☆ 4.7 Article

Prevention and management of dermatological toxicities related to anticancer agents: ESMO Clinical Practice Guidelines

ANNALS OF ONCOLOGY (2021)

期刊

ANNALS OF ONCOLOGY

卷 32, 期 2, 页码 157-170

出版社

ELSEVIER

DOI: 10.1016/j.annonc.2020.11.005

关键词

Supportive care; dermatological toxicities; acneiform rash; hand-foot syndrome; drug-induced pruritus; chemotherapy-induced alopecia

类别

Oncology

资金

ESMO from central funds

向作者/读者索取更多资源

Protocol

社区支持

Reagent

社区支持

作者

我是这篇论文的作者

点击您的名字以认领此论文并将其添加到您的个人资料中。

主要评分

4.7

评分不足

次要评分

新颖性

重要性

科学严谨性

评价这篇论文

Reducing Acneiform Rash Induced by EGFR Inhibitors With Honeysuckle Therapy: A Prospective, Randomized, Controlled Study

Zhen Liu, Tian Tian, Binbin Wang, Demin Lu, Jian Ruan, Jianzhen Shan

Summary: Honeysuckle has been proven to be effective in reducing the incidences and severities of EGFRIs induced acneiform rash, especially for prophylactic treatment.

FRONTIERS IN PHARMACOLOGY (2022)

添加到收藏夹

Review Oncology

Case report: Zanubrutinib-induced dermatological toxicities: A single-center experience and review

Lingling Wang, Jiao Tang, Jun Feng, Yongfen Huang, Yuexin Cheng, Hao Xu, Yuqing Miao

Summary: Zanubrutinib, a next-generation BTK inhibitor, demonstrates efficacy in treating B cell malignancies. However, some patients may experience severe dermatological toxicities after treatment, leading to discontinuation of the drug.

FRONTIERS IN ONCOLOGY (2022)

添加到收藏夹

Article Medicine, Research & Experimental

Capecitabine-induced hand-foot syndrome: A pharmacogenetic study beyond DPYD

Mirjam de With, Leni van Doorn, Demi C. Maasland, Tessa A. M. Mulder, Esther Oomen-de Hoop, Bianca Mostert, Marjolein Y. V. Homs, Samira El Bouazzaoui, Ron H. J. Mathijssen, Ron H. N. van Schaik, Sander Bins

Summary: This study investigated whether single nucleotide polymorphisms (SNPs) in genes involved in capecitabine metabolism other than DPYD are associated with an increased risk for capecitabine-induced hand-foot syndrome (HFS). The results showed that carriers of the CES1 1165-33 C>A (rs2244613) and CDA 266 + 242 A>G (rs10916825) variant alleles have a higher risk of HFS grade 2.

BIOMEDICINE & PHARMACOTHERAPY (2023)

添加到收藏夹

Article Medical Laboratory Technology

Nitric oxide in multikinase inhibitor-induced hand-foot skin reaction

L. E. Y. I. N. G. CHEN, Z. H. A. O. Y. U. WU, L. I. N. A. N. YANG, Y. U. Y. U. N. CHEN, W. E. N. H. O. N. G. WANG, L. I. T. I. N. G. CHENG, C. H. O. N. G. L, D. A. Z. H. A. O. L, L. I. A. N. G. Y. O. N. G. XIA, J. I. A. CHEN, L. I. N. A. TANG, L. I. ZHANG, S. H. I. Y. I. ZHANG, J. I. E. LUO

Summary: Hand-foot skin reaction (HFSR) is a common and debilitating side effect caused by multikinase inhibitors (MKIs). This study proposes a potential treatment using glyceryl trinitrate (GTN) to reverse MKI-induced toxicity and alleviate HFSR symptoms. The mechanism of action involves upregulation of VEGF/VEGFR downstream signaling pathways.

