Review
Immunology
Amina I. Makandar, Mannat Jain, Eiji Yuba, Gautam Sethi, Rajesh Kumar Gupta
Summary: In light of the limitations of traditional cancer therapies, the development of alternative strategies is crucial. This article explores the potential of glyco-nanovaccines (GNVs) for anti-tumor immunotherapy by targeting dendritic cells (DCs). The study discusses the efficacy of GNVs in stimulating a strong cytotoxic T lymphocyte (CTL) response and addresses the challenges posed by tumor glycosylation and lectin receptor expression on cancer cells.
Article
Immunology
Nataschja I. Ho, Marcel G. Camps, Juan J. Garcia-Vallejo, Erik Bos, Abraham J. Koster, Martijn Verdoes, Yvette van Kooyk, Ferry Ossendorp
Summary: Dendritic cells have the unique ability to present exogenous antigens through MHC class I molecules, with the antigen being conserved in storage compartments for days. These compartments in DCs lack certain molecules involved in MHC class I processing, and the co-localization of active cathepsin X with protein antigen suggests a novel role for cathepsin X in antigen processing and cross-presentation. These compartments can preserve protein antigens from different uptake routes and contribute to long-lasting antigen cross-presentation.
Review
Immunology
Michal Scur, Brendon D. Parsons, Sayanti Dey, Andrew P. Makrigiannis
Summary: Our understanding of CTLRs has expanded beyond their initial roles in pathogen recognition, now encompassing scavenger receptor activity, cell death and cell transformation sensing, and immune response regulation. The diversity in expression and signaling activity among individual CTLR members, as well as the discovery of new receptor binding capabilities and interactions, cellular expression profiles, and receptor structures and signaling mechanisms, has revealed the defining roles of CTLRs in immunity. NK cell receptors, specifically the NKRP1 family of CTLRs, exemplify this functional diversity, displaying essential immune functions beyond NK cells. It is crucial to better understand the functional potential of these receptor families in immune defense and pathology, given the ever-expanding evidence for their involvement in various biological processes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kathleen Schoen, Dimitri L. Lindenwald, Joao T. Monteiro, Julien Glanz, Klaus Jung, Stefanie C. Becker, Bernd Lepenies
Summary: RVFV, a mosquito-borne virus, enters host cells by interacting with CLRs of different species. This study identified novel RVFV candidate receptors in mice, sheep, and Aedes aegypti, through cross-species experiments. It also revealed the differences and similarities in RVFV binding preferences between mammalian CLR homologues and more distant vector/host CLRs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ronit Vogt Sionov, Chrystelle Lamagna, Zvi Granot
Summary: This study identifies the mechanism of interaction between neutrophils and tumor cells, showing that the interaction between Cathepsin G on neutrophil surface and tumor RAGE, as well as the involvement of C-type lectin receptors, contribute to neutrophil-mediated cytotoxicity towards tumor cells.
Article
Fisheries
Zhiqiang Zhang, Xinchao Liu, Qi Li, Miao Xie, Yongxiong Huang, Baijian Jiang, Xing Li, Yu Huang, Jichang Jian
Summary: This study identified a hepatic lectin molecule from Nile tilapia and uncovered its functions in the tilapia immune response to bacteria. The hepatic lectin plays a crucial role in recognizing and agglutinating pathogens, and it is primarily expressed in nonspecific cytotoxic cells and monocytes/macrophages. Blocking hepatic lectin significantly affects the antibacterial immune responses in tilapia.
Article
Immunology
Angela Holder, Jeannine Kolakowski, Chloe Rosentreter, Ellen Knuepfer, Sabine A. F. Jegouzo, Oliver Rosenwasser, Heather Harris, Lotta Baumgaertel, Amanda Gibson, Dirk Werling
Summary: Innate immune receptors form complexes with secondary receptors to activate multiple signaling pathways, regulating homeostasis and immunity. A bovine homologue of Mincle (boMincle) has been characterized to be structurally and functionally similar to the human orthologue (huMincle), although there are some differences. BoMincle is predominantly expressed by myeloid cells, but mRNA transcripts were also detected in granulocytes, B cells, and T cells. BoMincle has the potential to recognize endogenous ligands, suggesting its role in homeostasis in cattle.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Lillian F. Zhang, Bernd Lepenies, Sayuri Nakamae, Briana M. Young, Renato L. Santos, Manuela Raffatellu, Brian A. Cobb, Hirotaka Hiyoshi, Andreas J. Baeumler
Summary: Salmonella enterica subspecies enterica serovar Typhi is the causative agent of typhoid fever, and the recent emergence of antibiotic-resistant S. Typhi strains highlights the importance of vaccination. The study identified the human C-type lectin receptor DC-SIGN as the receptor for the Vi capsular polysaccharide, which contributes to the pathogenesis of typhoid fever.
