MYC-mediated ribosomal gene expression sensitizes enzalutamide-resistant prostate cancer cells to EP300/CREBBP inhibitors

p300 is upregulated by docetaxel and is a target in chemoresistant prostate cancer

(2020) Martina Gruber et al.   ENDOCRINE-RELATED CANCER

Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis

(2020) Richard Y. Ebright et al.   SCIENCE

Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells

(2020) Lingling Fan et al.   Cell Death & Disease

Pharmacological and genetic targeting of 5-lipoxygenase interrupts c-Myc oncogenic signaling and kills enzalutamide-resistant prostate cancer cells via apoptosis

(2020) Jitender Monga et al.   Scientific Reports

A Phase 1b/2a Study of the Pan-BET Bromodomain Inhibitor ZEN-3694 in Combination with Enzalutamide in Patients with Metastatic Castration Resistant Prostate Cancer

(2020) Rahul R. Aggarwal et al.   CLINICAL CANCER RESEARCH

GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistance

(2019) Eugine Lee et al.   eLife

BET bromodomain inhibition blocks the function of a critical AR-independent master regulator network in lethal prostate cancer

(2019) Daniel J. Coleman et al.   ONCOGENE

Genomic correlates of clinical outcome in advanced prostate cancer

(2019) Wassim Abida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drivers of AR indifferent anti-androgen resistance in prostate cancer cells

(2019) Florian Handle et al.   Scientific Reports

Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

(2018) Brian T. Weinert et al.   CELL

Molecular underpinnings of enzalutamide resistance

(2018) Stefan Prekovic et al.   ENDOCRINE-RELATED CANCER

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2018 update

(2018) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation

(2018) Katerina Cermakova et al.   MOLECULES

Aberrant expression of CITED2 promotes prostate cancer metastasis by activating the nucleolin-AKT pathway

(2018) Seung-Hyun Shin et al.   Nature Communications

Heterogeneous Ribosomes Preferentially Translate Distinct Subpools of mRNAs Genome-wide

(2017) Zhen Shi et al.   MOLECULAR CELL

Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

(2017) Neel Shah et al.   eLife

Expression of ribosomal proteins in normal and cancerous human prostate tissue

(2017) Callum Arthurs et al.   PLoS One

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

(2016) Alexander M. Taylor et al.   ACS Medicinal Chemistry Letters

Critical role of androgen receptor level in prostate cancer cell resistance to new generation antiandrogen enzalutamide

(2016) Julia Hoefer et al.   Oncotarget

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

(2015) S. Picaud et al.   CANCER RESEARCH

Protein Lysine Acetylation by p300/CBP

(2015) Beverley M. Dancy et al.   CHEMICAL REVIEWS

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia

(2015) G Giotopoulos et al.   ONCOGENE

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade

(2013) Vivek K. Arora et al.   CELL

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

(2013) Gai Yan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Selective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells

(2011) Irina Ianculescu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

(2011) F. R. Santer et al.   MOLECULAR CANCER THERAPEUTICS

siRNA Knockdown of Ribosomal Protein Gene RPL19 Abrogates the Aggressive Phenotype of Human Prostate Cancer

(2011) Alix Bee et al.   PLoS One

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

(2011) Hongkai Ji et al.   PLoS One

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes

(2010) Jihong Chen et al.   Epigenetics

Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways

(2009) M. Puhr et al.   CANCER RESEARCH

Chromosome 8p Deletions and 8q Gains are Associated with Tumor Progression and Poor Prognosis in Prostate Cancer

(2009) A. T. El Gammal et al.   CLINICAL CANCER RESEARCH

Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer

(2009) C. Tran et al.   SCIENCE

TMPRSS2:ERG Fusion Identifies a Subgroup of Prostate Cancers with a Favorable Prognosis

(2008) O. R. Saramaki et al.   CLINICAL CANCER RESEARCH