Article
Immunology
Zezhen Liu, Jiehui Zhong, Jie Zeng, Xiaolu Duan, Jianming Lu, Xinyuan Sun, Qinwei Liu, Yingke Liang, Zhuoyuan Lin, Weide Zhong, Wenzheng Wu, Chao Cai, Guohua Zeng
Summary: This study identified three distinct m6A regulation patterns in PCa, each with specific characteristics related to patient prognosis and tumor immune microenvironment. Among these patterns, patients in the low-m6Ascore group were more likely to benefit from ICIs therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaojun Zhang, Yilan Huang, Qian Li, Yiqing Zhong, Yuanzhou Zhang, Jingying Hu, Rui Liu, Xiaoying Luo
Summary: The developed Senescence Risk Score (SRRS) in this study provides a powerful prognostic tool for colorectal cancer (CRC) and paves the way for novel therapeutic strategies, underscoring its potential in transforming CRC patient management.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Shifeng Yang, Boshi Sun, Wenjing Li, Hao Yang, Nana Li, Xinyu Zhang
Summary: This study identified genes related to fatty acid metabolism in gastric cancer and developed a machine learning model to predict prognosis. It also found that certain anticancer drugs showed significant sensitivity in high-risk patients and identified a new target for immunotherapy in gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Songjiang He, Shi Zhang, Yi Yao, Bin Xu, Zhili Niu, Fuben Liao, Jie Wu, Qibin Song, Minglun Li, Zheming Liu
Summary: Glutamine metabolism is significant in the clinical outcomes of patients with pan-cancer and is closely associated with several hallmarks of a malignant tumor.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Zhen-Dong Huang, Lu-Lu Lin, Zi-Zhen Liu, Chao Hu, Hui-Yun Gu, Ren-Xiong Wei
Summary: The study revealed different m6A modification patterns in soft tissue sarcoma (STS) patients, impacting prognosis, immune cell infiltration, metabolic pathways, etc. Patients with lower m6Ascores were found to have increased antitumor immune responses and sensitivity to immunotherapy and chemotherapy, highlighting the potential of evaluating m6A modification patterns for guiding more effective treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Lili Lin, Wenda Zhang, Yongjian Chen, Wei Ren, Jianli Zhao, Wenhao Ouyang, Zifan He, Weifeng Su, Herui Yao, Yunfang Yu
Summary: By analyzing the transcriptome data of 6251 patients using a machine learning algorithm, we found that immune gene clusters can predict the efficacy of immunotherapy. The combination of immune gene score, tumor mutation burden, and long non-coding RNA score can better predict the efficacy of immunotherapy. It is recommended to evaluate the characteristics of the tumor immune microenvironment related to immunotherapy efficacy through multi-omics analysis.
Article
Immunology
Zhen-Dong Huang, Yong-Cheng Fu, Shu-Yan Liu, Ya-Juan Mao, Yan Zhang, Chao Hu, Ren-Xiong Wei
Summary: This study revealed the crucial role of m6A-regulated tumor metabolism processes in prognosis, tumor progression, and immune microenvironment of soft tissue sarcoma (STS). Two distinct m6A metabolic subtypes were identified among STS patients, which showed differences in survival, immunity, genomic, and stemness characteristics. The m6A-metabolic Scores accurately predicted the molecular subtype of STS, prognosis, immune cell infiltration, tumor metastasis status, and sensitivity to chemotherapeutics and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Meng-Ling Ye, Si-Qi Li, Yi-Xin Yin, Ke-Zhi Li, Ji-Lin Li, Bang-Li Hu
Summary: Cancer stem cells play crucial roles in colorectal cancer tumorigenesis and treatment response. This study found that the mRNA stemness index (mRNAsi) was associated with the clinical outcome in colorectal cancer (CRC) patients. A stemness-related classification based on mRNAsi scores and RNA sequence data was introduced and showed promise as a prognostic predictor for CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Jingwei Zhang, Zeyu Wang, Xun Zhang, Ziyu Dai, Wen Zhi-Peng, Jing Yu, Yun Peng, Wantao Wu, Nan Zhang, Peng Luo, Jian Zhang, Zaoqu Liu, Songshan Feng, Hao Zhang, Quan Cheng
Summary: CD147 plays an important role in promoting tumor proliferation and inhibiting cancer cell apoptosis in the tumor microenvironment. The study reveals the prognostic value and immune characteristics of CD147 in multiple cancer types. In addition, the study explores the expression of CD147 on different cell types in the tumor microenvironment and identifies potential therapeutic strategies for tumor immunotherapy based on CD147.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Wei Chong, Liang Shang, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Zhe Wang, Yang Chen, Shengtao Jia, Liming Chen, Leping Li, Hao Chen
Summary: Recent studies have shown that m(6)A modification is significantly associated with TME diversity, and different m(6)A modification patterns in colon cancer are correlated with distinct clinical outcomes and biological pathways.