Review
Biotechnology & Applied Microbiology
Jan Dohnalek, Tereza Skalova
Summary: The C-type lectin-like fold (CTL fold) is a versatile structural motif found in many proteins, and its interactions play significant roles in various biological processes. Understanding the rules governing these interactions can aid in the development of new protein binders for biomedical and biotechnological applications.
BIOTECHNOLOGY ADVANCES
(2022)
Article
Multidisciplinary Sciences
Marion Drouin, Javier Saenz, Vanessa Gauttier, Berangere Evrard, Geraldine Teppaz, Sabrina Pengam, Caroline Mary, Ariane Desselle, Virginie Thepenier, Emmanuelle Wilhelm, Emmanuel Merieau, Camille Ligeron, Isabelle Girault, Maria-Dolores Lopez, Cynthia Fourgeux, Debajyoti Sinha, Irene Baccelli, Aurelie Moreau, Cedric Louvet, Regis Josien, Jeremie Poschmann, Nicolas Poirier, Elise Chiffoleau
Summary: The study reveals that CLEC-1 acts as an immune checkpoint in myeloid cells, with its blockade enhancing antitumor immunity and showing potential as a novel target for cancer immunotherapy.
Article
Engineering, Biomedical
Aaron T. Hendricksen, Shahrzad Ezzatpour, Anunay J. Pulukuri, Austin T. Ryan, Tatum J. Flanagan, William Frantz, David W. Buchholz, Victoria Ortega, Isaac A. Monreal, Julie M. Sahler, Amy E. Nielsen, Hector C. Aguilar, Rock J. Mancini
Summary: This work presents a synthetic vaccine adjuvant that can adjust its potency in response to temperature changes. The adjuvant enhances vaccine efficacy but can also cause inflammatory side effects like fever, limiting its use. To address this issue, a temperature-sensitive adjuvant is designed to decrease its potency at fever temperatures. The adjuvant exhibits thermophobic behavior and improves the effectiveness of an influenza vaccine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Hematology
Silvia Maria Grazia Trivigno, Mauro Vismara, Ilaria Canobbio, Serena Rustichelli, Federico Galvagni, Maurizio Orlandini, Mauro Torti, Gianni Francesco Guidetti
Summary: The study found that CD93 supports platelet activation triggered by PAR4 stimulation and is required to stabilize the expression of the thrombin receptor on the cell surface.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Biotechnology & Applied Microbiology
Tomoyuki Shimazu, Mai Suzuki, Ryo Takasaki, Asuka Besshi, Yuna Suzuki, Yoichiro Iwakura
Summary: This study investigated the relationship between lactic acid bacteria (LAB) and innate immune receptors. The researchers found that C-type lectin receptors (CLRs) are involved in the immune-stimulating function of LAB. The interaction between LAB and CLRs can reduce the levels of certain cytokines and is only observed in heat-killed LAB. These findings contribute to a better understanding of the immunomodulatory effects of LAB.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Multidisciplinary Sciences
Courtney Christoforo, Beth Fleming, Matthew Zeitler, Haley Haws, Andrew M. Smith
Summary: The study investigates the role of metals in slug glue formation, specifically identifying metal-binding proteins present in the defensive glue produced by slugs. Surprisingly, the results suggest that metal coordination is not involved in the primary cross-links of the hydrogel glue, with stable cross-links likely formed through a catalytic event involving protein oxidation. Additionally, efforts to prevent cross-linking were unexpectedly difficult, indicating that primary cross-links may form before secretion.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Review
Biochemistry & Molecular Biology
Maxine A. Hoft, Lucian Duvenage, J. Claire Hoving
Summary: This article summarizes the major endemic dimorphic fungal pathogens associated with epidemics, describes their route of infection and clinical presentation, and focuses on the host's pattern recognition receptors and innate immune response to these pathogens.
