Review
Rheumatology
Alessia Alunno, Aurelie Najm, Pedro M. Machado, Heidi Bertheussen, Gerd R. Burmester, Francesco Carubbi, Gabriele De Marco, Roberto Giacomelli, Olivier Hermine, John D. Isaacs, Isabelle Kone-Paut, Cesar Magro-Checa, Iain McInnes, Pier Luigi Meroni, Luca Quartuccio, Athimalaipet Ramanan, Manuel Ramos-Casals, Javier Rodriguez Carrio, Hendrik Schulze-Koops, Tanja A. Stamm, Sander W. Tas, Benjamin Terrier, Dennis G. McGonagle, Xavier Mariette
Summary: EULAR developed Points to Consider on COVID-19 pathophysiology and immunomodulatory therapies, highlighting the heterogeneous clinical spectrum of SARS-CoV-2 infection and the need for a multifaceted approach to target different pathophysiological mechanisms.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Christina Torres Kozycki, Shilpa Kodati, Laryssa Huryn, Hongying Wang, Blake M. Warner, Priyam Jani, Dima Hammoud, Mones S. Abu-Asab, Yingyos Jittayasothorn, Mary J. Mattapallil, Wanxia Li Tsai, Ehsan Ullah, Ping Zhou, Xiaoying Tian, Ariane Soldatos, Niki Moutsopoulos, Marie Kao-Hsieh, Theo Heller, Edward W. Cowen, Chyi-Chia Richard Lee, Camilo Toro, Shelley Kalsi, Zohreh Khavandgar, Alan Baer, Margaret Beach, Debra Long Priel, Michele Nehrebecky, Sofia Rosenzweig, Tina Romeo, Natalie Deuitch, Laurie Brenchley, Eileen Pelayo, Wadih Zein, Nida Sen, Alexander H. Yang, Gary Farley, David A. Sweetser, Lauren Briere, Janine Yang, Fabiano de Oliveira Poswar, Ida Schwartz, Tamires Silva Alves, Perrine Dusser, Isabelle Kone-Paut, Isabelle Touitou, Salah Mohamed Titah, Petrus Martin van Hagen, Rogier T. A. van Wijck, Peter J. van der Spek, Hiromi Yano, Andreas Benneche, Ellen M. Apalset, Ragnhild Wivestad Jansson, Rachel R. Caspi, Douglas Byron Kuhns, Massimo Gadina, Hidetoshi Takada, Hiroaki Ida, Ryuta Nishikomori, Elena Verrecchia, Eugenio Sangiorgi, Raffaele Manna, Brian P. Brooks, Lucia Sobrin, Robert Hufnagel, David Beck, Feng Shao, Amanda K. Ombrello, Ivona Aksentijevich, Daniel L. Kastner
Summary: This study discovered that ROSAH syndrome is an autoinflammatory disease caused by ALPK1 gene mutations. Patients with ROSAH syndrome often exhibit signs of inflammation and show sensitivity to anti-cytokine therapy.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Marco Bocchetti, Marianna Scrima, Federica Melisi, Amalia Luce, Rossella Sperlongano, Michele Caraglia, Silvia Zappavigna, Alessia Maria Cossu
Summary: lncRNAs play a crucial role in regulating gene transcription during inflammatory responses, and recent studies have shown their dysregulation in human diseases is linked to immune mechanisms, offering insights into resolving complex disease relationships.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Mpiko Ntsekhe, Jason V. Baker
Summary: The widespread use of contemporary antiretroviral therapy has transformed HIV into a chronic illness associated with increased risk for cardiovascular diseases. Current clinical care and research aim to improve outcomes, survival, and quality of life for individuals with HIV-related cardiovascular diseases. However, individuals on effective antiretroviral therapy still face a higher risk of ischemic events such as myocardial infarction and stroke compared to those without HIV.
Article
Biochemistry & Molecular Biology
Andres Tittarelli
Summary: Connexin-mediated intercellular communication mechanisms play important roles in immune system activities, especially in infections, wounds, cancer, and other inflammatory conditions. Modulating connexin expression and channel activities may be a promising approach for designing therapeutic tools.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Nutrition & Dietetics
Man Liu, Samuel C. Dudley
Summary: Magnesium is essential for cell functions and its deficiency (HypoMg) can lead to cardiovascular diseases. Magnesium supplementation and TRPM7 kinase inhibition may have therapeutic effects for HypoMg and other diseases.
Review
Biochemistry & Molecular Biology
Emanuela Senjor, Janko Kos, Milica Perisic Nanut
Summary: Cysteine cathepsins, the most abundant proteases in lysosomes, play essential roles in various cellular processes. Their upregulation is associated with pathological conditions such as cancer and neurodegeneration. This review provides an overview of their involvement in immune disorders and suggests potential targeting options.
