Article
Health Care Sciences & Services
Tak Kyu Oh, In-Ae Song, Young-Tae Jeon
Summary: Statin therapy may have potential benefits for the prevention of COVID-19 in South Korea, but it does not affect the hospital mortality of patients diagnosed with COVID-19.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Prateek Lohia, Shweta Kapur, Sindhuri Benjaram, Tanveer Mir
Summary: The study revealed a significant reduction in mortality among COVID-19 patients who used statins. Even after propensity score matching, statin users continued to exhibit lower mortality rates.
JOURNAL OF CLINICAL LIPIDOLOGY
(2021)
Article
Clinical Neurology
Geert J. Lefeber, Wilma Knol, Patrick C. Souverein, Marcel L. Bouvy, Anthonius de Boer, Huiberdina L. Koek
Summary: In patients aged 65 and older, those aged 80 and older who were prescribed statins for 2 years after a first ischemic stroke had a lower risk of recurrent stroke, myocardial infarction, and cardiovascular mortality, as well as reduced all-cause mortality.
Article
Neurosciences
Guangshuo Li, Shang Wang, Yunyun Xiong, Hongqiu Gu, Kaixuan Yang, Xin Yang, Chunjuan Wang, Chuanying Wang, Zixiao Li, Xingquan Zhao
Summary: This study aimed to compare in-hospital mortality and evacuation rates of intracranial hematoma in patients with primary intracerebral hemorrhage who were prior statin users and nonusers. The results showed that prior statin use was not associated with in-hospital mortality but reduced the proportion of patients undergoing evacuation of intracranial hematoma.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Jennifer L. Dearborn-Tomazos, Xin Hu, Dawn M. Bravata, Manali A. Phadke, Fitsum M. Baye, Laura J. Myers, John Concato, Alan J. Zillich, Mathew J. Reeves, Jason J. Sico
Summary: A significant portion of veterans do not receive adequate statin therapy after ischemic stroke or TIA, with patients who deintensified treatment or received no treatment showing higher mortality rates compared to those who were at goal for statin prescription dosing.
Review
Biochemistry & Molecular Biology
Amirmohammad Khalaji, Amir Hossein Behnoush, Sanam Alilou, Malihe Rezaee, Soheil Peiman, Amirhossein Sahebkar
Summary: Many commonly used drugs were evaluated as repurposed treatment options for COVID-19, including lipid-lowering agents. This systematic review found no benefit in adding statins, fenofibrate, or nicotinamide to COVID-19 treatment, but PCSK9 inhibitors showed improved outcomes. The efficacy of omega-3 supplementation needs further evaluation.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Pharmacology & Pharmacy
Ruihao Li, Manqiu Yuan, Shixiong Yu, Wenlong Fu, Wu Yu, Siying Ling, Jianming Sun, Yikuan Chen
Summary: The use of statins may reduce the risk of disease recurrence and all-cause mortality in patients with VTE. However, further randomized clinical trials are needed to better explore the effect of statins in secondary prevention of VTE.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Clinical Neurology
Jong S. Kim
Summary: Hyperlipidemia is an important risk factor for ischemic stroke, and statins have been shown to benefit stroke patients. Guidelines now emphasize high-intensity statins and low LDL-C target strategies for stroke patients, but the benefits of lipid-lowering therapy vary among patients with different levels of cerebral arterial diseases.
Article
Cardiac & Cardiovascular Systems
Bom Lee, Sung-Jin Hong, Seung-Woon Rha, Jung Ho Heo, Seung-Ho Hur, Hyun Hee Choi, Kyung-Jin Kim, Ju Han Kim, Hyun Kuk Kim, Ung Kim, Yu Jeong Choi, Yong-Joon Lee, Seung-Jun Lee, Chul-Min Ahn, Young-Guk Ko, Byeong-Keuk Kim, Donghoon Choi, Myeong-Ki Hong, Yangsoo Jang, Jung-Sun Kim
Summary: The combination therapy of moderate-intensity statin plus ezetimibe showed consistent effectiveness in reducing cardiovascular outcomes for patients with atherosclerotic cardiovascular disease (ASCVD), regardless of their baseline low-density lipoprotein cholesterol (LDL-C) levels.
