4.7 Correction

Intra-arterial transplantation of HLA-matched donor mesoangioblasts in Duchenne musculardystrophy (vol 7, pg 1513, 2015)

期刊

EMBO MOLECULAR MEDICINE
卷 8, 期 12, 页码 1470-1471

出版社

WILEY-BLACKWELL
DOI: 10.15252/emmm.201607129

关键词

-

向作者/读者索取更多资源

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Review Clinical Neurology

Early onset hereditary neuronopathies: an update on non-5q motor neuron diseases

Alberto A. Zambon, Veronica Pini, Luca Bosco, Yuri M. Falzone, Pinki Munot, Francesco Muntoni, Stefano C. Previtali

Summary: Hereditary motor neuropathies (HMN) are a group of neuromuscular disorders characterized by lower motor neuron dysfunction, slowly progressive muscle weakness and atrophy, without sensory involvement. Although many causative genes have been identified, a large percentage of HMN patients remain genetically uncharacterized. There is also clinical and genetic overlap with other conditions, such as Charcot-Marie-Tooth type 2 and juvenile ALS. This review summarizes key clinical features and recent findings on novel phenotypes in pediatric forms of HMN, and discusses newly identified causative genes and molecular mechanisms.
Article Clinical Neurology

Frequency, entity and determinants of fatigue in Charcot--Marie--Tooth disease

Marta Bellofatto, Alessandro Bertini, Irene Tramacere, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Marina Grandis, Stefano C. Previtali, Yuri Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Daniela Calabrese, Paola Saveri, Aldo Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Sylvie Piacentini, Chiara Pisciotta, Davide Pareyson

Summary: This study investigated fatigue in CMT patients and found that 36% of the patients experienced abnormal fatigue. Abnormal fatigue was correlated with disease severity, anxiety, depression, sleepiness, and obesity. Therefore, the management of CMT patients should involve treating fatigue and addressing other factors such as anxiety, depression, sleepiness, and obesity.

EUROPEAN JOURNAL OF NEUROLOGY (2023)

Article Biochemistry & Molecular Biology

Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia

Silvia Galbiati, Daniela Gabellini, Alessandro Ambrosi, Nadia Soriani, Federica Pasi, Massimo Locatelli, Roberta Luciano, Massimo Candiani, Luca Valsecchi, Gianpaolo Zerbini, Maddalena Smid

Summary: Preeclampsia is a severe complication of pregnancy, and finding predictive biomarkers is crucial for prevention. This study compared the diagnostic accuracy of carbonic anhydrase IX (CAIX) and sFlt1/PlGF ratio as biomarkers for predicting preeclampsia. CAIX levels significantly increased before the onset of preeclampsia, and it performed better than sFlt1/PlGF ratio in predicting the disease. CAIX could be an effective predictive biomarker for preeclampsia, but further studies are needed to confirm this finding.

FRONTIERS IN MOLECULAR BIOSCIENCES (2023)

Letter Cardiac & Cardiovascular Systems

Buffalo Chest: An Overlooked Risk Factor for Thoracic Interventional Procedures?

Saad Salman, Ludovica Lofino, Sara Mastinu, Angela Ammirabile, Marco Francone, Letterio Salvatore Politi, Ezio Lanza

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY (2023)

Article Oncology

Temporal correlation between the first melanoma and the first noncutaneous tumor in CKDN2A genotyped patients

Laura Cristina Gironi, Elia Esposto, Francesca Zottarelli, Roberto Giorgione, Pamela Farinelli, Elisa Zavattaro, Edoardo Cammarata, Nunzia Di Cristo, Paola Ogliara, Lara Camillo, Mara Giordano, Simona Mellone, Barbara Pasini, Alessandro Ambrosi, Paola Savoia

Summary: We investigated the correlation between the occurrence of cutaneous melanoma and noncutaneous tumors in CDKN2A mutation carriers and wild-type melanoma patients. The study found that mutation carriers had a significantly higher number of cutaneous melanoma cases compared to the wild-type patients. Additionally, both groups had a similar rate of diagnosis for malignant NCTs. The onset of cutaneous melanoma generally preceded the occurrence of NCTs, emphasizing the importance of comprehensive surveillance for melanoma patients.

