Article
Chemistry, Multidisciplinary
Jiaxin Yuan, Hanghang Liu, Hao Zhang, Tingting Wang, Qing Zheng, Zhen Li
Summary: This study reports the enhancement of microglial autophagy through the phagocytosis and degradation of alpha-synuclein, leading to improved therapeutic efficacy in Parkinson's disease. By using a rationally designed photothermal nanoagent, the surface TRPV1 channels of microglia are controlled, resulting in the activation of autophagy and clearance of alpha-synuclein. In mouse models, this treatment significantly improves motor ability and restores biomarker levels to those of healthy mice.
ADVANCED MATERIALS
(2022)
Review
Clinical Neurology
Ashley S. Harms, Sara A. Ferreira, Marina Romero-Ramos
Summary: Parkinson's disease involves both neuronal events and a significant immune component, with changes in the immune system occurring in both the central nervous system and the periphery. Alpha-synuclein plays a crucial role in activating the innate and adaptive immune system, contributing to neuronal degeneration and symptomatology in patients.
ACTA NEUROPATHOLOGICA
(2021)
Article
Chemistry, Medicinal
Nermin Eissa, Karthikkumar Venkatachalam, Petrilla Jayaprakash, Priya Yuvaraju, Markus Falkenstein, Holger Stark, Bassem Sadek
Summary: The study demonstrates the significant mitigating effects of a multiple-active H3R/D2R/D3R antagonist on social deficits related to ASD.
Article
Pharmacology & Pharmacy
Mariza Bortolanza, Glauce C. do Nascimento, Rita Raisman-Vozari, Elaine Del-Bel
Summary: The study demonstrates that doxycycline and its analogue compound COL-3 have the potential to reduce l-DOPA-induced dyskinesia in hemiparkinsonian rats. Doxycycline can also suppress the onset of dyskinesia when administered together with l-DOPA, while reducing immunoreactivity and activity of certain proteins in the basal ganglia.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Clinical Neurology
Tai Wang, Changhe Shi, Haiyang Luo, Huimin Zheng, Liyuan Fan, Mibo Tang, Yun Su, Jing Yang, Chengyuan Mao, Yuming Xu
Summary: Parkinson's disease is a heterogeneous neurodegenerative disease involving neuroinflammation as a common factor. This review highlights the relationship between the common pathological mechanisms of PD and neuroinflammation, discussing the role of the immune system in the pathogenesis of PD.
Review
Neurosciences
Michael Bartl, Mary Xylaki, Mathias Bahn, Sandrina Weber, Claudia Trenkwalder, Brit Mollenhauer
Summary: Immune-related alterations in Parkinson's disease, such as chronic pro-inflammatory status, specific inflammatory pathways, and gut microbiome differences, play a crucial role in the development and progression of PD. In-depth understanding of these inflammatory mechanisms can help design novel immunomodulatory approaches to delay or even stop PD.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Gagandeep Kaur, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Arun Kumar, Sandeep Arora, Simona Bungau
Summary: TLRs are an integral part of innate immunity and play a crucial role in inflammation and neurodegenerative diseases such as PD. The link between inflammation-mediated TLR expression and the molecular hallmark of PD pathogenesis has been established, with activated microglia promoting the progression of PD pathology. Targeting TLR signaling presents a promising avenue for developing effective treatments for PD.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Review
Cell Biology
Elodie Kip, Louise C. Parr-Brownlie
Summary: This article discusses the role of neuroinflammation in the onset and progression of Parkinson's disease (PD) and emphasizes the importance of reducing neuroinflammation early on to prevent PD. The article also mentions some risk and protective factors and discusses treatments for neuroinflammation associated with PD.