Article
Immunology
Olalekan Chris Akinsulie, Sammuel Shahzad, Seto Charles Ogunleye, Ifeoluwa Peace Oladapo, Melina Joshi, Charles Egede Ugwu, Joy Olaoluwa Gbadegoye, Fasilat Oluwakemi Hassan, Richard Adeleke, Qudus Afolabi Akande, Ridwan Olamilekan Adesola
Summary: There are reports on the influence of hypoxia on cancer cells, but there may be more interesting functions of a hypoxic cellular micro-environment. The interaction between HIF and NF-κB is complex and has common factors and targets. This understanding could lead to novel therapeutic targets for infectious diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gyu Seong Heo, Lanlan Lou, Deborah Sultan, Yongjian Liu
Summary: Inflammation and fibrosis are key pathological processes in cardiovascular diseases, with molecular imaging agents developed to visualize biomarkers and reveal the pathogenesis of fibrosis.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Review
Rheumatology
Aaron Z. Reyes, Kelly A. Hu, Jacob Teperman, Theresa L. Wampler Muskardin, Jean-Claude Tardif, Binita Shah, Michael H. Pillinger
Summary: The search for effective COVID-19 management strategies is ongoing, with colchicine showing promise in targeting multiple mechanisms associated with excessive inflammation. Outpatient treatment with colchicine could potentially reduce the need for hospitalization and mortality due to COVID-19, benefiting both resource-replete and resource-poor regions by reducing the demand for rare or expensive care resources.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Caitlin A. Moran, Lauren F. Collins, Nour Beydoun, Puja K. Mehta, Yetunde Fatade, Ijeoma Isiadinso, Tene T. Lewis, Brittany Weber, Jill Goldstein, Igho Ofotokun, Arshed Quyyumi, May Y. Choi, Kehmia Titanji, Cecile D. Lahiri
Summary: Immune responses differ between men and women, with women more prone to chronic autoimmune diseases. Current ASCVD risk assessment tools underestimate the risk in immune dysregulation populations, especially women. This review focuses on the impact of immune dysregulation on ASCVD and discusses factors contributing to ASCVD in women with immune disorders.
CIRCULATION RESEARCH
(2022)
Article
Rheumatology
Leo Placais, Stephane Dalle, Olivier Dereure, Sabiha Trabelsi, Sophie Dalac, Delphine Legoupil, Henri Montaudie, Jean-Philippe Arnault, Julie De Quatrebarbes, Philippe Saiag, Florence Brunet-Possenti, Thierry Lesimple, Eve Maubec, Francois Aubin, Florence Granel-Brocard, Jean-Jacques Grob, Pierre-Emmanuel Stoebner, Clara Allayous, Bastien Oriano, Caroline Dutriaux, Laurent Mortier, Celeste Lebbe
Summary: This study found that patients with pre-existing autoimmune disease (pAID) who received immune checkpoint inhibitors (ICIs) for melanoma treatment were at higher risk of immune-related adverse events (irAEs). However, they had a better 24-month survival rate compared to the control group.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Berengere Molina, Roberto Padoan, Maria Letizia Urban, Pavel Novikov, Marco Caminati, Camille Taille, Antoine Neel, Laurence Bouillet, Paolo Fraticelli, Nicolas Schleinitz, Christine Christides, Laura Moi, Bertrand Godeau, Ann Knight, Jan Walter Schroeder, Sylvain Marchand-Adam, Helder Gil, Vincent Cottin, Cecile-Audrey Durel, Elena Gelain, Boris Lerais, Marc Ruivard, Matthieu Groh, Maxime Samson, Luca Moroni, Jens Thiel, Anna Kernder, Jan Willem Cohen Tervaert, Giulia Costanzo, Marco Folci, Sonia Rizzello, Pascal Cohen, Giacomo Emmi, Benjamin Terrier
Summary: This study investigated the safety and efficacy of off-label use of Dupilumab in patients with relapsing and/or refractory EGPA. The results suggest that Dupilumab may be effective in treating EGPA-related ENT manifestations, but caution is required as EGPA flares occurred in one-third of patients and were preceded by eosinophilia in 88% of cases.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Pharmacology & Pharmacy
Dany Perocheau, Loukia Touramanidou, Sonam Gurung, Paul Gissen, Julien Baruteau