TRANSLATIONAL RESEARCH (2022)

添加到收藏夹

Article Dermatology

Hand and foot dermatitis in patients referred for patch testing: Analysis of North American Contact Dermatitis Group Data, 2001-2018

Jonathan Silverberg, Nisha Patel, Erin M. Warshaw, Joel G. DeKoven, Donald Belsito, Amber Reck Atwater, Marie-Claude Houle, James S. Taylor, Margo J. Reeder, Kathryn A. Zug, Denis Sasseville, Vincent A. DeLeo, Melanie D. Pratt, Joseph F. Fowler, Howard Maibach

Summary: This study retrospectively analyzed patch testing data and found differences in patient characteristics, etiologies, and allergens between hand dermatitis, foot dermatitis, and hand-foot dermatitis.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2022)

添加到收藏夹

Review Oncology

Apatinib-Induced Hand-Foot Skin Reaction in Chinese Patients With Liver Cancer

Hui Xia, Cheng Zhou, Zhaoxia Luo, Ping Zhang, Liping Zhu, Zhao Gong

Summary: Apatinib, a drug targeting VEGFR2, has shown effectiveness in Chinese liver cancer patients, but with a high incidence of hand-foot skin reactions. The potential molecular mechanisms behind AI-HFSR are poorly understood and require further investigation.

FRONTIERS IN ONCOLOGY (2021)

添加到收藏夹

Article Dermatology

Alopecia totalis following hand-foot-and-mouth disease

Sandra Oska, Lisa M. Bedford, Geoffrey A. Potts

Summary: A 13-month-old boy developed alopecia totalis two months after an episode of hand-foot-and-mouth disease, suggesting a potential link between viral infection and autoimmune response leading to hair loss. Further research is needed to investigate the pathophysiology of alopecia totalis triggered by viral infection.

PEDIATRIC DERMATOLOGY (2021)

添加到收藏夹

Article Oncology

Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome

Katie Watts, Christopher Wills, Ayman Madi, Claire Palles, Timothy S. Maughan, Richard Kaplan, Nada A. Al-Tassan, Rachel Kerr, David J. Kerr, Richard S. Houlston, Valentina Escott-Price, Jeremy P. Cheadle

Summary: Cancer patients treated with XELOX often develop hand-foot syndrome, which is associated with genetic variation in the ST6GAL1 gene. This study found that hand-foot syndrome is a biomarker of treatment outcome and that rs6783836 in ST6GAL1 is a potential biomarker for hand-foot syndrome with links to type-2 diabetes and inflammation.

INTERNATIONAL JOURNAL OF CANCER (2022)

添加到收藏夹

Article Pharmacology & Pharmacy

Regulatory CDH4 Genetic Variants Associate With Risk to Develop Capecitabine-Induced Hand-Foot Syndrome

Sara Ruiz-Pinto, Guillermo Pita, Miguel Martin, Rocio Nunez-Torres, Ana Cuadrado, Marta N. Shahbazi, Daniela Caronia, Alexander Kojic, Leticia T. Moreno, Julio C. de la Torre-Montero, Maria Lozano, Luis A. Lopez-Fernandez, Nuria Ribelles, Jose A. Garcia-Saenz, Emilio Alba, Roger L. Milne, Ana Losada, Mirna Perez-Moreno, Javier Benitez, Anna Gonzalez-Neira

Summary: The study identified novel genetic factors associated with Capecitabine-induced hand-foot syndrome (CiHFS) and revealed a molecular mechanism underlying individual genetic susceptibility, with implications for clinically relevant risk prediction.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

添加到收藏夹

Article Nanoscience & Nanotechnology

Reactive Oxygen Species-Mediated Inflammation and Apoptosis in Hand-Foot Syndrome Induced by PEGylated Liposomal Doxorubicin

Xiaolin Hu, Mengmeng Dong, Xiao Liang, Ziling Liu, Quanshun Li

Summary: The administration of PLD has been shown to induce histological damage of skin tissues, including destruction of collagen fibers and severe inflammation and apoptosis of epidermal cells. This mechanism is likely due to the accumulation of PLD in skin tissues during long-term circulation, leading to the generation of ROS and oxidative damage to keratinocytes. ROS generation induced by PLD administration is a crucial factor in the development of HFS and may be a potential therapeutic target for alleviating symptoms.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

添加到收藏夹

Review Oncology

Identifying the supportive care needs of men and women affected by chemotherapy-induced alopecia? A systematic review

C. Paterson, M. Kozlovskaia, M. Turner, K. Strickland, C. Roberts, R. Ogilvie, G. Pranavan, P. Craft

Summary: The study systematically evaluated the impact of chemotherapy-induced alopecia on men and women, emphasizing the need for individualized supportive care to alleviate psychological burden.

