Article
Immunology
Munish Puri, Socorro Miranda-Hernandez, Selvakumar Subbian, Andreas Kupz
Summary: Tuberculosis (TB) is a deadly infectious disease, and the only approved vaccine, BCG, provides limited protection against pulmonary TB in adults. Delivering BCG directly into the lungs has shown enhanced immune responses and greater protection against TB. This article discusses the repurposing of existing inhalation devices for mucosal delivery of live attenuated TB vaccines and outlines the challenges and research questions that need to be addressed for their use in TB endemic countries.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Natalia Moreno-Castellanos, Sarah A. Stewart, Camila J. Picco, Qonita Kurnia Anjani, Jon Ander Simon, Ivan Penuelas, Ryan F. Donnelly, Eneko Larraneta
Summary: This study describes the preparation and characterisation of intranasal implants for the delivery of risperidone. The implants showed potential for prolonged drug release and exhibited desirable permeation rate through a model membrane simulating nasal mucosa. The study provides insights into developing better therapies for chronic brain conditions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Emilia Utomo, Juan Dominguez-Robles, Natalia Moreno-Castellanos, Sarah A. Stewart, Camila J. Picco, Qonita Kurnia Anjani, Jon Ander Simon, Ivan Penuelas, Ryan F. Donnelly, Eneko Larraneta
Summary: In this study, intranasal implants were prepared for the delivery of risperidone using biodegradable materials. The results showed that the implants have the potential to provide prolonged drug release for brain-targeting drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Regina Scherliess, Simon Bock, Nicholas Bungert, Anna Neustock, Lena Valentin
Summary: Dry powder inhalation is an effective method for treating respiratory diseases, but faces challenges in formulation development. This review provides an overview of particle engineering as a formulation technique and optimization approach, and discusses future possibilities for carrier engineering.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Bharti Mangla, Shamama Javed, Muhammad H. Sultan, Waquar Ahsan, Geeta Aggarwal, Kanchan Kohli
Summary: Drug delivery via the oral route is popular due to its convenience, safety, and cost-effectiveness. Transmucosal delivery, especially through the oral mucosa, is being investigated for efficient administration of bioactive compounds, including vaccines. Needle-free devices have been developed to improve patient compliance by reducing anxiety and pain. Nanocarriers enhance vaccine bioavailability and immune response, leading to increased efficacy. This review summarizes recent research on needle-free and non-invasive approaches for oral transmucosal vaccine delivery, highlighting their strengths and challenges.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Ilin Sadeghi, James Byrne, Rameen Shakur, Robert Langer
Summary: There is a pressing need for innovative solutions to address global health needs. Polymeric systems have shown significant benefits in healthcare, especially in drug delivery. This review focuses on polymeric drug delivery devices for vaccines, tuberculosis, and contraception.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Yu-Sheng Yu, Khaled AboulFotouh, Haiyue Xu, Gerallt Williams, Julie Suman, Chris Cano, Zachary N. Warnken, Kevin C. -W Wu, Robert O. Williams III, Zhengrong Cui
Summary: In this study, a model vaccine containing liposomal monophosphoryl lipid A, QS-21 adjuvant, and ovalbumin (OVA) was successfully transformed from a liquid to a dry powder using thin-film freeze-drying technology. The dry powder was then administered to the desired regions of the nasal cavity using Aptar Pharma's Unidose Powder Nasal Spray System (UDSP), demonstrating the feasibility of intranasal vaccination.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yuqing Ye, Ying Ma, Jesse Zhu
Summary: Dry powder inhalation therapy has been proven effective in the treatment of respiratory diseases and has gained wide acceptance in clinical practices. There is growing interest in using this therapy for systemic diseases, including its potential application in COVID-19 treatment. This paper reviews the current status of marketed and in-development dry powder inhalers for systemic diseases and summarizes the advancements and challenges in DPI systems. It concludes that dry powder inhalation therapy holds great potential and promise for the treatment of systemic disorders.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Suryanarayana Polaka, Vaishali Makwana, Nupur Vasdev, Anjani Sheth, Kuldeep Rajpoot, Pinaki Sengupta, Rakesh Kumar Tekade