Article
Cell Biology
Oliver Schulz, Pavel Hanc, Jan P. Bottcher, Robbert Hoogeboom, Sandra S. Diebold, Pavel Tolar, Caetano Reis e Sousa
Review
Biochemistry & Molecular Biology
Pierre V. Maillard, Annemarthe G. van der Veen, Enzo Z. Poirier, Caetano Reis e Sousa
Article
Biochemistry & Molecular Biology
Oliver Gordon, Caetano Reis e Sousa
Article
Oncology
Stephen M. Shaw, Jenny Middleton, Kim Wigglesworth, Amber Charlemagne, Oliver Schulz, Melanie S. Glossop, Giles F. Whalen, Robert Old, Mike Westby, Chris Pickford, Rinat Tabakman, Irit Carmi-Levy, Abi Vainstein, Ella Sorani, Arik A. Zur, Sascha A. Kristian
CANCER CELL INTERNATIONAL
(2019)
Article
Multidisciplinary Sciences
Enzo Z. Poirier, Michael D. Buck, Probir Chakravarty, Joana Carvalho, Bruno Frederico, Ana Cardoso, Lyn Healy, Rachel Ulferts, Rupert Beale, Caetano Reis e Sousa
Summary: The discovery of a Dicer isoform called antiviral Dicer provides protection for tissue stem cells against RNA viruses, shedding light on the molecular regulation of antiviral RNAi in mammalian innate immunity. Different cell-intrinsic antiviral pathways can be tailored to the differentiation status of cells.
Article
Biochemistry & Molecular Biology
Jorn E. Stok, Timo Oosenbrug, Laurens R. ter Haar, Dennis Gravekamp, Christian P. Bromley, Santiago Zelenay, Caetano Reis e Sousa, Annemarthe G. van der Veen
Summary: This study reveals the crucial role of LGP2 in inducing a type I interferon response in ADAR1-deficient cells. In addition, the sensitivity of tumor cells to ADAR1 loss is dependent on LGP2 expression.
Review
Biochemistry & Molecular Biology
Eleanor Childs, Conor M. Henry, Johnathan Canton, Caetano Reis e Sousa
Summary: Cells have mechanisms to protect the integrity of endocytic organelle membranes and to repair damaged membranes when necessary. In some cases, cells may deliberately induce damage to these organelles. Understanding these mechanisms could lead to improvements in vaccination and intracellular drug delivery.
Article
Oncology
Kok Haw Jonathan Lim, Evangelos Giampazolias, Oliver Schulz, Neil C. Rogers, Anna Wilkins, Erik Sahai, Jessica Strid, Caetano Reis E. Sousa
Summary: Loss of sGSN enhances the responsiveness of cDC1 and DNGR-1 to chemotherapy, targeted therapy, and radiotherapy, leading to improved tumor control.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Pavel Hanc, Rodrigo J. Gonzalez, Irina B. Mazo, Yidi Wang, Talley Lambert, Gloria Ortiz, Evan W. Miller, Ulrich H. von Andrian
Review
Immunology
Conor M. Henry, Carlos A. Castellanos, Caetano Reis E. Sousa
Summary: In this review, the role of dendritic cell natural killer group receptor-1 (DNGR-1) in cDC1 and its functions in anti-viral and anti-tumor immunity are discussed. The study found that DNGR-1 can promote inducible rupture of phagocytic or endocytic compartments containing dead cell debris, making dead cell-associated antigens accessible to cDC1. Additionally, DNGR-1 can recognize dead cells and participate in immune response. Therefore, the study of DNGR-1 has opened new perspectives into cross-presentation, which may have applications in immunotherapy of cancer and vaccination against viral diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Review
Immunology
Pavel Hanc, Marie-Angele Messou, Yidi Wang, Ulrich H. von Andrian
Summary: The immune system and the somatosensory branch of the peripheral nervous system work together to form an integrated defense system. Nociceptors, sensory neurons that detect noxious stimuli, have immunomodulatory capabilities and can play different roles based on the context and their communication partners.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Mar Cabeza-Cabrerizo, Janneke van Blijswijk, Stephan Wienert, Daniel Heim, Robert P. Jenkins, Probir Chakravarty, Neil Rogers, Bruno Frederico, Sophie Acton, Evelyne Beerling, Jacco van Rheenen, Hans Clevers, Barbara U. Schraml, Marc Bajenoff, Michael Gerner, Ronald N. Germain, Erik Sahai, Frederick Klauschen, Caetano Reis e Sousa
SCIENCE IMMUNOLOGY
(2019)
Review
Oncology
Jan P. Boettcher, Caetano Reis e Sousa
Article
Immunology
Fabio F. Rosa, Cristiana F. Pires, Ilia Kurochkin, Alexandra G. Ferreira, Andreia M. Gomes, Luis G. Palma, Kritika Shaiv, Laura Solanas, Claudia Azenha, Dmitri Papatsenko, Oliver Schulz, Caetano Reis E. Sousa, Carlos-Filipe Pereira
SCIENCE IMMUNOLOGY
(2018)