Article
Biochemistry & Molecular Biology
Steffen Spoerl, Michael Gerken, Rene Fischer, Silvia Spoerl, Christian Kirschneck, Stefanie Wolf, Juergen Taxis, Nils Ludwig, Niklas Biermann, Torsten E. Reichert, Gerrit Spanier
Summary: The study investigated the prognostic role of statins in oral squamous cell carcinoma (OSCC). The results showed that long-term medication with statins was associated with improved overall survival and recurrence-free survival in OSCC patients. These findings suggest that statin use may ameliorate the oncological outcome in primarily resected OSCC patients.
Article
Dentistry, Oral Surgery & Medicine
Sebastian-Edgar Baumeister, Birte Holtfreter, Stefan Lars Reckelkamm, Thomas Kocher, Zoheir Alayash, Benjamin Ehmke, Hansjorg Baurecht, Michael Nolde
Summary: Genetically proxied inhibition of NCP1L1 and PCSK9 was associated with lower odds of periodontitis, while genetically proxied HMGCR inhibition was not associated with periodontitis.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
An-Yi Wang, Guan-Ling Lin, Joseph Jordan Keller, Li-Hsuan Wang
Summary: The study found that in patients with hyperlipidemia, the combination of statins and fibrates can reduce the risk of chronic periodontitis, and long-term use of these drugs can also lower the risk of developing the disease.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Hematology
Shmeylan Al Harbi, Raed Kensara, Ohoud Aljuhani, Ghazwa B. Korayem, Ali F. Altebainawi, Abdullah Al Harthi, Ramesh Vishwakarma, Alaa M. Alenazi, Abdulmajed Almutairi, Omar Alshaya, Sultan Alraddadi, Tareq Al Sulaiman, Latifah Aldakkan, Reem Mahboob, Kholoud Alaamer, Abdulrahman Alissa, Awatif Hafiz, Nada Aldhayyan, Sara Althewaibi, Farhan Alenezi, Nadeen Y. Alkhotani, Sara A. Alghamdi, Abeer A. Alenazi, Khalid Al Sulaiman
Summary: Coagulation abnormalities and thrombosis are important complications of severe COVID-19. This study evaluated the effectiveness of statins in reducing the risk of thrombosis among critically ill patients with COVID-19. It found that statin therapy did not reduce thrombosis but was associated with improved survival.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Article
Endocrinology & Metabolism
You-Bin Lee, Minji Koo, Eunjin Noh, Soon Young Hwang, Jung A. Kim, Eun Roh, So-Hyeon Hong, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo
Summary: This study explored the relationship between low-density lipoprotein cholesterol (LDL-C) levels and the risks of myocardial infarction (MI), stroke, and all-cause death among older adults. The findings indicate that lower LDL-C is associated with reduced risks of MI and stroke. However, the risk of all-cause death follows an inverted J-shaped pattern with LDL-C levels. Intensive statin therapy, which lowers LDL-C, is beneficial for older adults with cardiovascular risk factors like diabetes.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Urology & Nephrology
Sunjae Bae, JiYoon B. Ahn, Corey Joseph, Ryan Whisler, Mark A. Schnitzler, Krista L. Lentine, Bernard S. Kadosh, Dorry L. Segev, Mara A. McAdams-DeMarco
Summary: Statins appear to be well tolerated in kidney transplant recipients, but their use may be associated with a slightly higher risk of post-transplant diabetes mellitus, cataract, and rhabdomyolysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Emergency Medicine
Sol Han, Sung Wook Song, Hansol Hong, Woo Jeong Kim, Young Joon Kang, Chang Bae Park, Jeong Ho Kang, Ji Hwan Bu, Sung Kgun Lee, Seo Young Ko, Soo Hoon Lee, Chul-Hoo Kang
Summary: This study investigated the hospital diagnoses and characteristics of uncooperative prehospital patients suspected of acute stroke. Three scenario-based prehospital stroke screening performances were analyzed using final hospital diagnoses. The results showed that among the patients who met the prehospital criteria for suspicion of acute stroke, a significant number were uncooperative, and the diagnosis in the uncooperative group did not differ from that in the cooperative group.
CLINICAL AND EXPERIMENTAL EMERGENCY MEDICINE
(2023)
Review
Critical Care Medicine
Hyeon-Jeong Lee, Hye Jin Jang, Won-Il Choi, Joonsung Joh, Junghyun Kim, Jungeun Park, Miyoung Choi
Summary: Therapeutic heparin is associated with a reduced risk of thromboembolic events but an increased risk of bleeding in COVID-19 patients. It is more effective than prophylactic heparin in moderate patients but carries a higher bleeding risk. In severe patients, therapeutic heparin is associated with lower rates of thromboembolic events and bleeding.