Summary: This article explores methods and vehicles for skin immunization and discusses various vaccine delivery systems used currently. The article points out that there are still many issues to be addressed in the translation of vaccines from the laboratory to practical use.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Alberto Baldelli, Chun Wong, Hale Oguzlu, Hanieh Mahvizani, Hui Xin Ong, Athenea Pascual Rodriguez, Gurpreet Singhera, Andrew Thamboo, Anika Singh, Daniela Traini, Anubhav Pratap-Singh
Summary: Spray freeze drying is a suitable method for producing inhalable encapsulated drugs for nasal delivery, with different amino acids affecting stability and performance. Leucine enhances stability, while lysine enables targeting of the olfactory region.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ashlee D. Brunaugh, Shivam Sharma, Hugh Smyth
Summary: Inhaled fixed-dose combination powders (I-FDCs) offer a promising approach for the treatment of respiratory infections by enabling simultaneous drug delivery at the site of infection. The use of co-spray drying shows potential for the development of composite anti-infective particles for inhalation. Future research may focus on including immunomodulatory agents or repurposed non-antibiotics in fixed-dose combinations.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Review
Pharmacology & Pharmacy
Laura Chaffey, Annabell Roberti, David R. Greaves
Summary: Drug repurposing is a promising approach in drug discovery for cardiovascular disease. Chronic inflammation plays a significant role in cardiovascular pathology, and targeting inflammation is a potential therapeutic strategy. However, challenges remain due to off-target effects and long-term conditions. Assessing repurposed anti-inflammatory drugs in cardiovascular clinical trials has shown mixed successes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Tuksin Jearanaiwitayakul, Mathurin Seesen, Runglawan Chawengkirttikul, Jitra Limthongkul, Suttikarn Apichirapokey, Sompong Sapsutthipas, Supaporn Phumiamorn, Panya Sunintaboon, Sukathida Ubol
Summary: The study showed that loading the receptor-binding domain of SARS-CoV-2 spike glycoprotein into N,N,N-trimethyl chitosan nanoparticles and administering it intranasally to mice induced robust local mucosal immunity and systemic antibody responses. This alternative route of vaccination not only stimulated local mucosal responses, but also the systemic compartment of the immune system.
Article
Pharmacology & Pharmacy
Ho Wan Chan, Hok Wai Lee, Stephanie Chow, David Chi Leung Lam, Shing Fung Chow
Summary: This study developed a continuous process for fabricating inhalable nanoagglomerate dry powder formulations of remdesivir (RDV). The optimized formulation showed good redispersibility and aerosol performance, and the RDV nanoparticles displayed enhanced cell uptake and low cytotoxicity in vitro. Moreover, the continuous manufacturing process showed no significant differences in the quality attributes compared to the standalone batch mode.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Vividha Dhapte, Vivek Kadam, Varsha Pokharkar
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2013)
Article
Instruments & Instrumentation
Varsha Pokharkar, Smita Suryawanshi, Vividha Dhapte-Pawar
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2020)
Review
Instruments & Instrumentation
Prashant Pingale, Shilpa Dawre, Vividha Dhapte-Pawar, Namdev Dhas, Amarjitsing Rajput
Summary: The advancement of 4D printing is driven by the demand for additive manufacturing and shape-memory materials. It allows the printing of substances that respond to external stimuli and simulate physiological environments. This review focuses on the basics and methods of 4D printing, as well as the time-dependent behavior of stimulus-sensitive compounds. It also discusses material aspects and potential applications in the biomedical sector.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Prasad G. Joshi, Minakshi S. More, Neha Bisht, Priyanka Phalswal, Vividha Dhapte-Pawar, Pawan K. Khanna
Summary: In this study, silver nanoparticles were synthesized using semicarbazones, exploring their potential in nanotechnology. The synthesized silver nanoparticles showed enhanced antimicrobial properties, indicating promising applications in the field.
NEW JOURNAL OF CHEMISTRY
(2021)
Review
Instruments & Instrumentation
Piyush P. Mehta, Vividha S. Dhapte-Pawar
Summary: The article provides a comprehensive account of the importance of drug repurposing in the treatment of pulmonary diseases, highlighting both challenges and advantages.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Vividha Dhapte-Pawar, Shivajirao Kadam, Shai Saptarsi, Prathmesh P. Kenjale