4.5 Review

Novel and Evolving Therapies for COVID-19 Related Pulmonary Complications,

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AMERICAN JOURNAL OF THE MEDICAL SCIENCES
卷 361, 期 5, 页码 557-566

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.amjms.2021.02.019

关键词

COVID-19; Pulmonary therapy; Inhaled vaccine; Intranasal drug delivery; Dry powders; Drug repurposing and disposable medical devices

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COVID-19 is a critical threat to the world, confirmed by the World Health Organization as a global public health crisis. Research on the natural route of infection and treatment of COVID-19 is still in its early stages, with studies on pulmonary delivery potentially offering a more rational approach to managing the disease.
Coronaviruses disease 2019 (COVID-19) is the most crucial threat, the world has ever witnessed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of this disease pandemic. The World Health Organization has confirmed the continuing epidemic as a worldwide public health crisis. Presently, the research on COVID-19 is even in the primitive stage. Studies on unveiling the natural route of COVID-19 infection and related pathophysiology, the biology of pul-monary airways pose a more rational restorative approach in the management of COVID-19. Thus, based on the existing facts, we methodically reviewed the efforts put forth by various research institutes, pharmaceutical companies and biotechnol-ogy firms in pulmonary delivery to prevent and control the COVID-19. This article would be valuable for the healthcare commu-nity, which is efficiently dealing with the SARS-CoV-2 crisis.

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