Summary: Exosomes, a subset of extracellular vesicles, play a crucial role in cell-cell communication and have shown promising potential as diagnostic biomarkers and therapeutic carriers. Their reduced immunogenicity and ability to cross physiological barriers make them an appealing option for clinical application.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Claudia Sirbe, Simona Rednic, Alina Grama, Tudor Lucian Pop
Summary: Vitamin D plays a crucial role in immune system and endothelial membrane stability, and low levels of serum 25(OH)D are associated with an increased risk of immune-related diseases. Although the outcomes of vitamin D supplementation vary greatly, it is recommended to increase vitamin D intake and ensure sufficient sunlight exposure to obtain optimal health benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Rheumatology
Milena Gianfrancesco, Kimme L. Hyrich, Jinoos Yazdany, Pedro M. Machado, Philip C. Robinson
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Letter
Rheumatology
Pedro M. Machado, Martin Schaefer, Anja Strangfeld, Laure Gossec, Milena Gianfrancesco, Saskia Lawson-Tovey, Elsa F. Mateus, Loreto Carmona, Kimme L. Hyrich, Philip C. Robinson, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Jeffrey A. Sparks, Zachary S. Wallace, Andrea M. Seet, Philip C. Robinson, Pedro M. Machado, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Ricardo J. O. Ferreira, Paco M. J. Welsing, Johannes W. G. Jacobs, Laure Gossec, Mwidimi Ndosi, Pedro M. Machado, Desiree van der Heijde, Jose A. P. Da Silva
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Aurelie Najm, Felicie Costantino, Catherine Weill, Andrew Filer, Maria Antonieta D'Agostino
Summary: This study aims to summarize the impact of biopsy procedures, tissue handling, tissue quality, and disease-specific factors on synovial tissue outcome. The study found that study design, population, sample handling, randomization, and analysis can affect the final results of synovial tissue research.
Meeting Abstract
Rheumatology
S. A. Yeoh, M. Gianfrancesco, S. Lawson-Tovey, K. Hyrich, A. Strangfeld, L. Gossec, L. Carmona, E. Mateus, M. Schaefer, C. Richez, E. Hachulla, M. Holmqvist, C. A. Scire, R. Hasseli, A. Jayatilleke, T. Hsu, K. D'Silva, V. Pimentel-Quiroz, M. Vasquez del Mercado, S. Katsuyuki Shinjo, E. Reis Neto, L. Rocha, A. C. D. O. E. S. Montandon, P. Jordan, E. Sirotich, J. Hausmann, J. Liew, L. Jacobsohn, M. Gore-Massy, P. Sufka, R. Grainger, S. Bhana, Z. Wallace, P. Robinson, J. Yazdany, P. Machado
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Mikhail Protopopov, Fabian Proft, Stephanie Wichuk, Pedro M. Machado, Robert G. Lambert, Ulrich Weber, Susanne Juhl Pedersen, Mikkel Ostergaard, Joachim Sieper, Martin Rudwaleit, Xenofon Baraliakos, Walter P. Maksymowych, Denis Poddubnyy
Summary: This study compares the ability of MRI and conventional radiography to detect structural lesions indicative of axSpA.
Article
Rheumatology
Saskia Lawson-Tovey, Pedro M. Machado, Anja Strangfeld, Elsa Mateus, Laure Gossec, Loreto Carmona, Bernd Raffeiner, Inita Bulina, Daniel Clemente, Julija Zepa, Ana M. Rodrigues, Xavier Mariette, Kimme L. Hyrich
Summary: This study investigates the safety of SARS-CoV-2 vaccination in adolescents with inflammatory rheumatic diseases and adults with juvenile idiopathic arthritis. The results show a low frequency of disease flares and adverse events in both populations after vaccination.
Review
Rheumatology
Penelope Esther Palominos, Daniel G. Fernandez-Avila, Laura C. Coates, Adewale Adebajo, Adrien Nzeusseu Toukap, Ahmed Abogamal, Ari Polachek, Arno W. R. van Kuijk, Francesco Caso, Gabriele de Marco, Gurjit S. Kaeley, Ingrid Steinkoenig, Jeffrey Chau, Marie Feletar, Marijn Vis, Ori Elkayam, Philipp Sewerin, Salvatore d'Angelo, Sibel Zehra Aydin, Waleed Alshehhi, Philip S. Helliwell
Summary: This literature review aimed to identify the most efficacious current interventions for dactylitis and provide up-to-date scientific evidence to support the 2021 GRAPPA recommendations on the management of psoriatic arthritis. The analysis of original articles revealed a lack of consensus regarding dactylitis assessment and the paucity of data concerning the effect of certain medications.
