Article
Biochemistry & Molecular Biology
Congcong Wang, Yajie Liu, Xinglai Liu, Jin Zhao, Bing Lang, Fan Wu, Ziyu Wen, Caijun Sun
Summary: Deeply understanding virus-host interactions is crucial for developing effective strategies against emerging infectious diseases. This study reveals that SerpinA5, a novel IFN-stimulated gene, plays an important role in antiviral activity. Mechanistically, SerpinA5 enhances STAT1 phosphorylation and nuclear translocation, leading to the activation of IFN-related signaling pathways and impairing viral infections. These findings provide insights into SerpinA5-mediated innate immune signaling during virus-host interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Elisa Fanunza, Nicole Grandi, Marina Quartu, Fabrizio Carletti, Laura Ermellino, Jessica Milia, Angela Corona, Maria Rosaria Capobianchi, Giuseppe Ippolito, Enzo Tramontano
Summary: The study revealed that Zika virus NS4B protein acts as an antagonist of interferon signaling cascade by suppressing IFN-stimulated response element and transcription, as well as by reducing the expression levels of interferon-stimulated genes. This viral protein also inhibits STAT1 phosphorylation, blocking the nuclear transport of both STAT1 and STAT2.
Article
Biochemistry & Molecular Biology
Xiaomin Guo, Pengcheng Ma, Yuwei Li, Yanan Yang, Chaoming Wang, Tao Xu, Huishan Wang, Chaocui Li, Bingyu Mao, Xiaopeng Qi
Summary: The study demonstrated that ubiquitination of STAT1 by the E3 ligase RNF220 plays a significant role in STAT1 activation and innate immune responses. Deficiency in Rnf220 gene leads to downregulation of IFN signaling and decreased expression of ISGs, making RNF220 a potential therapeutic target against bacterial and viral infection and inflammatory diseases.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Multidisciplinary Sciences
Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U. Jung, Huaping Liang, Xiaozhen Liang
Summary: Type I interferons (IFNs) are the first line of defense against invading pathogens. This study identified a previously unknown protein, PINLYP, that interacts with TBK1 to induce the production of type I IFN. Loss of PINLYP impaired the activation of IRF3 and the production of IFN induced by various viruses and Toll-like receptor ligands. Mice lacking PINLYP were more susceptible to lethal virus infection, highlighting the importance of PINLYP in the host defense against viral infections.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Gayathri Manokaran, Michelle D. Audsley, Haruka Funakoda, Cassandra T. David, Katherine A. Garnham, Stephen M. Rawlinson, Celine Deffrasnes, Naoto Ito, Gregory W. Moseley
Summary: This study reveals the mechanism by which rabies virus overcomes a pre-established antiviral state in cells. The ability to disable the antiviral state correlates with pathogenicity, highlighting a crucial step in lethal rabies virus infection.
Article
Biochemistry & Molecular Biology
Linyuan Feng, Wanwei Li, Xiaowen Li, Xiaotian Li, Yanhong Ran, Xiaoping Yang, Zemin Deng, Hongjian Li
Summary: Signaling desensitization plays a crucial role in limiting the duration and intensity of signal transduction. This study demonstrates that NMI enhances STAT1 phosphorylation and IFNγ-induced immune responses by sequestering UBC9 and blocking STAT1 sumoylation. NMI also facilitates the translocation of UBC9 from the nucleus to the cytoplasm, inhibiting STAT1 sumoylation. This research reveals the importance of NMI in modulating IFNγ signaling through a desensitization mechanism.