MELANOMA RESEARCH (2023)

Article Clinical Neurology

Clinical Impact and Predictors of Aneurysmal Rebleeding in Poor-Grade Subarachnoid Hemorrhage: Results From the National POGASH Registry

Pietro Panni, Lucia Riccio, Roberta Cao, Alessandro Pedicelli, Enrico Marchese, Anselmo Caricato, Alberto Feletti, Mattia Testa, Paolo Zanatta, Nicola Gitti, Simone Piva, Dikran Mardighian, Vittorio Semeraro, Giordano Nardin, Emilio Lozupone, Giafranco Paiano, Edoardo Picetti, Vito Montanaro, Massimo Petranca, Carlo Bortolotti, Antonino Scibilia, Luigi Cirillo, Andrea Luigi Lanterna, Alessandro Ambrosi, Pietro Mortini, Luigi Beretta, Andrea Falini

Summary: This study aimed to investigate predictors and clinical impact of rebleeding in poor-grade aneurysmal subarachnoid hemorrhage (aSAH). The study found that ultra-early vasospasm (UEV) and presence of dissecting aneurysm were the strongest predictors of aneurysmal rebleeding, while a history of hypertension reduced the chances of rebleeding. Additionally, rebleeding emerged as an independent predictor of intrahospital mortality.

NEUROSURGERY (2023)

Article Medicine, General & Internal

Endometriosis-Related Ovarian Cancers: Evidence for a Dichotomy in the Histogenesis of the Two Associated Histotypes

Alice Bergamini, Giorgia Mangili, Alessandro Ambrosi, Gianluca Taccagni, Emanuela Rabaiotti, Luca Bocciolone, Giorgio Candotti, Raffaella Cioffi, Francesca Pella, Giulia Sabetta, Costanza Saponaro, Massimo Candiani

Summary: The study compares data from patients with endometrioid and clear cell ovarian tumors associated with endometriosis to investigate the hypothesis of a dichotomy in their histogenesis. It found that the occurrence of endometriosis is more frequent in patients with clear cell ovarian cancer. The EAOEC group showed higher bilateral occurrences and a higher solid/cystic rate at gross pathology. ECC patients had a more advanced disease stage and a synchronous endometrial carcinoma was found in 38% of EAEOC patients.

DIAGNOSTICS (2023)

Article Medicine, General & Internal

Gestational Diabetes-Placental Expression of Human Equilibrative Nucleoside Transporter 1 (hENT1): Is Delayed Villous Maturation an Adaptive Pattern?

Cinzia Giacometti, Kathrin Ludwig, Monica Guidi, Elvira Colantuono, Anna Coracina, Marcello Rigano, Mauro Cassaro, Alessandro Ambrosi

Summary: Gestational diabetes mellitus (GDM) can affect placental villous maturation and vascularity. The expression of hENT1 and the formation of vasculo-syncytial membranes (VSM) are reduced in GDM placentas, while the proliferative pattern of trophoblasts is increased.

DIAGNOSTICS (2023)

Article Multidisciplinary Sciences

Going for a stroll on lurasidone: Considerations on an atypical case of acute compartment syndrome of both legs

L. Bosco, T. Russo, Y. M. Falzone, C. Butera, A. Del Prete, R. Mellone, U. Del Carro, M. Filippi, S. C. Previtali

Summary: Non-traumatic acute bilateral compartment syndrome is a rare condition that may lead to limb ischemia. We presented a case of a young woman who developed this syndrome after a five-kilometer walk while receiving chronic treatment with lurasidone. The syndrome resulted in bilateral foot drop and rhabdomyolysis. A conservative approach was taken due to the patient's late presentation, and there was subsequent clinical and biochemical improvement over time.

HELIYON (2023)

Article Clinical Neurology

Use, tolerability, benefits and side effects of orthotic devices in Charcot-Marie-Tooth disease

Alessandro Bertini, Fiore Manganelli, Gian Maria Fabrizi, Angelo Schenone, Lucio Santoro, Tiziana Cavallaro, Matteo Tagliapietra, Marina Grandis, Stefano Carlo Previtali, Yuri Matteo Falzone, Isabella Allegri, Luca Padua, Costanza Pazzaglia, Irene Tramacere, Eleonora Cavalca, Paola Saveri, Andrea Quattrone, Paola Valentino, Stefano Tozza, Luca Gentile, Massimo Russo, Anna Mazzeo, Giuseppe Vita, Valeria Prada, Riccardo Zuccarino, Francesco Ferraro, Chiara Pisciotta, Davide Pareyson, Italian CMT Network

Summary: This study investigated the use, benefits, and tolerance of shoe inserts, orthopaedic shoes, and ankle-foot orthoses (AFOs) in Charcot-Marie-Tooth disease (CMT) patients. The results showed that although most patients were prescribed these devices, there was a low usage rate and high rates of complications and emotional distress, leading to reduced use of AFOs. Thus, a patient-oriented and multidisciplinary approach to orthoses prescription should be encouraged.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2023)