AGEING RESEARCH REVIEWS
(2022)
Article
Neurosciences
Ryan D. Hallam, Brodie Buchner-Duby, Morgan G. Stykel, Carla L. Coackley, Scott D. Ryan
Summary: Cortical synucleinopathies, characterized by the abnormal aggregation of α-synuclein protein, can lead to neurodegeneration. This study found that the exposure of rat cortical neurons to exogenous α-syn preformed fibrils resulted in the accumulation of insoluble deposits at synaptic terminals, inhibiting synaptic response to glutamate. These impairments in synaptic function may be correlated with nitric oxide synthesis and S-nitrosylation of dendritic scaffold protein.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Sandra Villar-Conde, Veronica Astillero-Lopez, Melania Gonzalez-Rodriguez, Patricia Villanueva-Anguita, Daniel Saiz-Sanchez, Alino Martinez-Marcos, Alicia Flores-Cuadrado, Isabel Ubeda-Banon
Summary: This study found that the distribution of alpha-synuclein in the hippocampus of PD patients is not associated with volumetric, neural, or glial changes. Proteomic analysis revealed changes in proteins associated with synaptic structures in the diseased hippocampus, indicating that hippocampal changes occur at the synapse level during PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Alla B. Salmina, Marina R. Kapkaeva, Anna S. Vetchinova, Sergey N. Illarioshkin
Summary: Neurogenesis is crucial for brain development and plasticity, but it is impaired in chronic neurodegenerative diseases like Parkinson's disease. The accumulation of aberrant alpha-synuclein in PD leads to neurotoxic effects and impaired synaptic plasticity, affecting neurogenesis. The development of optogenetics offers new hopes for treating PD neurodegeneration by targeting neurogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Chutian Zhang, Shiya Chen, Xiyu Li, Qian Xu, Yao Lin, Fan Lin, Mingzhou Yuan, Yong Zi, Jing Cai
Summary: This review summarizes animal models of genetic defects in various pathogenesis of Parkinson's disease, including abnormal encoding of alpha-synuclein, defects in the autophagy-lysosome system, defects in the ubiquitin protease system, and mitochondria-related dysfunction. The advantages, limitations, and application directions of these models are discussed, providing a reference for the application of animal models in Parkinson's disease research and therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Haodong Guo, Jingsong Yi, Fan Wang, Tong Lei, Hongwu Du
Summary: Parkinson's disease is a common chronic neurodegenerative disease, and heat shock proteins play important roles in this disease by maintaining protein homeostasis, degrading aggregates, promoting autophagy, and inhibiting neuronal apoptosis.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Immunology
Jingyi Li, Jingwei Zhao, Longmin Chen, Hongling Gao, Jing Zhang, Danlei Wang, Yuan Zou, Qixiong Qin, Yi Qu, Jiangting Li, Yongjie Xiong, Zhe Min, Manli Yan, Zhijuan Mao, Zheng Xue
Summary: Parkinson's disease (PD) is characterized by loss of dopaminergic neurons and accumulation of alpha-Synuclein (alpha-Syn). Th17 cells and dysfunctional regulatory T cells (Tregs) are associated with the loss of dopaminergic neurons in PD. The mechanism underlying the Th17/Treg imbalance remains unknown.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Min-Kyung Nam, Youngmo Seong, Gi Heon Jeong, Seung-Ah Yoo, Hyangshuk Rhim
Summary: This study demonstrates the selective interaction between HtrA2 protease and the NAC region of α-Synuclein, leading to the inhibition of mitochondrial accumulation of α-Synuclein and the production of reactive oxygen species. It further shows that the knockdown of HtrA2 promotes α-Synuclein-mediated mitochondrial ROS production and activation of microglial cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Neurosciences
Ariadna Laguna, Helena Xicoy, Eduardo Tolosa, Monica Serradell, Dolores Vilas, Carles Gaig, Manel Fernandez, Oscar Yanes, Joan Santamaria, Nuria Amigo, Alex Iranzo, Miquel Vila
Summary: Nuclear magnetic resonance spectroscopy was used to analyze the lipoprotein and protein glycosylation profiles of iRBD patients. Differences were found in the profiles between patients with initial predominant parkinsonism or dementia. Predictive models were constructed to predict the future clinical outcomes of iRBD patients.
NPJ PARKINSONS DISEASE
(2021)
Article
Clinical Neurology
Ling Shan, Rawien Balesar, Dick F. Swaab, Gert Jan Lammers, Rolf Fronczek
Summary: The study discovered that narcolepsy type 1 leads to the loss of hypocretin neurons in the hypothalamus, while sparing other neuronal populations. This selective decrease in hypocretin neurons provides novel targets for diagnostics and therapeutic interventions.
ANNALS OF NEUROLOGY
(2022)
Review
Neurosciences
Ling Shan, Dick F. Swaab
Summary: Compared to other monoamine neurotransmitters, the link between the histaminergic system and neuropsychiatric disorders is not well established. However, recent studies using animal models, genetic and neuroimaging approaches, and clinical trials suggest a potential role of the histaminergic system in these disorders, which may lead to the development of novel histamine-related therapeutic strategies.
CURRENT NEUROPHARMACOLOGY
(2022)
Article
Environmental Sciences
Xufeng Cui, Cuicui Liu, Ling Shan, Jiaqi Lin, Jing Zhang, Yuehua Jiang, Guanghong Zhang
Summary: This study analyzed the characteristics of land use change and transformation driven by urbanization in Hubei Province, and measured the spatial-temporal response and evolution of ecosystem services value (ESV). The study found that the expansion of built-up land resulted in significant reduction of cropland and forest, leading to ESV losses.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Ling Shan, Yuehua Jiang, Cuicui Liu, Jing Zhang, Guanghong Zhang, Xufeng Cui
Summary: The coordinated relationship between urban population-land spatial patterns and ecological efficiency is important for resource utilization, environmental protection, and sustainable development. This study reveals that the matching degree of urban population-land spatial patterns has increased, but the overall level is still low. The ecological efficiency shows a radial distribution with higher values in the middle and lower values in the periphery, conflicting with the spatial patterns. The study provides a new framework for urban environmental assessment and planning decision-making.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Kim M. A. De Kleijn, Kirsten R. Straasheijm, Wieteke A. Zuure, Gerard J. M. Martens
Summary: Neuroinflammation is crucial in the pathogenesis of neurodegenerative diseases. Through stimulation experiments on human cortical spheroids, transcriptomic analysis reveals that the main response induced by the pro-inflammatory cytokines TNF alpha and IL-1 beta is neuroinflammation. Endothelial cells, microglia, astrocytes, and dysregulated genes encoding cytokines, chemokines, and pathway components are central in the neuroinflammatory response.