Article
Fisheries
Sylvie M. A. Quiniou, Jonathan Crider, Kristianna L. Felch, Eva Bengten, Pierre Boudinot
Summary: In this study, we identified the complete repertoire of IFNs and IFN receptor genes in channel catfish. We found 16 type I IFN genes representing six previously defined subgroups, as well as two type II IFN genes and their respective receptors. Our findings provide a comprehensive resource for future research on the innate antiviral immunity of channel catfish.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Microbiology
Manuel Albert, Jesus Vazquez, Juan M. Falcon-Perez, Maria A. Balboa, Marc Liesa, Jesus Balsinde, Susana Guerra
Summary: This study reveals the role of ISG15 in regulating lipid metabolism in macrophages and its importance in the context of viral infections. The findings provide insights into macrophage immunometabolism and the interaction between poxviruses and the host.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Yu-Qing Lu, Jing Wu, Xiang-Ji Wu, Hui Ma, Yan-Xiu Ma, Rong Zhang, Meng-Nan Su, Nan Wu, Gong-Yin Chen, Hong-Song Chen, Xiao-Ben Pan
Summary: Research shows that IFI16 plays a role in sensing HBV infection and early changes in IFI16 mRNA in PBMCs can predict HBeAg seroconversion. Additionally, interferons can influence IFI16 degradation and subcellular location.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Virology
Sam Drury, Grace Claussen, Allison Zetterman, Hideaki Moriyama, Etsuko N. N. Moriyama, Luwen Zhang
Summary: The study identified the existence of the IRF9 gene in cartilaginous fish and discovered unique isoforms of IRF9 in old world monkeys and great apes. These isoforms, named primate-specific IRF9 (PS-IRF9), have a different C-terminal region compared to canonical IRF9. Two PS-IRF9s were found in humans, and their RNA transcripts and proteins were detected. PS-IRF9 may have unique biological functions and be involved in the regulation of the IFN pathway in a primate-specific manner.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Fisheries
Yuelian Zou, Xin Xu, Qilin Hu, Yilei Wang, Huiping Yang, Ziping Zhang
Summary: This study identified and analyzed the FREP genes in abalones, revealing their important role in the immune system and significance for disease prevention and control in aquaculture species.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Oncology
Remya Raja, Christopher Wu, Esen Yonca Bassoy, Thomas E. Rubino Jr, Emma C. Utagawa, Paul M. Magtibay, Kristina A. Butler, Marion Curtis
Summary: This study found that PP4 inhibition can increase the sensitivity of ovarian cancer cells to carboplatin and enhance the anti-tumor immune response by activating inflammatory signaling and promoting immune cell effector function.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Jing-Ping Huang, Jing Li, Yan-Ping Xiao, Liang-Guo Xu
Summary: Our research reveals that BAG6 is a critical regulator in the RIG-I/VISA-mediated innate immune response. It inhibits the aggregation of VISA and attenuates the recruitment of TRAF2, thereby inhibiting the activation of the RLR signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Elisabet Diaz-Beneitez, Liliana Lilibeth Cubas-Gaona, Oscar Candelas-Rivera, Ana Benito-Zafra, Maria Teresa Sanchez-Aparicio, Lisa Miorin, Jose F. Rodriguez, Adolfo Garcia-Sastre, Dolores Rodriguez
Summary: Infectious Bursal Disease Virus (IBDV) is an immunosuppressive disease that affects domestic chickens. This study found that TRIM25 plays an important role in the pathogenesis of IBDV by enhancing the activation of IFN-inducing pathway mediated by MDA5.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
James F. Read, Michael Serralha, Danny Mok, Barbara J. Holt, Mark Cruickshank, Yuliya V. Karpievitch, David I. Broadhurst, Peter D. Sly, Deborah H. Strickland, Stacey N. Reinke, Patrick G. Holt, Anthony Bosco
Summary: Activation intensity of an LPS-induced interferon gene network at birth was found to predict the risk of severe lower respiratory infections in infants, providing potential for early intervention and drug development. Developmental status of LPS-induced interferon responses may be a key determinant of susceptibility.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Prachi Bagadia, Kevin W. O'Connor, Renee Wu, Stephen T. Ferris, Jeffrey P. Ward, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy
Summary: Bcl6 is required for the development of a subset of cDC1-specific markers in vitro but not in vivo. Its deficiency selectively reduces CD8 alpha expression in cDC1 without affecting XCR1 or CD24 expression.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Priyank Shukla, Preeti Pandey, Bodhayan Prasad, Tony Robinson, Rituraj Purohit, Leon G. D'Cruz, Murtaza M. Tambuwala, Ankur Mutreja, Jim Harkin, Taranjit Singh Rai, Elaine K. Murray, David S. Gibson, Anthony J. Bjourson
Summary: This study utilizes immuno-informatics tools and bioinformatics databases to identify potential immunogenic epitopes of SARS-CoV-2 and validates their binding and interaction with HLA proteins. These findings have significant implications for the development of globally effective SARS-CoV-2 vaccines.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Hematology
Katharina Woess, Sabine Macho-Maschler, Dorette S. van Ingen Schenau, Miriam Butler, Caroline Lassnig, Daniel Valcanover, Andrea Poelzl, Katrin Meissl, Barbara Maurer, Tania Brandstoetter, Claus Vogl, Anna Koren, Stefan Kubicek, Anna Orlova, Richard Moriggl, Birgit Strobl, Veronika Sexl, Frank N. van Leeuwen, Roland P. Kuiper, Mathias Muelle
Summary: TYK2 mutations can cause leukemia, and this study shows that TYK2 inhibitors combined with mTOR or CDK4/6 inhibitors can be a potential treatment for TYK2-driven acute leukemia.