JOURNAL OF RHEUMATOLOGY
(2023)
Article
Health Care Sciences & Services
Helena Santos, Ana Rita Henriques, Jaime Branco, Pedro M. Machado, Helena Canhao, Fernando M. Pimentel-Santos, Ana Maria Rodrigues
Summary: The study found that both spondyloarthritis and chronic low back pain have similar impacts on health-related quality of life (HRQoL), including mental, physical, and social domains. Patients with spondyloarthritis and chronic low back pain reported significantly lower HRQoL compared to those without rheumatic diseases. Modifiable factors such as multimorbidity, active disease, obesity, and regular physical exercise were associated with HRQoL in these conditions.
QUALITY OF LIFE RESEARCH
(2023)
Review
Rheumatology
Aurelie Najm, Carl S. Goodyear, Iain B. McInnes, Stefan Siebert
Summary: This review discusses the tissue, cellular, and molecular mechanisms underlying the clinical heterogeneity of PsA. It highlights the importance of tissue-based therapy in PsA treatment and its potential implications for improving clinical outcomes and trial design.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Rheumatology
Alen Zabotti, Gabriele De Marco, Laure Gossec, Xenofon Baraliakos, Daniel Aletaha, Annamaria Iagnocco, Paolo Gisondi, Peter Balint, Heidi Bertheussen, Wolf-Henning Boehncke, Nemanja S. Damjanov, Maarten de Wit, Enzo Errichetti, Helena Marzo-Ortega, Mikhail Protopopov, Lluis Puig, Ruben Queiro, Piero Ruscitti, Laura Savage, Georg Schett, Stefan Siebert, Tanja A. Stamm, Paul Studenic, Ilaria Tinazzi, Filip E. Van den Bosch, Annette van der Helm-van Mil, Abdulla Watad, Josef S. Smolen, Dennis G. McGonagle
Summary: This study proposes EULAR guidelines for the early diagnosis of psoriatic arthritis (PsA) by conducting research on multiple patients. It also establishes standardized operating procedures for clinical practice and trials, providing guidance and consensus in the field of prevention and interception of PsA for psoriasis patients.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Rheumatology
Evelyn Hsieh, Dzifa Dey, Rebecca Grainger, Mengtao Li, Pedro M. Machado, Manuel F. Ugarte-Gil, Jinoos Yazdany
Summary: Although the public health emergency associated with the COVID-19 pandemic has ended, challenges remain for individuals with rheumatic diseases. Disruptions in healthcare and medication supply shortages have impacted the health and mental well-being of these individuals. Telemedicine and changes in healthcare utilization have also affected rheumatology practices globally. Efforts are needed to improve healthcare access, stabilize rheumatology drug supplies, and implement evidence-based vaccination practices to reduce COVID-19 morbidity and mortality among individuals with rheumatic diseases.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Rheumatology
Pedro M. Machado, Martin Schaefer, Satveer K. Mahil, Jean Liew, Laure Gossec, Nick Dand, Alexander Pfeil, Anja Strangfeld, Anne Constanze Regierer, Bruno Fautrel, Carla Gimena Alonso, Carla G. S. Saad, Christopher E. M. Griffiths, Claudia Lomater, Corinne Miceli-Richard, Daniel Wendling, Deshire Alpizar Rodriguez, Dieter Wiek, Elsa F. Mateus, Emily Sirotich, Enrique R. Soriano, Francinne Machado Ribeiro, Felipe Omura, Frederico Rajao Martins, Helena Santos, Jonathan Dau, Jonathan N. Barker, Jonathan Hausmann, Kimme L. Hyrich, Lianne Gensler, Ligia Silva, Lindsay Jacobsohn, Loreto Carmona, Marcelo M. Pinheiro, Marcos David Zelaya, Maria de los Angeles Severina, Mark Yates, Maureen Dubreuil, Monique Gore-Massy, Nicoletta Romeo, Nigil Haroon, Paul Sufka, Rebecca Grainger, Rebecca Hasseli, Saskia Lawson-Tovey, Suleman Bhana, Thao Pham, Tor Olofsson, Wilson Bautista-Molano, Zachary S. Wallace, Zenas Z. N. Yiu, Jinoos Yazdany, Philip C. Robinson, Catherine H. Smith
Summary: This study investigated factors associated with severe COVID-19 in patients with psoriasis, psoriatic arthritis, and axial spondyloarthritis. The study found that age, sex, comorbidities, disease activity, and glucocorticoid use were associated with the severity of COVID-19. Additionally, later pandemic time periods, psoriasis, and the use of TNFi, IL17i, and IL-23i/IL-12+23i were associated with a reduced risk of severe COVID-19.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Zachary S. Wallace, Jeffrey A. Sparks, Philip C. Robinson, Pedro M. Machado, Jinoos Yazdany
ANNALS OF THE RHEUMATIC DISEASES
(2023)