Physiologically‐Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID‐19

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical Characteristics and Outcomes of Hospitalized and Critically Ill Children and Adolescents with Coronavirus Disease 2019 (COVID-19) at a Tertiary Care Medical Center in New York City

(2020) Jerry Y. Chao et al.   JOURNAL OF PEDIATRICS

Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020

(2020) et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Multisystem Inflammatory Syndrome in Children during the COVID-19 pandemic: a case series

(2020) Kathleen Chiotos et al.   Journal of the Pediatric Infectious Diseases Society

Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID-19): a multicentre cohort

(2020) Marie Pouletty et al.   ANNALS OF THE RHEUMATIC DISEASES

Multisystem Inflammatory Syndrome in U.S. Children and Adolescents

(2020) Leora R. Feldstein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Kawasaki-like multisystem inflammatory syndrome in children during the covid-19 pandemic in Paris, France: prospective observational study

(2020) Julie Toubiana et al.   BMJ-British Medical Journal

How to Rapidly Determine First-in-Children Dosing for COVID-19 Therapeutics

(2020) Kevin M. Watt   JAMA Pediatrics

Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019

(2020) Anil R. Maharaj et al.   JAMA Pediatrics

Epidemiology, Clinical Features, and Disease Severity in Patients With Coronavirus Disease 2019 (COVID-19) in a Children’s Hospital in New York City, New York

(2020) Philip Zachariah et al.   JAMA Pediatrics

COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study

(2020) Florian Götzinger et al.   Lancet Child & Adolescent Health

Scaling Drug Clearance from Adults to the Young Children for Drugs Undergoing Hepatic Metabolism: A Simulation Study to Search for the Simplest Scaling Method

(2019) E. A. M. Calvier et al.   AAPS Journal

Ontogeny of Phase I Metabolism of Drugs

(2019) Karel Allegaert et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic–Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance

(2018) Eva Germovsek et al.   CLINICAL PHARMACOKINETICS

Physiologically Based Pharmacokinetic Model Qualification and Reporting Procedures for Regulatory Submissions: A Consortium Perspective

(2018) Mohamad Shebley et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Development of Drug Therapies for Newborns and Children

(2017) Yeruk (Lily) Mulugeta et al.   PEDIATRIC CLINICS OF NORTH AMERICA

Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants

(2016) Mikael Boberg et al.   DRUG METABOLISM AND DISPOSITION

A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients

(2016) Wen Lin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Synthesis and antiviral activity of a series of 1′-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

(2012) Aesop Cho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

First dose in children: physiological insights into pharmacokinetic scaling approaches and their implications in paediatric drug development

(2012) Ashley Strougo et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Knowledge-driven approaches for the guidance of first-in-children dosing

(2010) Andrea N. Edginton   PEDIATRIC ANESTHESIA