Editorial Material
Oncology
Robert D. Schreiber, Philip D. Greenberg
Summary: Looking back at 2021, the challenges brought by the COVID-19 pandemic highlighted the importance of scientific research and collaboration. Cancer Immunology Research plays a central role in this rapidly growing field. The Journal received a record number of original research articles and achieved a high Impact Factor in 2021. The success of Cancer Immunology Research is attributed to the hard work of many individuals, including editors, reviewers, and researchers. The Journal remains committed to publishing innovative research and advancing cancer immunology and immunotherapy education.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Pei Kee Goh, Florian Wiede, Mara N. Zeissig, Kara L. Britt, Shuwei Liang, Tim Molloy, Nathan Goode, Rachel Xu, Sherene Loi, Mathias Muller, Patrick O. Humbert, Catriona McLean, Tony Tiganis
Summary: The tumor-suppressor gene PTPN2 is often diminished in a specific type of breast cancer. Surprisingly, the absence of PTPN2 in tumors or T cells can actually promote the recruitment and activation of T cells, leading to enhanced anti-tumor immunity. Targeting PTPN2 in tumor cells and T cells has therapeutic potential, as PTPN2 deficiency is associated with T cell infiltration and increased expression of PD-L1 in triple-negative breast cancers (TNBCs). Furthermore, deleting PTPN2 in mouse TNBC models can enhance T cell recruitment and PD-L1 expression, leading to suppressed tumor growth and improved efficacy of anti-PD-1 treatment. Additionally, deleting PTPN2 in both tumors and T cells can further facilitate T cell recruitment and activation, resulting in repression of tumor growth or even elimination of tumors dominated by exhausted T cells. Therefore, targeting PTPN2 in tumors and/or T cells can enhance T cell recruitment and alleviate inhibitory effects on T cells to combat TNBC.
Article
Oncology
Stephen T. Ferris, Ray A. Ohara, Feiya Ou, Renee Wu, Xiao Huang, Sunkyung Kim, Jing Chen, Tian-Tian Liu, Robert D. Schreiber, Theresa L. Murphy, Kenneth M. Murphy
Summary: It has been found that dendritic cells (DC) do not directly activate tumor-specific T cells, but induce anti-tumor immune responses by transferring their antigens to host DCs. Type 1 conventional DCs (cDC1) are more effective than GMDC as cancer vaccines. Vaccination with cDC1 can activate tumor-specific CD8+ T cells and lead to tumor rejection.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ekaterini Platanitis, Stephan Gruener, Aarathy Ravi Sundar Jose Geetha, Laura Boccuni, Alexander Vogt, Maria Novatchkova, Andreas Sommer, Iros Barozzi, Mathias Mueller, Thomas Decker
Summary: This study investigates the role of macrophages in innate immune responses and reveals that interferons trigger significant changes in cellular transcriptomes through JAK-STAT signal transduction and STAT transcription factors. Additionally, it shows that interferons cause rearrangement of chromatin structure and increased DNA accessibility, highlighting the importance of three-dimensional nuclear space and epigenome in transcriptional control by the IFN-induced JAK-STAT pathway.
Article
Biochemical Research Methods
Bodhayan Prasad, Cathy McGeough, Amanda J. Eakin, Tan S. Ahmed, Dawn Small, Philip Gardiner, Adrian Pendleton, Gary Wright, Anthony Bjourson, David Gibson, Priyank Shukla
Summary: This study examines the plasma protein profiles of rheumatoid arthritis (RA) patients and identifies two molecular subgroups. A machine learning-based classifier called ATRPred is developed to predict the response to anti-TNF treatment in RA patients with 81% accuracy. This research helps optimize treatment selection and improve the life quality of non-responsive RA patients.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Biochemical Research Methods
Bodhayan Prasad, Anthony J. Bjourson, Priyank Shukla
Summary: Multimorbidity refers to the concurrent occurrence of multiple chronic conditions. This study developed a pipeline that can stratify patients into different subgroups based on their disease diagnosis and demographic features. The researchers identified five distinct endotypes of multimorbidity using this pipeline and validated their accuracy using machine learning. The study highlights the importance of dementia, stroke, and paralysis as drivers of multimorbidity stratification. The findings suggest that including patient stratification at the primary care setting can improve the observation and treatment of multiple chronic conditions.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Bodhayan Prasad, Anthony J. Bjourson, Priyank Shukla
Summary: We have developed an algorithm called muSignAl that selects multiple signatures with similar predictive performance for multidimensional omic datasets. This algorithm bypasses the need to explore all feature combinations, addressing the limitations of low sample size and high computational cost.
