期刊
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
卷 106, 期 5, 页码 740-746出版社
SPRINGER
DOI: 10.1007/s00128-021-03166-y
关键词
Benzophenone-3; Zebrafish (Danio rerio); Sex ratio; Parental exposure; F1 embryos
资金
- Major Scientific Research Project of Guangdong Provincial Education Department [2019GDZXM009]
The study found that exposure to environmental residual concentrations of BP-3 can affect the sex ratio and offspring developmental toxicity of zebrafish. Additionally, chronic low-concentration exposure resulted in stronger toxicity for both F0 and F1 generations.
Benzophenone-3 (BP-3) is an important ultraviolet (UV)-screening agent using in cosmetics, however, the associated environmental pollution and the toxicity to organisms, particularly aquatic organisms, cannot be neglected. In this study, the potential risks posed to zebrafish when exposed to environmental residual concentrations of BP-3 were evaluated. Zebrafish embryos (F0) were exposed to 0, 0.056, 2.3, and 38 mu g/L BP-3 until 42 days' post-fertilization (dpf). The effects of BP-3 on the sex ratio and gene expression of F0 zebrafish were investigated. In the F1 embryos, cumulative hatching rate, body length, and heartbeats were observed. The result showed that F0 and F1 exposure to concentrations of 0.056 and 38 mu g/L BP-3 elicited stronger toxicity at 96 hpf than single generation exposures. Overall, our results provide a new understanding on the effects of low BP-3 concentration chronic exposure on sex ratio and offspring developmental toxicity of the F0 zebrafish.
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