Article
Oncology
Jian Hu, Dongxu Qiu, Anze Yu, Jiao Hu, Hao Deng, Huihuang Li, Zhenglin Yi, Jinbo Chen, Xiongbing Zu
Summary: YTHDF1 is implicated in human cancers with potential as a prognostic and immunological biomarker across cancer types. It plays a crucial role in the tumor microenvironment, immune regulation, and has associations with prognosis, immune checkpoints, and tumor mutational burden. YTHDF1 may serve as a novel target for tumor immunotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Renwang Liu, Guangsheng Zhu, Mingbiao Li, Peijun Cao, Xuanguang Li, Xiuwen Zhang, Hua Huang, Zuoqing Song, Jun Chen
Summary: In this study, the researchers collected and analyzed the expression data of RAD51AP1 in various cancer types. They found that RAD51AP1 was over-expressed in multiple cancer types and correlated with poor prognosis in certain cancers. They also demonstrated that RAD51AP1 promoted cancer cell proliferation and had broad associations with tumor stemness and the tumor immune microenvironment. These findings suggest that RAD51AP1 plays a significant role in carcinogenesis.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Kun Zhao, Bing Wei, Yingxuan Zhang, Wenkai Shi, Guokun Zhang, Zhengfeng Wang
Summary: This study found that a classification model based on the m6A manner could predict HCC prognosis and response to immunotherapy for HCC patients, contributing to clinical individualized decision-making.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Kaili Liao, Jialing Hu, Yu Huang, Siji Yu, Qijun Yang, Fan Sun, Chengfeng Wu, Yunqi Cheng, Wenyige Zhang, Xue Zhang, Hongyu Li, Xiaozhong Wang
Summary: This study found that m6A modification plays a crucial role in the immune regulation and formation of tumor microenvironment in rectal cancer. Different m6A modification patterns are associated with clinical outcomes and biological pathways. Higher m6Ascore combined with tumor mutation burden is associated with better prognosis and enhanced immune infiltration. Patients with higher m6Ascore show higher PD-L1 expression levels, better immune response, and lasting clinical benefits.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Aibin Liu, Lin Shen, Na Li, Liangfang Shen, Zhanzhan Li
Summary: Through comprehensive analysis, it was found that pyroptosis is aberrantly expressed in different types of cancer, attributed to CAN frequency and differences in DNA methylation levels. A pyroptosis level model was established, revealing a dual role of pyroptosis in cancers, with different levels across multiple cancers significantly associated with clinical prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Hang Ji, Hongtao Zhao, Jiaqi Jin, Zhihui Liu, Xin Gao, Fang Wang, Jiawei Dong, Xiuwei Yan, Jiheng Zhang, Nan Wang, Jianyang Du, Shaoshan Hu
Summary: This study aimed to develop an immune-related gene (IRG) signature for predicting and improving the prognosis and treatment paradigm of glioblastoma (GBM). The IRG-based risk model showed superior prognostic performance and revealed the features of the immune microenvironment in the high-risk group, providing valuable information for clinical management.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Jiheng Zhang, Nan Wang, Jiasheng Wu, Xin Gao, Hongtao Zhao, Zhihui Liu, Xiuwei Yan, Jiawei Dong, Fang Wang, Yixu Ba, Shuai Ma, Jiaqi Jin, Jianyang Du, Hang Ji, Shaoshan Hu
Summary: This study revealed the mechanisms by which long non-coding RNAs regulate m5C modification, explored the impact of m5C on the biological properties of lower-grade gliomas (LGG), and established an effective prognostic m5C-related lncRNA signature.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Bo Li, Fang Wang, Nan Wang, Kuiyuan Hou, Jianyang Du
Summary: Angiogenesis in immunosuppressed low-grade gliomas is driven by m6A modification regulators and plays a role in mediating immunosuppression. This study investigated the relevance and mechanism of angiogenesis-related genes and m6A regulators, providing insights for the diagnosis and treatment of low-grade gliomas.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Shuai Ma, Fang Wang, Nan Wang, Jiaqi Jin, Yixu Ba, Hang Ji, Jianyang Du, Shaoshan Hu
Summary: This study explored the immune-related distinction in the genetic or epigenetic features of glioblastoma multiforme (GBM) and identified 28 immune-related hub genes. Three genes were used to construct an immune-related prognostic model for GBM. Survival analysis showed that patients in the low-risk group had better overall survival than those in the high-risk group. The two groups had differences in immune, mutation, and methylation characteristics.
FRONTIERS IN NEUROLOGY
(2022)
Article
Genetics & Heredity
Xiuwei Yan, Hang Ji, Zhihui Liu, Shuai Ma, Jiawei Dong, Xiaoyan Jiang, Xueyan Hu, Fang Wang, Hongtao Zhao, Jiaqi Jin, Jiheng Zhang, Nan Wang, Jianyang Du, Shaoshan Hu
Summary: This study identified three ferroptosis subtypes in LGG patients and developed a prognostic model based on nine FRGs that showed great predictive ability and potential for predicting sensitivity to chemotherapy and immunotherapy. The study also revealed a strong connection between the prognostic model and autophagy and hypoxia, highlighting the importance of ferroptosis in the diagnosis, treatment, prognosis, and recurrence of LGG.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Shuai Ma, Fang Wang, Jiawei Dong, Nan Wang, Shengzhong Tao, Jianyang Du, Shaoshan Hu
Summary: This study demonstrates that the combination of photodynamics therapy (PDT) and Aciflavine (ACF) can decrease the expression of HIF1α and regulate the downstream signaling pathways, thereby enhancing the efficacy of PDT in treating recalcitrant glioblastoma (GBM).
