Article
Chemistry, Medicinal
Jae-Min Kim, Kyung-Sook Chung, Young-Seo Yoon, Seo-Yun Jang, So-Won Heo, Geonha Park, Young-Pyo Jang, Hye-Shin Ahn, Yu-Kyong Shin, Sun-Hee Lee, Kyung-Tae Lee
Summary: The study found that dieckol can inhibit UVB-induced skin photoaging by regulating the TGF-beta/Smad2/3 and MAPKs/AP-1 signaling pathways, thereby suppressing collagen degradation and MMP expression. In addition, dieckol restored the production of hyaluronic acid, reducing transepidermal water loss, epidermal/dermal thickness, and wrinkle formation.
Article
Reproductive Biology
Changquan Guo, Juan Dong, Yanfen Ma, Shuo Zhou, Weidong Zeng, Guang Liu, Caiqiao Zhang
Summary: This study investigated the functions of LIF and bFGF in the development of chicken primordial follicles, finding a synergistic effect on follicle activation. The cytokines operated through AKT and ERK signaling pathways to suppress apoptosis and promote proliferation via the Wnt/beta-catenin signaling pathway.
Article
Orthopedics
Rouhollah Mousavizadeh, Charlie M. Waugh, Erin DeBruin, Robert G. McCormack, Vincent Duronio, Alex Scott
Summary: This study reveals that oxLDL, commonly found in patients with hypercholesterolemia, has mechanistic effects on tendon cells, leading to matrix remodeling. The findings suggest a potential link between high cholesterol and tendon damage.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Multidisciplinary Sciences
Camilla H. K. Hughes, Olivia E. Smith, Marie-Charlotte Meinsohn, Mylene Brunelle, Nicolas Gevry, Bruce D. Murphy
Summary: This study identifies SF-1 as a key regulator of the formation of the ovarian reserve, with its depletion leading to smaller ovaries and reduced primordial follicles. The study also identifies the dysregulated pathways and genes involved in follicle formation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Article
Environmental Sciences
Jianhui Ji, Yingjun Zhou, Zhengpeng Li, Juan Zhuang, Yuguan Ze, Fashui Hong
Summary: This study found that titanium dioxide nanoparticles can cause damage to the reproductive system in mice, particularly inhibiting ovarian follicular development. The inhibition appears to be mediated by changes in hormone levels and molecular expression, possibly through the TGF-beta signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Yanhong Zhang, Qiuyue Chen, Yuanyuan Guo, Li Kang, Yi Sun, Yunliang Jiang
Summary: Follicle selection in chickens is a crucial process controlled by sex hormones, which impacts egg production. In this study, the phosphoproteomes of small yellow (SY) and F6 follicles were compared, leading to the identification of differentially phosphorylated proteins. The expression of LSD1Ser54p, a phosphorylated protein, was found to be upregulated in F6 follicles, indicating its involvement in follicle selection.
Article
Biochemistry & Molecular Biology
Hagar Grunwald, Kristina L. Hunker, Isabelle Birt, Rohtem Aviram, Shelly Zaffryar-Eilot, Santhi K. Ganesh, Peleg Hasson
Summary: The interaction between VEGF, TGF beta, and LOX is crucial for the formation of mature vascular smooth muscle cells-coated vessels. Additionally, RNA sequencing analysis identified an interaction with the endothelin-1 pathway.
Article
Food Science & Technology
Hee Ho Song, Ki-Bae Hong, Sunhoo Kim, Byung-Yong Kim, Shin Hyung Shik, Hyung Joo Suh, Yejin Ahn
Summary: Fish collagen supplementation improves skin moisture and reduces wrinkles by regulating extracellular matrix homeostasis, reactive oxygen species and cytokine production, as well as gut microbiota composition.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Candida Nissola, Marcelo Luis Kuhn Marchioro, Eneri Vieira de Souza Leite Mello, Ana Carolina Guidi, Daniela Cristina de Medeiros, Camila Girotto da Silva, Joao Carlos Palazzo de Mello, Edimir Andrade Pereira, Aneli M. Barbosa-Dekker, Robert F. H. Dekker, Mario A. A. Cunha
Summary: A hydrogel containing exocellular (1 -> 6)-beta-D-glucan was developed for wound healing potential evaluation. The beta-glucan showed physicochemical stability, microbiological quality, antioxidant potential, and immunomodulatory activity in wound healing. It could be a promising alternative compound in wound care.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Fisheries
Hua Rong, Haoran Zhang, Lijun Ning, Kun Wu, Samwel Mchele Limbu, Qingchao Shi, Chuanjie Qin, Xiaobo Wen
Summary: This study investigated the effects of dietary Pro supplementation on collagen synthesis and deposition in the swim bladder of Chu's croaker. It was found that an optimal Pro supplementation level of 19.36 g kg(-1) significantly increased collagen content. The TGF-beta/Smad signaling pathway played a crucial role in regulating collagen synthesis and deposition in the swim bladder.