Article
Engineering, Civil
Xufeng Cui, Jing Zhang, Wei Huang, Cuicui Liu, Ling Shan, Yuehua Jiang
Summary: In this paper, the spatial distribution of the life service industry in Wuhan was studied using kernel density analysis, entropy index, and standard deviational ellipse methods. The results show that the industry displays a distribution of coexistence of single and multiple centers, with the centers located in Wuchang and Jianghan. Except for transportation, the other six types of the industry show a trend of development toward the southeast. This study provides important information for the spatial planning of the life service industry in polycentric cities.
JOURNAL OF URBAN PLANNING AND DEVELOPMENT
(2023)
Article
Multidisciplinary Sciences
Hongjie Bao, Xiaoqian Liu, Xiaoyong Xu, Ling Shan, Yongteng Ma, Xiaoshuang Qu, Xiangyu He
Summary: Measuring regional differences in agricultural green total factor productivity (AGTFP) provides a basis for policy guidance on agricultural green development in the Yangtze River Delta (YRD) region. This study used a two-period Malmquist-Luenberger index under the carbon emission constraint to measure the AGTFP of cities in the YRD region from 2001 to 2019. The results showed an increasing trend in AGTFP in the region, with different drivers of growth in the eastern and southern cities.
Article
Multidisciplinary Sciences
Ali Seifinejad, Mergim Ramosaj, Ling Shan, Sha Li, Marie-Laure Possovre, Corinne Pfister, Rolf Fronczek, Lee A. Garrett-Sinha, David Frieser, Makoto Honda, Yoan Arribat, Dogan Grepper, Francesca Amati, Marie Picot, Andrea Agnoletto, Christian Iseli, Nicolas Chartrel, Roland Liblau, Gert J. Lammers, Anne Vassalli, Mehdi Tafti
Summary: Narcolepsy with cataplexy is caused by deficiency in the neuropeptide hypocretin/orexin (HCRT), believed to result from autoimmune destruction of hypocretin-producing neurons. Loss of hypothalamic CRH-producing neurons suggests that mechanisms other than autoimmune attack are involved. HCRT, PDYN, and CRH are epigenetically silenced by hypothalamic inflammation in narcolepsy patients, without concurrent cell death. Methylation reversal may lead to a potential cure for narcolepsy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Ling Shan, Suzan Linssen, Zoe Harteman, Fleur den Dekker, Lamis Shuker, Rawien Balesar, Nicole Breesuwsma, Jasper Anink, Jingru Zhou, Gert Jan Lammers, Dick F. F. Swaab, Rolf Fronczek
Summary: The study found that NT1 patients have a significant reduction in CRH-positive neurons in the PVN and an increase in the percentage of CRH cells co-expressing AVP. There is also evidence of enhanced activity in histamine neurons and unchanged density of TH-positive LC neurons in NT1. These findings suggest upregulation of histamine and CRH neurons in NT1.
ANNALS OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Di Dai, Qian Qin, Xinyu Zhu, Qiuyuan Fang, Xianzong Meng, Lin Bai, Guang Yang, Ling Shan, Chunqing Liu
Summary: The detection of neurotransmitters has been widely used to study neuropsychiatric diseases. High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has advantages in determining neurotransmitter levels. However, there are still challenges in neurotransmitter detection. Our lab has developed a rapid and sensitive HPLC-MS/MS protocol that can simultaneously detect 5 neurotransmitters with an easy pretreatment procedure. The protocol provides reference values for the lab using an Agilent HPLC-MS/MS system with a triple quadrupole analyzer.
Article
Engineering, Electrical & Electronic
Gao Yibo, Yang Yong, Zhou Yugeng, Liu Zhenwei, Wu Wenjie, Gao Longbiao, Shi Qiyong, Kong Xiangbin, Zheng Jianming, Fu Jianzhong, Yu Guiying, Wu Jinhua, Wang Chunwei, Wang Bixia, Shan Ling
Summary: This paper introduces a self-developed high-temperature SLM system and innovative hybrid spot technology for fabricating mold steel H13, achieving better results in maximum density with the suitable configuration of composite spots.
LASER & OPTOELECTRONICS PROGRESS
(2021)
Article
Environmental Studies
Xufeng Cui, Sisi Huang, Cuicui Liu, Tingting Zhou, Ling Shan, Fengyuan Zhang, Min Chen, Fei Li, Walter T. de Vries
Summary: This study conducted a quantitative analysis of urban land use efficiency (ULUE) at the provincial scale in China from 2008 to 2017 using the SBM-GPA integration model. The analysis found possibilities for improvement in ULUE, strong correlation between ULUE and agglomeration characteristics, and identified three clusters of ULUE values (high, medium, low). The results can better support decision making in urban land use management.
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