JOURNAL OF CANCER SURVIVORSHIP (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Electric hand warmer versus observation to avoid discomfort during scalp cooling for chemotherapy-induced alopecia prevention: a randomized study

Luciana Castro Garcia Landeiro, Diego Lopes Paim Miranda, Roberto Mathias Machado, Rodrigo Dienstmann, Matheus Costa e Silva, Ceci Figueredo da Silva, Adriana Lisboa Ramalho de Castro, Ana Paula Teixeira dos Santos, Victor Hugo Valenca Bomfim, Bruno Teixeira Machado, Michele Viviane Carvalho Rodrigues Goncalves, Andrea Freitas Muniz Teixeira, Maira Jamile Santiago Costa, Priscila de Oliveira Dantas Viana, Pamela Almeida, Clarissa Maria de Cerqueira Mathias

Summary: This study suggests that the use of Electric Hand Warmers has a consistent positive impact on thermal comfort and general comfort for breast cancer patients undergoing scalp cooling to prevent chemotherapy-induced alopecia.

SCIENTIFIC REPORTS (2023)

添加到收藏夹

Letter Dermatology

Outcomes of Acitretin Treatment for Refractory Multikinase Inhibitor-Induced Hand-Foot Skin Reaction

Jordan T. Said, Sean Singer, Lisa Iannattone, Maxwell Sauder, Nicole R. LeBoeuf

Summary: This cohort study examines the outcomes of acitretin treatment for hand-foot skin reaction associated with multikinase inhibitors.

JAMA DERMATOLOGY (2022)

添加到收藏夹

Article Oncology

Risk factors of capecitabine-induced hand-foot syndrome: a single-institution, retrospective study

Yuko Kanbayashi, Tetsuya Taguchi, Takeshi Ishikawa, Eigo Otsuji, Koichi Takayama

Summary: This retrospective study aimed to identify risk factors for developing hand-foot syndrome (HFS) and determine new strategies for improving quality of life (QoL) in chemotherapy patients. The results showed that concomitant use of a renin angiotensin system (RAS) inhibitor, high body surface area (BSA), and low albumin were identified as risk factors for the development of HFS.

ONCOLOGY (2023)

添加到收藏夹

Article Biochemistry & Molecular Biology

A Potential Association of Zinc Deficiency and Tyrosine Kinase Inhibitor-Induced Hand-Foot Skin Reaction

Chun-Nan Yeh, Wen-Kuan Huang, Chun-Wei Lu, Chiao-Ping Chen, Sheng-Hsuan Lin, Yi-Ru Pan, Chiao-En Wu

Summary: Hand-foot skin reaction (HFSR) is a common adverse event induced by multikinase inhibitors, and there may be a possible association between HFSR and zinc deficiency. Zinc plays critical roles in skin cell development and differentiation. Current evidence suggests that zinc supplementation may relieve HFSR symptoms, but large-scale clinical studies are still needed to explore this potential link.

BIOLOGICAL TRACE ELEMENT RESEARCH (2023)

添加到收藏夹

Article Dermatology

Dermatology inpatient consultations in a tertiary hospital - a retrospective analysis

Joseph Joseph, Kelvin Truong, Annika Smith, Pablo Fernandez-Penas

Summary: This study analyzed 306 dermatology consultations in a tertiary Australian hospital for inpatients, showing that dermatologists changed or established management plans in 82% of cases. The most commonly misdiagnosed conditions were dermatitis and skin infections. The study highlights the importance of dermatology input in improving diagnosis and management for hospitalized patients, potentially reducing unnecessary investigations and improving healthcare quality.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2022)

添加到收藏夹

Article Dermatology

Clinicopathological characteristics of new primary melanomas in patients receiving immune checkpoint inhibitor therapy for metastatic melanoma

Thomas E. Pennington, Cathy Yunjia Zhao, Andrew J. Colebatch, Pablo Fernandez-Penas, Pascale Guitera, Hazel Burke, Richard A. Scolyer, Alexander M. Menzies, Matteo S. Carlino, Serigne Lo, Georgina Long, Robyn P. M. Saw

Summary: Rates of new primary melanomas in patients treated with immune checkpoint inhibitors are low, with the new melanomas typically being detected at an early stage and having features associated with a favorable prognosis, likely due to close surveillance. Further study is needed to determine the long-term risk in patients achieving a durable response to immune checkpoint inhibitors and to investigate the potential influence of immunotherapy on the development and biology of new primary melanomas.