Article
Oncology
Stefan Moritsch, Bernadette Moedl, Irene Scharf, Lukas Janker, Daniela Zwolanek, Gerald Timelthaler, Emilio Casanova, Maria Sibilia, Thomas Mohr, Lukas Kenner, Dietmar Herndler-Brandstetter, Christopher Gerner, Mathias Mueller, Birgit Strobl, Robert Eferl
Summary: This study investigates the role of Janus kinase Tyk2 in solid tumors and suggests its tumor-suppressive functions in immune cells and epithelial cancer cells. It also reveals the different immune editing patterns and regulation of immune checkpoint genes in Tyk2-deficient tumors, highlighting the importance of Tyk2 in colorectal cancer progression and immune surveillance.
Article
Biochemistry & Molecular Biology
Laura Boccuni, Elke Podgorschek, Moritz Schmiedeberg, Ekaterini Platanitis, Peter Traxler, Philipp Fischer, Alessia Schirripa, Philipp Novoszel, Angel R. Nebreda, J. Simon C. Arthur, Nikolaus Fortelny, Matthias Farlik, Veronika Sexl, Christoph Bock, Maria Sibilia, Pavel Kovarik, Mathias Mueller, Thomas Decker
Summary: This study reveals the synergistic effect of cell stress-induced p38 MAPK signaling and IFN-stimulated signal transduction, and the impact of this synergy on ISG expression and macrophage infection ability.
Article
Hematology
Nyamdelger Sukhbaatar, Maria Schoeller, Stephanie Deborah Fritsch, Monika Linke, Stefanie Horer, Manuela Traeger, Mario Mazic, Stephan Forisch, Karine Gonzales, Jan Pascal Kahler, Carina Binder, Caroline Lassnig, Birgit Strobl, Mathias Mueller, Barbara Scheiber-Mojdehkar, Claudia Gundacker, Stefanie Dabsch, Renate Kain, Markus Hengstschlaeger, Steven H. L. Verhelst, Guenter Weiss, Igor Theurl, Thomas Weichhart
Summary: Iron is a crucial cellular metal for various physiological functions. Its absorption from the diet and transport by transferrin is important for iron metabolism. Regulation of iron absorption and transfer remains poorly understood. In this study, macrophage-specific deletion of Tsc2, a negative regulator of mTORC1, in mice led to defects in iron metabolism, including impaired erythropoiesis and reduced Tf saturation. This was due to an iron import block in the duodenal epithelial cells. Activation of mTORC1 in duodenal macrophages promoted Tf degradation, while depletion of macrophages increased Tf levels. Inhibition of mTORC1 or serine protease activity restored Tf levels in the Tsc2-deficient mice. These findings suggest that duodenal macrophages regulate iron transfer by controlling Tf availability.
Article
Multidisciplinary Sciences
Ulrike Schmidt, Betuel Uluca, Iva Vokic, Barizah Malik, Thomas Kolbe, Caroline Lassnig, Martin Holcmann, Veronica Moreno-Viedma, Bernhard Robl, Carina Muehlberger, Dagmar Gotthardt, Maria Sibilia, Thomas Ruelicke, Mathias Mueller, Agnes Csiszar
Summary: FAM3C/ILEI is an important factor in epithelial-to-mesenchymal transition (EMT) induction, tumor progression, and metastasis. In this study, the researchers generated a new Tet-ON inducible Fam3c/ILEI transgenic mouse strain, providing a versatile tool to model the effect of elevated ILEI expression in various tissue entities and disease conditions, including cancer.
Article
Endocrinology & Metabolism
Andrew R. English, Bodhayan Prasad, Declan H. McGuigan, Geraldine Horigan, Maurice O'Kane, Anthony J. Bjourson, Priyank Shukla, Catriona Kelly, Paula L. McClean
Summary: This study compares the effects of simvastatin and atorvastatin on lipid and glycaemic control in men and women with and without T2DM. The research findings suggest that simvastatin provides better lipid and glycaemic control than atorvastatin, with a reduced risk of incident T2DM, in both genders. The results may help guide prescribing practices for better management of T2DM and its complications.
ENDOCRINOLOGY DIABETES & METABOLISM
(2022)