Article Neurosciences

Uncovering CNS access of lipidated exendin-4 analogues by quantitative whole-brain 3D light sheet imaging

Grethe Skovbjerg, Urmas Roostalu, Casper G. Salinas, Jacob L. Skytte, Johanna Perens, Christoffer Clemmensen, Lisbeth Elster, Camilla K. Frich, Henrik H. Hansen, Jacob Hecksher-Sorensen

Summary: Peptide-based drug development for CNS disorders is hindered by poor BBB penetrability. This study used LSFM to visualize the distribution of lipidated peptide drugs in the CNS. The results demonstrated that lipidation enhances the CNS accessibility of the peptide drug Ex4.

NEUROPHARMACOLOGY (2023)

Article Clinical Neurology

Hemodynamic nature of black-blood enhancement in long-term coiled cerebral aneurysms

Claudia Godi, Francesco Destro, Paolo Garofalo, Enrico Tombetti, Alessandro Ambrosi, Antonella Iadanza, Caterina Michelozzi, Andrea Falini, Nicoletta Anzalone

Summary: Vessel wall imaging (VWI) with black-blood (BB) technique can reveal aneurysmal enhancement prior to growth/rupture in treatment-naive cerebral aneurysms. Recent studies suggest that BB enhancement may also occur in endovascularly treated aneurysms, but its significance is debatable. This study explores the relationship between BB enhancement and incomplete occlusion status and coil packing density, hypothesizing a flow-related mechanism.

NEURORADIOLOGY (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

CT-based radiomics can identify physiological modifications of bone structure related to subjects' age and sex

Riccardo Levi, Federico Garoli, Massimiliano Battaglia, Dario A. A. Rizzo, Maximilliano Mollura, Giovanni Savini, Marco Riva, Massimo Tomei, Alessandro Ortolina, Maurizio Fornari, Saurabh Rohatgi, Giovanni Angelotti, Victor Savevski, Gherardo Mazziotti, Riccardo Barbieri, Marco Grimaldi, Letterio S. Politi

Summary: This study aimed to evaluate the accuracy of machine learning in identifying physiological changes related to subjects' sex and age through analysis of radiomics features from lumbar vertebral CT images, and to determine its generalizability across different scanners. Spherical volumes-of-interest (VOIs) were annotated in the center of the vertebral body for each lumbar vertebra in 233 subjects who had undergone lumbar CT on 3 different scanners, and radiomics features from each VOI were evaluated. Machine learning models were used to identify subjects' sex and age, and a voting model was computed to combine predictions.

RADIOLOGIA MEDICA (2023)

Article Multidisciplinary Sciences

Nerve pathology is prevented by linker proteins in mouse models for LAMA2-related muscular dystrophy

Judith R. Reinhard, Emanuela Porrello, Shuo Lin, Pawel Pelczar, Stefano C. Previtali, Markus A. Ruegg

Summary: LAMA2-related muscular dystrophy is a severe congenital muscular dystrophy caused by mutations in the LAMA2 gene. Expressing mini-agrin and alpha LNNd proteins in mice can improve the condition and prevent hind limb paralysis, which are the most affected areas in LAMA2 MD. This research is crucial for developing gene therapy for LAMA2 MD patients.

PNAS NEXUS (2023)

Article Radiology, Nuclear Medicine & Medical Imaging

Promoting the use of the PI-QUAL score for prostate MRI quality: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship

Francesco Giganti, Alexander P. Cole, Fiona M. Fennessy, Timothy Clinton, Pedro Lopes Da Frota Moreira, Mariana Costa Bernardes, Carl-Fredrik Westin, Deepa Krishnaswamy, Andriy Fedorov, Daniel A. Wollin, Bjoern Langbein, Nicola Frego, Muhieddine Labban, Joy S. Badaoui, Steven L. Chang, Logan G. Briggs, Junichi Tokuda, Alessandro Ambrosi, Alex Kirkham, Mark Emberton, Veeru Kasivisvanathan, Caroline M. Moore, Clare Allen, Clare M. Tempany

Summary: This study assessed the impact of a prostate MRI quality training lecture on the participants' ability to apply the PI-QUAL scoring system. The results showed that the teaching course significantly improved the participants' ability to evaluate the quality of prostate MRI examinations using the PI-QUAL score.

EUROPEAN RADIOLOGY (2023)

暂无数据