF effectively.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Lan Yang, Mary Dempsey, Attracta Brennan, Bryan Whelan, E. Erjiang, Tingyan Wang, Rebecca Egan, Kelly Gorham, Fiona Heaney, Catherine Armstrong, Guadalupe Morote Ibarrola, Amina Gsel, Ming J. Yu, John Carey
Summary: The appropriate use of FRAX can reduce the need for DXA scans and identify individuals at the highest risk. Comparing FRAX results with and without inclusion of BMD suggests that clinicians should carefully consider the importance of including BMD in fracture risk estimation for individual patients.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Endocrinology & Metabolism
Nico Sollmann, Maximilian T. Loeffler, Malek El Husseini, Anjany Sekuboyina, Michael Dieckmeyer, Sebastian Ruehling, Claus Zimmer, Bjoern Menze, Gabby B. Joseph, Thomas Baum, Jan S. Kirschke
Summary: This study compared lumbar volumetric bone mineral density (vBMD) assessed by a convolutional neural network (CNN)-based framework in routine CT to vBMD from dedicated quantitative CT (QCT). The study found that automated opportunistic osteoporosis screening in routine CT of various scanner setups is feasible and may demonstrate high diagnostic accuracy for prevalent vertebral fractures (VFs).
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.