A role of PIEZO1 in iron metabolism in mice and humans

A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans

(2020) Christian N. Nguetse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Piezo1 unleashes innate immunity against cancer and infectious disease

(2020) Berk Aykut et al.   Science Immunology

Clinical and biological features in PIEZO1-hereditary xerocytosis and Gardos-channelopathy: A retrospective series of 126 patients

(2019) Véronique Picard et al.   HAEMATOLOGICA

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank

(2019) Luke C Pilling et al.   BMJ-British Medical Journal

Benefits and limitations of genome-wide association studies

(2019) Vivian Tam et al.   NATURE REVIEWS GENETICS

Mechanobiology of Macrophages: How Physical Factors Coregulate Macrophage Plasticity and Phagocytosis

(2019) Nikhil Jain et al.   Annual Review of Biomedical Engineering

The mechanosensitive Piezo1 channel is required for bone formation

(2019) Weijia Sun et al.   eLife

Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity

(2019) Angel G. Solis et al.   NATURE

Locally renewing resident synovial macrophages provide a protective barrier for the joint

(2019) Stephan Culemann et al.   NATURE

Gain‐of‐function mutations in PIEZO1 directly impair hepatic iron metabolism via the inhibition of the BMP/SMADs pathway

(2019) Immacolata Andolfo et al.   AMERICAN JOURNAL OF HEMATOLOGY

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection

(2018) Shang Ma et al.   CELL

Piezo1 is a mechanically activated ion channel and mediates pressure induced pancreatitis

(2018) Joelle M.-J. Romac et al.   Nature Communications

Haemochromatosis

(2018) Pierre Brissot et al.   Nature Reviews Disease Primers

A common functional PIEZO1 deletion allele associates with red blood cell density in sickle cell disease patients

(2018) Yann Ilboudo et al.   AMERICAN JOURNAL OF HEMATOLOGY

A gain of function variant in PIEZO1 (E756del) and sickle cell disease

(2018) Helen Rooks et al.   HAEMATOLOGICA

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

(2018) et al.   NATURE

The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019

(2018) Annalisa Buniello et al.   NUCLEIC ACIDS RESEARCH

PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex

(2018) Wei-Zheng Zeng et al.   SCIENCE

Regulation of Hepcidin by Erythropoiesis: The Story So Far

(2016) Sant-Rayn Pasricha et al.   Annual Review of Nutrition

The Role of Iron and Iron Overload in Chronic Liver Disease

(2016) Sandra Milic et al.   MEDICAL SCIENCE MONITOR

Macrophages and iron trafficking at the birth and death of red cells

(2015) T. Korolnek et al.   BLOOD

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

Piezo2 is the principal mechanotransduction channel for proprioception

(2015) Seung-Hyun Woo et al.   NATURE NEUROSCIENCE

Piezo1 links mechanical forces to red blood cell volume

(2015) Stuart M Cahalan et al.   eLife

The African Genome Variation Project shapes medical genetics in Africa

(2014) Deepti Gurdasani et al.   NATURE

Piezo1 integration of vascular architecture with physiological force

(2014) Jing Li et al.   NATURE

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

(2014) S. S. Ranade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis

(2014) Beben Benyamin et al.   Nature Communications

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Plasma membrane tension orchestrates membrane trafficking, cytoskeletal remodeling, and biochemical signaling during phagocytosis

(2013) T. A. Masters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels

(2013) Juliette Albuisson et al.   Nature Communications

Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis

(2013) T. Ganz et al.   Cold Spring Harbor Perspectives in Medicine

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis

(2012) R. Zarychanski et al.   BLOOD

Macrophages and Systemic Iron Homeostasis

(2012) Tomas Ganz   Journal of Innate Immunity

Iron Overload in Human Disease

(2012) Robert E. Fleming et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Mechanosensitive Ion Channel Piezo1 Is Inhibited by the Peptide GsMTx4

(2011) Chilman Bae et al.   BIOCHEMISTRY

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

(2011) Z. Zhang et al.   BLOOD

Hepcidin and iron regulation, 10 years later

(2011) T. Ganz   BLOOD

Stress erythropoiesis: new signals and new stress progenitor cells

(2011) Robert F Paulson et al.   CURRENT OPINION IN HEMATOLOGY

Pathogenesis and management of iron toxicity in thalassemia

(2010) Chaim Hershko   Annals of the New York Academy of Sciences

The role of calcium signaling in phagocytosis

(2010) Paula Nunes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Iron Overload Cardiomyopathy

(2010) Pradeep Gujja et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Tumor-Associated Macrophages and Survival in Classic Hodgkin's Lymphoma

(2010) Christian Steidl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response

(2009) M A Gronski et al.   CELL DEATH AND DIFFERENTIATION

Ferritin for the clinician

(2008) Mary Ann Knovich et al.   BLOOD REVIEWS