Chemically Fueled Self-Assembly in Biology and Chemistry

Life is a non-equilibrium state of matter maintained at the expense of energy. Nature uses predominantly chemical energy stored in thermodynamically activated, but kinetically stable, molecules. These high-energy molecules are exploited for the synthesis of other biomolecules, for the activation of biological machinery such as pumps and motors, and for the maintenance of structural order. Knowledge of how chemical energy is transferred to biochemical processes is essential for the development of artificial systems with life-like processes. Here, we discuss how chemical energy can be used to control the structural organization of organic molecules. Four different strategies have been identified according to a distinguishable physical-organic basis. For each class, one example from biology and one from chemistry are discussed in detail to illustrate the practical implementation of each concept and the distinct opportunities they offer. Specific attention is paid to the discussion of chemically fueled non-equilibrium self-assembly. We discuss the meaning of non-equilibrium self-assembly, its kinetic origin, and strategies to develop synthetic non-equilibrium systems.

Automated summary

Life is a non-equilibrium state of matter sustained by energy expenditure, mostly utilizing chemical energy stored in molecules. Understanding the transfer of chemical energy to biochemical processes is crucial for developing artificial systems with life-like processes. Strategies for controlling the structural organization of organic molecules have been identified based on distinguishable physical-organic foundations, with examples from biology and chemistry illustrating their practical implementation and unique opportunities.