期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1867, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.166016
关键词
Metabolism; Mitochondria; mtDNA; Metabolic pathways; Cancer
资金
- FEDER (ERDF)-European Regional Development Fund through COMPETE 2020-Operational Programme for Competitiveness and Internationalisation (POCI), Portugal 2020
- FCT -Fundacao para a Ciencia e a Tecnologia (FCT) [POCI-01-0145-FEDER-016390]
- FCT -Fundacao para a Ciencia e a Tecnologia [POCI UIDB/04539/2020]
- project Summer Course in Interdisciplinary Research, Development and Innovation in Cellular and Molecular Metabolism - FCT [15-20/7/245]
- Directorate General for Higher Education (DGES)
This review summarizes how cells adapt their metabolism to survive in tumoral environment conditions and the crucial role of mitochondria in tumor metabolic programing and therapeutics. Mitochondria play a key role in carcinogenesis and tumor progression and could be potential therapeutic targets.
To adapt to tumoral environment conditions or even to escape chemotherapy, cells rapidly reprogram their metabolism to handle adversities and survive. Given the rapid rise of studies uncovering novel insights and therapeutic opportunities based on the role of mitochondria in tumor metabolic programing and therapeutics, this review summarizes most significant developments in the field. Taking in mind the key role of mitochondria on carcinogenesis and tumor progression due to their involvement on tumor plasticity, metabolic remodeling, and signaling re-wiring, those organelles are also potential therapeutic targets. Among other topics, we address the recent data intersecting mitochondria as of prognostic value and staging in cancer, by mitochondrial DNA (mtDNA) determination, and current inhibitors developments targeting mtDNA, OXPHOS machinery and metabolic pathways. We contribute for a holistic view of the role of mitochondria metabolism and directed therapeutics to understand tumor metabolism, to circumvent therapy resistance, and to control tumor development.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据