Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Fei Song, Xiao-Xia Zhou, Yu Hu, Gang Li, Yan Wang
Summary: The IGF system plays multiple roles in disease development by regulating cell proliferation and differentiation. IGFBPs can bind to IGFs and perform different functions, possibly having broader functions through IGF-independent mechanisms.
ADVANCES IN THERAPY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Tiancheng Li, Ziqi Yan, Shushu He, Chenchen Zhou, Han Wang, Xing Yin, Shujuan Zou, Peipei Duan
Summary: This study aimed to investigate the effects of intermittent parathyroid hormone (iPTH) on the stability of orthodontic retention and the regulatory role of insulin-like growth factor-1 (IGF-1). The results showed that iPTH improved stability of tooth movement by promoting periodontal regeneration, with IGF-1 playing an essential role in mediating the anabolic effects of iPTH.
Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Cheryl A. Conover, Claus Oxvig
Summary: PAPP-A is a placental protein that was initially discovered in pregnant women and later found to be a metalloproteinase expressed by nonplacental cells. It regulates local insulin-like growth factor (IGF) activity by cleaving high-affinity IGF binding proteins (IGFBPs). This proteolytic regulation is important for cell proliferation, differentiation, migration, and survival in normal and cancer cells.
Article
Endocrinology & Metabolism
Junia R. O. L. Schweizer, Katharina Schilbach, Michael Haenelt, Alexandre Giannetti, Mariana F. Bizzi, Beatriz S. Soares, Eduardo Paulino, Jochen Schopohl, Sylvere Stormann, Antonio Ribeiro-Oliveira, Martin Bidlingmaier
Summary: This study confirmed s-alpha KL as a biomarker for acromegaly, showing a close association with GH secretion status, a large dynamic range, and robustness towards biological confounders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Chemistry, Multidisciplinary
Bhavesh Premdjee, Asser S. Andersen, Mark Larance, Kilian W. Conde-Frieboes, Richard J. Payne
Summary: The text discusses the successful assembly of a 31.5 kDa phosphorylated IGFBP-2 protein using two ligation manifolds, incorporating phosphoserine post-translational modification and nine disulfide bonds.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Biochemical Research Methods
Mark S. Pratt, Martijn van Faassen, Noah Remmelts, Rainer Bischoff, Ido P. Kema
Summary: This study presents a simple and fast antibody-free LC-MS/MS method for the quantification of intact IGF-1 and IGF-2 in human plasma, allowing for reliable and simultaneous quantification without the need for enzymatic digestion. The method offers advantages of speed, accuracy, and potential wide application in clinical mass spectrometry laboratories.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Kuan-Yu Chen, Shin-Yu Lin, Chien-Nan Lee, Hung-Tsung Wu, Ching-Hua Kuo, Han-Chun Kuo, Chia-Chi Chuang, Chun-Heng Kuo, Szu-Chi Chen, Kang-Chih Fan, Ming-Wei Lin, Chi-Tai Fang, Hung-Yuan Li
Summary: This study investigated the relationship between maternal lipids during pregnancy and placental growth factors on excess fetal growth, finding that certain free fatty acids can induce placental IGF-1 secretion, potentially linking maternal plasma lipids and large-for-gestational-age (LGA) neonates.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kuan-Yu Chen, Shin-Yu Lin, Chien-Nan Lee, Hung-Tsung Wu, Ching-Hua Kuo, Han-Chun Kuo, Chia-Chi Chuang, Chun-Heng Kuo, Szu-Chi Chen, Kang-Chih Fan, Ming-Wei Lin, Chi-Tai Fang, Hung-Yuan Li
Summary: It was found in the study that maternal lipids during pregnancy and placental growth factors are closely associated with excess fetal growth, suggesting a potential link between certain free fatty acids and induction of placental IGF-1 secretion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Kangkang Chen, Xiaoyi Dou, Jai Hoon Eum, Ruby E. Harrison, Mark R. Brown, Michael R. Strand
Summary: This study assessed the expression of insulin-like peptides (ILPs) and ovary ecdysteroidogenic hormone (OEH) in Aedes aegypti during a gonadotrophic cycle and further functionally characterized these peptides to understand their roles in regulating egg formation. The results showed that all ILPs and OEH were expressed during the cycle, and there were differences in their biological activities and insulin- insulin growth factor signaling (IIS) phosphorylation levels.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
K. Berit Sellars, Brittany A. Ryan, Sarah A. Hartery, Beth J. Kirby, Christopher S. Kovacs
Summary: FGF23 appears to play no role in fetal phosphorus metabolism before birth, but maternal phosphate loading can induce a fetal FGF23 response without affecting fetal serum phosphorus levels.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.