期刊
CARBOHYDRATE POLYMERS
卷 253, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2020.117187
关键词
Chondroitin sulfate; Zein; Docetaxel; Nanoparticles; Tumor-targeting; CD44 receptor
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [NRF-2018R1C1B6005379, NRF-2018M3A7B4071204]
Chondroitin sulfate-hybridized zein nanoparticles were developed for targeted delivery of docetaxel, showing improved anti-tumor efficacy and pharmacokinetic properties.
Chondroitin sulfate-hybridized zein nanoparticles (zein/CS NPs) were developed for targeted delivery of docetaxel, which exhibited mean diameters of 157.8 +/- 3.6 nm and docetaxel encapsulation efficiency of 64.2 +/- 1.9 %. Docetaxel was released from the NPs in a sustained manner (similar to 72 h), following first-order kinetics. The zein/ CS NPs showed improved colloidal stability, maintaining the initial size in serum for 12 h. The pre-treatment of CS reduced the uptake efficiency of the NPs by 23 % in PC-3 cells, suggesting the involvement of CD44-mediated uptake mechanism. The NPs showed 2.79-fold lower IC50 values than free docetaxel. Enhanced tumor accumulation of the NPs was confirmed in PC-3 xenograft mice by near-infrared fluorescence imaging (35.3-fold, versus free Cy5.5). The NPs exhibited improved pharmacokinetic properties (9.5-fold longer terminal half-life, versus free docetaxel) and anti-tumor efficacy comparable to Taxotere with negligible systemic toxicity, suggesting zein/CS NPs could be a promising nanoplatform for targeted cancer therapy.
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