期刊
BMC MEDICINE
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12916-021-01913-w
关键词
White blood cell; Gut microbiome; Diet; Vegetable intake; Chronic inflammation
资金
- Zoe Global
- Wellcome Trust [212904/Z/18/Z]
- Medical Research Council (MRC)/British Heart Foundation Ancestry and Biological Informative Markers for Stratification of Hypertension (AIMHY) [MR/M016560/1]
- Medical Research Council
- European Union
- Chronic Disease Research Foundation (CDRF)
- National Institute for Health Research (NIHR)
- King's College London
- MRC AIMHY grant
- Chronic Disease Research Foundation
- BBSRC [BB/NO12739/1]
- European Research Council (ERC-STG project MetaPG)
- European H2020 program [ONCOBIOME-825410, MASTER-818368]
- National Cancer Institute of the National Institutes of Health [1U01CA230551]
- National Institute for Health Research Nottingham Biomedical Research Centre
- MRC [MR/N01183X/1] Funding Source: UKRI
The study found that white blood cells, lymphocytes, and basophils were significantly negatively correlated with vegetable intake, and vegetable intake explained 3.59% to 6.58% of the variation in white blood cells. Furthermore, 20% of the effect of vegetable intake on lymphocyte counts was mediated by the bacterial genus Collinsella.
Background: Chronic inflammation, which can be modulated by diet, is linked to high white blood cell counts and correlates with higher cardiometabolic risk and risk of more severe infections, as in the case of COVID-19. Methods: Here, we assessed the association between white blood cell profile (lymphocytes, basophils, eosinophils, neutrophils, monocytes and total white blood cells) as markers of chronic inflammation, habitual diet and gut microbiome composition (determined by sequencing of the 16S RNA) in 986 healthy individuals from the PREDICT-1 nutritional intervention study. We then investigated whether the gut microbiome mediates part of the benefits of vegetable intake on lymphocyte counts. Results: Higher levels of white blood cells, lymphocytes and basophils were all significantly correlated with lower habitual intake of vegetables, with vegetable intake explaining between 3.59 and 6.58% of variation in white blood cells after adjusting for covariates and multiple testing using false discovery rate (q < 0.1). No such association was seen with fruit intake. A mediation analysis found that 20.00% of the effect of vegetable intake on lymphocyte counts was mediated by one bacterial genus, Collinsella, known to increase with the intake of processed foods and previously associated with fatty liver disease. We further correlated white blood cells to other inflammatory markers including IL6 and GlycA, fasting and post-prandial glucose levels and found a significant relationship between inflammation and diet. Conclusion: A habitual diet high in vegetables, but not fruits, is linked to a lower inflammatory profile for white blood cells, and a fifth of the effect is mediated by the genus Collinsella.
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