Article
Engineering, Biomedical
Samantha Stewart, Wenquan Ou, Helim Aranda-Espinoza, Shaik O. Rahaman, Xiaoming He
Summary: Ovarian follicles develop in a regulated mechanical microenvironment, and disruptions to this microenvironment can cause infertility. The viscoelastic properties of ovarian tissue have not been extensively studied. This study characterizes the elastic and viscoelastic properties of ovarian tissue from both reproductive age groups of domestic cats and identifies possible connections between mechanical and compositional heterogeneities. These findings may have important implications for biomimetic follicle culture.
ACTA BIOMATERIALIA
(2023)
Review
Biochemistry & Molecular Biology
Dandan Peng, Minyang Fu, Manni Wang, Yuquan Wei, Xiawei Wei
Summary: TGF-beta plays essential roles in early embryonic development, organogenesis, immune regulation, tissue repair, and adult homeostasis. Its involvement in fibrosis and cancer is complex and context-dependent, showing both inhibitory and promoting effects. Therapeutics targeting TGF-beta signaling hold promise in treating fibrosis and cancer, although the development is hindered by potential systemic cytotoxicity.
Article
Multidisciplinary Sciences
Muhammad Umair Khan, Eman Mohammad, Yawar Abbas, Moh'd Rezeq, Baker Mohammad
Summary: This work introduces a high-performance, low-cost, biocompatible triboelectric nanogenerator (TENG) made from chicken skin (CS). The CS-TENG can power wearable devices, improving electronic monitoring, prediction, and treatment capabilities. It also supports sustainability by reducing waste in the poultry industry. The CS-TENG demonstrates impressive endurance and can scavenge energy for various applications, making it a promising step towards sustainable, battery-less devices or augmented energy sources.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Antonio Tejera-Munoz, Laura Marquez-Exposito, Lucia Tejedor-Santamaria, Sandra Rayego-Mateos, Macarena Orejudo, Beatriz Suarez-Alvarez, Carlos Lopez-Larrea, Marta Ruiz-Ortega, Raul R. Rodrigues-Diez
Summary: CCN2 plays a role in both fibrotic responses and growth factor-induced oxidative and proinflammatory responses. Its coexistence with TGF-β is necessary for persistent fibrotic response, but the mechanisms involved are not fully understood. CCN2 increases T beta RII expression in VSMCs and maintains TGF-β pathway activation through an EGFR-SMAD dependent manner.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Xin Lin, Xingting Liu, Changquan Guo, Mengqi Liu, Yuling Mi, Caiqiao Zhang
JOURNAL OF CELLULAR PHYSIOLOGY
(2018)
Article
Reproductive Biology
Changquan Guo, Guanglu Zhang, Xin Lin, Dan Zhao, Caiqiao Zhang, Yuling Mi
Article
Cell Biology
Jinwei Yao, Yanfen Ma, Xin Lin, Shuo Zhou, Yuling Mi, Caiqiao Zhang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Jinwei Yao, Yanfen Ma, Shuo Zhou, Tingting Bao, Yuling Mi, Weidong Zeng, Jian Li, Caiqiao Zhang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Cell Biology
Shuo Zhou, An Zhao, Yangyang Wu, Tingting Bao, Yuling Mi, Caiqiao Zhang
Summary: Aging in laying hens leads to increased follicular atresia and decreased fecundity, with FSH playing a crucial role in preventing reproductive aging. The study found that FSH can delay the progression of atretic small white follicles in hens by inhibiting DNA damage and promoting repair mechanisms, ultimately protecting granulosa cells from aging-related damage.
Article
Developmental Biology
Juan Dong, Changquan Guo, Shuo Zhou, Tingting Bao, Jian Li, Yuling Mi, Caiqiao Zhang
Summary: Autophagy plays a protective role in oocyte survival during chicken folliculogenesis by regulating ovarian glycolysis, involving Akt signaling to maintain germ cell cyst breakdown and primordial follicle assembly.
DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Juan Dong, Changquan Guo, Zhaoyu Yang, Yangyang Wu, Caiqiao Zhang
Summary: In this study, it is found that FSH can alleviate the aging of chicken granulosa cells by activating glycophagy and mitophagy. The regulation of energy metabolism is mediated by the PI3K/AKT and AMPK pathways.
Article
Cell Biology
Yangyang Wu, Shuo Zhou, An Zhao, Yuling Mi, Caiqiao Zhang
Summary: Oxidative stress is a major contributor to ovarian aging and follicular atresia. Rutin has been shown to have antioxidant properties, and this study demonstrates that rutin can alleviate oxidative stress in aging chicken small white follicles (SWFs) by promoting cell proliferation, preventing apoptosis, and inhibiting ferroptosis. The activation of the Nrf2/HO-1 pathway by rutin speeds up the dialogue between SWFs and oxidative damage, reducing ferroptosis. These findings provide a new approach to slowing ovarian aging in laying hens.
CELL BIOLOGY INTERNATIONAL
(2023)