ACUTE AND CRITICAL CARE
(2023)
Article
Infectious Diseases
Jun Hee Lee, Sang -Min Oh, Eunyoung Lee, Ji Hwan Bang, Sang -Won Park
Summary: Thrombocytopenia is a rare manifestation of both COVID-19 and COVID-19 vaccination. An 85-year-old man was diagnosed with immune thrombocytopenia and COVID-19, 7 days after receiving the COVID-19 vaccine. The patient responded well to a short course of intravenous immunoglobulin and oral corticosteroids.
INFECTION AND CHEMOTHERAPY
(2022)
Article
Medicine, General & Internal
Do Hyeon Park, Eunyoung Lee, Jongtak Jung, Chang Kyung Kang, Kyoung-Ho Song, Pyoeng Gyun Choe, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang-Won Park, Nam Joong Kim, Myoung-Don Oh
Summary: This study assessed the relationship between anxiety levels and personal protective equipment (PPE) use among healthcare workers involved in the care of COVID-19 patients. The results showed that anxiety levels were lower in healthcare workers, and there were changes in PPE usage, although excessive demand for PPE was observed.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Jihye Um, Youn Young Choi, Gayeon Kim, Min-Kyung Kim, Kyung-Shin Lee, Ho Kyung Sung, Byung Chul Kim, Yoo-Kyoung Lee, Hee-Chang Jang, Ji Hwan Bang, Ki-Hyun Chung, Myoung-Don Oh, Jun-Sun Park, Jaehyun Jeon
Summary: This study assessed neutralizing antibody activity against the wild-type, delta, and omicron variants after full primary and booster vaccinations with BNT162b2. The results showed that the booster vaccine significantly increased humoral immunity against the omicron variant, although it remained lower than the immunity against other variants.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Article
Infectious Diseases
Chan Mi Lee, Eunyoung Lee, Ji Hwan Bang, Sang-Won Park, Wan Beom Park, Myoung-Don Oh, Nam Joong Kim
Summary: This study investigated the prevalence of MDR-TB in HIV/TB co-infected patients in Korea and found that the prevalence rate was 15.9%.
INFECTION AND CHEMOTHERAPY
(2021)
Article
Medicine, General & Internal
Sejin Choi, Eunyoung Lee, Ji Hwan Bang
Summary: Korean correctional facilities have a higher prevalence of HIV infection, with nearly half of the inmates being drug users. Drug users in these facilities are more likely to be members of the LGBTQ community and have higher incidence of psychological disorders.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Health Policy & Services
Eunyoung Lee, Jungmee Kim, Ji Hwan Bang, Jin Yong Lee
Summary: This study examined the epidemiological characteristics of women living with HIV in South Korea through analyzing claims data. Findings showed that factors like young age, having AIDS, and low economic status with the need for National Medical Aid were associated with lower medication adherence. Attention is needed for enhancing adherence among women, especially young patients with low economic status.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2021)
Article
Health Policy & Services
Hye-Jin Yang, Jungmee Kim, Ji Hwan Bang, Cho Ryork Kang, Sung-Il Cho, Myoung-don Oh, Eung Soo Hwang, Jong-Koo Lee
Summary: The introduction of rapid HIV screening tests at public health centers in South Korea significantly increased the number of HIV screening tests and confirmed cases, indicating the effectiveness of this approach in encouraging voluntary HIV testing.
AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
(2021)
Article
Medicine, General & Internal
Soyeoun Lim, Jong Han Leem, Young-Seoub Hong, Jungwon Kim, Soyoung Park, Joon-Sung Joh, Woon-Jung Kwon, Yangho Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
Article
Medicine, General & Internal
Euijin Chang, Kyoung-Ho Song, Wan Beom Park, Ji Hwan Bang, Eu Suk Kim, Sang Won Park, Nam Joong Kim
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
Letter
Medicine, General & Internal
Yeonjae Kim, Ho Kyung Sung, Ji Hwan Bang, Im-Seok Koh, Joon-Sung Joh, Young-Su Ju, Hye Sook Min, Bum Sik Chin, Ki-hyun Chung
JOURNAL OF KOREAN MEDICAL SCIENCE
(2020)
Review
Allergy
You-Young Kim, Joon Sung Joh, Ji Yeon Lee
ASIA PACIFIC ALLERGY
(2020)