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nan Wang, Xin Gao, Hang Ji, Shuai Ma, Jiasheng Wu, Jiawei Dong, Fang Wang, Hongtao Zhao, Zhihui Liu, Xiuwei Yan, Bo Li, Jianyang Du, Jiheng Zhang, Shaoshan Hu
Summary: This study comprehensively analyzed and screened EMT-related lncRNAs to characterize lower-grade glioma tumor biology and provide new ideas for current therapeutic approaches.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Jiawei Dong, Fang Wang, Xin Gao, Hongtao Zhao, Jiheng Zhang, Nan Wang, Zhihui Liu, Xiuwei Yan, Jiaqi Jin, Yixu Ba, Shuai Ma, Jianyang Du, Hang Ji, Shaoshan Hu
Summary: This study reveals the characteristics of cancer-associated fibroblasts (CAFs) in lower-grade gliomas (LGGs) and establishes a prognostic gene signature that can guide tailored anti-CAFs therapy in combination with immunotherapy. The findings have clinical implications for the treatment of LGGs patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhihui Liu, Jiasheng Wu, Hang Ji, Hongtao Zhao, Fang Wang, Jiawei Dong, Jiheng Zhang, Nan Wang, Xiuwei Yan, Kaikai Wang, Shaoshan Hu
Summary: The expression of CCN4 is associated with poor prognosis in LGG. The CCNScore has potential implications in prognosis prediction, subtype assessment, and therapy selection. The high-CCNScore group is similar to glioblastoma, while the low-CCNScore group consists mainly of IDH-mutation LGG.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Medicine, Research & Experimental
Yan Xu, Chengzu Zheng, Muhammad Sameer Ashaq, Qian Zhou, Yuan Li, Chunhua Lu, Baobing Zhao
Summary: This comprehensive review summarizes the roles of E3 ubiquitin ligases in B-cell development and related malignances, providing important insights into the molecular mechanism of normal B-cell development and potential therapeutic targets.
Article
Plant Sciences
Jun Cai, Wenyuan Shen, Guixian Zhang, Xia Li, Hongsheng Shen, Wenchang Li, Cheng Tan, Ting Zhang, Mengrou Shi, Zibo Yang, Yuan Li, Hongbin Liu, Xiumei Zhao
Summary: This study demonstrates that Xiao Chai Hu Tang (XCHT) has therapeutic effects on the malignant transformation of PanIN to PDAC and reveals its mechanism. The mouse model confirms that XCHT inhibits the occurrence and development of pancreatic cancer and restores mitochondrial dysfunction. This study reveals a new molecular mechanism of pancreatic tumorigenesis and provides the first evidence of the therapeutic efficacy of XCHT in pancreatic tumorigenesis.
Article
Immunology
Hang Ji, Zhihui Liu, Nan Wang, Jiaqi Jin, Jiheng Zhang, Jiawei Dong, Fang Wang, Xiuwei Yan, Qin Gong, Hongtao Zhao, Haogeng Sun, Yongzhe Li, Shaoshan Hu, Chao You
Summary: This study developed a gene signature associated with M2 macrophages using comprehensive bioinformatics approaches and explored their immunological and metabolic features in the glioma microenvironment. The results showed that certain pathways and genes could predict the functional status of macrophages, T-cell dysfunction, and prognosis of glioblastoma. Additionally, these cells were also associated with glioma responsiveness to anti-PD1 treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Jiasheng Wu, Jinru He, Jiheng Zhang, Hang Ji, Nan Wang, Shuai Ma, Xiuwei Yan, Xin Gao, Jianyang Du, Zhihui Liu, Shaoshan Hu
Summary: This study investigated the effects of EMT-related genes on the biological properties of LGG and revealed the potential mechanism by which adjacent non-tumor tissue participates in the malignant progression of LGG.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Shuai Ma, Fang Wang, Nan Wang, Jiaqi Jin, Xiuwei Yan, Lili Wang, Xiangrong Zheng, Shaoshan Hu, Jianyang Du
Summary: This study analyzed multi-omics data of glioma patients and constructed pyroptosis immune subgroups and identified nine novel pyroptosis immune signatures to assess the heterogeneity of glioma. The pyroptosis immune prognostic model (PIPM) based on these signatures was established and found to correlate with tumor microenvironment, therapy response, and clinical outcome. These pyroptosis immune signatures may be a helpful tool for survival prediction and treatment guidance in glioma and other tumors.
FRONTIERS IN PHARMACOLOGY
(2022)
